Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules

Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important...
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Autor*in:	Ćoćić, Dušan [verfasserIn] Jovanović, Snežana [verfasserIn] Rajković, Snežana [verfasserIn] Petrović, Biljana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Dinuclear Pt(II) complexes Kinetics Mechanism

Übergeordnetes Werk:	Enthalten in: Inorganica chimica acta - New York, NY [u.a.] : Elsevier, 1967, 482, Seite 635-642
Übergeordnetes Werk:	volume:482 ; pages:635-642

DOI / URN:	10.1016/j.ica.2018.07.004

Katalog-ID:	ELV000359548

Internformat


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100	1		\|a Ćoćić, Dušan \|e verfasserin \|4 aut
245	1	0	\|a Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules
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520			\|a Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a.
650		4	\|a Dinuclear Pt(II) complexes
650		4	\|a Kinetics
650		4	\|a Mechanism
700	1		\|a Jovanović, Snežana \|e verfasserin \|4 aut
700	1		\|a Rajković, Snežana \|e verfasserin \|4 aut
700	1		\|a Petrović, Biljana \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Inorganica chimica acta \|d New York, NY [u.a.] : Elsevier, 1967 \|g 482, Seite 635-642 \|h Online-Ressource \|w (DE-627)301510946 \|w (DE-600)1484441-2 \|w (DE-576)081952694 \|x 0020-1693 \|7 nnns
773	1	8	\|g volume:482 \|g pages:635-642
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912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 35.00 \|j Chemie: Allgemeines
951			\|a AR
952			\|d 482 \|h 635-642

Indexfelder

author_variant	d ć dć s j sj s r sr b p bp
matchkey_str	article:00201693:2018----::ieisnmcaimfhsbtttoratosfiulapaiuicmlx
hierarchy_sort_str	2018
bklnumber	35.00
publishDate	2018
allfields	10.1016/j.ica.2018.07.004 doi (DE-627)ELV000359548 (ELSEVIER)S0020-1693(18)30449-3 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Ćoćić, Dušan verfasserin aut Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a. Dinuclear Pt(II) complexes Kinetics Mechanism Jovanović, Snežana verfasserin aut Rajković, Snežana verfasserin aut Petrović, Biljana verfasserin aut Enthalten in Inorganica chimica acta New York, NY [u.a.] : Elsevier, 1967 482, Seite 635-642 Online-Ressource (DE-627)301510946 (DE-600)1484441-2 (DE-576)081952694 0020-1693 nnns volume:482 pages:635-642 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 482 635-642
spelling	10.1016/j.ica.2018.07.004 doi (DE-627)ELV000359548 (ELSEVIER)S0020-1693(18)30449-3 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Ćoćić, Dušan verfasserin aut Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a. Dinuclear Pt(II) complexes Kinetics Mechanism Jovanović, Snežana verfasserin aut Rajković, Snežana verfasserin aut Petrović, Biljana verfasserin aut Enthalten in Inorganica chimica acta New York, NY [u.a.] : Elsevier, 1967 482, Seite 635-642 Online-Ressource (DE-627)301510946 (DE-600)1484441-2 (DE-576)081952694 0020-1693 nnns volume:482 pages:635-642 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 482 635-642
allfields_unstemmed	10.1016/j.ica.2018.07.004 doi (DE-627)ELV000359548 (ELSEVIER)S0020-1693(18)30449-3 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Ćoćić, Dušan verfasserin aut Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a. Dinuclear Pt(II) complexes Kinetics Mechanism Jovanović, Snežana verfasserin aut Rajković, Snežana verfasserin aut Petrović, Biljana verfasserin aut Enthalten in Inorganica chimica acta New York, NY [u.a.] : Elsevier, 1967 482, Seite 635-642 Online-Ressource (DE-627)301510946 (DE-600)1484441-2 (DE-576)081952694 0020-1693 nnns volume:482 pages:635-642 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 482 635-642
allfieldsGer	10.1016/j.ica.2018.07.004 doi (DE-627)ELV000359548 (ELSEVIER)S0020-1693(18)30449-3 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Ćoćić, Dušan verfasserin aut Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a. Dinuclear Pt(II) complexes Kinetics Mechanism Jovanović, Snežana verfasserin aut Rajković, Snežana verfasserin aut Petrović, Biljana verfasserin aut Enthalten in Inorganica chimica acta New York, NY [u.a.] : Elsevier, 1967 482, Seite 635-642 Online-Ressource (DE-627)301510946 (DE-600)1484441-2 (DE-576)081952694 0020-1693 nnns volume:482 pages:635-642 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 482 635-642
allfieldsSound	10.1016/j.ica.2018.07.004 doi (DE-627)ELV000359548 (ELSEVIER)S0020-1693(18)30449-3 DE-627 ger DE-627 rda eng 540 DE-600 35.00 bkl Ćoćić, Dušan verfasserin aut Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a. Dinuclear Pt(II) complexes Kinetics Mechanism Jovanović, Snežana verfasserin aut Rajković, Snežana verfasserin aut Petrović, Biljana verfasserin aut Enthalten in Inorganica chimica acta New York, NY [u.a.] : Elsevier, 1967 482, Seite 635-642 Online-Ressource (DE-627)301510946 (DE-600)1484441-2 (DE-576)081952694 0020-1693 nnns volume:482 pages:635-642 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines AR 482 635-642
language	English
source	Enthalten in Inorganica chimica acta 482, Seite 635-642 volume:482 pages:635-642
sourceStr	Enthalten in Inorganica chimica acta 482, Seite 635-642 volume:482 pages:635-642
format_phy_str_mv	Article
bklname	Chemie: Allgemeines
institution	findex.gbv.de
topic_facet	Dinuclear Pt(II) complexes Kinetics Mechanism
dewey-raw	540
isfreeaccess_bool	false
container_title	Inorganica chimica acta
authorswithroles_txt_mv	Ćoćić, Dušan @@aut@@ Jovanović, Snežana @@aut@@ Rajković, Snežana @@aut@@ Petrović, Biljana @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	301510946
dewey-sort	3540
id	ELV000359548
language_de	englisch
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In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. 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author	Ćoćić, Dušan
spellingShingle	Ćoćić, Dušan ddc 540 bkl 35.00 misc Dinuclear Pt(II) complexes misc Kinetics misc Mechanism Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules
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topic_title	540 DE-600 35.00 bkl Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules Dinuclear Pt(II) complexes Kinetics Mechanism
topic	ddc 540 bkl 35.00 misc Dinuclear Pt(II) complexes misc Kinetics misc Mechanism
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title	Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules
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title_full	Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules
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author_browse	Ćoćić, Dušan Jovanović, Snežana Rajković, Snežana Petrović, Biljana
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title_sort	kinetics and mechanism of the substitution reactions of dinuclear platinum(ii) complexes with important bio-molecules
title_auth	Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules
abstract	Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a.
abstractGer	Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a.
abstract_unstemmed	Substitution reactions of the series of dinuclear platinum(II) complexes with the general formula {[Pt(L)Cl]2(μ-pz)}Cl2 (1–4) (where L is ethylenediamine (en), 1; (±)-1,2-propylenediamine (1,2-pn), 2; isobutylenediamine (ibn) 3; trans-(±)-1,2-diaminocyclohexane (dach), 4) and biologically important ligands such as thiourea (Tu), glutathione (GSH) and l-methionine (l-Met) were studied in a medium consisting of 25 mM Hepes buffer and 40 mM NaCl, at pH 7.2 and 310 K using UV-Vis spectrophotometry. In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. Furthermore, the two pK a values for the aqua complexes, {[Pt(1,2-pn)(H2O)]2(μ-pz)}4+ 2a and {[Pt(ibn)(H2O)]2(μ-pz)}4+ 3a were determined and compared with those previously reported for complexes {[Pt(en)(H2O)]2(μ-pz)}4+ 1a and {[Pt(dach)(H2O)]2(μ-pz)}4+ 4a.
collection_details	GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393
title_short	Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules
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author2	Jovanović, Snežana Rajković, Snežana Petrović, Biljana
author2Str	Jovanović, Snežana Rajković, Snežana Petrović, Biljana
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doi_str	10.1016/j.ica.2018.07.004
up_date	2024-07-06T17:42:01.940Z
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In addition, substitution reactions of complexes 2 and 3 with l-histidine (l-His) and guanosine-5′-monophosphate (5′-GMP) were investigated and the obtained results were compared with those previously published for complexes 1 and 4. The observed order of reactivity of the studied complexes toward selected nucleophiles is: 1 > 2 > 3 > 4, while the reactivity of nucleophiles follows the order: Tu > l-Met > GSH > l-His > 5′-GMP. The reactions with Tu and l-Met were followed by decomposition of the starting dinuclear platinum(II) complexes, whereas the structures of all complexes were preserved during substitution with GSH, l-His and 5′-GMP. To confirm the reaction pathways, 1H NMR spectroscopy and the HPLC method were additionally used. 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Kinetics and mechanism of the substitution reactions of dinuclear platinum(II) complexes with important bio-molecules

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