Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence

Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns...
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Autor*in:	Hiemstra, Marieke [verfasserIn] Nelemans, Stefanie A. [verfasserIn] Branje, Susan [verfasserIn] van Eijk, Kristel R. [verfasserIn] Hottenga, Jouke-Jan [verfasserIn] Vinkers, Christiaan H. [verfasserIn] van Lier, Pol [verfasserIn] Meeus, Wim [verfasserIn] Boks, Marco P. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic

Übergeordnetes Werk:	Enthalten in: Drug and alcohol dependence - Amsterdam [u.a.] : Elsevier Science, 1975, 190, Seite 143-150
Übergeordnetes Werk:	volume:190 ; pages:143-150

DOI / URN:	10.1016/j.drugalcdep.2018.05.024

Katalog-ID:	ELV000208329

Internformat


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100	1		\|a Hiemstra, Marieke \|e verfasserin \|4 aut
245	1	0	\|a Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
264		1	\|c 2018
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.
650		4	\|a Adolescence
650		4	\|a Schizophrenia
650		4	\|a Polygenic risk score
650		4	\|a Cannabis use
650		4	\|a Smoking
650		4	\|a Alcohol use
650		4	\|a Substance use
650		4	\|a Genetic
700	1		\|a Nelemans, Stefanie A. \|e verfasserin \|4 aut
700	1		\|a Branje, Susan \|e verfasserin \|4 aut
700	1		\|a van Eijk, Kristel R. \|e verfasserin \|4 aut
700	1		\|a Hottenga, Jouke-Jan \|e verfasserin \|4 aut
700	1		\|a Vinkers, Christiaan H. \|e verfasserin \|4 aut
700	1		\|a van Lier, Pol \|e verfasserin \|4 aut
700	1		\|a Meeus, Wim \|e verfasserin \|4 aut
700	1		\|a Boks, Marco P. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Drug and alcohol dependence \|d Amsterdam [u.a.] : Elsevier Science, 1975 \|g 190, Seite 143-150 \|h Online-Ressource \|w (DE-627)320441059 \|w (DE-600)2004927-4 \|w (DE-576)252887816 \|x 1879-0046 \|7 nnns
773	1	8	\|g volume:190 \|g pages:143-150
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912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.39 \|j Toxikologie
936	b	k	\|a 44.91 \|j Psychiatrie \|j Psychopathologie
951			\|a AR
952			\|d 190 \|h 143-150

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matchkey_str	article:18790046:2018----::eeivleaiiyocioheiiascaewtcnaiue
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publishDate	2018
allfields	10.1016/j.drugalcdep.2018.05.024 doi (DE-627)ELV000208329 (ELSEVIER)S0376-8716(18)30339-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.39 bkl 44.91 bkl Hiemstra, Marieke verfasserin aut Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established. Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic Nelemans, Stefanie A. verfasserin aut Branje, Susan verfasserin aut van Eijk, Kristel R. verfasserin aut Hottenga, Jouke-Jan verfasserin aut Vinkers, Christiaan H. verfasserin aut van Lier, Pol verfasserin aut Meeus, Wim verfasserin aut Boks, Marco P. verfasserin aut Enthalten in Drug and alcohol dependence Amsterdam [u.a.] : Elsevier Science, 1975 190, Seite 143-150 Online-Ressource (DE-627)320441059 (DE-600)2004927-4 (DE-576)252887816 1879-0046 nnns volume:190 pages:143-150 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.39 Toxikologie 44.91 Psychiatrie Psychopathologie AR 190 143-150
spelling	10.1016/j.drugalcdep.2018.05.024 doi (DE-627)ELV000208329 (ELSEVIER)S0376-8716(18)30339-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.39 bkl 44.91 bkl Hiemstra, Marieke verfasserin aut Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established. Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic Nelemans, Stefanie A. verfasserin aut Branje, Susan verfasserin aut van Eijk, Kristel R. verfasserin aut Hottenga, Jouke-Jan verfasserin aut Vinkers, Christiaan H. verfasserin aut van Lier, Pol verfasserin aut Meeus, Wim verfasserin aut Boks, Marco P. verfasserin aut Enthalten in Drug and alcohol dependence Amsterdam [u.a.] : Elsevier Science, 1975 190, Seite 143-150 Online-Ressource (DE-627)320441059 (DE-600)2004927-4 (DE-576)252887816 1879-0046 nnns volume:190 pages:143-150 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.39 Toxikologie 44.91 Psychiatrie Psychopathologie AR 190 143-150
allfields_unstemmed	10.1016/j.drugalcdep.2018.05.024 doi (DE-627)ELV000208329 (ELSEVIER)S0376-8716(18)30339-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.39 bkl 44.91 bkl Hiemstra, Marieke verfasserin aut Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established. Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic Nelemans, Stefanie A. verfasserin aut Branje, Susan verfasserin aut van Eijk, Kristel R. verfasserin aut Hottenga, Jouke-Jan verfasserin aut Vinkers, Christiaan H. verfasserin aut van Lier, Pol verfasserin aut Meeus, Wim verfasserin aut Boks, Marco P. verfasserin aut Enthalten in Drug and alcohol dependence Amsterdam [u.a.] : Elsevier Science, 1975 190, Seite 143-150 Online-Ressource (DE-627)320441059 (DE-600)2004927-4 (DE-576)252887816 1879-0046 nnns volume:190 pages:143-150 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.39 Toxikologie 44.91 Psychiatrie Psychopathologie AR 190 143-150
allfieldsGer	10.1016/j.drugalcdep.2018.05.024 doi (DE-627)ELV000208329 (ELSEVIER)S0376-8716(18)30339-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.39 bkl 44.91 bkl Hiemstra, Marieke verfasserin aut Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established. Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic Nelemans, Stefanie A. verfasserin aut Branje, Susan verfasserin aut van Eijk, Kristel R. verfasserin aut Hottenga, Jouke-Jan verfasserin aut Vinkers, Christiaan H. verfasserin aut van Lier, Pol verfasserin aut Meeus, Wim verfasserin aut Boks, Marco P. verfasserin aut Enthalten in Drug and alcohol dependence Amsterdam [u.a.] : Elsevier Science, 1975 190, Seite 143-150 Online-Ressource (DE-627)320441059 (DE-600)2004927-4 (DE-576)252887816 1879-0046 nnns volume:190 pages:143-150 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.39 Toxikologie 44.91 Psychiatrie Psychopathologie AR 190 143-150
allfieldsSound	10.1016/j.drugalcdep.2018.05.024 doi (DE-627)ELV000208329 (ELSEVIER)S0376-8716(18)30339-9 DE-627 ger DE-627 rda eng 610 DE-600 15,3 ssgn PHARM DE-84 fid 44.39 bkl 44.91 bkl Hiemstra, Marieke verfasserin aut Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established. Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic Nelemans, Stefanie A. verfasserin aut Branje, Susan verfasserin aut van Eijk, Kristel R. verfasserin aut Hottenga, Jouke-Jan verfasserin aut Vinkers, Christiaan H. verfasserin aut van Lier, Pol verfasserin aut Meeus, Wim verfasserin aut Boks, Marco P. verfasserin aut Enthalten in Drug and alcohol dependence Amsterdam [u.a.] : Elsevier Science, 1975 190, Seite 143-150 Online-Ressource (DE-627)320441059 (DE-600)2004927-4 (DE-576)252887816 1879-0046 nnns volume:190 pages:143-150 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.39 Toxikologie 44.91 Psychiatrie Psychopathologie AR 190 143-150
language	English
source	Enthalten in Drug and alcohol dependence 190, Seite 143-150 volume:190 pages:143-150
sourceStr	Enthalten in Drug and alcohol dependence 190, Seite 143-150 volume:190 pages:143-150
format_phy_str_mv	Article
bklname	Toxikologie Psychiatrie Psychopathologie
institution	findex.gbv.de
topic_facet	Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic
dewey-raw	610
isfreeaccess_bool	false
container_title	Drug and alcohol dependence
authorswithroles_txt_mv	Hiemstra, Marieke @@aut@@ Nelemans, Stefanie A. @@aut@@ Branje, Susan @@aut@@ van Eijk, Kristel R. @@aut@@ Hottenga, Jouke-Jan @@aut@@ Vinkers, Christiaan H. @@aut@@ van Lier, Pol @@aut@@ Meeus, Wim @@aut@@ Boks, Marco P. @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	320441059
dewey-sort	3610
id	ELV000208329
language_de	englisch
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The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. 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author	Hiemstra, Marieke
spellingShingle	Hiemstra, Marieke ddc 610 ssgn 15,3 fid PHARM bkl 44.39 bkl 44.91 misc Adolescence misc Schizophrenia misc Polygenic risk score misc Cannabis use misc Smoking misc Alcohol use misc Substance use misc Genetic Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
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topic_title	610 DE-600 15,3 ssgn PHARM DE-84 fid 44.39 bkl 44.91 bkl Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence Adolescence Schizophrenia Polygenic risk score Cannabis use Smoking Alcohol use Substance use Genetic
topic	ddc 610 ssgn 15,3 fid PHARM bkl 44.39 bkl 44.91 misc Adolescence misc Schizophrenia misc Polygenic risk score misc Cannabis use misc Smoking misc Alcohol use misc Substance use misc Genetic
topic_unstemmed	ddc 610 ssgn 15,3 fid PHARM bkl 44.39 bkl 44.91 misc Adolescence misc Schizophrenia misc Polygenic risk score misc Cannabis use misc Smoking misc Alcohol use misc Substance use misc Genetic
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title	Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
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title_full	Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
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author_browse	Hiemstra, Marieke Nelemans, Stefanie A. Branje, Susan van Eijk, Kristel R. Hottenga, Jouke-Jan Vinkers, Christiaan H. van Lier, Pol Meeus, Wim Boks, Marco P.
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doi_str_mv	10.1016/j.drugalcdep.2018.05.024
dewey-full	610
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title_sort	genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
title_auth	Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
abstract	Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.
abstractGer	Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.
abstract_unstemmed	Background: Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13–16 with 16–20 years).Method: Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001.Results: High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16–20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found.Conclusions: In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.
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title_short	Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence
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author2	Nelemans, Stefanie A. Branje, Susan van Eijk, Kristel R. Hottenga, Jouke-Jan Vinkers, Christiaan H. van Lier, Pol Meeus, Wim Boks, Marco P.
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up_date	2024-07-06T17:12:15.735Z
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