Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study

Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	George Valasoulis [verfasserIn] Abraham Pouliakis [verfasserIn] Georgios Michail [verfasserIn] Ioulia Magaliou [verfasserIn] Christos Parthenis [verfasserIn] Niki Margari [verfasserIn] Christine Kottaridi [verfasserIn] Aris Spathis [verfasserIn] Danai Leventakou [verfasserIn] Argyro-Ioanna Ieronimaki [verfasserIn] Georgios Androutsopoulos [verfasserIn] Periklis Panagopoulos [verfasserIn] Alexandros Daponte [verfasserIn] Sotirios Tsiodras [verfasserIn] Ioannis G. Panayiotides [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections

Übergeordnetes Werk:	In: Pathogens - MDPI AG, 2012, 12(2023), 11, p 1347
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:11, p 1347

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pathogens12111347

Katalog-ID:	DOAJ101202911

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520			\|a Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation.
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700	0		\|a Christos Parthenis \|e verfasserin \|4 aut
700	0		\|a Niki Margari \|e verfasserin \|4 aut
700	0		\|a Christine Kottaridi \|e verfasserin \|4 aut
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700	0		\|a Ioannis G. Panayiotides \|e verfasserin \|4 aut
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allfields	10.3390/pathogens12111347 doi (DE-627)DOAJ101202911 (DE-599)DOAJ96dc0a888c314f84922c5dd85a48efc9 DE-627 ger DE-627 rakwb eng George Valasoulis verfasserin aut Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation. epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections Medicine R Abraham Pouliakis verfasserin aut Georgios Michail verfasserin aut Ioulia Magaliou verfasserin aut Christos Parthenis verfasserin aut Niki Margari verfasserin aut Christine Kottaridi verfasserin aut Aris Spathis verfasserin aut Danai Leventakou verfasserin aut Argyro-Ioanna Ieronimaki verfasserin aut Georgios Androutsopoulos verfasserin aut Periklis Panagopoulos verfasserin aut Alexandros Daponte verfasserin aut Sotirios Tsiodras verfasserin aut Ioannis G. Panayiotides verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 11, p 1347 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:11, p 1347 https://doi.org/10.3390/pathogens12111347 kostenfrei https://doaj.org/article/96dc0a888c314f84922c5dd85a48efc9 kostenfrei https://www.mdpi.com/2076-0817/12/11/1347 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1347
spelling	10.3390/pathogens12111347 doi (DE-627)DOAJ101202911 (DE-599)DOAJ96dc0a888c314f84922c5dd85a48efc9 DE-627 ger DE-627 rakwb eng George Valasoulis verfasserin aut Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation. epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections Medicine R Abraham Pouliakis verfasserin aut Georgios Michail verfasserin aut Ioulia Magaliou verfasserin aut Christos Parthenis verfasserin aut Niki Margari verfasserin aut Christine Kottaridi verfasserin aut Aris Spathis verfasserin aut Danai Leventakou verfasserin aut Argyro-Ioanna Ieronimaki verfasserin aut Georgios Androutsopoulos verfasserin aut Periklis Panagopoulos verfasserin aut Alexandros Daponte verfasserin aut Sotirios Tsiodras verfasserin aut Ioannis G. Panayiotides verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 11, p 1347 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:11, p 1347 https://doi.org/10.3390/pathogens12111347 kostenfrei https://doaj.org/article/96dc0a888c314f84922c5dd85a48efc9 kostenfrei https://www.mdpi.com/2076-0817/12/11/1347 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1347
allfields_unstemmed	10.3390/pathogens12111347 doi (DE-627)DOAJ101202911 (DE-599)DOAJ96dc0a888c314f84922c5dd85a48efc9 DE-627 ger DE-627 rakwb eng George Valasoulis verfasserin aut Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation. epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections Medicine R Abraham Pouliakis verfasserin aut Georgios Michail verfasserin aut Ioulia Magaliou verfasserin aut Christos Parthenis verfasserin aut Niki Margari verfasserin aut Christine Kottaridi verfasserin aut Aris Spathis verfasserin aut Danai Leventakou verfasserin aut Argyro-Ioanna Ieronimaki verfasserin aut Georgios Androutsopoulos verfasserin aut Periklis Panagopoulos verfasserin aut Alexandros Daponte verfasserin aut Sotirios Tsiodras verfasserin aut Ioannis G. Panayiotides verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 11, p 1347 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:11, p 1347 https://doi.org/10.3390/pathogens12111347 kostenfrei https://doaj.org/article/96dc0a888c314f84922c5dd85a48efc9 kostenfrei https://www.mdpi.com/2076-0817/12/11/1347 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1347
allfieldsGer	10.3390/pathogens12111347 doi (DE-627)DOAJ101202911 (DE-599)DOAJ96dc0a888c314f84922c5dd85a48efc9 DE-627 ger DE-627 rakwb eng George Valasoulis verfasserin aut Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation. epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections Medicine R Abraham Pouliakis verfasserin aut Georgios Michail verfasserin aut Ioulia Magaliou verfasserin aut Christos Parthenis verfasserin aut Niki Margari verfasserin aut Christine Kottaridi verfasserin aut Aris Spathis verfasserin aut Danai Leventakou verfasserin aut Argyro-Ioanna Ieronimaki verfasserin aut Georgios Androutsopoulos verfasserin aut Periklis Panagopoulos verfasserin aut Alexandros Daponte verfasserin aut Sotirios Tsiodras verfasserin aut Ioannis G. Panayiotides verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 11, p 1347 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:11, p 1347 https://doi.org/10.3390/pathogens12111347 kostenfrei https://doaj.org/article/96dc0a888c314f84922c5dd85a48efc9 kostenfrei https://www.mdpi.com/2076-0817/12/11/1347 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1347
allfieldsSound	10.3390/pathogens12111347 doi (DE-627)DOAJ101202911 (DE-599)DOAJ96dc0a888c314f84922c5dd85a48efc9 DE-627 ger DE-627 rakwb eng George Valasoulis verfasserin aut Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation. epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections Medicine R Abraham Pouliakis verfasserin aut Georgios Michail verfasserin aut Ioulia Magaliou verfasserin aut Christos Parthenis verfasserin aut Niki Margari verfasserin aut Christine Kottaridi verfasserin aut Aris Spathis verfasserin aut Danai Leventakou verfasserin aut Argyro-Ioanna Ieronimaki verfasserin aut Georgios Androutsopoulos verfasserin aut Periklis Panagopoulos verfasserin aut Alexandros Daponte verfasserin aut Sotirios Tsiodras verfasserin aut Ioannis G. Panayiotides verfasserin aut In Pathogens MDPI AG, 2012 12(2023), 11, p 1347 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:12 year:2023 number:11, p 1347 https://doi.org/10.3390/pathogens12111347 kostenfrei https://doaj.org/article/96dc0a888c314f84922c5dd85a48efc9 kostenfrei https://www.mdpi.com/2076-0817/12/11/1347 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1347
language	English
source	In Pathogens 12(2023), 11, p 1347 volume:12 year:2023 number:11, p 1347
sourceStr	In Pathogens 12(2023), 11, p 1347 volume:12 year:2023 number:11, p 1347
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections Medicine R
isfreeaccess_bool	true
container_title	Pathogens
authorswithroles_txt_mv	George Valasoulis @@aut@@ Abraham Pouliakis @@aut@@ Georgios Michail @@aut@@ Ioulia Magaliou @@aut@@ Christos Parthenis @@aut@@ Niki Margari @@aut@@ Christine Kottaridi @@aut@@ Aris Spathis @@aut@@ Danai Leventakou @@aut@@ Argyro-Ioanna Ieronimaki @@aut@@ Georgios Androutsopoulos @@aut@@ Periklis Panagopoulos @@aut@@ Alexandros Daponte @@aut@@ Sotirios Tsiodras @@aut@@ Ioannis G. Panayiotides @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	732627885
id	DOAJ101202911
language_de	englisch
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A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). 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author	George Valasoulis
spellingShingle	George Valasoulis misc epidemiology misc public health misc cervical screening misc HPV misc human papillomavirus misc sexually transmitted infections misc Medicine misc R Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study
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topic_title	Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study epidemiology public health cervical screening HPV human papillomavirus sexually transmitted infections
topic	misc epidemiology misc public health misc cervical screening misc HPV misc human papillomavirus misc sexually transmitted infections misc Medicine misc R
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title	Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study
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title_full	Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study
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author_browse	George Valasoulis Abraham Pouliakis Georgios Michail Ioulia Magaliou Christos Parthenis Niki Margari Christine Kottaridi Aris Spathis Danai Leventakou Argyro-Ioanna Ieronimaki Georgios Androutsopoulos Periklis Panagopoulos Alexandros Daponte Sotirios Tsiodras Ioannis G. Panayiotides
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title_sort	cervical hpv infections, sexually transmitted bacterial pathogens and cytology findings—a molecular epidemiology study
title_auth	Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study
abstract	Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation.
abstractGer	Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation.
abstract_unstemmed	Prevalent cervical HPV infection and high-risk HPV persistence consequences have been extensively investigated in the literature; nevertheless, any causative interrelations of other sexually transmitted bacterial infections (STIs) with cervical HPV infection have not yet been fully elucidated. This study aimed to investigate the possible association of STIs with cervical cytology aberrations and HPV genotyping results in a representative sample of predominantly young Greek women. Liquid-based cytology and molecular detection for bacterial STIs and HPV as well as extended HPV genotyping were simultaneously assessed in cervical samples from 2256 individuals visiting several urban outpatient Gynecology Departments for well-woman visits or cervical screening throughout a 20-month period. All specimens were centrally processed with validated molecular assays. The mean age of the studied women was 37.0 ± 11.7 years; 722 women (33.30%) tested positive for STI (mean age 34.23 ± 10.87 years). A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation.
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title_short	Cervical HPV Infections, Sexually Transmitted Bacterial Pathogens and Cytology Findings—A Molecular Epidemiology Study
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A higher mean age (38.34 ± 11.83 years (<i<p</i< < 0.05)) was associated with negative STI testing. <i<Chlamydia trachomatis</i< was detected in 59 individuals (8.2%), <i<Mycoplasma hominis</i< in 156 (21.6%), <i<Mycoplasma genitalium</i< in 14 (1.9%), and <i<Ureaplasma</i< spp. in 555 (76.9%); infections with two bacterial pathogens were identified in 73 samples (10.1%). Cervical HPV was detected in 357 out of 1385 samples with a valid HPV typing result (25.8%). The mean age of HPV-positive women was 32.0 ± 8.4 years; individuals testing HPV-negative were slightly older (N = 1028): 34.4 ± 9.2 (<i<p</i< < 0.05). Among the 1371 individuals with valid results both for bacterial STIs and cervical HPV detection, women with an HPV-positive sample were more likely to harbor an STI (OR: 2.69, 95% CI 2.10–3.46, <i<p</i< < 0.05). Interestingly, bacterial STI positivity illustrated significant heterogeneity between NILM and LSIL cases, with 28.88% of NILM and 46.33% of LSIL cases harboring an STI, respectively (<i<p</i< < 0.05). In brief, in a population with a high prevalence for STIs, especially <i<Ureaplasma</i< spp., an association was documented between bacterial pathogen detection and cervical HPV infection, as well as abnormal cytology; these findings merit further investigation.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">epidemiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">public health</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cervical screening</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HPV</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">human papillomavirus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sexually transmitted infections</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abraham Pouliakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Michail</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioulia Magaliou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christos Parthenis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Niki Margari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christine Kottaridi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aris Spathis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Danai Leventakou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Argyro-Ioanna Ieronimaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Androutsopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Periklis Panagopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexandros Daponte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sotirios Tsiodras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis G. 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