Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model
Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber,...
Ausführliche Beschreibung
Autor*in: |
Trinidad Eugenia Cu-Cañetas [verfasserIn] Laura A. Velázquez-Villegas [verfasserIn] Mariana Manzanilla-Franco [verfasserIn] Teresa del Rosario Ayora-Talavera [verfasserIn] Juan José Acevedo-Fernández [verfasserIn] Enrique Barbosa-Martín [verfasserIn] Claudia C. Márquez-Mota [verfasserIn] Adriana M. López-Barradas [verfasserIn] Lilia G. Noriega [verfasserIn] Martha Guevara-Cruz [verfasserIn] Ana Ligia Gutiérrez-Solís [verfasserIn] Azalia Avila-Nava [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: Antioxidants - MDPI AG, 2013, 12(2023), 11, p 1957 |
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Übergeordnetes Werk: |
volume:12 ; year:2023 ; number:11, p 1957 |
Links: |
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DOI / URN: |
10.3390/antiox12111957 |
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Katalog-ID: |
DOAJ101282206 |
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245 | 1 | 0 | |a Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model |
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520 | |a Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. | ||
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10.3390/antiox12111957 doi (DE-627)DOAJ101282206 (DE-599)DOAJf675b3a54670411f834bcef3e38b6feb DE-627 ger DE-627 rakwb eng RM1-950 Trinidad Eugenia Cu-Cañetas verfasserin aut Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. Ramon flour lipid metabolism adipocytes fatty liver polyphenols Therapeutics. Pharmacology Laura A. Velázquez-Villegas verfasserin aut Mariana Manzanilla-Franco verfasserin aut Teresa del Rosario Ayora-Talavera verfasserin aut Juan José Acevedo-Fernández verfasserin aut Enrique Barbosa-Martín verfasserin aut Claudia C. Márquez-Mota verfasserin aut Adriana M. López-Barradas verfasserin aut Lilia G. Noriega verfasserin aut Martha Guevara-Cruz verfasserin aut Ana Ligia Gutiérrez-Solís verfasserin aut Azalia Avila-Nava verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 11, p 1957 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:11, p 1957 https://doi.org/10.3390/antiox12111957 kostenfrei https://doaj.org/article/f675b3a54670411f834bcef3e38b6feb kostenfrei https://www.mdpi.com/2076-3921/12/11/1957 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1957 |
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10.3390/antiox12111957 doi (DE-627)DOAJ101282206 (DE-599)DOAJf675b3a54670411f834bcef3e38b6feb DE-627 ger DE-627 rakwb eng RM1-950 Trinidad Eugenia Cu-Cañetas verfasserin aut Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. Ramon flour lipid metabolism adipocytes fatty liver polyphenols Therapeutics. Pharmacology Laura A. Velázquez-Villegas verfasserin aut Mariana Manzanilla-Franco verfasserin aut Teresa del Rosario Ayora-Talavera verfasserin aut Juan José Acevedo-Fernández verfasserin aut Enrique Barbosa-Martín verfasserin aut Claudia C. Márquez-Mota verfasserin aut Adriana M. López-Barradas verfasserin aut Lilia G. Noriega verfasserin aut Martha Guevara-Cruz verfasserin aut Ana Ligia Gutiérrez-Solís verfasserin aut Azalia Avila-Nava verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 11, p 1957 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:11, p 1957 https://doi.org/10.3390/antiox12111957 kostenfrei https://doaj.org/article/f675b3a54670411f834bcef3e38b6feb kostenfrei https://www.mdpi.com/2076-3921/12/11/1957 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1957 |
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10.3390/antiox12111957 doi (DE-627)DOAJ101282206 (DE-599)DOAJf675b3a54670411f834bcef3e38b6feb DE-627 ger DE-627 rakwb eng RM1-950 Trinidad Eugenia Cu-Cañetas verfasserin aut Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. Ramon flour lipid metabolism adipocytes fatty liver polyphenols Therapeutics. Pharmacology Laura A. Velázquez-Villegas verfasserin aut Mariana Manzanilla-Franco verfasserin aut Teresa del Rosario Ayora-Talavera verfasserin aut Juan José Acevedo-Fernández verfasserin aut Enrique Barbosa-Martín verfasserin aut Claudia C. Márquez-Mota verfasserin aut Adriana M. López-Barradas verfasserin aut Lilia G. Noriega verfasserin aut Martha Guevara-Cruz verfasserin aut Ana Ligia Gutiérrez-Solís verfasserin aut Azalia Avila-Nava verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 11, p 1957 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:11, p 1957 https://doi.org/10.3390/antiox12111957 kostenfrei https://doaj.org/article/f675b3a54670411f834bcef3e38b6feb kostenfrei https://www.mdpi.com/2076-3921/12/11/1957 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1957 |
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10.3390/antiox12111957 doi (DE-627)DOAJ101282206 (DE-599)DOAJf675b3a54670411f834bcef3e38b6feb DE-627 ger DE-627 rakwb eng RM1-950 Trinidad Eugenia Cu-Cañetas verfasserin aut Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. Ramon flour lipid metabolism adipocytes fatty liver polyphenols Therapeutics. Pharmacology Laura A. Velázquez-Villegas verfasserin aut Mariana Manzanilla-Franco verfasserin aut Teresa del Rosario Ayora-Talavera verfasserin aut Juan José Acevedo-Fernández verfasserin aut Enrique Barbosa-Martín verfasserin aut Claudia C. Márquez-Mota verfasserin aut Adriana M. López-Barradas verfasserin aut Lilia G. Noriega verfasserin aut Martha Guevara-Cruz verfasserin aut Ana Ligia Gutiérrez-Solís verfasserin aut Azalia Avila-Nava verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 11, p 1957 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:11, p 1957 https://doi.org/10.3390/antiox12111957 kostenfrei https://doaj.org/article/f675b3a54670411f834bcef3e38b6feb kostenfrei https://www.mdpi.com/2076-3921/12/11/1957 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1957 |
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10.3390/antiox12111957 doi (DE-627)DOAJ101282206 (DE-599)DOAJf675b3a54670411f834bcef3e38b6feb DE-627 ger DE-627 rakwb eng RM1-950 Trinidad Eugenia Cu-Cañetas verfasserin aut Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. Ramon flour lipid metabolism adipocytes fatty liver polyphenols Therapeutics. Pharmacology Laura A. Velázquez-Villegas verfasserin aut Mariana Manzanilla-Franco verfasserin aut Teresa del Rosario Ayora-Talavera verfasserin aut Juan José Acevedo-Fernández verfasserin aut Enrique Barbosa-Martín verfasserin aut Claudia C. Márquez-Mota verfasserin aut Adriana M. López-Barradas verfasserin aut Lilia G. Noriega verfasserin aut Martha Guevara-Cruz verfasserin aut Ana Ligia Gutiérrez-Solís verfasserin aut Azalia Avila-Nava verfasserin aut In Antioxidants MDPI AG, 2013 12(2023), 11, p 1957 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:12 year:2023 number:11, p 1957 https://doi.org/10.3390/antiox12111957 kostenfrei https://doaj.org/article/f675b3a54670411f834bcef3e38b6feb kostenfrei https://www.mdpi.com/2076-3921/12/11/1957 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1957 |
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Trinidad Eugenia Cu-Cañetas @@aut@@ Laura A. Velázquez-Villegas @@aut@@ Mariana Manzanilla-Franco @@aut@@ Teresa del Rosario Ayora-Talavera @@aut@@ Juan José Acevedo-Fernández @@aut@@ Enrique Barbosa-Martín @@aut@@ Claudia C. Márquez-Mota @@aut@@ Adriana M. López-Barradas @@aut@@ Lilia G. Noriega @@aut@@ Martha Guevara-Cruz @@aut@@ Ana Ligia Gutiérrez-Solís @@aut@@ Azalia Avila-Nava @@aut@@ |
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Trinidad Eugenia Cu-Cañetas Laura A. Velázquez-Villegas Mariana Manzanilla-Franco Teresa del Rosario Ayora-Talavera Juan José Acevedo-Fernández Enrique Barbosa-Martín Claudia C. Márquez-Mota Adriana M. López-Barradas Lilia G. Noriega Martha Guevara-Cruz Ana Ligia Gutiérrez-Solís Azalia Avila-Nava |
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ramon flour (<i<brosimum alicastrum</i< swartz) ameliorates hepatic lipid accumulation, induction of ampk phosphorylation, and expression of the hepatic antioxidant system in a high-fat-diet-induced obesity mouse model |
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Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model |
abstract |
Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. |
abstractGer |
Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. |
abstract_unstemmed |
Excessive consumption of fat and carbohydrates, together with a decrease in traditional food intake, has been related to obesity and the development of metabolic alterations. Ramon seed is a traditional Mayan food used to obtain Ramon flour (RF) with high biological value in terms of protein, fiber, micronutrients, and bioactive compounds such as polyphenols. However, few studies have evaluated the beneficial effects of RF. Thus, we aimed to determine the metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse model. We divided male <i<BALB/c</i< mice into four groups (<i<n</i< = 5 each group) and fed them for 90 days with the following diets: Control (C): control diet (AIN-93), C + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF prevented the increase in serum total cholesterol (TC) and alanine transaminase (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD increased serum polyphenols and antioxidant activity, and it promoted a decrease in the adipocyte size in white adipose tissue, along with lower hepatic lipid accumulation than in the HFD group. In the liver, the HFD + RF group showed an increase in the expression of β-oxidation-related genes, and downregulation of the fatty acid synthase (<i<Fas</i<) gene compared with the HFD group. Moreover, the HFD + RF group had increased hepatic phosphorylation of AMP-activated protein kinase (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. Thus, RF may be used as a nutritional strategy to decrease metabolic alterations during obesity. |
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11, p 1957 |
title_short |
Ramon Flour (<i<Brosimum alicastrum</i< Swartz) Ameliorates Hepatic Lipid Accumulation, Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant System in a High-Fat-Diet-Induced Obesity Mouse Model |
url |
https://doi.org/10.3390/antiox12111957 https://doaj.org/article/f675b3a54670411f834bcef3e38b6feb https://www.mdpi.com/2076-3921/12/11/1957 https://doaj.org/toc/2076-3921 |
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Laura A. Velázquez-Villegas Mariana Manzanilla-Franco Teresa del Rosario Ayora-Talavera Juan José Acevedo-Fernández Enrique Barbosa-Martín Claudia C. Márquez-Mota Adriana M. López-Barradas Lilia G. Noriega Martha Guevara-Cruz Ana Ligia Gutiérrez-Solís Azalia Avila-Nava |
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Laura A. Velázquez-Villegas Mariana Manzanilla-Franco Teresa del Rosario Ayora-Talavera Juan José Acevedo-Fernández Enrique Barbosa-Martín Claudia C. Márquez-Mota Adriana M. López-Barradas Lilia G. Noriega Martha Guevara-Cruz Ana Ligia Gutiérrez-Solís Azalia Avila-Nava |
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2024-07-03T19:46:19.142Z |
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