Overcoming wound complications in head and neck salvage surgery

Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications rela...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kwon, Daniel [verfasserIn] Genden, Eric M. [verfasserIn] de Bree, Remco [verfasserIn] Rodrigo, Juan P. [verfasserIn] Rinaldo, Alessandra [verfasserIn] Sanabria, Alvaro [verfasserIn] Rapidis, Alexander D. [verfasserIn] Takes, Robert P. [verfasserIn] Ferlito, Alfio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula

Übergeordnetes Werk:	Enthalten in: Auris, nasus, larynx - Amsterdam [u.a.] : Elsevier Science, 1974, 45, Seite 1135-1142
Übergeordnetes Werk:	volume:45 ; pages:1135-1142

DOI / URN:	10.1016/j.anl.2018.03.008

Katalog-ID:	ELV000309710

Internformat


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245	1	0	\|a Overcoming wound complications in head and neck salvage surgery
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520			\|a Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes.
650		4	\|a Salvage surgery
650		4	\|a Radiation
650		4	\|a Radiotherapy
650		4	\|a Chemoradiation
650		4	\|a Chronic wound
650		4	\|a Fistula
700	1		\|a Genden, Eric M. \|e verfasserin \|4 aut
700	1		\|a de Bree, Remco \|e verfasserin \|0 (orcid)0000-0001-7128-5814 \|4 aut
700	1		\|a Rodrigo, Juan P. \|e verfasserin \|0 (orcid)0000-0003-3063-0890 \|4 aut
700	1		\|a Rinaldo, Alessandra \|e verfasserin \|4 aut
700	1		\|a Sanabria, Alvaro \|e verfasserin \|4 aut
700	1		\|a Rapidis, Alexander D. \|e verfasserin \|4 aut
700	1		\|a Takes, Robert P. \|e verfasserin \|4 aut
700	1		\|a Ferlito, Alfio \|e verfasserin \|4 aut
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773	1	8	\|g volume:45 \|g pages:1135-1142
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publishDate	2018
allfields	10.1016/j.anl.2018.03.008 doi (DE-627)ELV000309710 (ELSEVIER)S0385-8146(18)30147-0 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Kwon, Daniel verfasserin aut Overcoming wound complications in head and neck salvage surgery 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes. Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula Genden, Eric M. verfasserin aut de Bree, Remco verfasserin (orcid)0000-0001-7128-5814 aut Rodrigo, Juan P. verfasserin (orcid)0000-0003-3063-0890 aut Rinaldo, Alessandra verfasserin aut Sanabria, Alvaro verfasserin aut Rapidis, Alexander D. verfasserin aut Takes, Robert P. verfasserin aut Ferlito, Alfio verfasserin aut Enthalten in Auris, nasus, larynx Amsterdam [u.a.] : Elsevier Science, 1974 45, Seite 1135-1142 Online-Ressource (DE-627)320430286 (DE-600)2003679-6 (DE-576)26099359X 1879-1476 nnns volume:45 pages:1135-1142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 45 1135-1142
spelling	10.1016/j.anl.2018.03.008 doi (DE-627)ELV000309710 (ELSEVIER)S0385-8146(18)30147-0 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Kwon, Daniel verfasserin aut Overcoming wound complications in head and neck salvage surgery 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes. Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula Genden, Eric M. verfasserin aut de Bree, Remco verfasserin (orcid)0000-0001-7128-5814 aut Rodrigo, Juan P. verfasserin (orcid)0000-0003-3063-0890 aut Rinaldo, Alessandra verfasserin aut Sanabria, Alvaro verfasserin aut Rapidis, Alexander D. verfasserin aut Takes, Robert P. verfasserin aut Ferlito, Alfio verfasserin aut Enthalten in Auris, nasus, larynx Amsterdam [u.a.] : Elsevier Science, 1974 45, Seite 1135-1142 Online-Ressource (DE-627)320430286 (DE-600)2003679-6 (DE-576)26099359X 1879-1476 nnns volume:45 pages:1135-1142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 45 1135-1142
allfields_unstemmed	10.1016/j.anl.2018.03.008 doi (DE-627)ELV000309710 (ELSEVIER)S0385-8146(18)30147-0 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Kwon, Daniel verfasserin aut Overcoming wound complications in head and neck salvage surgery 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes. Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula Genden, Eric M. verfasserin aut de Bree, Remco verfasserin (orcid)0000-0001-7128-5814 aut Rodrigo, Juan P. verfasserin (orcid)0000-0003-3063-0890 aut Rinaldo, Alessandra verfasserin aut Sanabria, Alvaro verfasserin aut Rapidis, Alexander D. verfasserin aut Takes, Robert P. verfasserin aut Ferlito, Alfio verfasserin aut Enthalten in Auris, nasus, larynx Amsterdam [u.a.] : Elsevier Science, 1974 45, Seite 1135-1142 Online-Ressource (DE-627)320430286 (DE-600)2003679-6 (DE-576)26099359X 1879-1476 nnns volume:45 pages:1135-1142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 45 1135-1142
allfieldsGer	10.1016/j.anl.2018.03.008 doi (DE-627)ELV000309710 (ELSEVIER)S0385-8146(18)30147-0 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Kwon, Daniel verfasserin aut Overcoming wound complications in head and neck salvage surgery 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes. Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula Genden, Eric M. verfasserin aut de Bree, Remco verfasserin (orcid)0000-0001-7128-5814 aut Rodrigo, Juan P. verfasserin (orcid)0000-0003-3063-0890 aut Rinaldo, Alessandra verfasserin aut Sanabria, Alvaro verfasserin aut Rapidis, Alexander D. verfasserin aut Takes, Robert P. verfasserin aut Ferlito, Alfio verfasserin aut Enthalten in Auris, nasus, larynx Amsterdam [u.a.] : Elsevier Science, 1974 45, Seite 1135-1142 Online-Ressource (DE-627)320430286 (DE-600)2003679-6 (DE-576)26099359X 1879-1476 nnns volume:45 pages:1135-1142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 45 1135-1142
allfieldsSound	10.1016/j.anl.2018.03.008 doi (DE-627)ELV000309710 (ELSEVIER)S0385-8146(18)30147-0 DE-627 ger DE-627 rda eng 610 DE-600 44.94 bkl Kwon, Daniel verfasserin aut Overcoming wound complications in head and neck salvage surgery 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes. Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula Genden, Eric M. verfasserin aut de Bree, Remco verfasserin (orcid)0000-0001-7128-5814 aut Rodrigo, Juan P. verfasserin (orcid)0000-0003-3063-0890 aut Rinaldo, Alessandra verfasserin aut Sanabria, Alvaro verfasserin aut Rapidis, Alexander D. verfasserin aut Takes, Robert P. verfasserin aut Ferlito, Alfio verfasserin aut Enthalten in Auris, nasus, larynx Amsterdam [u.a.] : Elsevier Science, 1974 45, Seite 1135-1142 Online-Ressource (DE-627)320430286 (DE-600)2003679-6 (DE-576)26099359X 1879-1476 nnns volume:45 pages:1135-1142 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.94 Hals-Nasen-Ohrenheilkunde AR 45 1135-1142
language	English
source	Enthalten in Auris, nasus, larynx 45, Seite 1135-1142 volume:45 pages:1135-1142
sourceStr	Enthalten in Auris, nasus, larynx 45, Seite 1135-1142 volume:45 pages:1135-1142
format_phy_str_mv	Article
bklname	Hals-Nasen-Ohrenheilkunde
institution	findex.gbv.de
topic_facet	Salvage surgery Radiation Radiotherapy Chemoradiation Chronic wound Fistula
dewey-raw	610
isfreeaccess_bool	false
container_title	Auris, nasus, larynx
authorswithroles_txt_mv	Kwon, Daniel @@aut@@ Genden, Eric M. @@aut@@ de Bree, Remco @@aut@@ Rodrigo, Juan P. @@aut@@ Rinaldo, Alessandra @@aut@@ Sanabria, Alvaro @@aut@@ Rapidis, Alexander D. @@aut@@ Takes, Robert P. @@aut@@ Ferlito, Alfio @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	320430286
dewey-sort	3610
id	ELV000309710
language_de	englisch
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spellingShingle	Kwon, Daniel ddc 610 bkl 44.94 misc Salvage surgery misc Radiation misc Radiotherapy misc Chemoradiation misc Chronic wound misc Fistula Overcoming wound complications in head and neck salvage surgery
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title	Overcoming wound complications in head and neck salvage surgery
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title_sort	overcoming wound complications in head and neck salvage surgery
title_auth	Overcoming wound complications in head and neck salvage surgery
abstract	Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes.
abstractGer	Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes.
abstract_unstemmed	Background: Loco-regional treatment failure after radiotherapy with or without chemotherapy and/or prior surgery represents a significant portion of head and neck cancer patients. Due to a wide array of biological interactions, these patients have a significantly increased risk of complications related to wound healing.Methods: Review of the current literature was performed for wound healing pathophysiology, head and neck salvage surgery, and wound therapy.Results: The biology of altered wound healing in the face of previous surgery and chemoradiotherapy is well described in the literature. This is reflected in multiple clinical studies demonstrating increased rates of wound healing complications in salvage surgery, most commonly in the context of previous irradiation. Despite these disadvantages, multiple studies have described strategies to optimize healing outcomes. The literature supports preoperative optimization of known wound healing factors, adjunctive wound care modalities, and microvascular free tissue transfer for salvage surgery defects and wounds.Conclusion: Previously treated head and neck patients requiring salvage surgery have had a variety of disadvantages related to wound healing. Recognition and treatment of these factors can help to reverse adverse tissue conditions. A well-informed approach to salvage surgery with utilization of free vascularized or pedicled tissue transfer as well as optimizing wound healing factors is essential to obtaining favorable outcomes.
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title_short	Overcoming wound complications in head and neck salvage surgery
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up_date	2024-07-06T17:31:56.585Z
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Overcoming wound complications in head and neck salvage surgery

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