Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals

AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hy...
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Autor*in:	Bowen Zhu [verfasserIn] Fang Li [verfasserIn] Weidong Zhang [verfasserIn] Shuan Zhao [verfasserIn] Nana Song [verfasserIn] Shi Jin [verfasserIn] Ziyan Shen [verfasserIn] Yufei Lu [verfasserIn] Yang Li [verfasserIn] Hong Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Hypertension serum uric acid chronic kidney disease CHARLS

Übergeordnetes Werk:	In: Renal Failure - Taylor & Francis Group, 2018, 46(2024), 1
Übergeordnetes Werk:	volume:46 ; year:2024 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/0886022X.2023.2301041

Katalog-ID:	DOAJ101456581

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520			\|a AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control.
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allfields	10.1080/0886022X.2023.2301041 doi (DE-627)DOAJ101456581 (DE-599)DOAJc92085b8ae2d463f84d3eb25efb8539c DE-627 ger DE-627 rakwb eng RC870-923 Bowen Zhu verfasserin aut Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control. Hypertension serum uric acid chronic kidney disease CHARLS Diseases of the genitourinary system. Urology Fang Li verfasserin aut Weidong Zhang verfasserin aut Shuan Zhao verfasserin aut Nana Song verfasserin aut Shi Jin verfasserin aut Ziyan Shen verfasserin aut Yufei Lu verfasserin aut Yang Li verfasserin aut Hong Liu verfasserin aut In Renal Failure Taylor & Francis Group, 2018 46(2024), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:46 year:2024 number:1 https://doi.org/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/article/c92085b8ae2d463f84d3eb25efb8539c kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2024 1
spelling	10.1080/0886022X.2023.2301041 doi (DE-627)DOAJ101456581 (DE-599)DOAJc92085b8ae2d463f84d3eb25efb8539c DE-627 ger DE-627 rakwb eng RC870-923 Bowen Zhu verfasserin aut Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control. Hypertension serum uric acid chronic kidney disease CHARLS Diseases of the genitourinary system. Urology Fang Li verfasserin aut Weidong Zhang verfasserin aut Shuan Zhao verfasserin aut Nana Song verfasserin aut Shi Jin verfasserin aut Ziyan Shen verfasserin aut Yufei Lu verfasserin aut Yang Li verfasserin aut Hong Liu verfasserin aut In Renal Failure Taylor & Francis Group, 2018 46(2024), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:46 year:2024 number:1 https://doi.org/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/article/c92085b8ae2d463f84d3eb25efb8539c kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2024 1
allfields_unstemmed	10.1080/0886022X.2023.2301041 doi (DE-627)DOAJ101456581 (DE-599)DOAJc92085b8ae2d463f84d3eb25efb8539c DE-627 ger DE-627 rakwb eng RC870-923 Bowen Zhu verfasserin aut Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control. Hypertension serum uric acid chronic kidney disease CHARLS Diseases of the genitourinary system. Urology Fang Li verfasserin aut Weidong Zhang verfasserin aut Shuan Zhao verfasserin aut Nana Song verfasserin aut Shi Jin verfasserin aut Ziyan Shen verfasserin aut Yufei Lu verfasserin aut Yang Li verfasserin aut Hong Liu verfasserin aut In Renal Failure Taylor & Francis Group, 2018 46(2024), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:46 year:2024 number:1 https://doi.org/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/article/c92085b8ae2d463f84d3eb25efb8539c kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2024 1
allfieldsGer	10.1080/0886022X.2023.2301041 doi (DE-627)DOAJ101456581 (DE-599)DOAJc92085b8ae2d463f84d3eb25efb8539c DE-627 ger DE-627 rakwb eng RC870-923 Bowen Zhu verfasserin aut Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control. Hypertension serum uric acid chronic kidney disease CHARLS Diseases of the genitourinary system. Urology Fang Li verfasserin aut Weidong Zhang verfasserin aut Shuan Zhao verfasserin aut Nana Song verfasserin aut Shi Jin verfasserin aut Ziyan Shen verfasserin aut Yufei Lu verfasserin aut Yang Li verfasserin aut Hong Liu verfasserin aut In Renal Failure Taylor & Francis Group, 2018 46(2024), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:46 year:2024 number:1 https://doi.org/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/article/c92085b8ae2d463f84d3eb25efb8539c kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2024 1
allfieldsSound	10.1080/0886022X.2023.2301041 doi (DE-627)DOAJ101456581 (DE-599)DOAJc92085b8ae2d463f84d3eb25efb8539c DE-627 ger DE-627 rakwb eng RC870-923 Bowen Zhu verfasserin aut Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control. Hypertension serum uric acid chronic kidney disease CHARLS Diseases of the genitourinary system. Urology Fang Li verfasserin aut Weidong Zhang verfasserin aut Shuan Zhao verfasserin aut Nana Song verfasserin aut Shi Jin verfasserin aut Ziyan Shen verfasserin aut Yufei Lu verfasserin aut Yang Li verfasserin aut Hong Liu verfasserin aut In Renal Failure Taylor & Francis Group, 2018 46(2024), 1 (DE-627)320528421 (DE-600)2015459-8 15256049 nnns volume:46 year:2024 number:1 https://doi.org/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/article/c92085b8ae2d463f84d3eb25efb8539c kostenfrei https://www.tandfonline.com/doi/10.1080/0886022X.2023.2301041 kostenfrei https://doaj.org/toc/0886-022X Journal toc kostenfrei https://doaj.org/toc/1525-6049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2024 1
language	English
source	In Renal Failure 46(2024), 1 volume:46 year:2024 number:1
sourceStr	In Renal Failure 46(2024), 1 volume:46 year:2024 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hypertension serum uric acid chronic kidney disease CHARLS Diseases of the genitourinary system. Urology
isfreeaccess_bool	true
container_title	Renal Failure
authorswithroles_txt_mv	Bowen Zhu @@aut@@ Fang Li @@aut@@ Weidong Zhang @@aut@@ Shuan Zhao @@aut@@ Nana Song @@aut@@ Shi Jin @@aut@@ Ziyan Shen @@aut@@ Yufei Lu @@aut@@ Yang Li @@aut@@ Hong Liu @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	320528421
id	DOAJ101456581
language_de	englisch
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This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). 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callnumber-first	R - Medicine
author	Bowen Zhu
spellingShingle	Bowen Zhu misc RC870-923 misc Hypertension misc serum uric acid misc chronic kidney disease misc CHARLS misc Diseases of the genitourinary system. Urology Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals
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topic_title	RC870-923 Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals Hypertension serum uric acid chronic kidney disease CHARLS
topic	misc RC870-923 misc Hypertension misc serum uric acid misc chronic kidney disease misc CHARLS misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Hypertension misc serum uric acid misc chronic kidney disease misc CHARLS misc Diseases of the genitourinary system. Urology
topic_browse	misc RC870-923 misc Hypertension misc serum uric acid misc chronic kidney disease misc CHARLS misc Diseases of the genitourinary system. Urology
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title	Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals
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title_full	Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals
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author_browse	Bowen Zhu Fang Li Weidong Zhang Shuan Zhao Nana Song Shi Jin Ziyan Shen Yufei Lu Yang Li Hong Liu
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title_sort	disparity of serum uric acid threshold for ckd among hypertensive and non-hypertensive individuals
callnumber	RC870-923
title_auth	Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals
abstract	AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control.
abstractGer	AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control.
abstract_unstemmed	AbstractIntroduction Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.Materials and methods The study included 4180 individuals aged 45–85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.Results Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.Conclusion Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control.
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title_short	Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals
url	https://doi.org/10.1080/0886022X.2023.2301041 https://doaj.org/article/c92085b8ae2d463f84d3eb25efb8539c https://www.tandfonline.com/doi/10.1080/0886022X.2023.2301041 https://doaj.org/toc/0886-022X https://doaj.org/toc/1525-6049
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Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals

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