AB
In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ramesh, Kalyan [verfasserIn] Thangagiri, Baskaran [verfasserIn] Mishra, Avnish Kumar [verfasserIn] Ahn, Byung-Hyun [verfasserIn] Gal, Yeong-Soon [verfasserIn] Lim, Kwon Taek [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Reactive & functional polymers - Amsterdam [u.a.] : Elsevier, 1995, 132, Seite 112-119 |
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| Übergeordnetes Werk: |
volume:132 ; pages:112-119 |
| DOI / URN: |
10.1016/j.reactfunctpolym.2018.09.019 |
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ELV000923303 |
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| 520 | |a In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. | ||
| 650 | 4 | |a RAFT polymerization | |
| 650 | 4 | |a Ring opening polymerization | |
| 650 | 4 | |a Miktoarm star block copolymer | |
| 650 | 4 | |a Micelles | |
| 650 | 4 | |a Drug delivery | |
| 700 | 1 | |a Thangagiri, Baskaran |e verfasserin |4 aut | |
| 700 | 1 | |a Mishra, Avnish Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Byung-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Gal, Yeong-Soon |e verfasserin |0 (orcid)0000-0002-5788-8907 |4 aut | |
| 700 | 1 | |a Lim, Kwon Taek |e verfasserin |4 aut | |
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| 936 | b | k | |a 35.61 |j Funktionelle Gruppen |x Organische Chemie |
| 936 | b | k | |a 35.80 |j Makromolekulare Chemie |
| 936 | b | k | |a 58.22 |j Kunststofftechnologie |
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2018 |
| allfields |
10.1016/j.reactfunctpolym.2018.09.019 doi (DE-627)ELV000923303 (ELSEVIER)S1381-5148(18)30720-X DE-627 ger DE-627 rda eng 540 660 DE-600 35.61 bkl 35.80 bkl 58.22 bkl Ramesh, Kalyan verfasserin aut AB 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. RAFT polymerization Ring opening polymerization Miktoarm star block copolymer Micelles Drug delivery Thangagiri, Baskaran verfasserin aut Mishra, Avnish Kumar verfasserin aut Ahn, Byung-Hyun verfasserin aut Gal, Yeong-Soon verfasserin (orcid)0000-0002-5788-8907 aut Lim, Kwon Taek verfasserin aut Enthalten in Reactive & functional polymers Amsterdam [u.a.] : Elsevier, 1995 132, Seite 112-119 Online-Ressource (DE-627)320594572 (DE-600)2019384-1 (DE-576)259485063 1381-5148 nnns volume:132 pages:112-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.61 Funktionelle Gruppen Organische Chemie 35.80 Makromolekulare Chemie 58.22 Kunststofftechnologie AR 132 112-119 |
| spelling |
10.1016/j.reactfunctpolym.2018.09.019 doi (DE-627)ELV000923303 (ELSEVIER)S1381-5148(18)30720-X DE-627 ger DE-627 rda eng 540 660 DE-600 35.61 bkl 35.80 bkl 58.22 bkl Ramesh, Kalyan verfasserin aut AB 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. RAFT polymerization Ring opening polymerization Miktoarm star block copolymer Micelles Drug delivery Thangagiri, Baskaran verfasserin aut Mishra, Avnish Kumar verfasserin aut Ahn, Byung-Hyun verfasserin aut Gal, Yeong-Soon verfasserin (orcid)0000-0002-5788-8907 aut Lim, Kwon Taek verfasserin aut Enthalten in Reactive & functional polymers Amsterdam [u.a.] : Elsevier, 1995 132, Seite 112-119 Online-Ressource (DE-627)320594572 (DE-600)2019384-1 (DE-576)259485063 1381-5148 nnns volume:132 pages:112-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.61 Funktionelle Gruppen Organische Chemie 35.80 Makromolekulare Chemie 58.22 Kunststofftechnologie AR 132 112-119 |
| allfields_unstemmed |
10.1016/j.reactfunctpolym.2018.09.019 doi (DE-627)ELV000923303 (ELSEVIER)S1381-5148(18)30720-X DE-627 ger DE-627 rda eng 540 660 DE-600 35.61 bkl 35.80 bkl 58.22 bkl Ramesh, Kalyan verfasserin aut AB 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. RAFT polymerization Ring opening polymerization Miktoarm star block copolymer Micelles Drug delivery Thangagiri, Baskaran verfasserin aut Mishra, Avnish Kumar verfasserin aut Ahn, Byung-Hyun verfasserin aut Gal, Yeong-Soon verfasserin (orcid)0000-0002-5788-8907 aut Lim, Kwon Taek verfasserin aut Enthalten in Reactive & functional polymers Amsterdam [u.a.] : Elsevier, 1995 132, Seite 112-119 Online-Ressource (DE-627)320594572 (DE-600)2019384-1 (DE-576)259485063 1381-5148 nnns volume:132 pages:112-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.61 Funktionelle Gruppen Organische Chemie 35.80 Makromolekulare Chemie 58.22 Kunststofftechnologie AR 132 112-119 |
| allfieldsGer |
10.1016/j.reactfunctpolym.2018.09.019 doi (DE-627)ELV000923303 (ELSEVIER)S1381-5148(18)30720-X DE-627 ger DE-627 rda eng 540 660 DE-600 35.61 bkl 35.80 bkl 58.22 bkl Ramesh, Kalyan verfasserin aut AB 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. RAFT polymerization Ring opening polymerization Miktoarm star block copolymer Micelles Drug delivery Thangagiri, Baskaran verfasserin aut Mishra, Avnish Kumar verfasserin aut Ahn, Byung-Hyun verfasserin aut Gal, Yeong-Soon verfasserin (orcid)0000-0002-5788-8907 aut Lim, Kwon Taek verfasserin aut Enthalten in Reactive & functional polymers Amsterdam [u.a.] : Elsevier, 1995 132, Seite 112-119 Online-Ressource (DE-627)320594572 (DE-600)2019384-1 (DE-576)259485063 1381-5148 nnns volume:132 pages:112-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.61 Funktionelle Gruppen Organische Chemie 35.80 Makromolekulare Chemie 58.22 Kunststofftechnologie AR 132 112-119 |
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10.1016/j.reactfunctpolym.2018.09.019 doi (DE-627)ELV000923303 (ELSEVIER)S1381-5148(18)30720-X DE-627 ger DE-627 rda eng 540 660 DE-600 35.61 bkl 35.80 bkl 58.22 bkl Ramesh, Kalyan verfasserin aut AB 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. RAFT polymerization Ring opening polymerization Miktoarm star block copolymer Micelles Drug delivery Thangagiri, Baskaran verfasserin aut Mishra, Avnish Kumar verfasserin aut Ahn, Byung-Hyun verfasserin aut Gal, Yeong-Soon verfasserin (orcid)0000-0002-5788-8907 aut Lim, Kwon Taek verfasserin aut Enthalten in Reactive & functional polymers Amsterdam [u.a.] : Elsevier, 1995 132, Seite 112-119 Online-Ressource (DE-627)320594572 (DE-600)2019384-1 (DE-576)259485063 1381-5148 nnns volume:132 pages:112-119 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.61 Funktionelle Gruppen Organische Chemie 35.80 Makromolekulare Chemie 58.22 Kunststofftechnologie AR 132 112-119 |
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In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. |
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In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. |
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In this study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(l-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles. |
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