Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells
Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The acti...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bitner, Benjamin F. [verfasserIn] Ray, Jason D. [verfasserIn] Kener, Kyle B. [verfasserIn] Herring, Jacob A. [verfasserIn] Tueller, Josie A. [verfasserIn] Johnson, Deborah K. [verfasserIn] Tellez Freitas, Claudia M. [verfasserIn] Fausnacht, Dane W. [verfasserIn] Allen, Mitchell E. [verfasserIn] Thomson, Alexander H. [verfasserIn] Weber, K. Scott [verfasserIn] McMillan, Ryan P. [verfasserIn] Hulver, Matthew W. [verfasserIn] Brown, David A. [verfasserIn] Tessem, Jeffery S. [verfasserIn] Neilson, Andrew P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: The journal of nutritional biochemistry - New York, NY [u.a.] : Elsevier, 1990, 62, Seite 95-107 |
|---|---|
| Übergeordnetes Werk: |
volume:62 ; pages:95-107 |
| DOI / URN: |
10.1016/j.jnutbio.2018.09.004 |
|---|
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| 245 | 1 | 0 | |a Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells |
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| 520 | |a Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. | ||
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| 650 | 4 | |a 5-Phenylvaleric acid | |
| 650 | 4 | |a (−)-Epicatechin | |
| 650 | 4 | |a Insulin | |
| 650 | 4 | |a Respiration | |
| 700 | 1 | |a Ray, Jason D. |e verfasserin |4 aut | |
| 700 | 1 | |a Kener, Kyle B. |e verfasserin |4 aut | |
| 700 | 1 | |a Herring, Jacob A. |e verfasserin |4 aut | |
| 700 | 1 | |a Tueller, Josie A. |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Deborah K. |e verfasserin |4 aut | |
| 700 | 1 | |a Tellez Freitas, Claudia M. |e verfasserin |4 aut | |
| 700 | 1 | |a Fausnacht, Dane W. |e verfasserin |4 aut | |
| 700 | 1 | |a Allen, Mitchell E. |e verfasserin |4 aut | |
| 700 | 1 | |a Thomson, Alexander H. |e verfasserin |4 aut | |
| 700 | 1 | |a Weber, K. Scott |e verfasserin |4 aut | |
| 700 | 1 | |a McMillan, Ryan P. |e verfasserin |4 aut | |
| 700 | 1 | |a Hulver, Matthew W. |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, David A. |e verfasserin |4 aut | |
| 700 | 1 | |a Tessem, Jeffery S. |e verfasserin |4 aut | |
| 700 | 1 | |a Neilson, Andrew P. |e verfasserin |4 aut | |
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10.1016/j.jnutbio.2018.09.004 doi (DE-627)ELV001134264 (ELSEVIER)S0955-2863(18)30490-X DE-627 ger DE-627 rda eng 540 630 640 DE-600 44.21 bkl Bitner, Benjamin F. verfasserin aut Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. Hippuric acid Homovanillic acid 5-Phenylvaleric acid (−)-Epicatechin Insulin Respiration Ray, Jason D. verfasserin aut Kener, Kyle B. verfasserin aut Herring, Jacob A. verfasserin aut Tueller, Josie A. verfasserin aut Johnson, Deborah K. verfasserin aut Tellez Freitas, Claudia M. verfasserin aut Fausnacht, Dane W. verfasserin aut Allen, Mitchell E. verfasserin aut Thomson, Alexander H. verfasserin aut Weber, K. Scott verfasserin aut McMillan, Ryan P. verfasserin aut Hulver, Matthew W. verfasserin aut Brown, David A. verfasserin aut Tessem, Jeffery S. verfasserin aut Neilson, Andrew P. verfasserin aut Enthalten in The journal of nutritional biochemistry New York, NY [u.a.] : Elsevier, 1990 62, Seite 95-107 Online-Ressource (DE-627)30059593X (DE-600)1483155-7 (DE-576)259483869 1873-4847 nnns volume:62 pages:95-107 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.21 Ernährung Medizin AR 62 95-107 |
| spelling |
10.1016/j.jnutbio.2018.09.004 doi (DE-627)ELV001134264 (ELSEVIER)S0955-2863(18)30490-X DE-627 ger DE-627 rda eng 540 630 640 DE-600 44.21 bkl Bitner, Benjamin F. verfasserin aut Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. Hippuric acid Homovanillic acid 5-Phenylvaleric acid (−)-Epicatechin Insulin Respiration Ray, Jason D. verfasserin aut Kener, Kyle B. verfasserin aut Herring, Jacob A. verfasserin aut Tueller, Josie A. verfasserin aut Johnson, Deborah K. verfasserin aut Tellez Freitas, Claudia M. verfasserin aut Fausnacht, Dane W. verfasserin aut Allen, Mitchell E. verfasserin aut Thomson, Alexander H. verfasserin aut Weber, K. Scott verfasserin aut McMillan, Ryan P. verfasserin aut Hulver, Matthew W. verfasserin aut Brown, David A. verfasserin aut Tessem, Jeffery S. verfasserin aut Neilson, Andrew P. verfasserin aut Enthalten in The journal of nutritional biochemistry New York, NY [u.a.] : Elsevier, 1990 62, Seite 95-107 Online-Ressource (DE-627)30059593X (DE-600)1483155-7 (DE-576)259483869 1873-4847 nnns volume:62 pages:95-107 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.21 Ernährung Medizin AR 62 95-107 |
| allfields_unstemmed |
10.1016/j.jnutbio.2018.09.004 doi (DE-627)ELV001134264 (ELSEVIER)S0955-2863(18)30490-X DE-627 ger DE-627 rda eng 540 630 640 DE-600 44.21 bkl Bitner, Benjamin F. verfasserin aut Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. Hippuric acid Homovanillic acid 5-Phenylvaleric acid (−)-Epicatechin Insulin Respiration Ray, Jason D. verfasserin aut Kener, Kyle B. verfasserin aut Herring, Jacob A. verfasserin aut Tueller, Josie A. verfasserin aut Johnson, Deborah K. verfasserin aut Tellez Freitas, Claudia M. verfasserin aut Fausnacht, Dane W. verfasserin aut Allen, Mitchell E. verfasserin aut Thomson, Alexander H. verfasserin aut Weber, K. Scott verfasserin aut McMillan, Ryan P. verfasserin aut Hulver, Matthew W. verfasserin aut Brown, David A. verfasserin aut Tessem, Jeffery S. verfasserin aut Neilson, Andrew P. verfasserin aut Enthalten in The journal of nutritional biochemistry New York, NY [u.a.] : Elsevier, 1990 62, Seite 95-107 Online-Ressource (DE-627)30059593X (DE-600)1483155-7 (DE-576)259483869 1873-4847 nnns volume:62 pages:95-107 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.21 Ernährung Medizin AR 62 95-107 |
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10.1016/j.jnutbio.2018.09.004 doi (DE-627)ELV001134264 (ELSEVIER)S0955-2863(18)30490-X DE-627 ger DE-627 rda eng 540 630 640 DE-600 44.21 bkl Bitner, Benjamin F. verfasserin aut Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. Hippuric acid Homovanillic acid 5-Phenylvaleric acid (−)-Epicatechin Insulin Respiration Ray, Jason D. verfasserin aut Kener, Kyle B. verfasserin aut Herring, Jacob A. verfasserin aut Tueller, Josie A. verfasserin aut Johnson, Deborah K. verfasserin aut Tellez Freitas, Claudia M. verfasserin aut Fausnacht, Dane W. verfasserin aut Allen, Mitchell E. verfasserin aut Thomson, Alexander H. verfasserin aut Weber, K. Scott verfasserin aut McMillan, Ryan P. verfasserin aut Hulver, Matthew W. verfasserin aut Brown, David A. verfasserin aut Tessem, Jeffery S. verfasserin aut Neilson, Andrew P. verfasserin aut Enthalten in The journal of nutritional biochemistry New York, NY [u.a.] : Elsevier, 1990 62, Seite 95-107 Online-Ressource (DE-627)30059593X (DE-600)1483155-7 (DE-576)259483869 1873-4847 nnns volume:62 pages:95-107 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.21 Ernährung Medizin AR 62 95-107 |
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10.1016/j.jnutbio.2018.09.004 doi (DE-627)ELV001134264 (ELSEVIER)S0955-2863(18)30490-X DE-627 ger DE-627 rda eng 540 630 640 DE-600 44.21 bkl Bitner, Benjamin F. verfasserin aut Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. Hippuric acid Homovanillic acid 5-Phenylvaleric acid (−)-Epicatechin Insulin Respiration Ray, Jason D. verfasserin aut Kener, Kyle B. verfasserin aut Herring, Jacob A. verfasserin aut Tueller, Josie A. verfasserin aut Johnson, Deborah K. verfasserin aut Tellez Freitas, Claudia M. verfasserin aut Fausnacht, Dane W. verfasserin aut Allen, Mitchell E. verfasserin aut Thomson, Alexander H. verfasserin aut Weber, K. Scott verfasserin aut McMillan, Ryan P. verfasserin aut Hulver, Matthew W. verfasserin aut Brown, David A. verfasserin aut Tessem, Jeffery S. verfasserin aut Neilson, Andrew P. verfasserin aut Enthalten in The journal of nutritional biochemistry New York, NY [u.a.] : Elsevier, 1990 62, Seite 95-107 Online-Ressource (DE-627)30059593X (DE-600)1483155-7 (DE-576)259483869 1873-4847 nnns volume:62 pages:95-107 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.21 Ernährung Medizin AR 62 95-107 |
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Enthalten in The journal of nutritional biochemistry 62, Seite 95-107 volume:62 pages:95-107 |
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Bitner, Benjamin F. @@aut@@ Ray, Jason D. @@aut@@ Kener, Kyle B. @@aut@@ Herring, Jacob A. @@aut@@ Tueller, Josie A. @@aut@@ Johnson, Deborah K. @@aut@@ Tellez Freitas, Claudia M. @@aut@@ Fausnacht, Dane W. @@aut@@ Allen, Mitchell E. @@aut@@ Thomson, Alexander H. @@aut@@ Weber, K. Scott @@aut@@ McMillan, Ryan P. @@aut@@ Hulver, Matthew W. @@aut@@ Brown, David A. @@aut@@ Tessem, Jeffery S. @@aut@@ Neilson, Andrew P. @@aut@@ |
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Bitner, Benjamin F. |
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Bitner, Benjamin F. ddc 540 bkl 44.21 misc Hippuric acid misc Homovanillic acid misc 5-Phenylvaleric acid misc (−)-Epicatechin misc Insulin misc Respiration Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells |
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Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells |
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Bitner, Benjamin F. Ray, Jason D. Kener, Kyle B. Herring, Jacob A. Tueller, Josie A. Johnson, Deborah K. Tellez Freitas, Claudia M. Fausnacht, Dane W. Allen, Mitchell E. Thomson, Alexander H. Weber, K. Scott McMillan, Ryan P. Hulver, Matthew W. Brown, David A. Tessem, Jeffery S. Neilson, Andrew P. |
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common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells |
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Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells |
| abstract |
Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. |
| abstractGer |
Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. |
| abstract_unstemmed |
Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought. |
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Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells |
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Ray, Jason D. Kener, Kyle B. Herring, Jacob A. Tueller, Josie A. Johnson, Deborah K. Tellez Freitas, Claudia M. Fausnacht, Dane W. Allen, Mitchell E. Thomson, Alexander H. Weber, K. Scott McMillan, Ryan P. Hulver, Matthew W. Brown, David A. Tessem, Jeffery S. Neilson, Andrew P. |
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Many flavonoids have poor bioavailability and thus low circulating concentrations. Unabsorbed flavonoids are metabolized by the gut microbiota to smaller metabolites, which are more bioavailable than their precursors. The activities of these metabolites may be partly responsible for associations between flavonoids and health. However, these activities remain poorly understood. We investigated bioactivities of flavonoid microbial metabolites [hippuric acid (HA), homovanillic acid (HVA), and 5-phenylvaleric acid (5PVA)] in primary skeletal muscle and β-cells compared to a native flavonoid [(−)-epicatechin, EC]. In muscle, EC was the most potent stimulator of glucose oxidation, while 5PVA and HA simulated glucose metabolism at 25 μM, and all compounds preserved mitochondrial function after insult. However, EC and the metabolites did not uncouple mitochonndrial respiration, with the exception of 5PVA at10 μM. In β-cells, all metabolites more potently enhanced glucose-stimulated insulin secretion (GSIS) compared to EC. Unlike EC, the metabolites appear to enhance GSIS without enhancing β-cell mitochondrial respiration or increasing expression of mitochondrial electron transport chain components, and with varying effects on β-cell insulin content. The present results demonstrate the activities of flavonoid microbial metabolites for preservation of β-cell function and glucose utilization. Additionally, our data suggest that metabolites and native compounds may act by distinct mechanisms, suggesting complementary and synergistic activities in vivo which warrant further investigation. This raises the intriguing prospect that bioavailability of native dietary flavonoids may not be as critical of a limiting factor to bioactivity as previously thought.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hippuric acid</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Homovanillic acid</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">5-Phenylvaleric acid</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">(−)-Epicatechin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Insulin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Respiration</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ray, Jason D.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kener, Kyle B.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Herring, Jacob A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tueller, Josie A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Johnson, Deborah K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tellez Freitas, Claudia M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fausnacht, Dane W.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Allen, Mitchell E.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thomson, Alexander H.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weber, K. Scott</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McMillan, Ryan P.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hulver, Matthew W.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brown, David A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tessem, Jeffery S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Neilson, Andrew P.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" 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| score |
7.399617 |