Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses

Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ziv, Noam E. [verfasserIn] Brenner, Naama [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes

Übergeordnetes Werk:	Enthalten in: Trends in neurosciences - Amsterdam [u.a.] : Elsevier Science, 1978, 41, Seite 89-99
Übergeordnetes Werk:	volume:41 ; pages:89-99

DOI / URN:	10.1016/j.tins.2017.12.003

Katalog-ID:	ELV000099023

Internformat


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245	1	0	\|a Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses
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520			\|a Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research.
650		4	\|a synaptic plasticity
650		4	\|a synaptic tenacity
650		4	\|a synaptic remodeling
650		4	\|a stochastic processes
700	1		\|a Brenner, Naama \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Trends in neurosciences \|d Amsterdam [u.a.] : Elsevier Science, 1978 \|g 41, Seite 89-99 \|h Online-Ressource \|w (DE-627)32049084X \|w (DE-600)2011000-5 \|w (DE-576)105796921 \|x 1878-108X \|7 nnns
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936	b	k	\|a 44.90 \|j Neurologie
951			\|a AR
952			\|d 41 \|h 89-99

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author_variant	n e z ne nez n b nb
matchkey_str	article:1878108X:2017----::yatceaiyrakhrosotnoseo
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bklnumber	44.90
publishDate	2017
allfields	10.1016/j.tins.2017.12.003 doi (DE-627)ELV000099023 (ELSEVIER)S0166-2236(17)30237-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Ziv, Noam E. verfasserin aut Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research. synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes Brenner, Naama verfasserin aut Enthalten in Trends in neurosciences Amsterdam [u.a.] : Elsevier Science, 1978 41, Seite 89-99 Online-Ressource (DE-627)32049084X (DE-600)2011000-5 (DE-576)105796921 1878-108X nnns volume:41 pages:89-99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 41 89-99
spelling	10.1016/j.tins.2017.12.003 doi (DE-627)ELV000099023 (ELSEVIER)S0166-2236(17)30237-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Ziv, Noam E. verfasserin aut Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research. synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes Brenner, Naama verfasserin aut Enthalten in Trends in neurosciences Amsterdam [u.a.] : Elsevier Science, 1978 41, Seite 89-99 Online-Ressource (DE-627)32049084X (DE-600)2011000-5 (DE-576)105796921 1878-108X nnns volume:41 pages:89-99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 41 89-99
allfields_unstemmed	10.1016/j.tins.2017.12.003 doi (DE-627)ELV000099023 (ELSEVIER)S0166-2236(17)30237-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Ziv, Noam E. verfasserin aut Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research. synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes Brenner, Naama verfasserin aut Enthalten in Trends in neurosciences Amsterdam [u.a.] : Elsevier Science, 1978 41, Seite 89-99 Online-Ressource (DE-627)32049084X (DE-600)2011000-5 (DE-576)105796921 1878-108X nnns volume:41 pages:89-99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 41 89-99
allfieldsGer	10.1016/j.tins.2017.12.003 doi (DE-627)ELV000099023 (ELSEVIER)S0166-2236(17)30237-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Ziv, Noam E. verfasserin aut Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research. synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes Brenner, Naama verfasserin aut Enthalten in Trends in neurosciences Amsterdam [u.a.] : Elsevier Science, 1978 41, Seite 89-99 Online-Ressource (DE-627)32049084X (DE-600)2011000-5 (DE-576)105796921 1878-108X nnns volume:41 pages:89-99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 41 89-99
allfieldsSound	10.1016/j.tins.2017.12.003 doi (DE-627)ELV000099023 (ELSEVIER)S0166-2236(17)30237-0 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Ziv, Noam E. verfasserin aut Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research. synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes Brenner, Naama verfasserin aut Enthalten in Trends in neurosciences Amsterdam [u.a.] : Elsevier Science, 1978 41, Seite 89-99 Online-Ressource (DE-627)32049084X (DE-600)2011000-5 (DE-576)105796921 1878-108X nnns volume:41 pages:89-99 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie AR 41 89-99
language	English
source	Enthalten in Trends in neurosciences 41, Seite 89-99 volume:41 pages:89-99
sourceStr	Enthalten in Trends in neurosciences 41, Seite 89-99 volume:41 pages:89-99
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes
dewey-raw	610
isfreeaccess_bool	false
container_title	Trends in neurosciences
authorswithroles_txt_mv	Ziv, Noam E. @@aut@@ Brenner, Naama @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	32049084X
dewey-sort	3610
id	ELV000099023
language_de	englisch
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author	Ziv, Noam E.
spellingShingle	Ziv, Noam E. ddc 610 bkl 44.90 misc synaptic plasticity misc synaptic tenacity misc synaptic remodeling misc stochastic processes Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses
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topic_title	610 DE-600 44.90 bkl Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses synaptic plasticity synaptic tenacity synaptic remodeling stochastic processes
topic	ddc 610 bkl 44.90 misc synaptic plasticity misc synaptic tenacity misc synaptic remodeling misc stochastic processes
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title	Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses
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title_full	Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses
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title_sort	synaptic tenacity or lack thereof: spontaneous remodeling of synapses
title_auth	Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses
abstract	Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research.
abstractGer	Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research.
abstract_unstemmed	Synaptic plasticity – the directed modulation of synaptic connections by specific activity histories or physiological signals – is believed to be a major mechanism for the modification of neuronal network function. This belief, however, has a ‘flip side’: the supposition that synapses do not change spontaneously in manners unrelated to such signals. Contrary to this supposition, recent studies reveal that synapses do change spontaneously, and to a fairly large extent. Here we review experimental results on spontaneous synaptic remodeling, its relative contributions to total synaptic remodeling, its statistical characteristics, and its physiological importance. We also address challenges it poses and avenues it opens for future experimental and theoretical research.
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title_short	Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses
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up_date	2024-07-06T16:51:35.626Z
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