Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against

Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium api...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pfaller, Michael A. [verfasserIn] Rhomberg, Paul R. [verfasserIn] Castanheira, Mariana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds

Übergeordnetes Werk:	Enthalten in: Diagnostic microbiology and infectious disease - Amsterdam [u.a.] : Elsevier Science, 1983, 92, Seite 43-45
Übergeordnetes Werk:	volume:92 ; pages:43-45

DOI / URN:	10.1016/j.diagmicrobio.2018.04.005

Katalog-ID:	ELV000225673

Internformat


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520			\|a Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates.
650		4	\|a Isavuconazonium sulfate, prodrug
650		4	\|a Isavuconazole
650		4	\|a Rare moulds
700	1		\|a Rhomberg, Paul R. \|e verfasserin \|4 aut
700	1		\|a Castanheira, Mariana \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Diagnostic microbiology and infectious disease \|d Amsterdam [u.a.] : Elsevier Science, 1983 \|g 92, Seite 43-45 \|h Online-Ressource \|w (DE-627)32360479X \|w (DE-600)2026024-6 \|w (DE-576)264424107 \|x 1879-0070 \|7 nnns
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912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_252
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
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936	b	k	\|a 44.43 \|j Medizinische Mikrobiologie
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952			\|d 92 \|h 43-45

Indexfelder

author_variant	m a p ma map p r r pr prr m c mc
matchkey_str	article:18790070:2018----::ietnircmaiooterduiauoaoimuftwttesvcn
hierarchy_sort_str	2018
bklnumber	44.43 44.75
publishDate	2018
allfields	10.1016/j.diagmicrobio.2018.04.005 doi (DE-627)ELV000225673 (ELSEVIER)S0732-8893(18)30118-4 DE-627 ger DE-627 rda eng 610 DE-600 44.43 bkl 44.75 bkl Pfaller, Michael A. verfasserin aut Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates. Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds Rhomberg, Paul R. verfasserin aut Castanheira, Mariana verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 92, Seite 43-45 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:92 pages:43-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.43 Medizinische Mikrobiologie 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 92 43-45
spelling	10.1016/j.diagmicrobio.2018.04.005 doi (DE-627)ELV000225673 (ELSEVIER)S0732-8893(18)30118-4 DE-627 ger DE-627 rda eng 610 DE-600 44.43 bkl 44.75 bkl Pfaller, Michael A. verfasserin aut Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates. Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds Rhomberg, Paul R. verfasserin aut Castanheira, Mariana verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 92, Seite 43-45 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:92 pages:43-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.43 Medizinische Mikrobiologie 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 92 43-45
allfields_unstemmed	10.1016/j.diagmicrobio.2018.04.005 doi (DE-627)ELV000225673 (ELSEVIER)S0732-8893(18)30118-4 DE-627 ger DE-627 rda eng 610 DE-600 44.43 bkl 44.75 bkl Pfaller, Michael A. verfasserin aut Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates. Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds Rhomberg, Paul R. verfasserin aut Castanheira, Mariana verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 92, Seite 43-45 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:92 pages:43-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.43 Medizinische Mikrobiologie 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 92 43-45
allfieldsGer	10.1016/j.diagmicrobio.2018.04.005 doi (DE-627)ELV000225673 (ELSEVIER)S0732-8893(18)30118-4 DE-627 ger DE-627 rda eng 610 DE-600 44.43 bkl 44.75 bkl Pfaller, Michael A. verfasserin aut Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates. Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds Rhomberg, Paul R. verfasserin aut Castanheira, Mariana verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 92, Seite 43-45 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:92 pages:43-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.43 Medizinische Mikrobiologie 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 92 43-45
allfieldsSound	10.1016/j.diagmicrobio.2018.04.005 doi (DE-627)ELV000225673 (ELSEVIER)S0732-8893(18)30118-4 DE-627 ger DE-627 rda eng 610 DE-600 44.43 bkl 44.75 bkl Pfaller, Michael A. verfasserin aut Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates. Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds Rhomberg, Paul R. verfasserin aut Castanheira, Mariana verfasserin aut Enthalten in Diagnostic microbiology and infectious disease Amsterdam [u.a.] : Elsevier Science, 1983 92, Seite 43-45 Online-Ressource (DE-627)32360479X (DE-600)2026024-6 (DE-576)264424107 1879-0070 nnns volume:92 pages:43-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.43 Medizinische Mikrobiologie 44.75 Infektionskrankheiten parasitäre Krankheiten Medizin AR 92 43-45
language	English
source	Enthalten in Diagnostic microbiology and infectious disease 92, Seite 43-45 volume:92 pages:43-45
sourceStr	Enthalten in Diagnostic microbiology and infectious disease 92, Seite 43-45 volume:92 pages:43-45
format_phy_str_mv	Article
bklname	Medizinische Mikrobiologie Infektionskrankheiten parasitäre Krankheiten
institution	findex.gbv.de
topic_facet	Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds
dewey-raw	610
isfreeaccess_bool	false
container_title	Diagnostic microbiology and infectious disease
authorswithroles_txt_mv	Pfaller, Michael A. @@aut@@ Rhomberg, Paul R. @@aut@@ Castanheira, Mariana @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	32360479X
dewey-sort	3610
id	ELV000225673
language_de	englisch
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author	Pfaller, Michael A.
spellingShingle	Pfaller, Michael A. ddc 610 bkl 44.43 bkl 44.75 misc Isavuconazonium sulfate, prodrug misc Isavuconazole misc Rare moulds Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against
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topic_title	610 DE-600 44.43 bkl 44.75 bkl Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against Isavuconazonium sulfate, prodrug Isavuconazole Rare moulds
topic	ddc 610 bkl 44.43 bkl 44.75 misc Isavuconazonium sulfate, prodrug misc Isavuconazole misc Rare moulds
topic_unstemmed	ddc 610 bkl 44.43 bkl 44.75 misc Isavuconazonium sulfate, prodrug misc Isavuconazole misc Rare moulds
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title	Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against
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title_full	Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against
author_sort	Pfaller, Michael A.
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author_browse	Pfaller, Michael A. Rhomberg, Paul R. Castanheira, Mariana
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title_sort	direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against
title_auth	Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against
abstract	Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates.
abstractGer	Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates.
abstract_unstemmed	Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp., 96.4% of isolates were wild type (WT) to isavuconazole and only 75% were WT to the prodrug. The essential agreement (±2 log2 dilutions) between prodrug and isavuconazole MIC values was 96.4% across all tested isolates. The active metabolite, isavuconazole, is recommended to use during in vitro susceptibility testing of fungal isolates.
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title_short	Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against
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author2	Rhomberg, Paul R. Castanheira, Mariana
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up_date	2024-07-06T17:15:42.085Z
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Direct in vitro comparison of the prodrug isavuconazonium sulfate with the isavuconazole active compound against

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