Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti-
Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the cl...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Baldim, Iara [verfasserIn] Tonani, Ludmilla [verfasserIn] von Zeska Kress, Marcia Regina [verfasserIn] Pereira Oliveira, Wanderley [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: Industrial crops and products - New York, NY [u.a.] : Elsevier, 1992, 127, Seite 73-81 |
|---|---|
| Übergeordnetes Werk: |
volume:127 ; pages:73-81 |
| DOI / URN: |
10.1016/j.indcrop.2018.10.064 |
|---|
| Katalog-ID: |
ELV001070517 |
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| 520 | |a Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. | ||
| 650 | 4 | |a Essential oil | |
| 650 | 4 | |a Nanostructured lipid system | |
| 650 | 4 | |a Pepper-rosmarin | |
| 650 | 4 | |a Natural antimicrobial agent | |
| 650 | 4 | |a Thymol | |
| 650 | 4 | |a Antifungal activity | |
| 700 | 1 | |a Tonani, Ludmilla |e verfasserin |4 aut | |
| 700 | 1 | |a von Zeska Kress, Marcia Regina |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira Oliveira, Wanderley |e verfasserin |0 (orcid)0000-0003-4356-2508 |4 aut | |
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| 773 | 1 | 8 | |g volume:127 |g pages:73-81 |
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| 912 | |a GBV_ILN_224 | ||
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| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2003 | ||
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| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
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10.1016/j.indcrop.2018.10.064 doi (DE-627)ELV001070517 (ELSEVIER)S0926-6690(18)30937-3 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Baldim, Iara verfasserin aut Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. Essential oil Nanostructured lipid system Pepper-rosmarin Natural antimicrobial agent Thymol Antifungal activity Tonani, Ludmilla verfasserin aut von Zeska Kress, Marcia Regina verfasserin aut Pereira Oliveira, Wanderley verfasserin (orcid)0000-0003-4356-2508 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 127, Seite 73-81 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:127 pages:73-81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 127 73-81 |
| spelling |
10.1016/j.indcrop.2018.10.064 doi (DE-627)ELV001070517 (ELSEVIER)S0926-6690(18)30937-3 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Baldim, Iara verfasserin aut Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. Essential oil Nanostructured lipid system Pepper-rosmarin Natural antimicrobial agent Thymol Antifungal activity Tonani, Ludmilla verfasserin aut von Zeska Kress, Marcia Regina verfasserin aut Pereira Oliveira, Wanderley verfasserin (orcid)0000-0003-4356-2508 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 127, Seite 73-81 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:127 pages:73-81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 127 73-81 |
| allfields_unstemmed |
10.1016/j.indcrop.2018.10.064 doi (DE-627)ELV001070517 (ELSEVIER)S0926-6690(18)30937-3 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Baldim, Iara verfasserin aut Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. Essential oil Nanostructured lipid system Pepper-rosmarin Natural antimicrobial agent Thymol Antifungal activity Tonani, Ludmilla verfasserin aut von Zeska Kress, Marcia Regina verfasserin aut Pereira Oliveira, Wanderley verfasserin (orcid)0000-0003-4356-2508 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 127, Seite 73-81 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:127 pages:73-81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 127 73-81 |
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10.1016/j.indcrop.2018.10.064 doi (DE-627)ELV001070517 (ELSEVIER)S0926-6690(18)30937-3 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Baldim, Iara verfasserin aut Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. Essential oil Nanostructured lipid system Pepper-rosmarin Natural antimicrobial agent Thymol Antifungal activity Tonani, Ludmilla verfasserin aut von Zeska Kress, Marcia Regina verfasserin aut Pereira Oliveira, Wanderley verfasserin (orcid)0000-0003-4356-2508 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 127, Seite 73-81 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:127 pages:73-81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 127 73-81 |
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10.1016/j.indcrop.2018.10.064 doi (DE-627)ELV001070517 (ELSEVIER)S0926-6690(18)30937-3 DE-627 ger DE-627 rda eng 630 640 DE-600 48.30 bkl Baldim, Iara verfasserin aut Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. Essential oil Nanostructured lipid system Pepper-rosmarin Natural antimicrobial agent Thymol Antifungal activity Tonani, Ludmilla verfasserin aut von Zeska Kress, Marcia Regina verfasserin aut Pereira Oliveira, Wanderley verfasserin (orcid)0000-0003-4356-2508 aut Enthalten in Industrial crops and products New York, NY [u.a.] : Elsevier, 1992 127, Seite 73-81 Online-Ressource (DE-627)300894678 (DE-600)1483245-8 (DE-576)259270792 1872-633X nnns volume:127 pages:73-81 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 48.30 Natürliche Ressourcen Land- und Forstwirtschaft AR 127 73-81 |
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Baldim, Iara @@aut@@ Tonani, Ludmilla @@aut@@ von Zeska Kress, Marcia Regina @@aut@@ Pereira Oliveira, Wanderley @@aut@@ |
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630 640 DE-600 48.30 bkl Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- Essential oil Nanostructured lipid system Pepper-rosmarin Natural antimicrobial agent Thymol Antifungal activity |
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lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- |
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Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti- |
| abstract |
Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. |
| abstractGer |
Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. |
| abstract_unstemmed |
Essential oils (EOs) have high importance in various industrial sectors, due to their wide range of confirmed biological activity, such as antibacterial, antiviral, antifungal, antiparasitic, insecticide, analgesic, anti-inflammatory, and so on. The main components of essential oils belong to the classes of monoterpenes, diterpenes, and sesquiterpenes, compounds generally sensitive to oxygen, light, heat, and moisture. These substances may undergo irreversible changes when in contact with other materials or external agents, without adequate protection. In this way, micro and nanoencapsulation technologies arise as a viable and effective solution, since they furnish protection against instability problems, change product solubility, release of the bioactive substances, and might enhance the biological activity. In this study, essential oil (EO) of Lippia sidoides Cham. (L. sidoides) was loaded in lipid-based systems through emulsification by phase inversion. Gelucire® 50/13, stearic acid or Compritol® 888 ATO (solid lipids) and oleic acid or Labrasol® (liquid lipids) comprised the lipid phase, while Poloxamer® 188 or a combination of Tween® 80 and Span® 80 were the surfactants used. Twelve formulations were prepared, and their stability examined by visual inspection. Accelerated stability tests were carried out with the formulations containing Gelucire® 50/13, which appeared more stable. Formulations were characterised by the determination of the droplet size (214.4–423.2 nm), polydispersity index (around 0.3) and ζ-potential (−40.6 to −23.0). The antifungal activity against Candida albicans of the lipid base compositions loaded with L. sidoides EO, pure EO, and its major compound, thymol, was evaluated. The lipid-based formulations and the pure EO exhibited potent activity against this yeast, exhibiting Minimum Inhibitory Concentration (MIC) between 156 and 312 μg/mL. This study contributes to the development of an effective approach to enhance the essential oil stability and to form promising antimicrobial systems, which can be used in the most diverse sectors of the industry. |
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| score |
7.3985004 |