Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions

Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as m...
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Gespeichert in:

Autor*in:	Fornaro, Lorenzo [verfasserIn] Vasile, Enrico [verfasserIn] Aprile, Giuseppe [verfasserIn] Goetze, Thorsten Oliver [verfasserIn] Vivaldi, Caterina [verfasserIn] Falcone, Alfredo [verfasserIn] Al-Batran, Salah-Eddin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma

Übergeordnetes Werk:	Enthalten in: Cancer treatment reviews - Amsterdam [u.a.] : Elsevier, 1974, 69, Seite 90-100
Übergeordnetes Werk:	volume:69 ; pages:90-100

DOI / URN:	10.1016/j.ctrv.2018.06.012

Katalog-ID:	ELV00052039X

Internformat


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520			\|a Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field.
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650		4	\|a Chemoradiotherapy
650		4	\|a Gastric adenocarcinoma
650		4	\|a Locally advanced resectable disease
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650		4	\|a Esophago-gastric junction adenocarcinoma
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700	1		\|a Vivaldi, Caterina \|e verfasserin \|4 aut
700	1		\|a Falcone, Alfredo \|e verfasserin \|4 aut
700	1		\|a Al-Batran, Salah-Eddin \|e verfasserin \|4 aut
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936	b	k	\|a 44.81 \|j Onkologie
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author_variant	l f lf e v ev g a ga t o g to tog c v cv a f af s e a b seab
matchkey_str	article:15321967:2018----::oalavnegsrospaelacreethrpuiavne
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publishDate	2018
allfields	10.1016/j.ctrv.2018.06.012 doi (DE-627)ELV00052039X (ELSEVIER)S0305-7372(18)30106-3 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Fornaro, Lorenzo verfasserin aut Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field. Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma Vasile, Enrico verfasserin aut Aprile, Giuseppe verfasserin aut Goetze, Thorsten Oliver verfasserin aut Vivaldi, Caterina verfasserin aut Falcone, Alfredo verfasserin aut Al-Batran, Salah-Eddin verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 69, Seite 90-100 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:69 pages:90-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 69 90-100
spelling	10.1016/j.ctrv.2018.06.012 doi (DE-627)ELV00052039X (ELSEVIER)S0305-7372(18)30106-3 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Fornaro, Lorenzo verfasserin aut Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field. Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma Vasile, Enrico verfasserin aut Aprile, Giuseppe verfasserin aut Goetze, Thorsten Oliver verfasserin aut Vivaldi, Caterina verfasserin aut Falcone, Alfredo verfasserin aut Al-Batran, Salah-Eddin verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 69, Seite 90-100 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:69 pages:90-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 69 90-100
allfields_unstemmed	10.1016/j.ctrv.2018.06.012 doi (DE-627)ELV00052039X (ELSEVIER)S0305-7372(18)30106-3 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Fornaro, Lorenzo verfasserin aut Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field. Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma Vasile, Enrico verfasserin aut Aprile, Giuseppe verfasserin aut Goetze, Thorsten Oliver verfasserin aut Vivaldi, Caterina verfasserin aut Falcone, Alfredo verfasserin aut Al-Batran, Salah-Eddin verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 69, Seite 90-100 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:69 pages:90-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 69 90-100
allfieldsGer	10.1016/j.ctrv.2018.06.012 doi (DE-627)ELV00052039X (ELSEVIER)S0305-7372(18)30106-3 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Fornaro, Lorenzo verfasserin aut Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field. Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma Vasile, Enrico verfasserin aut Aprile, Giuseppe verfasserin aut Goetze, Thorsten Oliver verfasserin aut Vivaldi, Caterina verfasserin aut Falcone, Alfredo verfasserin aut Al-Batran, Salah-Eddin verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 69, Seite 90-100 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:69 pages:90-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 69 90-100
allfieldsSound	10.1016/j.ctrv.2018.06.012 doi (DE-627)ELV00052039X (ELSEVIER)S0305-7372(18)30106-3 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Fornaro, Lorenzo verfasserin aut Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field. Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma Vasile, Enrico verfasserin aut Aprile, Giuseppe verfasserin aut Goetze, Thorsten Oliver verfasserin aut Vivaldi, Caterina verfasserin aut Falcone, Alfredo verfasserin aut Al-Batran, Salah-Eddin verfasserin aut Enthalten in Cancer treatment reviews Amsterdam [u.a.] : Elsevier, 1974 69, Seite 90-100 Online-Ressource (DE-627)320417158 (DE-600)2002084-3 (DE-576)104194154 1532-1967 nnns volume:69 pages:90-100 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie AR 69 90-100
language	English
source	Enthalten in Cancer treatment reviews 69, Seite 90-100 volume:69 pages:90-100
sourceStr	Enthalten in Cancer treatment reviews 69, Seite 90-100 volume:69 pages:90-100
format_phy_str_mv	Article
bklname	Onkologie
institution	findex.gbv.de
topic_facet	Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma
dewey-raw	610
isfreeaccess_bool	false
container_title	Cancer treatment reviews
authorswithroles_txt_mv	Fornaro, Lorenzo @@aut@@ Vasile, Enrico @@aut@@ Aprile, Giuseppe @@aut@@ Goetze, Thorsten Oliver @@aut@@ Vivaldi, Caterina @@aut@@ Falcone, Alfredo @@aut@@ Al-Batran, Salah-Eddin @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	320417158
dewey-sort	3610
id	ELV00052039X
language_de	englisch
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author	Fornaro, Lorenzo
spellingShingle	Fornaro, Lorenzo ddc 610 bkl 44.81 misc Adjuvant misc Chemoradiotherapy misc Gastric adenocarcinoma misc Locally advanced resectable disease misc Neoadjuvant misc Esophago-gastric junction adenocarcinoma Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions
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topic_title	610 DE-600 44.81 bkl Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions Adjuvant Chemoradiotherapy Gastric adenocarcinoma Locally advanced resectable disease Neoadjuvant Esophago-gastric junction adenocarcinoma
topic	ddc 610 bkl 44.81 misc Adjuvant misc Chemoradiotherapy misc Gastric adenocarcinoma misc Locally advanced resectable disease misc Neoadjuvant misc Esophago-gastric junction adenocarcinoma
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title	Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions
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title_full	Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions
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title_sort	locally advanced gastro-oesophageal cancer: recent therapeutic advances and research directions
title_auth	Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions
abstract	Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field.
abstractGer	Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field.
abstract_unstemmed	Gastric (GC) and gastro-oesophageal (GOJC) adenocarcinomas are often considered as a single entity, even though differences exist in epidemiology, clinical presentation, molecular biology and treatment options. Locally advanced, resectable disease represents a particularly challenging scenario, as many critical issues need to be addressed. In both GC and GOJC among Western countries, systemic chemotherapy demonstrated the greatest benefit when administered before and after surgery and perioperative chemotherapy has been set as a standard in this setting. Nonetheless, multiple chemotherapy regimens have been tested and direct comparisons have been only recently presented. Adjuvant chemoradiotherapy is an option as well, but several trials have questioned its role when more effective combination regimens are used. With regards to GOJC, preoperative chemoradiotherapy is an alternative to perioperative chemotherapy, as it is associated with higher pathologic responses and a different toxicity profile: however, a definitive comparison with chemotherapy is ongoing. Herein, we review the current options for the treatment of resectable GC and GOJC and the main open questions in the management of these patients, trying to depict an update of the available algorithms for everyday practice. Moreover, we summarize the design and preliminary results of the randomized trials in progress that will hopefully give definitive answers to the most debated issues in the field.
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title_short	Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions
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author2	Vasile, Enrico Aprile, Giuseppe Goetze, Thorsten Oliver Vivaldi, Caterina Falcone, Alfredo Al-Batran, Salah-Eddin
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up_date	2024-07-06T18:15:02.645Z
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Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions

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