Human prion diseases and the prion protein – what is the current state of knowledge?
Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presenta...
Ausführliche Beschreibung
Autor*in: |
Nafe Reinhold [verfasserIn] Arendt Christophe T. [verfasserIn] Hattingen Elke [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2023 |
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Schlagwörter: |
variably protease-sensitive prionopathy |
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Übergeordnetes Werk: |
In: Translational Neuroscience - De Gruyter, 2015, 14(2023), 1, Seite 60-83 |
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Übergeordnetes Werk: |
volume:14 ; year:2023 ; number:1 ; pages:60-83 |
Links: |
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DOI / URN: |
10.1515/tnsci-2022-0315 |
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Katalog-ID: |
DOAJ101306865 |
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10.1515/tnsci-2022-0315 doi (DE-627)DOAJ101306865 (DE-599)DOAJ4b467cf5c7a54ea283fbe27c0387d6ef DE-627 ger DE-627 rakwb eng RC321-571 Nafe Reinhold verfasserin aut Human prion diseases and the prion protein – what is the current state of knowledge? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical aspects. Starting with the prion protein, current insights concerning its physiological functions and the process of pathological conversion will be highlighted. Diagnostic, molecular, and clinical aspects of all human prion diseases will be discussed, including information concerning rare diseases like prion-associated amyloidoses and Huntington disease-like 1, as well as the question about a potential human threat due to the transmission of prions from prion diseases of other species such as chronic wasting disease. Finally, recent attempts to develop future therapeutic strategies will be addressed. creutzfeldt–jakob disease variably protease-sensitive prionopathy fatal familial insomnia gerstmann–sträussler–scheinker disease kuru Neurosciences. Biological psychiatry. Neuropsychiatry Arendt Christophe T. verfasserin aut Hattingen Elke verfasserin aut In Translational Neuroscience De Gruyter, 2015 14(2023), 1, Seite 60-83 (DE-627)640087507 (DE-600)2581219-1 20816936 nnns volume:14 year:2023 number:1 pages:60-83 https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/article/4b467cf5c7a54ea283fbe27c0387d6ef kostenfrei https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/toc/2081-6936 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 60-83 |
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10.1515/tnsci-2022-0315 doi (DE-627)DOAJ101306865 (DE-599)DOAJ4b467cf5c7a54ea283fbe27c0387d6ef DE-627 ger DE-627 rakwb eng RC321-571 Nafe Reinhold verfasserin aut Human prion diseases and the prion protein – what is the current state of knowledge? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical aspects. Starting with the prion protein, current insights concerning its physiological functions and the process of pathological conversion will be highlighted. Diagnostic, molecular, and clinical aspects of all human prion diseases will be discussed, including information concerning rare diseases like prion-associated amyloidoses and Huntington disease-like 1, as well as the question about a potential human threat due to the transmission of prions from prion diseases of other species such as chronic wasting disease. Finally, recent attempts to develop future therapeutic strategies will be addressed. creutzfeldt–jakob disease variably protease-sensitive prionopathy fatal familial insomnia gerstmann–sträussler–scheinker disease kuru Neurosciences. Biological psychiatry. Neuropsychiatry Arendt Christophe T. verfasserin aut Hattingen Elke verfasserin aut In Translational Neuroscience De Gruyter, 2015 14(2023), 1, Seite 60-83 (DE-627)640087507 (DE-600)2581219-1 20816936 nnns volume:14 year:2023 number:1 pages:60-83 https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/article/4b467cf5c7a54ea283fbe27c0387d6ef kostenfrei https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/toc/2081-6936 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 60-83 |
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10.1515/tnsci-2022-0315 doi (DE-627)DOAJ101306865 (DE-599)DOAJ4b467cf5c7a54ea283fbe27c0387d6ef DE-627 ger DE-627 rakwb eng RC321-571 Nafe Reinhold verfasserin aut Human prion diseases and the prion protein – what is the current state of knowledge? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical aspects. Starting with the prion protein, current insights concerning its physiological functions and the process of pathological conversion will be highlighted. Diagnostic, molecular, and clinical aspects of all human prion diseases will be discussed, including information concerning rare diseases like prion-associated amyloidoses and Huntington disease-like 1, as well as the question about a potential human threat due to the transmission of prions from prion diseases of other species such as chronic wasting disease. Finally, recent attempts to develop future therapeutic strategies will be addressed. creutzfeldt–jakob disease variably protease-sensitive prionopathy fatal familial insomnia gerstmann–sträussler–scheinker disease kuru Neurosciences. Biological psychiatry. Neuropsychiatry Arendt Christophe T. verfasserin aut Hattingen Elke verfasserin aut In Translational Neuroscience De Gruyter, 2015 14(2023), 1, Seite 60-83 (DE-627)640087507 (DE-600)2581219-1 20816936 nnns volume:14 year:2023 number:1 pages:60-83 https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/article/4b467cf5c7a54ea283fbe27c0387d6ef kostenfrei https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/toc/2081-6936 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 60-83 |
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10.1515/tnsci-2022-0315 doi (DE-627)DOAJ101306865 (DE-599)DOAJ4b467cf5c7a54ea283fbe27c0387d6ef DE-627 ger DE-627 rakwb eng RC321-571 Nafe Reinhold verfasserin aut Human prion diseases and the prion protein – what is the current state of knowledge? 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical aspects. Starting with the prion protein, current insights concerning its physiological functions and the process of pathological conversion will be highlighted. Diagnostic, molecular, and clinical aspects of all human prion diseases will be discussed, including information concerning rare diseases like prion-associated amyloidoses and Huntington disease-like 1, as well as the question about a potential human threat due to the transmission of prions from prion diseases of other species such as chronic wasting disease. Finally, recent attempts to develop future therapeutic strategies will be addressed. creutzfeldt–jakob disease variably protease-sensitive prionopathy fatal familial insomnia gerstmann–sträussler–scheinker disease kuru Neurosciences. Biological psychiatry. Neuropsychiatry Arendt Christophe T. verfasserin aut Hattingen Elke verfasserin aut In Translational Neuroscience De Gruyter, 2015 14(2023), 1, Seite 60-83 (DE-627)640087507 (DE-600)2581219-1 20816936 nnns volume:14 year:2023 number:1 pages:60-83 https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/article/4b467cf5c7a54ea283fbe27c0387d6ef kostenfrei https://doi.org/10.1515/tnsci-2022-0315 kostenfrei https://doaj.org/toc/2081-6936 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 60-83 |
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Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical aspects. Starting with the prion protein, current insights concerning its physiological functions and the process of pathological conversion will be highlighted. Diagnostic, molecular, and clinical aspects of all human prion diseases will be discussed, including information concerning rare diseases like prion-associated amyloidoses and Huntington disease-like 1, as well as the question about a potential human threat due to the transmission of prions from prion diseases of other species such as chronic wasting disease. Finally, recent attempts to develop future therapeutic strategies will be addressed. |
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Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge. The main objective of the present review article is to provide a comprehensive up-to-date presentation of all major features of human prion diseases bridging the gap between basic research and clinical aspects. Starting with the prion protein, current insights concerning its physiological functions and the process of pathological conversion will be highlighted. Diagnostic, molecular, and clinical aspects of all human prion diseases will be discussed, including information concerning rare diseases like prion-associated amyloidoses and Huntington disease-like 1, as well as the question about a potential human threat due to the transmission of prions from prion diseases of other species such as chronic wasting disease. Finally, recent attempts to develop future therapeutic strategies will be addressed. |
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|
score |
7.401184 |