Tracheostomy and mortality in patients with severe burns: A nationwide observational study

Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality...
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Autor*in:	Tsuchiya, Asuka [verfasserIn] Yamana, Hayato [verfasserIn] Kawahara, Takuya [verfasserIn] Tsutsumi, Yusuke [verfasserIn] Matsui, Hiroki [verfasserIn] Fushimi, Kiyohide [verfasserIn] Yasunaga, Hideo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model

Übergeordnetes Werk:	Enthalten in: Burns - Amsterdam [u.a.] : Elsevier Science, 1974, 44, Seite 1954-1961
Übergeordnetes Werk:	volume:44 ; pages:1954-1961

DOI / URN:	10.1016/j.burns.2018.06.012

Katalog-ID:	ELV001163949

Internformat


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024	7		\|a 10.1016/j.burns.2018.06.012 \|2 doi
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100	1		\|a Tsuchiya, Asuka \|e verfasserin \|4 aut
245	1	0	\|a Tracheostomy and mortality in patients with severe burns: A nationwide observational study
264		1	\|c 2018
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns.
650		4	\|a Tracheotomy
650		4	\|a Burns
650		4	\|a mortality
650		4	\|a Time-dependent confounder
650		4	\|a Inverse probability of treatment weighting
650		4	\|a Marginal structural model
700	1		\|a Yamana, Hayato \|e verfasserin \|0 (orcid)0000-0003-2214-6695 \|4 aut
700	1		\|a Kawahara, Takuya \|e verfasserin \|4 aut
700	1		\|a Tsutsumi, Yusuke \|e verfasserin \|0 (orcid)0000-0002-9160-0241 \|4 aut
700	1		\|a Matsui, Hiroki \|e verfasserin \|4 aut
700	1		\|a Fushimi, Kiyohide \|e verfasserin \|4 aut
700	1		\|a Yasunaga, Hideo \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Burns \|d Amsterdam [u.a.] : Elsevier Science, 1974 \|g 44, Seite 1954-1961 \|h Online-Ressource \|w (DE-627)320640817 \|w (DE-600)2025040-X \|w (DE-576)094480532 \|x 1879-1409 \|7 nnns
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912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
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912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
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912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 44.80 \|j Unfallmedizin \|j Notfallmedizin
936	b	k	\|a 44.65 \|j Chirurgie
951			\|a AR
952			\|d 44 \|h 1954-1961

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author_variant	a t at h y hy t k tk y t yt h m hm k f kf h y hy
matchkey_str	article:18791409:2018----::rcesoynmraiynainsiheeeunaain
hierarchy_sort_str	2018
bklnumber	44.80 44.65
publishDate	2018
allfields	10.1016/j.burns.2018.06.012 doi (DE-627)ELV001163949 (ELSEVIER)S0305-4179(18)30524-2 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl 44.65 bkl Tsuchiya, Asuka verfasserin aut Tracheostomy and mortality in patients with severe burns: A nationwide observational study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns. Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model Yamana, Hayato verfasserin (orcid)0000-0003-2214-6695 aut Kawahara, Takuya verfasserin aut Tsutsumi, Yusuke verfasserin (orcid)0000-0002-9160-0241 aut Matsui, Hiroki verfasserin aut Fushimi, Kiyohide verfasserin aut Yasunaga, Hideo verfasserin aut Enthalten in Burns Amsterdam [u.a.] : Elsevier Science, 1974 44, Seite 1954-1961 Online-Ressource (DE-627)320640817 (DE-600)2025040-X (DE-576)094480532 1879-1409 nnns volume:44 pages:1954-1961 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin 44.65 Chirurgie AR 44 1954-1961
spelling	10.1016/j.burns.2018.06.012 doi (DE-627)ELV001163949 (ELSEVIER)S0305-4179(18)30524-2 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl 44.65 bkl Tsuchiya, Asuka verfasserin aut Tracheostomy and mortality in patients with severe burns: A nationwide observational study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns. Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model Yamana, Hayato verfasserin (orcid)0000-0003-2214-6695 aut Kawahara, Takuya verfasserin aut Tsutsumi, Yusuke verfasserin (orcid)0000-0002-9160-0241 aut Matsui, Hiroki verfasserin aut Fushimi, Kiyohide verfasserin aut Yasunaga, Hideo verfasserin aut Enthalten in Burns Amsterdam [u.a.] : Elsevier Science, 1974 44, Seite 1954-1961 Online-Ressource (DE-627)320640817 (DE-600)2025040-X (DE-576)094480532 1879-1409 nnns volume:44 pages:1954-1961 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin 44.65 Chirurgie AR 44 1954-1961
allfields_unstemmed	10.1016/j.burns.2018.06.012 doi (DE-627)ELV001163949 (ELSEVIER)S0305-4179(18)30524-2 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl 44.65 bkl Tsuchiya, Asuka verfasserin aut Tracheostomy and mortality in patients with severe burns: A nationwide observational study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns. Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model Yamana, Hayato verfasserin (orcid)0000-0003-2214-6695 aut Kawahara, Takuya verfasserin aut Tsutsumi, Yusuke verfasserin (orcid)0000-0002-9160-0241 aut Matsui, Hiroki verfasserin aut Fushimi, Kiyohide verfasserin aut Yasunaga, Hideo verfasserin aut Enthalten in Burns Amsterdam [u.a.] : Elsevier Science, 1974 44, Seite 1954-1961 Online-Ressource (DE-627)320640817 (DE-600)2025040-X (DE-576)094480532 1879-1409 nnns volume:44 pages:1954-1961 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin 44.65 Chirurgie AR 44 1954-1961
allfieldsGer	10.1016/j.burns.2018.06.012 doi (DE-627)ELV001163949 (ELSEVIER)S0305-4179(18)30524-2 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl 44.65 bkl Tsuchiya, Asuka verfasserin aut Tracheostomy and mortality in patients with severe burns: A nationwide observational study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns. Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model Yamana, Hayato verfasserin (orcid)0000-0003-2214-6695 aut Kawahara, Takuya verfasserin aut Tsutsumi, Yusuke verfasserin (orcid)0000-0002-9160-0241 aut Matsui, Hiroki verfasserin aut Fushimi, Kiyohide verfasserin aut Yasunaga, Hideo verfasserin aut Enthalten in Burns Amsterdam [u.a.] : Elsevier Science, 1974 44, Seite 1954-1961 Online-Ressource (DE-627)320640817 (DE-600)2025040-X (DE-576)094480532 1879-1409 nnns volume:44 pages:1954-1961 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin 44.65 Chirurgie AR 44 1954-1961
allfieldsSound	10.1016/j.burns.2018.06.012 doi (DE-627)ELV001163949 (ELSEVIER)S0305-4179(18)30524-2 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl 44.65 bkl Tsuchiya, Asuka verfasserin aut Tracheostomy and mortality in patients with severe burns: A nationwide observational study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns. Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model Yamana, Hayato verfasserin (orcid)0000-0003-2214-6695 aut Kawahara, Takuya verfasserin aut Tsutsumi, Yusuke verfasserin (orcid)0000-0002-9160-0241 aut Matsui, Hiroki verfasserin aut Fushimi, Kiyohide verfasserin aut Yasunaga, Hideo verfasserin aut Enthalten in Burns Amsterdam [u.a.] : Elsevier Science, 1974 44, Seite 1954-1961 Online-Ressource (DE-627)320640817 (DE-600)2025040-X (DE-576)094480532 1879-1409 nnns volume:44 pages:1954-1961 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin 44.65 Chirurgie AR 44 1954-1961
language	English
source	Enthalten in Burns 44, Seite 1954-1961 volume:44 pages:1954-1961
sourceStr	Enthalten in Burns 44, Seite 1954-1961 volume:44 pages:1954-1961
format_phy_str_mv	Article
bklname	Unfallmedizin Notfallmedizin Chirurgie
institution	findex.gbv.de
topic_facet	Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model
dewey-raw	610
isfreeaccess_bool	false
container_title	Burns
authorswithroles_txt_mv	Tsuchiya, Asuka @@aut@@ Yamana, Hayato @@aut@@ Kawahara, Takuya @@aut@@ Tsutsumi, Yusuke @@aut@@ Matsui, Hiroki @@aut@@ Fushimi, Kiyohide @@aut@@ Yasunaga, Hideo @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	320640817
dewey-sort	3610
id	ELV001163949
language_de	englisch
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However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tracheotomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Burns</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mortality</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Time-dependent confounder</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inverse probability of treatment weighting</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Marginal structural model</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield 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author	Tsuchiya, Asuka
spellingShingle	Tsuchiya, Asuka ddc 610 bkl 44.80 bkl 44.65 misc Tracheotomy misc Burns misc mortality misc Time-dependent confounder misc Inverse probability of treatment weighting misc Marginal structural model Tracheostomy and mortality in patients with severe burns: A nationwide observational study
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topic_title	610 DE-600 44.80 bkl 44.65 bkl Tracheostomy and mortality in patients with severe burns: A nationwide observational study Tracheotomy Burns mortality Time-dependent confounder Inverse probability of treatment weighting Marginal structural model
topic	ddc 610 bkl 44.80 bkl 44.65 misc Tracheotomy misc Burns misc mortality misc Time-dependent confounder misc Inverse probability of treatment weighting misc Marginal structural model
topic_unstemmed	ddc 610 bkl 44.80 bkl 44.65 misc Tracheotomy misc Burns misc mortality misc Time-dependent confounder misc Inverse probability of treatment weighting misc Marginal structural model
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title	Tracheostomy and mortality in patients with severe burns: A nationwide observational study
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title_full	Tracheostomy and mortality in patients with severe burns: A nationwide observational study
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author_browse	Tsuchiya, Asuka Yamana, Hayato Kawahara, Takuya Tsutsumi, Yusuke Matsui, Hiroki Fushimi, Kiyohide Yasunaga, Hideo
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title_sort	tracheostomy and mortality in patients with severe burns: a nationwide observational study
title_auth	Tracheostomy and mortality in patients with severe burns: A nationwide observational study
abstract	Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns.
abstractGer	Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns.
abstract_unstemmed	Background: Tracheostomy is often performed in patients with severe burns who are undergoing prolonged mechanical ventilation. However, the appropriate timing of tracheostomy and its effect on mortality remain unknown. The aim of this study was to determine whether tracheostomy can reduce mortality in patients with severe burns.Methods: Using the Japanese Diagnosis Procedure Combination database from April 2010 to March 2014, we extracted data on adult patients with severe burns (burn index score of ≥15) who started mechanical ventilation within 3days of admission. We estimated the hazard ratio for 28-day in-hospital mortality associated with tracheotomy performed from day 5 to 28. We adjusted for baseline and time-dependent confounders using inverse probability of treatment weighting methods and fitted a marginal structural Cox proportional hazard model.Results: We identified 680 eligible patients (94 in the tracheostomy group, 2289 person-days; 586 in the non-tracheostomy group, 11,197 person-days). Patients who underwent a tracheostomy had worse prognostic factors for mortality. After adjustment for these factors, the hazard ratio for 28-day mortality associated with tracheostomy compared with non-tracheostomy was 0.73 (95% confidence interval, 0.39–1.34).Conclusions: There was no significant association between 28-day in-hospital mortality and early tracheostomy in adult patients with severe burns.
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title_short	Tracheostomy and mortality in patients with severe burns: A nationwide observational study
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author2	Yamana, Hayato Kawahara, Takuya Tsutsumi, Yusuke Matsui, Hiroki Fushimi, Kiyohide Yasunaga, Hideo
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up_date	2024-07-06T20:26:33.979Z
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Tracheostomy and mortality in patients with severe burns: A nationwide observational study

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