New brain protection strategies for infants with hypoxic-ischaemic encephalopathy
Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Greenwood, Annabel [verfasserIn] Evans, Jamie [verfasserIn] Smit, Elisa [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Paediatrics and child health - Amsterdam : Elsevier, 2007, 28, Seite 405-411 |
|---|---|
| Übergeordnetes Werk: |
volume:28 ; pages:405-411 |
| DOI / URN: |
10.1016/j.paed.2018.06.004 |
|---|
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| 520 | |a Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. | ||
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10.1016/j.paed.2018.06.004 doi (DE-627)ELV000476927 (ELSEVIER)S1751-7222(18)30117-3 DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Greenwood, Annabel verfasserin aut New brain protection strategies for infants with hypoxic-ischaemic encephalopathy 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. hypoxic ischaemic encephalopathy neonatal encephalopathy neuroprotection neuroprotective agents newborn therapeutic hypothermia Evans, Jamie verfasserin aut Smit, Elisa verfasserin aut Enthalten in Paediatrics and child health Amsterdam : Elsevier, 2007 28, Seite 405-411 Online-Ressource (DE-627)527641685 (DE-600)2278392-1 (DE-576)272351245 1878-206X nnns volume:28 pages:405-411 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 28 405-411 |
| spelling |
10.1016/j.paed.2018.06.004 doi (DE-627)ELV000476927 (ELSEVIER)S1751-7222(18)30117-3 DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Greenwood, Annabel verfasserin aut New brain protection strategies for infants with hypoxic-ischaemic encephalopathy 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. hypoxic ischaemic encephalopathy neonatal encephalopathy neuroprotection neuroprotective agents newborn therapeutic hypothermia Evans, Jamie verfasserin aut Smit, Elisa verfasserin aut Enthalten in Paediatrics and child health Amsterdam : Elsevier, 2007 28, Seite 405-411 Online-Ressource (DE-627)527641685 (DE-600)2278392-1 (DE-576)272351245 1878-206X nnns volume:28 pages:405-411 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 28 405-411 |
| allfields_unstemmed |
10.1016/j.paed.2018.06.004 doi (DE-627)ELV000476927 (ELSEVIER)S1751-7222(18)30117-3 DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Greenwood, Annabel verfasserin aut New brain protection strategies for infants with hypoxic-ischaemic encephalopathy 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. hypoxic ischaemic encephalopathy neonatal encephalopathy neuroprotection neuroprotective agents newborn therapeutic hypothermia Evans, Jamie verfasserin aut Smit, Elisa verfasserin aut Enthalten in Paediatrics and child health Amsterdam : Elsevier, 2007 28, Seite 405-411 Online-Ressource (DE-627)527641685 (DE-600)2278392-1 (DE-576)272351245 1878-206X nnns volume:28 pages:405-411 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 28 405-411 |
| allfieldsGer |
10.1016/j.paed.2018.06.004 doi (DE-627)ELV000476927 (ELSEVIER)S1751-7222(18)30117-3 DE-627 ger DE-627 rda eng 610 DE-600 44.67 bkl Greenwood, Annabel verfasserin aut New brain protection strategies for infants with hypoxic-ischaemic encephalopathy 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. hypoxic ischaemic encephalopathy neonatal encephalopathy neuroprotection neuroprotective agents newborn therapeutic hypothermia Evans, Jamie verfasserin aut Smit, Elisa verfasserin aut Enthalten in Paediatrics and child health Amsterdam : Elsevier, 2007 28, Seite 405-411 Online-Ressource (DE-627)527641685 (DE-600)2278392-1 (DE-576)272351245 1878-206X nnns volume:28 pages:405-411 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.67 Kinderheilkunde AR 28 405-411 |
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New brain protection strategies for infants with hypoxic-ischaemic encephalopathy |
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new brain protection strategies for infants with hypoxic-ischaemic encephalopathy |
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New brain protection strategies for infants with hypoxic-ischaemic encephalopathy |
| abstract |
Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. |
| abstractGer |
Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. |
| abstract_unstemmed |
Hypoxic ischaemic encephalopathy (HIE) occurs in 1.5–2/1000 births in developed countries and 26/1000 births in developing countries. Therapeutic cooling to a core temperature of 33.5°C for 72 h has become the mainstay of treatment for term infants with moderate and severe HIE with clinically proven improvements in both mortality and morbidity. This review article first explores current knowledge and limits of the use for therapeutic hypothermia, and then goes on to explore the potential new therapies that can provide additional neuroprotection. Currently researched neuroprotective treatments include pharmacological therapies (allopurinol, cannabinoids, erythropoietin, magnesium sulphate, melatonin, topiramate, and the noble gases xenon and argon), remote ischaemic post-conditioning, and the use of stem cells. The evidence available for these therapies and the current stage of their research are discussed. |
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