Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli
Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hautasaari, Pekka [verfasserIn] Kujala, Urho M. [verfasserIn] Tarkka, Ina M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neuroscience methods - Amsterdam [u.a.] : Elsevier Science, 1979, 311, Seite 331-337 |
|---|---|
| Übergeordnetes Werk: |
volume:311 ; pages:331-337 |
| DOI / URN: |
10.1016/j.jneumeth.2018.09.014 |
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| 520 | |a Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. | ||
| 650 | 4 | |a Functional brain imaging | |
| 650 | 4 | |a Human sensory cortex | |
| 650 | 4 | |a Mismatch response | |
| 650 | 4 | |a Cutaneous nerve stimulation | |
| 650 | 4 | |a Tactile stimulation | |
| 700 | 1 | |a Kujala, Urho M. |e verfasserin |0 (orcid)0000-0002-9262-1992 |4 aut | |
| 700 | 1 | |a Tarkka, Ina M. |e verfasserin |0 (orcid)0000-0002-7552-5819 |4 aut | |
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10.1016/j.jneumeth.2018.09.014 doi (DE-627)ELV001146548 (ELSEVIER)S0165-0270(18)30283-8 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hautasaari, Pekka verfasserin (orcid)0000-0002-0403-9602 aut Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. Functional brain imaging Human sensory cortex Mismatch response Cutaneous nerve stimulation Tactile stimulation Kujala, Urho M. verfasserin (orcid)0000-0002-9262-1992 aut Tarkka, Ina M. verfasserin (orcid)0000-0002-7552-5819 aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 311, Seite 331-337 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:311 pages:331-337 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 311 331-337 |
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10.1016/j.jneumeth.2018.09.014 doi (DE-627)ELV001146548 (ELSEVIER)S0165-0270(18)30283-8 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hautasaari, Pekka verfasserin (orcid)0000-0002-0403-9602 aut Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. Functional brain imaging Human sensory cortex Mismatch response Cutaneous nerve stimulation Tactile stimulation Kujala, Urho M. verfasserin (orcid)0000-0002-9262-1992 aut Tarkka, Ina M. verfasserin (orcid)0000-0002-7552-5819 aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 311, Seite 331-337 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:311 pages:331-337 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 311 331-337 |
| allfields_unstemmed |
10.1016/j.jneumeth.2018.09.014 doi (DE-627)ELV001146548 (ELSEVIER)S0165-0270(18)30283-8 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hautasaari, Pekka verfasserin (orcid)0000-0002-0403-9602 aut Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. Functional brain imaging Human sensory cortex Mismatch response Cutaneous nerve stimulation Tactile stimulation Kujala, Urho M. verfasserin (orcid)0000-0002-9262-1992 aut Tarkka, Ina M. verfasserin (orcid)0000-0002-7552-5819 aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 311, Seite 331-337 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:311 pages:331-337 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 311 331-337 |
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10.1016/j.jneumeth.2018.09.014 doi (DE-627)ELV001146548 (ELSEVIER)S0165-0270(18)30283-8 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hautasaari, Pekka verfasserin (orcid)0000-0002-0403-9602 aut Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. Functional brain imaging Human sensory cortex Mismatch response Cutaneous nerve stimulation Tactile stimulation Kujala, Urho M. verfasserin (orcid)0000-0002-9262-1992 aut Tarkka, Ina M. verfasserin (orcid)0000-0002-7552-5819 aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 311, Seite 331-337 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:311 pages:331-337 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 311 331-337 |
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10.1016/j.jneumeth.2018.09.014 doi (DE-627)ELV001146548 (ELSEVIER)S0165-0270(18)30283-8 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Hautasaari, Pekka verfasserin (orcid)0000-0002-0403-9602 aut Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. Functional brain imaging Human sensory cortex Mismatch response Cutaneous nerve stimulation Tactile stimulation Kujala, Urho M. verfasserin (orcid)0000-0002-9262-1992 aut Tarkka, Ina M. verfasserin (orcid)0000-0002-7552-5819 aut Enthalten in Journal of neuroscience methods Amsterdam [u.a.] : Elsevier Science, 1979 311, Seite 331-337 Online-Ressource (DE-627)306659786 (DE-600)1500499-5 (DE-576)081986416 1872-678X nnns volume:311 pages:331-337 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_4037 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4326 GBV_ILN_4334 GBV_ILN_4338 44.90 Neurologie AR 311 331-337 |
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Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. 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Hautasaari, Pekka |
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Hautasaari, Pekka ddc 610 bkl 44.90 misc Functional brain imaging misc Human sensory cortex misc Mismatch response misc Cutaneous nerve stimulation misc Tactile stimulation Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli |
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610 DE-600 44.90 bkl Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli Functional brain imaging Human sensory cortex Mismatch response Cutaneous nerve stimulation Tactile stimulation |
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ddc 610 bkl 44.90 misc Functional brain imaging misc Human sensory cortex misc Mismatch response misc Cutaneous nerve stimulation misc Tactile stimulation |
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ddc 610 bkl 44.90 misc Functional brain imaging misc Human sensory cortex misc Mismatch response misc Cutaneous nerve stimulation misc Tactile stimulation |
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detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli |
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Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli |
| abstract |
Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. |
| abstractGer |
Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. |
| abstract_unstemmed |
Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain’s automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli.Method: 306-channel magnetoencephalography recordings were made with 16 healthy adults under two conditions: electrical (eSMMR) and tactile (tSMMR) stimulations. The SMMR protocol consisted of 1000 stimuli with 10% deviants to fingers.Results: Sensor-level analysis revealed stronger activation after deviant stimulation in bilateral channel locations approximately corresponding to parietal cortical areas within both stimulation conditions. Between conditions, deviant tSMMR showed stronger activation in the ipsilateral channels. Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing. |
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Based on sensor-level results, two components, M50 and SMMR (40–58 and 110–185 ms), were compared at the source-level. Deviant stimulation elicited stronger contralateral SI activation during M50 component in both conditions. SMMR was observed with both conditions, activating contralateral SII after deviant stimulation. However, only tSMMR showed long latency activation in bilateral SI cortices. This suggests that there is an integration of both body sides during the automatic stages of tactile processing in SI cortices.Conclusions: This study indicates that tactile stimulation (tSMMR) is a feasible method for investigating the brain’s mechanism for detecting somatosensory changes; this may extend the clinical utility of tSMMR for assessing disorders involving altered somatosensory processing.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Functional brain imaging</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human sensory cortex</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mismatch response</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cutaneous nerve stimulation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tactile stimulation</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kujala, Urho M.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-9262-1992</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tarkka, Ina M.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-7552-5819</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of neuroscience methods</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier Science, 1979</subfield><subfield code="g">311, Seite 331-337</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)306659786</subfield><subfield code="w">(DE-600)1500499-5</subfield><subfield code="w">(DE-576)081986416</subfield><subfield code="x">1872-678X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield 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