The relationship between salivary C-reactive protein and cognitive function in children aged 11–14
Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early...
Ausführliche Beschreibung
Autor*in: |
Cullen, Alexis E. [verfasserIn] Tappin, Ben M. [verfasserIn] Zunszain, Patricia A. [verfasserIn] Dickson, Hannah [verfasserIn] Roberts, Ruth E. [verfasserIn] Nikkheslat, Naghmeh [verfasserIn] Khondoker, Mizan [verfasserIn] Pariante, Carmine M. [verfasserIn] Fisher, Helen L. [verfasserIn] Laurens, Kristin R. [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
Enthalten in: Brain, behavior and immunity - Orlando, Fla. [u.a.] : Elsevier, 1987, 66, Seite 221-229 |
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Übergeordnetes Werk: |
volume:66 ; pages:221-229 |
DOI / URN: |
10.1016/j.bbi.2017.07.002 |
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Katalog-ID: |
ELV000468363 |
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245 | 1 | 0 | |a The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 |
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520 | |a Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. | ||
650 | 4 | |a Inflammation | |
650 | 4 | |a Diurnal sampling | |
650 | 4 | |a Neurocognitive function | |
650 | 4 | |a Paediatric | |
650 | 4 | |a Psychiatric symptoms | |
650 | 4 | |a Psychosis | |
650 | 4 | |a Depression | |
700 | 1 | |a Tappin, Ben M. |e verfasserin |4 aut | |
700 | 1 | |a Zunszain, Patricia A. |e verfasserin |4 aut | |
700 | 1 | |a Dickson, Hannah |e verfasserin |0 (orcid)0000-0002-4156-9506 |4 aut | |
700 | 1 | |a Roberts, Ruth E. |e verfasserin |4 aut | |
700 | 1 | |a Nikkheslat, Naghmeh |e verfasserin |4 aut | |
700 | 1 | |a Khondoker, Mizan |e verfasserin |4 aut | |
700 | 1 | |a Pariante, Carmine M. |e verfasserin |4 aut | |
700 | 1 | |a Fisher, Helen L. |e verfasserin |4 aut | |
700 | 1 | |a Laurens, Kristin R. |e verfasserin |4 aut | |
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10.1016/j.bbi.2017.07.002 doi (DE-627)ELV000468363 (ELSEVIER)S0889-1591(17)30209-X DE-627 ger DE-627 rda eng 610 150 DE-600 44.90 bkl Cullen, Alexis E. verfasserin aut The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. Inflammation Diurnal sampling Neurocognitive function Paediatric Psychiatric symptoms Psychosis Depression Tappin, Ben M. verfasserin aut Zunszain, Patricia A. verfasserin aut Dickson, Hannah verfasserin (orcid)0000-0002-4156-9506 aut Roberts, Ruth E. verfasserin aut Nikkheslat, Naghmeh verfasserin aut Khondoker, Mizan verfasserin aut Pariante, Carmine M. verfasserin aut Fisher, Helen L. verfasserin aut Laurens, Kristin R. verfasserin aut Enthalten in Brain, behavior and immunity Orlando, Fla. [u.a.] : Elsevier, 1987 66, Seite 221-229 Online-Ressource (DE-627)254634087 (DE-600)1462491-6 (DE-576)261631098 1090-2139 nnns volume:66 pages:221-229 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 66 221-229 |
spelling |
10.1016/j.bbi.2017.07.002 doi (DE-627)ELV000468363 (ELSEVIER)S0889-1591(17)30209-X DE-627 ger DE-627 rda eng 610 150 DE-600 44.90 bkl Cullen, Alexis E. verfasserin aut The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. Inflammation Diurnal sampling Neurocognitive function Paediatric Psychiatric symptoms Psychosis Depression Tappin, Ben M. verfasserin aut Zunszain, Patricia A. verfasserin aut Dickson, Hannah verfasserin (orcid)0000-0002-4156-9506 aut Roberts, Ruth E. verfasserin aut Nikkheslat, Naghmeh verfasserin aut Khondoker, Mizan verfasserin aut Pariante, Carmine M. verfasserin aut Fisher, Helen L. verfasserin aut Laurens, Kristin R. verfasserin aut Enthalten in Brain, behavior and immunity Orlando, Fla. [u.a.] : Elsevier, 1987 66, Seite 221-229 Online-Ressource (DE-627)254634087 (DE-600)1462491-6 (DE-576)261631098 1090-2139 nnns volume:66 pages:221-229 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 66 221-229 |
allfields_unstemmed |
10.1016/j.bbi.2017.07.002 doi (DE-627)ELV000468363 (ELSEVIER)S0889-1591(17)30209-X DE-627 ger DE-627 rda eng 610 150 DE-600 44.90 bkl Cullen, Alexis E. verfasserin aut The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. Inflammation Diurnal sampling Neurocognitive function Paediatric Psychiatric symptoms Psychosis Depression Tappin, Ben M. verfasserin aut Zunszain, Patricia A. verfasserin aut Dickson, Hannah verfasserin (orcid)0000-0002-4156-9506 aut Roberts, Ruth E. verfasserin aut Nikkheslat, Naghmeh verfasserin aut Khondoker, Mizan verfasserin aut Pariante, Carmine M. verfasserin aut Fisher, Helen L. verfasserin aut Laurens, Kristin R. verfasserin aut Enthalten in Brain, behavior and immunity Orlando, Fla. [u.a.] : Elsevier, 1987 66, Seite 221-229 Online-Ressource (DE-627)254634087 (DE-600)1462491-6 (DE-576)261631098 1090-2139 nnns volume:66 pages:221-229 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 66 221-229 |
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10.1016/j.bbi.2017.07.002 doi (DE-627)ELV000468363 (ELSEVIER)S0889-1591(17)30209-X DE-627 ger DE-627 rda eng 610 150 DE-600 44.90 bkl Cullen, Alexis E. verfasserin aut The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. Inflammation Diurnal sampling Neurocognitive function Paediatric Psychiatric symptoms Psychosis Depression Tappin, Ben M. verfasserin aut Zunszain, Patricia A. verfasserin aut Dickson, Hannah verfasserin (orcid)0000-0002-4156-9506 aut Roberts, Ruth E. verfasserin aut Nikkheslat, Naghmeh verfasserin aut Khondoker, Mizan verfasserin aut Pariante, Carmine M. verfasserin aut Fisher, Helen L. verfasserin aut Laurens, Kristin R. verfasserin aut Enthalten in Brain, behavior and immunity Orlando, Fla. [u.a.] : Elsevier, 1987 66, Seite 221-229 Online-Ressource (DE-627)254634087 (DE-600)1462491-6 (DE-576)261631098 1090-2139 nnns volume:66 pages:221-229 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 66 221-229 |
allfieldsSound |
10.1016/j.bbi.2017.07.002 doi (DE-627)ELV000468363 (ELSEVIER)S0889-1591(17)30209-X DE-627 ger DE-627 rda eng 610 150 DE-600 44.90 bkl Cullen, Alexis E. verfasserin aut The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. Inflammation Diurnal sampling Neurocognitive function Paediatric Psychiatric symptoms Psychosis Depression Tappin, Ben M. verfasserin aut Zunszain, Patricia A. verfasserin aut Dickson, Hannah verfasserin (orcid)0000-0002-4156-9506 aut Roberts, Ruth E. verfasserin aut Nikkheslat, Naghmeh verfasserin aut Khondoker, Mizan verfasserin aut Pariante, Carmine M. verfasserin aut Fisher, Helen L. verfasserin aut Laurens, Kristin R. verfasserin aut Enthalten in Brain, behavior and immunity Orlando, Fla. [u.a.] : Elsevier, 1987 66, Seite 221-229 Online-Ressource (DE-627)254634087 (DE-600)1462491-6 (DE-576)261631098 1090-2139 nnns volume:66 pages:221-229 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 66 221-229 |
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Cullen, Alexis E. @@aut@@ Tappin, Ben M. @@aut@@ Zunszain, Patricia A. @@aut@@ Dickson, Hannah @@aut@@ Roberts, Ruth E. @@aut@@ Nikkheslat, Naghmeh @@aut@@ Khondoker, Mizan @@aut@@ Pariante, Carmine M. @@aut@@ Fisher, Helen L. @@aut@@ Laurens, Kristin R. @@aut@@ |
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Cullen, Alexis E. |
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Cullen, Alexis E. ddc 610 bkl 44.90 misc Inflammation misc Diurnal sampling misc Neurocognitive function misc Paediatric misc Psychiatric symptoms misc Psychosis misc Depression The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 |
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610 150 DE-600 44.90 bkl The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 Inflammation Diurnal sampling Neurocognitive function Paediatric Psychiatric symptoms Psychosis Depression |
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The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 |
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Cullen, Alexis E. Tappin, Ben M. Zunszain, Patricia A. Dickson, Hannah Roberts, Ruth E. Nikkheslat, Naghmeh Khondoker, Mizan Pariante, Carmine M. Fisher, Helen L. Laurens, Kristin R. |
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the relationship between salivary c-reactive protein and cognitive function in children aged 11–14 |
title_auth |
The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 |
abstract |
Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. |
abstractGer |
Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. |
abstract_unstemmed |
Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11–14years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents. |
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title_short |
The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 |
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Tappin, Ben M. Zunszain, Patricia A. Dickson, Hannah Roberts, Ruth E. Nikkheslat, Naghmeh Khondoker, Mizan Pariante, Carmine M. Fisher, Helen L. Laurens, Kristin R. |
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Tappin, Ben M. Zunszain, Patricia A. Dickson, Hannah Roberts, Ruth E. Nikkheslat, Naghmeh Khondoker, Mizan Pariante, Carmine M. Fisher, Helen L. Laurens, Kristin R. |
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Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β =−0.24, p =0.006) and scores on the inhibition (β =−0.28, p =0.004) and inhibition/switching (β =−0.36, p <0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. 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