The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature

Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the liter...
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Gespeichert in:

Autor*in:	Emmanuel Giannas [verfasserIn] Christos Kontovounisios [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	heparin LMWH antineoplastic anticarcinogenic colorectal cancer

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 22, p 7173
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:22, p 7173

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12227173

Katalog-ID:	DOAJ101228929

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allfields	10.3390/jcm12227173 doi (DE-627)DOAJ101228929 (DE-599)DOAJ0daf3ec6c312488f8dd0788cfed3efc2 DE-627 ger DE-627 rakwb eng Emmanuel Giannas verfasserin aut The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC. heparin LMWH antineoplastic anticarcinogenic colorectal cancer Medicine R Christos Kontovounisios verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 22, p 7173 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:22, p 7173 https://doi.org/10.3390/jcm12227173 kostenfrei https://doaj.org/article/0daf3ec6c312488f8dd0788cfed3efc2 kostenfrei https://www.mdpi.com/2077-0383/12/22/7173 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 22, p 7173
spelling	10.3390/jcm12227173 doi (DE-627)DOAJ101228929 (DE-599)DOAJ0daf3ec6c312488f8dd0788cfed3efc2 DE-627 ger DE-627 rakwb eng Emmanuel Giannas verfasserin aut The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC. heparin LMWH antineoplastic anticarcinogenic colorectal cancer Medicine R Christos Kontovounisios verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 22, p 7173 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:22, p 7173 https://doi.org/10.3390/jcm12227173 kostenfrei https://doaj.org/article/0daf3ec6c312488f8dd0788cfed3efc2 kostenfrei https://www.mdpi.com/2077-0383/12/22/7173 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 22, p 7173
allfields_unstemmed	10.3390/jcm12227173 doi (DE-627)DOAJ101228929 (DE-599)DOAJ0daf3ec6c312488f8dd0788cfed3efc2 DE-627 ger DE-627 rakwb eng Emmanuel Giannas verfasserin aut The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC. heparin LMWH antineoplastic anticarcinogenic colorectal cancer Medicine R Christos Kontovounisios verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 22, p 7173 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:22, p 7173 https://doi.org/10.3390/jcm12227173 kostenfrei https://doaj.org/article/0daf3ec6c312488f8dd0788cfed3efc2 kostenfrei https://www.mdpi.com/2077-0383/12/22/7173 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 22, p 7173
allfieldsGer	10.3390/jcm12227173 doi (DE-627)DOAJ101228929 (DE-599)DOAJ0daf3ec6c312488f8dd0788cfed3efc2 DE-627 ger DE-627 rakwb eng Emmanuel Giannas verfasserin aut The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC. heparin LMWH antineoplastic anticarcinogenic colorectal cancer Medicine R Christos Kontovounisios verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 22, p 7173 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:22, p 7173 https://doi.org/10.3390/jcm12227173 kostenfrei https://doaj.org/article/0daf3ec6c312488f8dd0788cfed3efc2 kostenfrei https://www.mdpi.com/2077-0383/12/22/7173 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 22, p 7173
allfieldsSound	10.3390/jcm12227173 doi (DE-627)DOAJ101228929 (DE-599)DOAJ0daf3ec6c312488f8dd0788cfed3efc2 DE-627 ger DE-627 rakwb eng Emmanuel Giannas verfasserin aut The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC. heparin LMWH antineoplastic anticarcinogenic colorectal cancer Medicine R Christos Kontovounisios verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 22, p 7173 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:22, p 7173 https://doi.org/10.3390/jcm12227173 kostenfrei https://doaj.org/article/0daf3ec6c312488f8dd0788cfed3efc2 kostenfrei https://www.mdpi.com/2077-0383/12/22/7173 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 22, p 7173
language	English
source	In Journal of Clinical Medicine 12(2023), 22, p 7173 volume:12 year:2023 number:22, p 7173
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topic_facet	heparin LMWH antineoplastic anticarcinogenic colorectal cancer Medicine R
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container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Emmanuel Giannas @@aut@@ Christos Kontovounisios @@aut@@
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author	Emmanuel Giannas
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topic_title	The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature heparin LMWH antineoplastic anticarcinogenic colorectal cancer
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title	The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature
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title_sort	antineoplastic effect of heparin on colorectal cancer: a review of the literature
title_auth	The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature
abstract	Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC.
abstractGer	Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC.
abstract_unstemmed	Heparin and derivatives are commonly used for thrombophylaxis in surgical colorectal cancer (CRC) patients. Recent studies have suggested that, besides its protective effect on the incidence of venous thromboembolism, heparin has an anti-cancer effect. The aim of this review was to explore the literature and report the antineoplastic effect of heparin and derivatives on CRC. MEDLINE and EMBASE databases were searched for relevant articles. Nineteen studies were included (<i<n</i< = 19). Fifteen were lab studies conducted in vivo or in vitro on CRC cell lines and/or mice (<i<n</i< = 15). Four were in vivo clinical studies (<i<n</i< = 4). CRC tumor growth was reduced by 78% in one study, (<i<p</i< < 0.01), while tumorigenesis was suppressed in heparin-treated mice in seven studies. A high dose of low molecular weight heparin for extended duration significantly reduced post-operative VEGF, suggesting that such a regime may inhibit tumor angiogenesis and distant metastasis. A randomized trial demonstrated the antineoplastic effect of nadroparin as the 6 month survival in palliative patients increased. Another study has reported that disease-free survival of CRC patients was not affected by a similar tinzaparin regime. The anti-cancer properties of heparin and derivatives are promising, especially in lab studies. Further clinical trials are needed to investigate the anti-cancer benefit of heparin on CRC.
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title_short	The Antineoplastic Effect of Heparin on Colorectal Cancer: A Review of the Literature
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