Galectin-10 Expression in Placentas of Women with Gestational Diabetes
Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with ge...
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| Autor*in: |
Christina Buschmann [verfasserIn] Laura Unverdorben [verfasserIn] Julia Knabl [verfasserIn] Stefan Hutter [verfasserIn] Sarah Meister [verfasserIn] Susanne Beyer [verfasserIn] Maximiliane Burgmann [verfasserIn] Lucia Keilmann [verfasserIn] Alaleh Zati zehni [verfasserIn] Elisa Schmoeckel [verfasserIn] Mirjana Kessler [verfasserIn] Udo Jeschke [verfasserIn] Sven Mahner [verfasserIn] Thomas Kolben [verfasserIn] Franziska Ganster [verfasserIn] Alexander Burges [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Current Issues in Molecular Biology - MDPI AG, 2021, 45(2023), 11, Seite 8840-8851 |
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| Übergeordnetes Werk: |
volume:45 ; year:2023 ; number:11 ; pages:8840-8851 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.3390/cimb45110554 |
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| Katalog-ID: |
DOAJ10125959X |
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| 520 | |a Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. | ||
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10.3390/cimb45110554 doi (DE-627)DOAJ10125959X (DE-599)DOAJf3b37256f3df4904be4d65b037dceb5c DE-627 ger DE-627 rakwb eng QH301-705.5 Christina Buschmann verfasserin aut Galectin-10 Expression in Placentas of Women with Gestational Diabetes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. galectin-10 gestational diabetes mellitus pregnancy Biology (General) Laura Unverdorben verfasserin aut Julia Knabl verfasserin aut Stefan Hutter verfasserin aut Sarah Meister verfasserin aut Susanne Beyer verfasserin aut Maximiliane Burgmann verfasserin aut Lucia Keilmann verfasserin aut Alaleh Zati zehni verfasserin aut Elisa Schmoeckel verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Sven Mahner verfasserin aut Thomas Kolben verfasserin aut Franziska Ganster verfasserin aut Alexander Burges verfasserin aut In Current Issues in Molecular Biology MDPI AG, 2021 45(2023), 11, Seite 8840-8851 (DE-627)355690365 (DE-600)2090836-2 14673045 nnns volume:45 year:2023 number:11 pages:8840-8851 https://doi.org/10.3390/cimb45110554 kostenfrei https://doaj.org/article/f3b37256f3df4904be4d65b037dceb5c kostenfrei https://www.mdpi.com/1467-3045/45/11/554 kostenfrei https://doaj.org/toc/1467-3037 Journal toc kostenfrei https://doaj.org/toc/1467-3045 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 11 8840-8851 |
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10.3390/cimb45110554 doi (DE-627)DOAJ10125959X (DE-599)DOAJf3b37256f3df4904be4d65b037dceb5c DE-627 ger DE-627 rakwb eng QH301-705.5 Christina Buschmann verfasserin aut Galectin-10 Expression in Placentas of Women with Gestational Diabetes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. galectin-10 gestational diabetes mellitus pregnancy Biology (General) Laura Unverdorben verfasserin aut Julia Knabl verfasserin aut Stefan Hutter verfasserin aut Sarah Meister verfasserin aut Susanne Beyer verfasserin aut Maximiliane Burgmann verfasserin aut Lucia Keilmann verfasserin aut Alaleh Zati zehni verfasserin aut Elisa Schmoeckel verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Sven Mahner verfasserin aut Thomas Kolben verfasserin aut Franziska Ganster verfasserin aut Alexander Burges verfasserin aut In Current Issues in Molecular Biology MDPI AG, 2021 45(2023), 11, Seite 8840-8851 (DE-627)355690365 (DE-600)2090836-2 14673045 nnns volume:45 year:2023 number:11 pages:8840-8851 https://doi.org/10.3390/cimb45110554 kostenfrei https://doaj.org/article/f3b37256f3df4904be4d65b037dceb5c kostenfrei https://www.mdpi.com/1467-3045/45/11/554 kostenfrei https://doaj.org/toc/1467-3037 Journal toc kostenfrei https://doaj.org/toc/1467-3045 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 11 8840-8851 |
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10.3390/cimb45110554 doi (DE-627)DOAJ10125959X (DE-599)DOAJf3b37256f3df4904be4d65b037dceb5c DE-627 ger DE-627 rakwb eng QH301-705.5 Christina Buschmann verfasserin aut Galectin-10 Expression in Placentas of Women with Gestational Diabetes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. galectin-10 gestational diabetes mellitus pregnancy Biology (General) Laura Unverdorben verfasserin aut Julia Knabl verfasserin aut Stefan Hutter verfasserin aut Sarah Meister verfasserin aut Susanne Beyer verfasserin aut Maximiliane Burgmann verfasserin aut Lucia Keilmann verfasserin aut Alaleh Zati zehni verfasserin aut Elisa Schmoeckel verfasserin aut Mirjana Kessler verfasserin aut Udo Jeschke verfasserin aut Sven Mahner verfasserin aut Thomas Kolben verfasserin aut Franziska Ganster verfasserin aut Alexander Burges verfasserin aut In Current Issues in Molecular Biology MDPI AG, 2021 45(2023), 11, Seite 8840-8851 (DE-627)355690365 (DE-600)2090836-2 14673045 nnns volume:45 year:2023 number:11 pages:8840-8851 https://doi.org/10.3390/cimb45110554 kostenfrei https://doaj.org/article/f3b37256f3df4904be4d65b037dceb5c kostenfrei https://www.mdpi.com/1467-3045/45/11/554 kostenfrei https://doaj.org/toc/1467-3037 Journal toc kostenfrei https://doaj.org/toc/1467-3045 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2023 11 8840-8851 |
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Galectin-10 Expression in Placentas of Women with Gestational Diabetes |
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Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. |
| abstractGer |
Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. |
| abstract_unstemmed |
Galectins are known to play an important role in immunoregulatory processes and autoimmune diseases. Galectin-10 is a cytoplasmic protein of human eosinophils and is involved in various eosinophilic diseases. Since increased galectin expression is already detected in the placentas of mothers with gestational diabetes mellitus (GDM), this study focuses on the specific role of galectin-10 and hints at consequences for the diagnosis and therapeutic options of GDM. It is hypothesized that the difference in galectin-10 expression will raise the pathophysiological understanding of gestational diabetes. The study population consists of 80 women: 40 healthy mothers and 40 women suffering from gestational diabetes mellitus. The expression of galectin-10 was analyzed in the syncytiotrophoblast (SCT) and the decidua of the placenta via immunohistochemistry and immunofluorescence double staining. The immunoreactivity score (IRS) was used for evaluation. The results in this study were significant for an overexpression of galectin-10 in GDM placentas compared with the control group. The syncytiotrophoblast showed overexpression in the nucleus and the cytoplasm, whereas expression of galectin-10 in the decidua was significant in the cytoplasm only. This study identified the expression changes in galectin-10 in placental tissue between healthy and GDM mothers and intensified the understanding of gestational diabetes. Assuming that gestational diabetes mellitus is involved in inflammatory processes, galectin-10 might play a role in the development and maintenance of GDM. Further investigation is required to strengthen these findings. |
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11 |
| title_short |
Galectin-10 Expression in Placentas of Women with Gestational Diabetes |
| url |
https://doi.org/10.3390/cimb45110554 https://doaj.org/article/f3b37256f3df4904be4d65b037dceb5c https://www.mdpi.com/1467-3045/45/11/554 https://doaj.org/toc/1467-3037 https://doaj.org/toc/1467-3045 |
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Laura Unverdorben Julia Knabl Stefan Hutter Sarah Meister Susanne Beyer Maximiliane Burgmann Lucia Keilmann Alaleh Zati zehni Elisa Schmoeckel Mirjana Kessler Udo Jeschke Sven Mahner Thomas Kolben Franziska Ganster Alexander Burges |
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Laura Unverdorben Julia Knabl Stefan Hutter Sarah Meister Susanne Beyer Maximiliane Burgmann Lucia Keilmann Alaleh Zati zehni Elisa Schmoeckel Mirjana Kessler Udo Jeschke Sven Mahner Thomas Kolben Franziska Ganster Alexander Burges |
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10.3390/cimb45110554 |
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| up_date |
2024-07-03T19:37:36.771Z |
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