Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012

Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (...
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Gespeichert in:

Autor*in:	van Maaren, M.C. [verfasserIn] Lagendijk, M. [verfasserIn] Tilanus-Linthorst, M.M.A. [verfasserIn] de Munck, L. [verfasserIn] Pijnappel, R.M. [verfasserIn] Schmidt, M.K. [verfasserIn] Wesseling, J. [verfasserIn] Koppert, L.B. [verfasserIn] Siesling, S. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study

Übergeordnetes Werk:	Enthalten in: European journal of cancer - Amsterdam [u.a.] : Elsevier, 1965, 101, Seite 134-142
Übergeordnetes Werk:	volume:101 ; pages:134-142

DOI / URN:	10.1016/j.ejca.2018.07.003

Katalog-ID:	ELV000290165

Internformat


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100	1		\|a van Maaren, M.C. \|e verfasserin \|4 aut
245	1	0	\|a Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012
264		1	\|c 2018
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment.
650		4	\|a Breast cancer–related deaths
650		4	\|a Breast cancer-specific survival
650		4	\|a Ductal carcinoma in situ
650		4	\|a Population-based study
700	1		\|a Lagendijk, M. \|e verfasserin \|4 aut
700	1		\|a Tilanus-Linthorst, M.M.A. \|e verfasserin \|4 aut
700	1		\|a de Munck, L. \|e verfasserin \|4 aut
700	1		\|a Pijnappel, R.M. \|e verfasserin \|4 aut
700	1		\|a Schmidt, M.K. \|e verfasserin \|4 aut
700	1		\|a Wesseling, J. \|e verfasserin \|4 aut
700	1		\|a Koppert, L.B. \|e verfasserin \|4 aut
700	1		\|a Siesling, S. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t European journal of cancer \|d Amsterdam [u.a.] : Elsevier, 1965 \|g 101, Seite 134-142 \|w (DE-627)266883400 \|w (DE-600)1468190-0 \|w (DE-576)090954173 \|x 1879-2995 \|7 nnns
773	1	8	\|g volume:101 \|g pages:134-142
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912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
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912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.81 \|j Onkologie
951			\|a AR
952			\|d 101 \|h 134-142

Indexfelder

author_variant	m m v mm mmv m l ml m t l mtl m l d ml mld r p rp m s ms j w jw l k lk s s ss
matchkey_str	article:18792995:2018----::ratacreaedahacrigordidcacrioaniudthouainaesuyn
hierarchy_sort_str	2018
bklnumber	44.81
publishDate	2018
allfields	10.1016/j.ejca.2018.07.003 doi (DE-627)ELV000290165 (ELSEVIER)S0959-8049(18)30953-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl van Maaren, M.C. verfasserin aut Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment. Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study Lagendijk, M. verfasserin aut Tilanus-Linthorst, M.M.A. verfasserin aut de Munck, L. verfasserin aut Pijnappel, R.M. verfasserin aut Schmidt, M.K. verfasserin aut Wesseling, J. verfasserin aut Koppert, L.B. verfasserin aut Siesling, S. verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 101, Seite 134-142 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:101 pages:134-142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 101 134-142
spelling	10.1016/j.ejca.2018.07.003 doi (DE-627)ELV000290165 (ELSEVIER)S0959-8049(18)30953-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl van Maaren, M.C. verfasserin aut Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment. Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study Lagendijk, M. verfasserin aut Tilanus-Linthorst, M.M.A. verfasserin aut de Munck, L. verfasserin aut Pijnappel, R.M. verfasserin aut Schmidt, M.K. verfasserin aut Wesseling, J. verfasserin aut Koppert, L.B. verfasserin aut Siesling, S. verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 101, Seite 134-142 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:101 pages:134-142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 101 134-142
allfields_unstemmed	10.1016/j.ejca.2018.07.003 doi (DE-627)ELV000290165 (ELSEVIER)S0959-8049(18)30953-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl van Maaren, M.C. verfasserin aut Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment. Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study Lagendijk, M. verfasserin aut Tilanus-Linthorst, M.M.A. verfasserin aut de Munck, L. verfasserin aut Pijnappel, R.M. verfasserin aut Schmidt, M.K. verfasserin aut Wesseling, J. verfasserin aut Koppert, L.B. verfasserin aut Siesling, S. verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 101, Seite 134-142 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:101 pages:134-142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 101 134-142
allfieldsGer	10.1016/j.ejca.2018.07.003 doi (DE-627)ELV000290165 (ELSEVIER)S0959-8049(18)30953-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl van Maaren, M.C. verfasserin aut Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment. Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study Lagendijk, M. verfasserin aut Tilanus-Linthorst, M.M.A. verfasserin aut de Munck, L. verfasserin aut Pijnappel, R.M. verfasserin aut Schmidt, M.K. verfasserin aut Wesseling, J. verfasserin aut Koppert, L.B. verfasserin aut Siesling, S. verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 101, Seite 134-142 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:101 pages:134-142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 101 134-142
allfieldsSound	10.1016/j.ejca.2018.07.003 doi (DE-627)ELV000290165 (ELSEVIER)S0959-8049(18)30953-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl van Maaren, M.C. verfasserin aut Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment. Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study Lagendijk, M. verfasserin aut Tilanus-Linthorst, M.M.A. verfasserin aut de Munck, L. verfasserin aut Pijnappel, R.M. verfasserin aut Schmidt, M.K. verfasserin aut Wesseling, J. verfasserin aut Koppert, L.B. verfasserin aut Siesling, S. verfasserin aut Enthalten in European journal of cancer Amsterdam [u.a.] : Elsevier, 1965 101, Seite 134-142 (DE-627)266883400 (DE-600)1468190-0 (DE-576)090954173 1879-2995 nnns volume:101 pages:134-142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 101 134-142
language	English
source	Enthalten in European journal of cancer 101, Seite 134-142 volume:101 pages:134-142
sourceStr	Enthalten in European journal of cancer 101, Seite 134-142 volume:101 pages:134-142
format_phy_str_mv	Article
bklname	Onkologie
institution	findex.gbv.de
topic_facet	Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study
dewey-raw	610
isfreeaccess_bool	false
container_title	European journal of cancer
authorswithroles_txt_mv	van Maaren, M.C. @@aut@@ Lagendijk, M. @@aut@@ Tilanus-Linthorst, M.M.A. @@aut@@ de Munck, L. @@aut@@ Pijnappel, R.M. @@aut@@ Schmidt, M.K. @@aut@@ Wesseling, J. @@aut@@ Koppert, L.B. @@aut@@ Siesling, S. @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	266883400
dewey-sort	3610
id	ELV000290165
language_de	englisch
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author	van Maaren, M.C.
spellingShingle	van Maaren, M.C. ddc 610 bkl 44.81 misc Breast cancer–related deaths misc Breast cancer-specific survival misc Ductal carcinoma in situ misc Population-based study Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012
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topic_title	610 DE-600 44.81 bkl Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012 Breast cancer–related deaths Breast cancer-specific survival Ductal carcinoma in situ Population-based study
topic	ddc 610 bkl 44.81 misc Breast cancer–related deaths misc Breast cancer-specific survival misc Ductal carcinoma in situ misc Population-based study
topic_unstemmed	ddc 610 bkl 44.81 misc Breast cancer–related deaths misc Breast cancer-specific survival misc Ductal carcinoma in situ misc Population-based study
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title	Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012
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title_full	Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012
author_sort	van Maaren, M.C.
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author_browse	van Maaren, M.C. Lagendijk, M. Tilanus-Linthorst, M.M.A. de Munck, L. Pijnappel, R.M. Schmidt, M.K. Wesseling, J. Koppert, L.B. Siesling, S.
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title_sort	breast cancer–related deaths according to grade in ductal carcinoma in situ: a dutch population–based study on patients diagnosed between 1999 and 2012
title_auth	Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012
abstract	Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment.
abstractGer	Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment.
abstract_unstemmed	Background: The incidence of ductal carcinoma in situ (DCIS) has drastically increased over the past decades. Because DCIS is resected after diagnosis similar to invasive breast cancer, the natural cause and behaviour of DCIS is not well known. We aimed to determine breast cancer–specific survival (BCSS) and overall survival (OS) according to grade in DCIS patients after surgical treatment in the Netherlands.Patients and methods: All DCIS patients diagnosed between 1999 and 2012 were selected from the Netherlands Cancer Registry. The cause of death was obtained from ‘Statistics Netherlands’. BCSS and OS were estimated using multivariable Cox regression in the entire cohort and stratified for grades.Results: In total, 12,256 patients were included, of whom 1509 (12.3%) presented with grade I, 3675 (30.0%) with grade II, 6064 (49.5%) with grade III and 1008 (8.2%) with an unknown grade. During a median follow-up of 7.8 years, 1138 (9.3%) deaths were observed, and 179 (1.5%) were breast cancer–related. Of these, 10 patients had grade I; 46 grade II; 95 grade III and 28 an unknown grade. After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. Because superior rates were observed for low-grade DCIS, it seems justified to investigate whether active surveillance may be a balanced alternative for conventional surgical treatment.
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title_short	Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012
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author2	Lagendijk, M. Tilanus-Linthorst, M.M.A. de Munck, L. Pijnappel, R.M. Schmidt, M.K. Wesseling, J. Koppert, L.B. Siesling, S.
author2Str	Lagendijk, M. Tilanus-Linthorst, M.M.A. de Munck, L. Pijnappel, R.M. Schmidt, M.K. Wesseling, J. Koppert, L.B. Siesling, S.
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After adjustment for confounding, grade II and III were related to worse BCSS than grade I with hazard ratios of 1.92 (95% confidence interval [CI]: 0.97–3.81) and 2.14 (95% CI: 1.11–4.12), respectively. No association between grades and OS was observed.Conclusion: BCSS and OS in DCIS patients were excellent. 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Breast cancer–related deaths according to grade in ductal carcinoma in situ: A Dutch population–based study on patients diagnosed between 1999 and 2012

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