Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells

Natural polyphenol-rich plant resources, such as agricultural waste, were proven to diminish insulin resistance and weight gain in rats on a high-fat diet. To test whether date seed polyphenol pills (DSPPs) might lower adipose tissue accumulation by precisely affecting adipocytes, we explored the im...
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Autor*in:	Remah Sobhy [verfasserIn] Xiaobo Zou [verfasserIn] Osama M. Morsy [verfasserIn] Ahmed A. Zaky [verfasserIn] Ibrahim Khalifa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	agricultural waste date seed polyphenols industrial-scale pills 3T3-L1 cells obesity

Übergeordnetes Werk:	In: Applied Sciences - MDPI AG, 2012, 13(2023), 22, p 12533
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:22, p 12533

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/app132212533

Katalog-ID:	DOAJ101277164

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callnumber-first	T - Technology
author	Remah Sobhy
spellingShingle	Remah Sobhy misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc agricultural waste misc date seed polyphenols misc industrial-scale pills misc 3T3-L1 cells misc obesity misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells
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topic_title	TA1-2040 QH301-705.5 QC1-999 QD1-999 Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells agricultural waste date seed polyphenols industrial-scale pills 3T3-L1 cells obesity
topic	misc TA1-2040 misc QH301-705.5 misc QC1-999 misc QD1-999 misc agricultural waste misc date seed polyphenols misc industrial-scale pills misc 3T3-L1 cells misc obesity misc Technology misc T misc Engineering (General). Civil engineering (General) misc Biology (General) misc Physics misc Chemistry
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title	Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells
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title_sort	date seed polyphenol pills as renewable raw materials showed anti-obesity effects with high digestible antioxidants in 3t3-l1 cells
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title_auth	Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells
abstract	Natural polyphenol-rich plant resources, such as agricultural waste, were proven to diminish insulin resistance and weight gain in rats on a high-fat diet. To test whether date seed polyphenol pills (DSPPs) might lower adipose tissue accumulation by precisely affecting adipocytes, we explored the impacts of DSPPs on cell proliferation, differentiation, and lipolysis in 3T3-L1 cells. We utilized tablets made commercially from date seed polyphenols that were mostly composed of epicatechin (45.9 g/kg). The total polyphenol and antioxidant capacities of the digested and non-digested DSPPs were also evaluated. DSPPs at doses of 25, 50, and 100 µg/mL hindered the proliferation of both pre-confluent preadipocytes and mature post-confluent adipocytes. DSPPs decreased the quantity of viable cells in completely developed adipocytes. Treatment with 100 µg/mL of DSPPs decreased the basal lipolysis of completely differentiated adipocytes but modestly boosted epinephrine-induced lipolysis. A significant transcription factor for the adipogenic gene, the peroxisome proliferator-activated receptor (PPAR), was repressed by DSPPs, which significantly decreased lipid buildup. The total polyphenol and antioxidant capacities were also increased after digestion with a good bubble Pearson correlation between both. DSPPs may have anti-obesity and anti-diabetic characteristics by inhibiting adipocyte development and basal lipolysis, which could be commercially industrialized.
abstractGer	Natural polyphenol-rich plant resources, such as agricultural waste, were proven to diminish insulin resistance and weight gain in rats on a high-fat diet. To test whether date seed polyphenol pills (DSPPs) might lower adipose tissue accumulation by precisely affecting adipocytes, we explored the impacts of DSPPs on cell proliferation, differentiation, and lipolysis in 3T3-L1 cells. We utilized tablets made commercially from date seed polyphenols that were mostly composed of epicatechin (45.9 g/kg). The total polyphenol and antioxidant capacities of the digested and non-digested DSPPs were also evaluated. DSPPs at doses of 25, 50, and 100 µg/mL hindered the proliferation of both pre-confluent preadipocytes and mature post-confluent adipocytes. DSPPs decreased the quantity of viable cells in completely developed adipocytes. Treatment with 100 µg/mL of DSPPs decreased the basal lipolysis of completely differentiated adipocytes but modestly boosted epinephrine-induced lipolysis. A significant transcription factor for the adipogenic gene, the peroxisome proliferator-activated receptor (PPAR), was repressed by DSPPs, which significantly decreased lipid buildup. The total polyphenol and antioxidant capacities were also increased after digestion with a good bubble Pearson correlation between both. DSPPs may have anti-obesity and anti-diabetic characteristics by inhibiting adipocyte development and basal lipolysis, which could be commercially industrialized.
abstract_unstemmed	Natural polyphenol-rich plant resources, such as agricultural waste, were proven to diminish insulin resistance and weight gain in rats on a high-fat diet. To test whether date seed polyphenol pills (DSPPs) might lower adipose tissue accumulation by precisely affecting adipocytes, we explored the impacts of DSPPs on cell proliferation, differentiation, and lipolysis in 3T3-L1 cells. We utilized tablets made commercially from date seed polyphenols that were mostly composed of epicatechin (45.9 g/kg). The total polyphenol and antioxidant capacities of the digested and non-digested DSPPs were also evaluated. DSPPs at doses of 25, 50, and 100 µg/mL hindered the proliferation of both pre-confluent preadipocytes and mature post-confluent adipocytes. DSPPs decreased the quantity of viable cells in completely developed adipocytes. Treatment with 100 µg/mL of DSPPs decreased the basal lipolysis of completely differentiated adipocytes but modestly boosted epinephrine-induced lipolysis. A significant transcription factor for the adipogenic gene, the peroxisome proliferator-activated receptor (PPAR), was repressed by DSPPs, which significantly decreased lipid buildup. The total polyphenol and antioxidant capacities were also increased after digestion with a good bubble Pearson correlation between both. DSPPs may have anti-obesity and anti-diabetic characteristics by inhibiting adipocyte development and basal lipolysis, which could be commercially industrialized.
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title_short	Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells
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To test whether date seed polyphenol pills (DSPPs) might lower adipose tissue accumulation by precisely affecting adipocytes, we explored the impacts of DSPPs on cell proliferation, differentiation, and lipolysis in 3T3-L1 cells. We utilized tablets made commercially from date seed polyphenols that were mostly composed of epicatechin (45.9 g/kg). The total polyphenol and antioxidant capacities of the digested and non-digested DSPPs were also evaluated. DSPPs at doses of 25, 50, and 100 µg/mL hindered the proliferation of both pre-confluent preadipocytes and mature post-confluent adipocytes. DSPPs decreased the quantity of viable cells in completely developed adipocytes. Treatment with 100 µg/mL of DSPPs decreased the basal lipolysis of completely differentiated adipocytes but modestly boosted epinephrine-induced lipolysis. A significant transcription factor for the adipogenic gene, the peroxisome proliferator-activated receptor (PPAR), was repressed by DSPPs, which significantly decreased lipid buildup. The total polyphenol and antioxidant capacities were also increased after digestion with a good bubble Pearson correlation between both. 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Date Seed Polyphenol Pills as Renewable Raw Materials Showed Anti-Obesity Effects with High Digestible Antioxidants in 3T3-L1 Cells

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