Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study

Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether re...
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Autor*in:	Lei Liu [verfasserIn] Changfa Wang [verfasserIn] Zhongyang Hu [verfasserIn] Shuwen Deng [verfasserIn] Saiqi Yang [verfasserIn] Xiaoling Zhu [verfasserIn] Yuling Deng [verfasserIn] Yaqin Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology

Übergeordnetes Werk:	In: Environmental Health and Preventive Medicine - Komiyama Printing Co. Ltd, 2018, 29(2024), Seite 5-5
Übergeordnetes Werk:	volume:29 ; year:2024 ; pages:5-5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1265/ehpm.23-00289

Katalog-ID:	DOAJ101673051

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245	1	0	\|a Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
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520			\|a Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy.
650		4	\|a remnant cholesterol
650		4	\|a nonalcoholic fatty liver disease
650		4	\|a cumulative exposure
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700	0		\|a Changfa Wang \|e verfasserin \|4 aut
700	0		\|a Zhongyang Hu \|e verfasserin \|4 aut
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700	0		\|a Saiqi Yang \|e verfasserin \|4 aut
700	0		\|a Xiaoling Zhu \|e verfasserin \|4 aut
700	0		\|a Yuling Deng \|e verfasserin \|4 aut
700	0		\|a Yaqin Wang \|e verfasserin \|4 aut
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author_variant	l l ll c w cw z h zh s d sd s y sy x z xz y d yd y w yw
matchkey_str	article:13474715:2024----::oolbslnbtuuaiexouefenncoetrlrdcshdvlpetfoachl
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allfields	10.1265/ehpm.23-00289 doi (DE-627)DOAJ101673051 (DE-599)DOAJd41b7ae6f3c84bff9fc72aa68e1aeb19 DE-627 ger DE-627 rakwb eng RA1-1270 Lei Liu verfasserin aut Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy. remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology Public aspects of medicine Changfa Wang verfasserin aut Zhongyang Hu verfasserin aut Shuwen Deng verfasserin aut Saiqi Yang verfasserin aut Xiaoling Zhu verfasserin aut Yuling Deng verfasserin aut Yaqin Wang verfasserin aut In Environmental Health and Preventive Medicine Komiyama Printing Co. Ltd, 2018 29(2024), Seite 5-5 (DE-627)37775918X (DE-600)2133273-3 13474715 nnns volume:29 year:2024 pages:5-5 https://doi.org/10.1265/ehpm.23-00289 kostenfrei https://doaj.org/article/d41b7ae6f3c84bff9fc72aa68e1aeb19 kostenfrei https://www.jstage.jst.go.jp/article/ehpm/29/0/29_23-00289/_html/-char/en kostenfrei https://doaj.org/toc/1342-078X Journal toc kostenfrei https://doaj.org/toc/1347-4715 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4367 GBV_ILN_4700 AR 29 2024 5-5
spelling	10.1265/ehpm.23-00289 doi (DE-627)DOAJ101673051 (DE-599)DOAJd41b7ae6f3c84bff9fc72aa68e1aeb19 DE-627 ger DE-627 rakwb eng RA1-1270 Lei Liu verfasserin aut Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy. remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology Public aspects of medicine Changfa Wang verfasserin aut Zhongyang Hu verfasserin aut Shuwen Deng verfasserin aut Saiqi Yang verfasserin aut Xiaoling Zhu verfasserin aut Yuling Deng verfasserin aut Yaqin Wang verfasserin aut In Environmental Health and Preventive Medicine Komiyama Printing Co. Ltd, 2018 29(2024), Seite 5-5 (DE-627)37775918X (DE-600)2133273-3 13474715 nnns volume:29 year:2024 pages:5-5 https://doi.org/10.1265/ehpm.23-00289 kostenfrei https://doaj.org/article/d41b7ae6f3c84bff9fc72aa68e1aeb19 kostenfrei https://www.jstage.jst.go.jp/article/ehpm/29/0/29_23-00289/_html/-char/en kostenfrei https://doaj.org/toc/1342-078X Journal toc kostenfrei https://doaj.org/toc/1347-4715 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4367 GBV_ILN_4700 AR 29 2024 5-5
allfields_unstemmed	10.1265/ehpm.23-00289 doi (DE-627)DOAJ101673051 (DE-599)DOAJd41b7ae6f3c84bff9fc72aa68e1aeb19 DE-627 ger DE-627 rakwb eng RA1-1270 Lei Liu verfasserin aut Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy. remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology Public aspects of medicine Changfa Wang verfasserin aut Zhongyang Hu verfasserin aut Shuwen Deng verfasserin aut Saiqi Yang verfasserin aut Xiaoling Zhu verfasserin aut Yuling Deng verfasserin aut Yaqin Wang verfasserin aut In Environmental Health and Preventive Medicine Komiyama Printing Co. Ltd, 2018 29(2024), Seite 5-5 (DE-627)37775918X (DE-600)2133273-3 13474715 nnns volume:29 year:2024 pages:5-5 https://doi.org/10.1265/ehpm.23-00289 kostenfrei https://doaj.org/article/d41b7ae6f3c84bff9fc72aa68e1aeb19 kostenfrei https://www.jstage.jst.go.jp/article/ehpm/29/0/29_23-00289/_html/-char/en kostenfrei https://doaj.org/toc/1342-078X Journal toc kostenfrei https://doaj.org/toc/1347-4715 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4367 GBV_ILN_4700 AR 29 2024 5-5
allfieldsGer	10.1265/ehpm.23-00289 doi (DE-627)DOAJ101673051 (DE-599)DOAJd41b7ae6f3c84bff9fc72aa68e1aeb19 DE-627 ger DE-627 rakwb eng RA1-1270 Lei Liu verfasserin aut Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy. remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology Public aspects of medicine Changfa Wang verfasserin aut Zhongyang Hu verfasserin aut Shuwen Deng verfasserin aut Saiqi Yang verfasserin aut Xiaoling Zhu verfasserin aut Yuling Deng verfasserin aut Yaqin Wang verfasserin aut In Environmental Health and Preventive Medicine Komiyama Printing Co. Ltd, 2018 29(2024), Seite 5-5 (DE-627)37775918X (DE-600)2133273-3 13474715 nnns volume:29 year:2024 pages:5-5 https://doi.org/10.1265/ehpm.23-00289 kostenfrei https://doaj.org/article/d41b7ae6f3c84bff9fc72aa68e1aeb19 kostenfrei https://www.jstage.jst.go.jp/article/ehpm/29/0/29_23-00289/_html/-char/en kostenfrei https://doaj.org/toc/1342-078X Journal toc kostenfrei https://doaj.org/toc/1347-4715 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4367 GBV_ILN_4700 AR 29 2024 5-5
allfieldsSound	10.1265/ehpm.23-00289 doi (DE-627)DOAJ101673051 (DE-599)DOAJd41b7ae6f3c84bff9fc72aa68e1aeb19 DE-627 ger DE-627 rakwb eng RA1-1270 Lei Liu verfasserin aut Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy. remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology Public aspects of medicine Changfa Wang verfasserin aut Zhongyang Hu verfasserin aut Shuwen Deng verfasserin aut Saiqi Yang verfasserin aut Xiaoling Zhu verfasserin aut Yuling Deng verfasserin aut Yaqin Wang verfasserin aut In Environmental Health and Preventive Medicine Komiyama Printing Co. Ltd, 2018 29(2024), Seite 5-5 (DE-627)37775918X (DE-600)2133273-3 13474715 nnns volume:29 year:2024 pages:5-5 https://doi.org/10.1265/ehpm.23-00289 kostenfrei https://doaj.org/article/d41b7ae6f3c84bff9fc72aa68e1aeb19 kostenfrei https://www.jstage.jst.go.jp/article/ehpm/29/0/29_23-00289/_html/-char/en kostenfrei https://doaj.org/toc/1342-078X Journal toc kostenfrei https://doaj.org/toc/1347-4715 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4367 GBV_ILN_4700 AR 29 2024 5-5
language	English
source	In Environmental Health and Preventive Medicine 29(2024), Seite 5-5 volume:29 year:2024 pages:5-5
sourceStr	In Environmental Health and Preventive Medicine 29(2024), Seite 5-5 volume:29 year:2024 pages:5-5
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology Public aspects of medicine
isfreeaccess_bool	true
container_title	Environmental Health and Preventive Medicine
authorswithroles_txt_mv	Lei Liu @@aut@@ Changfa Wang @@aut@@ Zhongyang Hu @@aut@@ Shuwen Deng @@aut@@ Saiqi Yang @@aut@@ Xiaoling Zhu @@aut@@ Yuling Deng @@aut@@ Yaqin Wang @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	37775918X
id	DOAJ101673051
language_de	englisch
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Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. 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author	Lei Liu
spellingShingle	Lei Liu misc RA1-1270 misc remnant cholesterol misc nonalcoholic fatty liver disease misc cumulative exposure misc cohort study misc epidemiology misc Public aspects of medicine Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
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illustrated	Not Illustrated
issn	13474715
topic_title	RA1-1270 Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study remnant cholesterol nonalcoholic fatty liver disease cumulative exposure cohort study epidemiology
topic	misc RA1-1270 misc remnant cholesterol misc nonalcoholic fatty liver disease misc cumulative exposure misc cohort study misc epidemiology misc Public aspects of medicine
topic_unstemmed	misc RA1-1270 misc remnant cholesterol misc nonalcoholic fatty liver disease misc cumulative exposure misc cohort study misc epidemiology misc Public aspects of medicine
topic_browse	misc RA1-1270 misc remnant cholesterol misc nonalcoholic fatty liver disease misc cumulative exposure misc cohort study misc epidemiology misc Public aspects of medicine
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title	Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
ctrlnum	(DE-627)DOAJ101673051 (DE-599)DOAJd41b7ae6f3c84bff9fc72aa68e1aeb19
title_full	Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
author_sort	Lei Liu
journal	Environmental Health and Preventive Medicine
journalStr	Environmental Health and Preventive Medicine
callnumber-first-code	R
lang_code	eng
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publishDateSort	2024
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container_start_page	5
author_browse	Lei Liu Changfa Wang Zhongyang Hu Shuwen Deng Saiqi Yang Xiaoling Zhu Yuling Deng Yaqin Wang
container_volume	29
class	RA1-1270
format_se	Elektronische Aufsätze
author-letter	Lei Liu
doi_str_mv	10.1265/ehpm.23-00289
author2-role	verfasserin
title_sort	not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
callnumber	RA1-1270
title_auth	Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
abstract	Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy.
abstractGer	Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy.
abstract_unstemmed	Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_120 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4367 GBV_ILN_4700
title_short	Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study
url	https://doi.org/10.1265/ehpm.23-00289 https://doaj.org/article/d41b7ae6f3c84bff9fc72aa68e1aeb19 https://www.jstage.jst.go.jp/article/ehpm/29/0/29_23-00289/_html/-char/en https://doaj.org/toc/1342-078X https://doaj.org/toc/1347-4715
remote_bool	true
author2	Changfa Wang Zhongyang Hu Shuwen Deng Saiqi Yang Xiaoling Zhu Yuling Deng Yaqin Wang
author2Str	Changfa Wang Zhongyang Hu Shuwen Deng Saiqi Yang Xiaoling Zhu Yuling Deng Yaqin Wang
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doi_str	10.1265/ehpm.23-00289
callnumber-a	RA1-1270
up_date	2024-07-03T21:54:34.860Z
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Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study

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