CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex netw...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tao Zhang [verfasserIn] Ramez Wahib [verfasserIn] Dimitra E. Zazara [verfasserIn] Jöran Lücke [verfasserIn] Ahmad Mustafa Shiri [verfasserIn] Jan Kempski [verfasserIn] Lilan Zhao [verfasserIn] Theodora Agalioti [verfasserIn] Andres Pablo Machicote [verfasserIn] Olympia Giannou [verfasserIn] Ioannis Belios [verfasserIn] Rongrong Jia [verfasserIn] Siwen Zhang [verfasserIn] Joseph Tintelnot [verfasserIn] Hannes Seese [verfasserIn] Julia Kristin Grass [verfasserIn] Baris Mercanoglu [verfasserIn] Louisa Stern [verfasserIn] Pasquale Scognamiglio [verfasserIn] Mohammad Fard-Aghaie [verfasserIn] Philipp Seeger [verfasserIn] Jonas Wakker [verfasserIn] Marius Kemper [verfasserIn] Benjamin Brunswig [verfasserIn] Anna Duprée [verfasserIn] Panagis M. Lykoudis [verfasserIn] Anastasia Pikouli [verfasserIn] Emmanouil Giorgakis [verfasserIn] Pablo Stringa [verfasserIn] Natalia Lausada [verfasserIn] Maria Virginia Gentilini [verfasserIn] Gabriel E. Gondolesi [verfasserIn] Kai Bachmann [verfasserIn] Philipp Busch [verfasserIn] Rainer Grotelüschen [verfasserIn] Ioannis C. Maroulis [verfasserIn] Petra C. Arck [verfasserIn] Ryosuke Nakano [verfasserIn] Angus W. Thomson [verfasserIn] Tarik Ghadban [verfasserIn] Michael Tachezy [verfasserIn] Nathaniel Melling [verfasserIn] Eike-Gert Achilles [verfasserIn] Victor G. Puelles [verfasserIn] Felix Nickel [verfasserIn] Thilo Hackert [verfasserIn] Oliver Mann [verfasserIn] Jakob R. Izbicki [verfasserIn] Jun Li [verfasserIn] Nicola Gagliani [verfasserIn] Samuel Huber [verfasserIn] Anastasios D. Giannou [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2023 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
In: OncoImmunology - Taylor & Francis Group, 2020, 12(2023), 1 |
|---|---|
| Übergeordnetes Werk: |
volume:12 ; year:2023 ; number:1 |
| Links: |
|---|
| DOI / URN: |
10.1080/2162402X.2023.2269634 |
|---|
| Katalog-ID: |
DOAJ101343493 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ101343493 | ||
| 003 | DE-627 | ||
| 005 | 20240414161744.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240414s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/2162402X.2023.2269634 |2 doi | |
| 035 | |a (DE-627)DOAJ101343493 | ||
| 035 | |a (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RC581-607 | |
| 050 | 0 | |a RC254-282 | |
| 100 | 0 | |a Tao Zhang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. | ||
| 650 | 4 | |a IL-22 | |
| 650 | 4 | |a liver metastasis | |
| 650 | 4 | |a Th22 | |
| 653 | 0 | |a Immunologic diseases. Allergy | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Ramez Wahib |e verfasserin |4 aut | |
| 700 | 0 | |a Dimitra E. Zazara |e verfasserin |4 aut | |
| 700 | 0 | |a Jöran Lücke |e verfasserin |4 aut | |
| 700 | 0 | |a Ahmad Mustafa Shiri |e verfasserin |4 aut | |
| 700 | 0 | |a Jan Kempski |e verfasserin |4 aut | |
| 700 | 0 | |a Lilan Zhao |e verfasserin |4 aut | |
| 700 | 0 | |a Theodora Agalioti |e verfasserin |4 aut | |
| 700 | 0 | |a Andres Pablo Machicote |e verfasserin |4 aut | |
| 700 | 0 | |a Olympia Giannou |e verfasserin |4 aut | |
| 700 | 0 | |a Ioannis Belios |e verfasserin |4 aut | |
| 700 | 0 | |a Rongrong Jia |e verfasserin |4 aut | |
| 700 | 0 | |a Siwen Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Joseph Tintelnot |e verfasserin |4 aut | |
| 700 | 0 | |a Hannes Seese |e verfasserin |4 aut | |
| 700 | 0 | |a Julia Kristin Grass |e verfasserin |4 aut | |
| 700 | 0 | |a Baris Mercanoglu |e verfasserin |4 aut | |
| 700 | 0 | |a Louisa Stern |e verfasserin |4 aut | |
| 700 | 0 | |a Pasquale Scognamiglio |e verfasserin |4 aut | |
| 700 | 0 | |a Mohammad Fard-Aghaie |e verfasserin |4 aut | |
| 700 | 0 | |a Philipp Seeger |e verfasserin |4 aut | |
| 700 | 0 | |a Jonas Wakker |e verfasserin |4 aut | |
| 700 | 0 | |a Marius Kemper |e verfasserin |4 aut | |
| 700 | 0 | |a Benjamin Brunswig |e verfasserin |4 aut | |
| 700 | 0 | |a Anna Duprée |e verfasserin |4 aut | |
| 700 | 0 | |a Panagis M. Lykoudis |e verfasserin |4 aut | |
| 700 | 0 | |a Anastasia Pikouli |e verfasserin |4 aut | |
| 700 | 0 | |a Emmanouil Giorgakis |e verfasserin |4 aut | |
| 700 | 0 | |a Pablo Stringa |e verfasserin |4 aut | |
| 700 | 0 | |a Natalia Lausada |e verfasserin |4 aut | |
| 700 | 0 | |a Maria Virginia Gentilini |e verfasserin |4 aut | |
| 700 | 0 | |a Gabriel E. Gondolesi |e verfasserin |4 aut | |
| 700 | 0 | |a Kai Bachmann |e verfasserin |4 aut | |
| 700 | 0 | |a Philipp Busch |e verfasserin |4 aut | |
| 700 | 0 | |a Rainer Grotelüschen |e verfasserin |4 aut | |
| 700 | 0 | |a Ioannis C. Maroulis |e verfasserin |4 aut | |
| 700 | 0 | |a Petra C. Arck |e verfasserin |4 aut | |
| 700 | 0 | |a Ryosuke Nakano |e verfasserin |4 aut | |
| 700 | 0 | |a Angus W. Thomson |e verfasserin |4 aut | |
| 700 | 0 | |a Tarik Ghadban |e verfasserin |4 aut | |
| 700 | 0 | |a Michael Tachezy |e verfasserin |4 aut | |
| 700 | 0 | |a Nathaniel Melling |e verfasserin |4 aut | |
| 700 | 0 | |a Eike-Gert Achilles |e verfasserin |4 aut | |
| 700 | 0 | |a Victor G. Puelles |e verfasserin |4 aut | |
| 700 | 0 | |a Felix Nickel |e verfasserin |4 aut | |
| 700 | 0 | |a Thilo Hackert |e verfasserin |4 aut | |
| 700 | 0 | |a Oliver Mann |e verfasserin |4 aut | |
| 700 | 0 | |a Jakob R. Izbicki |e verfasserin |4 aut | |
| 700 | 0 | |a Jun Li |e verfasserin |4 aut | |
| 700 | 0 | |a Nicola Gagliani |e verfasserin |4 aut | |
| 700 | 0 | |a Samuel Huber |e verfasserin |4 aut | |
| 700 | 0 | |a Anastasios D. Giannou |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t OncoImmunology |d Taylor & Francis Group, 2020 |g 12(2023), 1 |w (DE-627)683365428 |w (DE-600)2645309-5 |x 2162402X |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2023 |g number:1 |
| 856 | 4 | 0 | |u https://doi.org/10.1080/2162402X.2023.2269634 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf |z kostenfrei |
| 856 | 4 | 0 | |u https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2162-402X |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4367 | ||
| 912 | |a GBV_ILN_4700 | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2023 |e 1 | ||
| author_variant |
t z tz r w rw d e z dez j l jl a m s ams j k jk l z lz t a ta a p m apm o g og i b ib r j rj s z sz j t jt h s hs j k g jkg b m bm l s ls p s ps m f a mfa p s ps j w jw m k mk b b bb a d ad p m l pml a p ap e g eg p s ps n l nl m v g mvg g e g geg k b kb p b pb r g rg i c m icm p c a pca r n rn a w t awt t g tg m t mt n m nm e g a ega v g p vgp f n fn t h th o m om j r i jri j l jl n g ng s h sh a d g adg |
|---|---|
| matchkey_str |
article:2162402X:2023----::dteleiei2ehnelvreatssyrm |
| hierarchy_sort_str |
2023 |
| callnumber-subject-code |
RC |
| publishDate |
2023 |
| allfields |
10.1080/2162402X.2023.2269634 doi (DE-627)DOAJ101343493 (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Tao Zhang verfasserin aut CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. IL-22 liver metastasis Th22 Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ramez Wahib verfasserin aut Dimitra E. Zazara verfasserin aut Jöran Lücke verfasserin aut Ahmad Mustafa Shiri verfasserin aut Jan Kempski verfasserin aut Lilan Zhao verfasserin aut Theodora Agalioti verfasserin aut Andres Pablo Machicote verfasserin aut Olympia Giannou verfasserin aut Ioannis Belios verfasserin aut Rongrong Jia verfasserin aut Siwen Zhang verfasserin aut Joseph Tintelnot verfasserin aut Hannes Seese verfasserin aut Julia Kristin Grass verfasserin aut Baris Mercanoglu verfasserin aut Louisa Stern verfasserin aut Pasquale Scognamiglio verfasserin aut Mohammad Fard-Aghaie verfasserin aut Philipp Seeger verfasserin aut Jonas Wakker verfasserin aut Marius Kemper verfasserin aut Benjamin Brunswig verfasserin aut Anna Duprée verfasserin aut Panagis M. Lykoudis verfasserin aut Anastasia Pikouli verfasserin aut Emmanouil Giorgakis verfasserin aut Pablo Stringa verfasserin aut Natalia Lausada verfasserin aut Maria Virginia Gentilini verfasserin aut Gabriel E. Gondolesi verfasserin aut Kai Bachmann verfasserin aut Philipp Busch verfasserin aut Rainer Grotelüschen verfasserin aut Ioannis C. Maroulis verfasserin aut Petra C. Arck verfasserin aut Ryosuke Nakano verfasserin aut Angus W. Thomson verfasserin aut Tarik Ghadban verfasserin aut Michael Tachezy verfasserin aut Nathaniel Melling verfasserin aut Eike-Gert Achilles verfasserin aut Victor G. Puelles verfasserin aut Felix Nickel verfasserin aut Thilo Hackert verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Jun Li verfasserin aut Nicola Gagliani verfasserin aut Samuel Huber verfasserin aut Anastasios D. Giannou verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 12(2023), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:12 year:2023 number:1 https://doi.org/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 1 |
| spelling |
10.1080/2162402X.2023.2269634 doi (DE-627)DOAJ101343493 (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Tao Zhang verfasserin aut CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. IL-22 liver metastasis Th22 Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ramez Wahib verfasserin aut Dimitra E. Zazara verfasserin aut Jöran Lücke verfasserin aut Ahmad Mustafa Shiri verfasserin aut Jan Kempski verfasserin aut Lilan Zhao verfasserin aut Theodora Agalioti verfasserin aut Andres Pablo Machicote verfasserin aut Olympia Giannou verfasserin aut Ioannis Belios verfasserin aut Rongrong Jia verfasserin aut Siwen Zhang verfasserin aut Joseph Tintelnot verfasserin aut Hannes Seese verfasserin aut Julia Kristin Grass verfasserin aut Baris Mercanoglu verfasserin aut Louisa Stern verfasserin aut Pasquale Scognamiglio verfasserin aut Mohammad Fard-Aghaie verfasserin aut Philipp Seeger verfasserin aut Jonas Wakker verfasserin aut Marius Kemper verfasserin aut Benjamin Brunswig verfasserin aut Anna Duprée verfasserin aut Panagis M. Lykoudis verfasserin aut Anastasia Pikouli verfasserin aut Emmanouil Giorgakis verfasserin aut Pablo Stringa verfasserin aut Natalia Lausada verfasserin aut Maria Virginia Gentilini verfasserin aut Gabriel E. Gondolesi verfasserin aut Kai Bachmann verfasserin aut Philipp Busch verfasserin aut Rainer Grotelüschen verfasserin aut Ioannis C. Maroulis verfasserin aut Petra C. Arck verfasserin aut Ryosuke Nakano verfasserin aut Angus W. Thomson verfasserin aut Tarik Ghadban verfasserin aut Michael Tachezy verfasserin aut Nathaniel Melling verfasserin aut Eike-Gert Achilles verfasserin aut Victor G. Puelles verfasserin aut Felix Nickel verfasserin aut Thilo Hackert verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Jun Li verfasserin aut Nicola Gagliani verfasserin aut Samuel Huber verfasserin aut Anastasios D. Giannou verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 12(2023), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:12 year:2023 number:1 https://doi.org/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 1 |
| allfields_unstemmed |
10.1080/2162402X.2023.2269634 doi (DE-627)DOAJ101343493 (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Tao Zhang verfasserin aut CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. IL-22 liver metastasis Th22 Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ramez Wahib verfasserin aut Dimitra E. Zazara verfasserin aut Jöran Lücke verfasserin aut Ahmad Mustafa Shiri verfasserin aut Jan Kempski verfasserin aut Lilan Zhao verfasserin aut Theodora Agalioti verfasserin aut Andres Pablo Machicote verfasserin aut Olympia Giannou verfasserin aut Ioannis Belios verfasserin aut Rongrong Jia verfasserin aut Siwen Zhang verfasserin aut Joseph Tintelnot verfasserin aut Hannes Seese verfasserin aut Julia Kristin Grass verfasserin aut Baris Mercanoglu verfasserin aut Louisa Stern verfasserin aut Pasquale Scognamiglio verfasserin aut Mohammad Fard-Aghaie verfasserin aut Philipp Seeger verfasserin aut Jonas Wakker verfasserin aut Marius Kemper verfasserin aut Benjamin Brunswig verfasserin aut Anna Duprée verfasserin aut Panagis M. Lykoudis verfasserin aut Anastasia Pikouli verfasserin aut Emmanouil Giorgakis verfasserin aut Pablo Stringa verfasserin aut Natalia Lausada verfasserin aut Maria Virginia Gentilini verfasserin aut Gabriel E. Gondolesi verfasserin aut Kai Bachmann verfasserin aut Philipp Busch verfasserin aut Rainer Grotelüschen verfasserin aut Ioannis C. Maroulis verfasserin aut Petra C. Arck verfasserin aut Ryosuke Nakano verfasserin aut Angus W. Thomson verfasserin aut Tarik Ghadban verfasserin aut Michael Tachezy verfasserin aut Nathaniel Melling verfasserin aut Eike-Gert Achilles verfasserin aut Victor G. Puelles verfasserin aut Felix Nickel verfasserin aut Thilo Hackert verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Jun Li verfasserin aut Nicola Gagliani verfasserin aut Samuel Huber verfasserin aut Anastasios D. Giannou verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 12(2023), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:12 year:2023 number:1 https://doi.org/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 1 |
| allfieldsGer |
10.1080/2162402X.2023.2269634 doi (DE-627)DOAJ101343493 (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Tao Zhang verfasserin aut CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. IL-22 liver metastasis Th22 Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ramez Wahib verfasserin aut Dimitra E. Zazara verfasserin aut Jöran Lücke verfasserin aut Ahmad Mustafa Shiri verfasserin aut Jan Kempski verfasserin aut Lilan Zhao verfasserin aut Theodora Agalioti verfasserin aut Andres Pablo Machicote verfasserin aut Olympia Giannou verfasserin aut Ioannis Belios verfasserin aut Rongrong Jia verfasserin aut Siwen Zhang verfasserin aut Joseph Tintelnot verfasserin aut Hannes Seese verfasserin aut Julia Kristin Grass verfasserin aut Baris Mercanoglu verfasserin aut Louisa Stern verfasserin aut Pasquale Scognamiglio verfasserin aut Mohammad Fard-Aghaie verfasserin aut Philipp Seeger verfasserin aut Jonas Wakker verfasserin aut Marius Kemper verfasserin aut Benjamin Brunswig verfasserin aut Anna Duprée verfasserin aut Panagis M. Lykoudis verfasserin aut Anastasia Pikouli verfasserin aut Emmanouil Giorgakis verfasserin aut Pablo Stringa verfasserin aut Natalia Lausada verfasserin aut Maria Virginia Gentilini verfasserin aut Gabriel E. Gondolesi verfasserin aut Kai Bachmann verfasserin aut Philipp Busch verfasserin aut Rainer Grotelüschen verfasserin aut Ioannis C. Maroulis verfasserin aut Petra C. Arck verfasserin aut Ryosuke Nakano verfasserin aut Angus W. Thomson verfasserin aut Tarik Ghadban verfasserin aut Michael Tachezy verfasserin aut Nathaniel Melling verfasserin aut Eike-Gert Achilles verfasserin aut Victor G. Puelles verfasserin aut Felix Nickel verfasserin aut Thilo Hackert verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Jun Li verfasserin aut Nicola Gagliani verfasserin aut Samuel Huber verfasserin aut Anastasios D. Giannou verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 12(2023), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:12 year:2023 number:1 https://doi.org/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 1 |
| allfieldsSound |
10.1080/2162402X.2023.2269634 doi (DE-627)DOAJ101343493 (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Tao Zhang verfasserin aut CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. IL-22 liver metastasis Th22 Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ramez Wahib verfasserin aut Dimitra E. Zazara verfasserin aut Jöran Lücke verfasserin aut Ahmad Mustafa Shiri verfasserin aut Jan Kempski verfasserin aut Lilan Zhao verfasserin aut Theodora Agalioti verfasserin aut Andres Pablo Machicote verfasserin aut Olympia Giannou verfasserin aut Ioannis Belios verfasserin aut Rongrong Jia verfasserin aut Siwen Zhang verfasserin aut Joseph Tintelnot verfasserin aut Hannes Seese verfasserin aut Julia Kristin Grass verfasserin aut Baris Mercanoglu verfasserin aut Louisa Stern verfasserin aut Pasquale Scognamiglio verfasserin aut Mohammad Fard-Aghaie verfasserin aut Philipp Seeger verfasserin aut Jonas Wakker verfasserin aut Marius Kemper verfasserin aut Benjamin Brunswig verfasserin aut Anna Duprée verfasserin aut Panagis M. Lykoudis verfasserin aut Anastasia Pikouli verfasserin aut Emmanouil Giorgakis verfasserin aut Pablo Stringa verfasserin aut Natalia Lausada verfasserin aut Maria Virginia Gentilini verfasserin aut Gabriel E. Gondolesi verfasserin aut Kai Bachmann verfasserin aut Philipp Busch verfasserin aut Rainer Grotelüschen verfasserin aut Ioannis C. Maroulis verfasserin aut Petra C. Arck verfasserin aut Ryosuke Nakano verfasserin aut Angus W. Thomson verfasserin aut Tarik Ghadban verfasserin aut Michael Tachezy verfasserin aut Nathaniel Melling verfasserin aut Eike-Gert Achilles verfasserin aut Victor G. Puelles verfasserin aut Felix Nickel verfasserin aut Thilo Hackert verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Jun Li verfasserin aut Nicola Gagliani verfasserin aut Samuel Huber verfasserin aut Anastasios D. Giannou verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 12(2023), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:12 year:2023 number:1 https://doi.org/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 1 |
| language |
English |
| source |
In OncoImmunology 12(2023), 1 volume:12 year:2023 number:1 |
| sourceStr |
In OncoImmunology 12(2023), 1 volume:12 year:2023 number:1 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
IL-22 liver metastasis Th22 Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| isfreeaccess_bool |
true |
| container_title |
OncoImmunology |
| authorswithroles_txt_mv |
Tao Zhang @@aut@@ Ramez Wahib @@aut@@ Dimitra E. Zazara @@aut@@ Jöran Lücke @@aut@@ Ahmad Mustafa Shiri @@aut@@ Jan Kempski @@aut@@ Lilan Zhao @@aut@@ Theodora Agalioti @@aut@@ Andres Pablo Machicote @@aut@@ Olympia Giannou @@aut@@ Ioannis Belios @@aut@@ Rongrong Jia @@aut@@ Siwen Zhang @@aut@@ Joseph Tintelnot @@aut@@ Hannes Seese @@aut@@ Julia Kristin Grass @@aut@@ Baris Mercanoglu @@aut@@ Louisa Stern @@aut@@ Pasquale Scognamiglio @@aut@@ Mohammad Fard-Aghaie @@aut@@ Philipp Seeger @@aut@@ Jonas Wakker @@aut@@ Marius Kemper @@aut@@ Benjamin Brunswig @@aut@@ Anna Duprée @@aut@@ Panagis M. Lykoudis @@aut@@ Anastasia Pikouli @@aut@@ Emmanouil Giorgakis @@aut@@ Pablo Stringa @@aut@@ Natalia Lausada @@aut@@ Maria Virginia Gentilini @@aut@@ Gabriel E. Gondolesi @@aut@@ Kai Bachmann @@aut@@ Philipp Busch @@aut@@ Rainer Grotelüschen @@aut@@ Ioannis C. Maroulis @@aut@@ Petra C. Arck @@aut@@ Ryosuke Nakano @@aut@@ Angus W. Thomson @@aut@@ Tarik Ghadban @@aut@@ Michael Tachezy @@aut@@ Nathaniel Melling @@aut@@ Eike-Gert Achilles @@aut@@ Victor G. Puelles @@aut@@ Felix Nickel @@aut@@ Thilo Hackert @@aut@@ Oliver Mann @@aut@@ Jakob R. Izbicki @@aut@@ Jun Li @@aut@@ Nicola Gagliani @@aut@@ Samuel Huber @@aut@@ Anastasios D. Giannou @@aut@@ |
| publishDateDaySort_date |
2023-01-01T00:00:00Z |
| hierarchy_top_id |
683365428 |
| id |
DOAJ101343493 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ101343493</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414161744.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240414s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1080/2162402X.2023.2269634</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ101343493</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC581-607</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tao Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IL-22</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">liver metastasis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Th22</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. Allergy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ramez Wahib</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitra E. Zazara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jöran Lücke</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmad Mustafa Shiri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jan Kempski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilan Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Theodora Agalioti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andres Pablo Machicote</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olympia Giannou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis Belios</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rongrong Jia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siwen Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joseph Tintelnot</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hannes Seese</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia Kristin Grass</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Baris Mercanoglu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Louisa Stern</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pasquale Scognamiglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohammad Fard-Aghaie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Philipp Seeger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jonas Wakker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marius Kemper</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Benjamin Brunswig</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Duprée</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Panagis M. Lykoudis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anastasia Pikouli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanouil Giorgakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pablo Stringa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Lausada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Virginia Gentilini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriel E. Gondolesi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kai Bachmann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Philipp Busch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rainer Grotelüschen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis C. Maroulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Petra C. Arck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryosuke Nakano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angus W. Thomson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tarik Ghadban</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael Tachezy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nathaniel Melling</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eike-Gert Achilles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Victor G. Puelles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Felix Nickel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thilo Hackert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oliver Mann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jakob R. Izbicki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jun Li</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicola Gagliani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samuel Huber</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anastasios D. Giannou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">OncoImmunology</subfield><subfield code="d">Taylor & Francis Group, 2020</subfield><subfield code="g">12(2023), 1</subfield><subfield code="w">(DE-627)683365428</subfield><subfield code="w">(DE-600)2645309-5</subfield><subfield code="x">2162402X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:1</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1080/2162402X.2023.2269634</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2162-402X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2023</subfield><subfield code="e">1</subfield></datafield></record></collection>
|
| callnumber-first |
R - Medicine |
| author |
Tao Zhang |
| spellingShingle |
Tao Zhang misc RC581-607 misc RC254-282 misc IL-22 misc liver metastasis misc Th22 misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| authorStr |
Tao Zhang |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)683365428 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
| collection |
DOAJ |
| remote_str |
true |
| callnumber-label |
RC581-607 |
| illustrated |
Not Illustrated |
| issn |
2162402X |
| topic_title |
RC581-607 RC254-282 CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis IL-22 liver metastasis Th22 |
| topic |
misc RC581-607 misc RC254-282 misc IL-22 misc liver metastasis misc Th22 misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| topic_unstemmed |
misc RC581-607 misc RC254-282 misc IL-22 misc liver metastasis misc Th22 misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| topic_browse |
misc RC581-607 misc RC254-282 misc IL-22 misc liver metastasis misc Th22 misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
OncoImmunology |
| hierarchy_parent_id |
683365428 |
| hierarchy_top_title |
OncoImmunology |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)683365428 (DE-600)2645309-5 |
| title |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| ctrlnum |
(DE-627)DOAJ101343493 (DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf |
| title_full |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| author_sort |
Tao Zhang |
| journal |
OncoImmunology |
| journalStr |
OncoImmunology |
| callnumber-first-code |
R |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2023 |
| contenttype_str_mv |
txt |
| author_browse |
Tao Zhang Ramez Wahib Dimitra E. Zazara Jöran Lücke Ahmad Mustafa Shiri Jan Kempski Lilan Zhao Theodora Agalioti Andres Pablo Machicote Olympia Giannou Ioannis Belios Rongrong Jia Siwen Zhang Joseph Tintelnot Hannes Seese Julia Kristin Grass Baris Mercanoglu Louisa Stern Pasquale Scognamiglio Mohammad Fard-Aghaie Philipp Seeger Jonas Wakker Marius Kemper Benjamin Brunswig Anna Duprée Panagis M. Lykoudis Anastasia Pikouli Emmanouil Giorgakis Pablo Stringa Natalia Lausada Maria Virginia Gentilini Gabriel E. Gondolesi Kai Bachmann Philipp Busch Rainer Grotelüschen Ioannis C. Maroulis Petra C. Arck Ryosuke Nakano Angus W. Thomson Tarik Ghadban Michael Tachezy Nathaniel Melling Eike-Gert Achilles Victor G. Puelles Felix Nickel Thilo Hackert Oliver Mann Jakob R. Izbicki Jun Li Nicola Gagliani Samuel Huber Anastasios D. Giannou |
| container_volume |
12 |
| class |
RC581-607 RC254-282 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Tao Zhang |
| doi_str_mv |
10.1080/2162402X.2023.2269634 |
| author2-role |
verfasserin |
| title_sort |
cd4+ t cell-derived il-22 enhances liver metastasis by promoting angiogenesis |
| callnumber |
RC581-607 |
| title_auth |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| abstract |
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. |
| abstractGer |
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. |
| abstract_unstemmed |
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
| container_issue |
1 |
| title_short |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| url |
https://doi.org/10.1080/2162402X.2023.2269634 https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634 https://doaj.org/toc/2162-402X |
| remote_bool |
true |
| author2 |
Ramez Wahib Dimitra E. Zazara Jöran Lücke Ahmad Mustafa Shiri Jan Kempski Lilan Zhao Theodora Agalioti Andres Pablo Machicote Olympia Giannou Ioannis Belios Rongrong Jia Siwen Zhang Joseph Tintelnot Hannes Seese Julia Kristin Grass Baris Mercanoglu Louisa Stern Pasquale Scognamiglio Mohammad Fard-Aghaie Philipp Seeger Jonas Wakker Marius Kemper Benjamin Brunswig Anna Duprée Panagis M. Lykoudis Anastasia Pikouli Emmanouil Giorgakis Pablo Stringa Natalia Lausada Maria Virginia Gentilini Gabriel E. Gondolesi Kai Bachmann Philipp Busch Rainer Grotelüschen Ioannis C. Maroulis Petra C. Arck Ryosuke Nakano Angus W. Thomson Tarik Ghadban Michael Tachezy Nathaniel Melling Eike-Gert Achilles Victor G. Puelles Felix Nickel Thilo Hackert Oliver Mann Jakob R. Izbicki Jun Li Nicola Gagliani Samuel Huber Anastasios D. Giannou |
| author2Str |
Ramez Wahib Dimitra E. Zazara Jöran Lücke Ahmad Mustafa Shiri Jan Kempski Lilan Zhao Theodora Agalioti Andres Pablo Machicote Olympia Giannou Ioannis Belios Rongrong Jia Siwen Zhang Joseph Tintelnot Hannes Seese Julia Kristin Grass Baris Mercanoglu Louisa Stern Pasquale Scognamiglio Mohammad Fard-Aghaie Philipp Seeger Jonas Wakker Marius Kemper Benjamin Brunswig Anna Duprée Panagis M. Lykoudis Anastasia Pikouli Emmanouil Giorgakis Pablo Stringa Natalia Lausada Maria Virginia Gentilini Gabriel E. Gondolesi Kai Bachmann Philipp Busch Rainer Grotelüschen Ioannis C. Maroulis Petra C. Arck Ryosuke Nakano Angus W. Thomson Tarik Ghadban Michael Tachezy Nathaniel Melling Eike-Gert Achilles Victor G. Puelles Felix Nickel Thilo Hackert Oliver Mann Jakob R. Izbicki Jun Li Nicola Gagliani Samuel Huber Anastasios D. Giannou |
| ppnlink |
683365428 |
| callnumber-subject |
RC - Internal Medicine |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1080/2162402X.2023.2269634 |
| callnumber-a |
RC581-607 |
| up_date |
2024-07-03T20:06:37.852Z |
| _version_ |
1803589724778004480 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ101343493</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414161744.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240414s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1080/2162402X.2023.2269634</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ101343493</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3cee1dcf7a0d46038cb4bbb3cfb81bcf</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC581-607</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tao Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IL-22</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">liver metastasis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Th22</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. Allergy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ramez Wahib</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitra E. Zazara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jöran Lücke</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmad Mustafa Shiri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jan Kempski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilan Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Theodora Agalioti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andres Pablo Machicote</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olympia Giannou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis Belios</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rongrong Jia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siwen Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joseph Tintelnot</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hannes Seese</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia Kristin Grass</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Baris Mercanoglu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Louisa Stern</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pasquale Scognamiglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohammad Fard-Aghaie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Philipp Seeger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jonas Wakker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marius Kemper</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Benjamin Brunswig</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Duprée</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Panagis M. Lykoudis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anastasia Pikouli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanouil Giorgakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pablo Stringa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalia Lausada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Virginia Gentilini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriel E. Gondolesi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kai Bachmann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Philipp Busch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rainer Grotelüschen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis C. Maroulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Petra C. Arck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryosuke Nakano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angus W. Thomson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tarik Ghadban</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael Tachezy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nathaniel Melling</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eike-Gert Achilles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Victor G. Puelles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Felix Nickel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thilo Hackert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oliver Mann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jakob R. Izbicki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jun Li</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicola Gagliani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samuel Huber</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anastasios D. Giannou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">OncoImmunology</subfield><subfield code="d">Taylor & Francis Group, 2020</subfield><subfield code="g">12(2023), 1</subfield><subfield code="w">(DE-627)683365428</subfield><subfield code="w">(DE-600)2645309-5</subfield><subfield code="x">2162402X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:1</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1080/2162402X.2023.2269634</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.tandfonline.com/doi/10.1080/2162402X.2023.2269634</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2162-402X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2023</subfield><subfield code="e">1</subfield></datafield></record></collection>
|
| score |
7.4004297 |