Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome

Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or seve...
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Autor*in:	Montaldo, Paolo [verfasserIn] Cuccaro, Pasquale [verfasserIn] Caredda, Elisabetta [verfasserIn] Pugliese, Umberto [verfasserIn] De Vivo, Massimiliano [verfasserIn] Orbinato, Francesco [verfasserIn] Magri, Daniela [verfasserIn] Rojo, Silvana [verfasserIn] Rosso, Roberto [verfasserIn] Santantonio, Alfredo [verfasserIn] Vitiello, Renato [verfasserIn] Vacchiano, Teresa [verfasserIn] Chello, Giovanni [verfasserIn] Del Giudice, Emanuele Miraglia [verfasserIn] Giliberti, Paolo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography

Übergeordnetes Werk:	Enthalten in: Resuscitation - Amsterdam [u.a.] : Elsevier Science, 1972, 130, Seite 99-104
Übergeordnetes Werk:	volume:130 ; pages:99-104

DOI / URN:	10.1016/j.resuscitation.2018.07.014

Katalog-ID:	ELV000238961

Internformat


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024	7		\|a 10.1016/j.resuscitation.2018.07.014 \|2 doi
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100	1		\|a Montaldo, Paolo \|e verfasserin \|4 aut
245	1	0	\|a Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
264		1	\|c 2018
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia.
650		4	\|a Therapeutic hypothermia
650		4	\|a Hypoxic–ischaemic encephalopathy
650		4	\|a Neonatal encephalopathy
650		4	\|a Echocardiography
650		4	\|a Electrocardiography
700	1		\|a Cuccaro, Pasquale \|e verfasserin \|4 aut
700	1		\|a Caredda, Elisabetta \|e verfasserin \|4 aut
700	1		\|a Pugliese, Umberto \|e verfasserin \|4 aut
700	1		\|a De Vivo, Massimiliano \|e verfasserin \|4 aut
700	1		\|a Orbinato, Francesco \|e verfasserin \|4 aut
700	1		\|a Magri, Daniela \|e verfasserin \|4 aut
700	1		\|a Rojo, Silvana \|e verfasserin \|4 aut
700	1		\|a Rosso, Roberto \|e verfasserin \|4 aut
700	1		\|a Santantonio, Alfredo \|e verfasserin \|4 aut
700	1		\|a Vitiello, Renato \|e verfasserin \|4 aut
700	1		\|a Vacchiano, Teresa \|e verfasserin \|4 aut
700	1		\|a Chello, Giovanni \|e verfasserin \|4 aut
700	1		\|a Del Giudice, Emanuele Miraglia \|e verfasserin \|4 aut
700	1		\|a Giliberti, Paolo \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Resuscitation \|d Amsterdam [u.a.] : Elsevier Science, 1972 \|g 130, Seite 99-104 \|h Online-Ressource \|w (DE-627)320488543 \|w (DE-600)2010733-X \|w (DE-576)099879042 \|x 1873-1570 \|7 nnns
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912			\|a GBV_ILN_2020
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912			\|a GBV_ILN_2049
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912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
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912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
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912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.80 \|j Unfallmedizin \|j Notfallmedizin
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publishDate	2018
allfields	10.1016/j.resuscitation.2018.07.014 doi (DE-627)ELV000238961 (ELSEVIER)S0300-9572(18)30345-9 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Montaldo, Paolo verfasserin aut Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia. Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography Cuccaro, Pasquale verfasserin aut Caredda, Elisabetta verfasserin aut Pugliese, Umberto verfasserin aut De Vivo, Massimiliano verfasserin aut Orbinato, Francesco verfasserin aut Magri, Daniela verfasserin aut Rojo, Silvana verfasserin aut Rosso, Roberto verfasserin aut Santantonio, Alfredo verfasserin aut Vitiello, Renato verfasserin aut Vacchiano, Teresa verfasserin aut Chello, Giovanni verfasserin aut Del Giudice, Emanuele Miraglia verfasserin aut Giliberti, Paolo verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 130, Seite 99-104 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:130 pages:99-104 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 130 99-104
spelling	10.1016/j.resuscitation.2018.07.014 doi (DE-627)ELV000238961 (ELSEVIER)S0300-9572(18)30345-9 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Montaldo, Paolo verfasserin aut Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia. Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography Cuccaro, Pasquale verfasserin aut Caredda, Elisabetta verfasserin aut Pugliese, Umberto verfasserin aut De Vivo, Massimiliano verfasserin aut Orbinato, Francesco verfasserin aut Magri, Daniela verfasserin aut Rojo, Silvana verfasserin aut Rosso, Roberto verfasserin aut Santantonio, Alfredo verfasserin aut Vitiello, Renato verfasserin aut Vacchiano, Teresa verfasserin aut Chello, Giovanni verfasserin aut Del Giudice, Emanuele Miraglia verfasserin aut Giliberti, Paolo verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 130, Seite 99-104 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:130 pages:99-104 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 130 99-104
allfields_unstemmed	10.1016/j.resuscitation.2018.07.014 doi (DE-627)ELV000238961 (ELSEVIER)S0300-9572(18)30345-9 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Montaldo, Paolo verfasserin aut Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia. Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography Cuccaro, Pasquale verfasserin aut Caredda, Elisabetta verfasserin aut Pugliese, Umberto verfasserin aut De Vivo, Massimiliano verfasserin aut Orbinato, Francesco verfasserin aut Magri, Daniela verfasserin aut Rojo, Silvana verfasserin aut Rosso, Roberto verfasserin aut Santantonio, Alfredo verfasserin aut Vitiello, Renato verfasserin aut Vacchiano, Teresa verfasserin aut Chello, Giovanni verfasserin aut Del Giudice, Emanuele Miraglia verfasserin aut Giliberti, Paolo verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 130, Seite 99-104 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:130 pages:99-104 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 130 99-104
allfieldsGer	10.1016/j.resuscitation.2018.07.014 doi (DE-627)ELV000238961 (ELSEVIER)S0300-9572(18)30345-9 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Montaldo, Paolo verfasserin aut Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia. Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography Cuccaro, Pasquale verfasserin aut Caredda, Elisabetta verfasserin aut Pugliese, Umberto verfasserin aut De Vivo, Massimiliano verfasserin aut Orbinato, Francesco verfasserin aut Magri, Daniela verfasserin aut Rojo, Silvana verfasserin aut Rosso, Roberto verfasserin aut Santantonio, Alfredo verfasserin aut Vitiello, Renato verfasserin aut Vacchiano, Teresa verfasserin aut Chello, Giovanni verfasserin aut Del Giudice, Emanuele Miraglia verfasserin aut Giliberti, Paolo verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 130, Seite 99-104 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:130 pages:99-104 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 130 99-104
allfieldsSound	10.1016/j.resuscitation.2018.07.014 doi (DE-627)ELV000238961 (ELSEVIER)S0300-9572(18)30345-9 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Montaldo, Paolo verfasserin aut Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia. Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography Cuccaro, Pasquale verfasserin aut Caredda, Elisabetta verfasserin aut Pugliese, Umberto verfasserin aut De Vivo, Massimiliano verfasserin aut Orbinato, Francesco verfasserin aut Magri, Daniela verfasserin aut Rojo, Silvana verfasserin aut Rosso, Roberto verfasserin aut Santantonio, Alfredo verfasserin aut Vitiello, Renato verfasserin aut Vacchiano, Teresa verfasserin aut Chello, Giovanni verfasserin aut Del Giudice, Emanuele Miraglia verfasserin aut Giliberti, Paolo verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 130, Seite 99-104 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:130 pages:99-104 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 130 99-104
language	English
source	Enthalten in Resuscitation 130, Seite 99-104 volume:130 pages:99-104
sourceStr	Enthalten in Resuscitation 130, Seite 99-104 volume:130 pages:99-104
format_phy_str_mv	Article
bklname	Unfallmedizin Notfallmedizin
institution	findex.gbv.de
topic_facet	Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography
dewey-raw	610
isfreeaccess_bool	false
container_title	Resuscitation
authorswithroles_txt_mv	Montaldo, Paolo @@aut@@ Cuccaro, Pasquale @@aut@@ Caredda, Elisabetta @@aut@@ Pugliese, Umberto @@aut@@ De Vivo, Massimiliano @@aut@@ Orbinato, Francesco @@aut@@ Magri, Daniela @@aut@@ Rojo, Silvana @@aut@@ Rosso, Roberto @@aut@@ Santantonio, Alfredo @@aut@@ Vitiello, Renato @@aut@@ Vacchiano, Teresa @@aut@@ Chello, Giovanni @@aut@@ Del Giudice, Emanuele Miraglia @@aut@@ Giliberti, Paolo @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	320488543
dewey-sort	3610
id	ELV000238961
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV000238961</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524140943.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230427s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.resuscitation.2018.07.014</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV000238961</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0300-9572(18)30345-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.80</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Montaldo, Paolo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. 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During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. 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author	Montaldo, Paolo
spellingShingle	Montaldo, Paolo ddc 610 bkl 44.80 misc Therapeutic hypothermia misc Hypoxic–ischaemic encephalopathy misc Neonatal encephalopathy misc Echocardiography misc Electrocardiography Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
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topic_title	610 DE-600 44.80 bkl Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome Therapeutic hypothermia Hypoxic–ischaemic encephalopathy Neonatal encephalopathy Echocardiography Electrocardiography
topic	ddc 610 bkl 44.80 misc Therapeutic hypothermia misc Hypoxic–ischaemic encephalopathy misc Neonatal encephalopathy misc Echocardiography misc Electrocardiography
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title	Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
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title_full	Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
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author_browse	Montaldo, Paolo Cuccaro, Pasquale Caredda, Elisabetta Pugliese, Umberto De Vivo, Massimiliano Orbinato, Francesco Magri, Daniela Rojo, Silvana Rosso, Roberto Santantonio, Alfredo Vitiello, Renato Vacchiano, Teresa Chello, Giovanni Del Giudice, Emanuele Miraglia Giliberti, Paolo
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doi_str_mv	10.1016/j.resuscitation.2018.07.014
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title_sort	electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
title_auth	Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
abstract	Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia.
abstractGer	Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia.
abstract_unstemmed	Aim: To assess the electrocardiography and echocardiography changes during therapeutic hypothermia and rewarming period in encephalopathic infants with long-term adverse neurological outcome.Methods: Prospective multicentre longitudinal study. We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. Infants with poor outcome have higher heart rate and shorter RR and QTc intervals during therapeutic hypothermia.
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title_short	Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome
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author2	Cuccaro, Pasquale Caredda, Elisabetta Pugliese, Umberto De Vivo, Massimiliano Orbinato, Francesco Magri, Daniela Rojo, Silvana Rosso, Roberto Santantonio, Alfredo Vitiello, Renato Vacchiano, Teresa Chello, Giovanni Del Giudice, Emanuele Miraglia Giliberti, Paolo
author2Str	Cuccaro, Pasquale Caredda, Elisabetta Pugliese, Umberto De Vivo, Massimiliano Orbinato, Francesco Magri, Daniela Rojo, Silvana Rosso, Roberto Santantonio, Alfredo Vitiello, Renato Vacchiano, Teresa Chello, Giovanni Del Giudice, Emanuele Miraglia Giliberti, Paolo
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doi_str	10.1016/j.resuscitation.2018.07.014
up_date	2024-07-06T17:18:11.954Z
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We included 64 consecutive infants with moderate or severe hypoxic ischaemic encephalopathy undergoing therapeutic hypothermia who had 18–24 month-outcome data. We analysed electrocardiography and heart rate changes before, during and after therapeutic hypothermia. Superior vena cava flow, left ventricular cardiac output and stroke volume were studied using echocardiography during and immediately after therapeutic hypothermia. An abnormal outcome was defined as death or moderate/severe disability at 18–24 months.Results: Neonates with higher superior vena cava flow pre-rewarming had signiﬁcantly higher odds of documented long-term adverse outcome when compared to newborns with good outcome (OR 1.57; 95%CI, 1.1–1.78; p = 0.01 after adjustment). QTc and RR intervals were significantly longer at 12, 24, 36 and 48 h in infants with good outcome compared with those with adverse outcome (p < 0.001). During therapeutic hypothermia, infants with poor outcome had a higher heart rate at 12, 24, 36, 48, 60 h after birth compared with those with good outcome (p < 0.001). From 36 h on, heart rate gradually increased and RR and QTc intervals progressively shortened with values back to normal after rewarming.Conclusions: Infants with hypoxic ischaemic encephalopathy who have adverse neurological outcome show a preferential cerebral blood flow redistribution during therapeutic hypothermia. 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Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome

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