A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury

Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess t...
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Gespeichert in:

Autor*in:	Manquen, Jack [verfasserIn] Combs, Tyler [verfasserIn] Mazur-Mosiewicz, Anya [verfasserIn] Sanders, Donald [verfasserIn] Schiesel, Michael [verfasserIn] Gordon, Joshua [verfasserIn] Farabough, Michelle [verfasserIn] Vassar, Matt [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine

Übergeordnetes Werk:	Enthalten in: The American journal of emergency medicine - Philadelphia, Pa. : Saunders, 1983, 37, Seite 73-79
Übergeordnetes Werk:	volume:37 ; pages:73-79

DOI / URN:	10.1016/j.ajem.2018.04.061

Katalog-ID:	ELV001171232

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245	1	0	\|a A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury
264		1	\|c 2018
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520			\|a Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors.
650		4	\|a Traumatic brain injury
650		4	\|a Research gaps
650		4	\|a Clinical practice guidelines
650		4	\|a Emergency medicine
700	1		\|a Combs, Tyler \|e verfasserin \|4 aut
700	1		\|a Mazur-Mosiewicz, Anya \|e verfasserin \|4 aut
700	1		\|a Sanders, Donald \|e verfasserin \|0 (orcid)0000-0002-9407-0880 \|4 aut
700	1		\|a Schiesel, Michael \|e verfasserin \|4 aut
700	1		\|a Gordon, Joshua \|e verfasserin \|4 aut
700	1		\|a Farabough, Michelle \|e verfasserin \|0 (orcid)0000-0001-5460-4801 \|4 aut
700	1		\|a Vassar, Matt \|e verfasserin \|4 aut
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allfields	10.1016/j.ajem.2018.04.061 doi (DE-627)ELV001171232 (ELSEVIER)S0735-6757(18)30356-5 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Manquen, Jack verfasserin (orcid)0000-0002-4104-7847 aut A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors. Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine Combs, Tyler verfasserin aut Mazur-Mosiewicz, Anya verfasserin aut Sanders, Donald verfasserin (orcid)0000-0002-9407-0880 aut Schiesel, Michael verfasserin aut Gordon, Joshua verfasserin aut Farabough, Michelle verfasserin (orcid)0000-0001-5460-4801 aut Vassar, Matt verfasserin aut Enthalten in The American journal of emergency medicine Philadelphia, Pa. : Saunders, 1983 37, Seite 73-79 Online-Ressource (DE-627)326646221 (DE-600)2041648-9 (DE-576)09442702X 1532-8171 nnns volume:37 pages:73-79 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 37 73-79
spelling	10.1016/j.ajem.2018.04.061 doi (DE-627)ELV001171232 (ELSEVIER)S0735-6757(18)30356-5 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Manquen, Jack verfasserin (orcid)0000-0002-4104-7847 aut A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors. Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine Combs, Tyler verfasserin aut Mazur-Mosiewicz, Anya verfasserin aut Sanders, Donald verfasserin (orcid)0000-0002-9407-0880 aut Schiesel, Michael verfasserin aut Gordon, Joshua verfasserin aut Farabough, Michelle verfasserin (orcid)0000-0001-5460-4801 aut Vassar, Matt verfasserin aut Enthalten in The American journal of emergency medicine Philadelphia, Pa. : Saunders, 1983 37, Seite 73-79 Online-Ressource (DE-627)326646221 (DE-600)2041648-9 (DE-576)09442702X 1532-8171 nnns volume:37 pages:73-79 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 37 73-79
allfields_unstemmed	10.1016/j.ajem.2018.04.061 doi (DE-627)ELV001171232 (ELSEVIER)S0735-6757(18)30356-5 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Manquen, Jack verfasserin (orcid)0000-0002-4104-7847 aut A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors. Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine Combs, Tyler verfasserin aut Mazur-Mosiewicz, Anya verfasserin aut Sanders, Donald verfasserin (orcid)0000-0002-9407-0880 aut Schiesel, Michael verfasserin aut Gordon, Joshua verfasserin aut Farabough, Michelle verfasserin (orcid)0000-0001-5460-4801 aut Vassar, Matt verfasserin aut Enthalten in The American journal of emergency medicine Philadelphia, Pa. : Saunders, 1983 37, Seite 73-79 Online-Ressource (DE-627)326646221 (DE-600)2041648-9 (DE-576)09442702X 1532-8171 nnns volume:37 pages:73-79 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 37 73-79
allfieldsGer	10.1016/j.ajem.2018.04.061 doi (DE-627)ELV001171232 (ELSEVIER)S0735-6757(18)30356-5 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Manquen, Jack verfasserin (orcid)0000-0002-4104-7847 aut A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors. Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine Combs, Tyler verfasserin aut Mazur-Mosiewicz, Anya verfasserin aut Sanders, Donald verfasserin (orcid)0000-0002-9407-0880 aut Schiesel, Michael verfasserin aut Gordon, Joshua verfasserin aut Farabough, Michelle verfasserin (orcid)0000-0001-5460-4801 aut Vassar, Matt verfasserin aut Enthalten in The American journal of emergency medicine Philadelphia, Pa. : Saunders, 1983 37, Seite 73-79 Online-Ressource (DE-627)326646221 (DE-600)2041648-9 (DE-576)09442702X 1532-8171 nnns volume:37 pages:73-79 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 37 73-79
allfieldsSound	10.1016/j.ajem.2018.04.061 doi (DE-627)ELV001171232 (ELSEVIER)S0735-6757(18)30356-5 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Manquen, Jack verfasserin (orcid)0000-0002-4104-7847 aut A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors. Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine Combs, Tyler verfasserin aut Mazur-Mosiewicz, Anya verfasserin aut Sanders, Donald verfasserin (orcid)0000-0002-9407-0880 aut Schiesel, Michael verfasserin aut Gordon, Joshua verfasserin aut Farabough, Michelle verfasserin (orcid)0000-0001-5460-4801 aut Vassar, Matt verfasserin aut Enthalten in The American journal of emergency medicine Philadelphia, Pa. : Saunders, 1983 37, Seite 73-79 Online-Ressource (DE-627)326646221 (DE-600)2041648-9 (DE-576)09442702X 1532-8171 nnns volume:37 pages:73-79 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 37 73-79
language	English
source	Enthalten in The American journal of emergency medicine 37, Seite 73-79 volume:37 pages:73-79
sourceStr	Enthalten in The American journal of emergency medicine 37, Seite 73-79 volume:37 pages:73-79
format_phy_str_mv	Article
bklname	Unfallmedizin Notfallmedizin
institution	findex.gbv.de
topic_facet	Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine
dewey-raw	610
isfreeaccess_bool	false
container_title	The American journal of emergency medicine
authorswithroles_txt_mv	Manquen, Jack @@aut@@ Combs, Tyler @@aut@@ Mazur-Mosiewicz, Anya @@aut@@ Sanders, Donald @@aut@@ Schiesel, Michael @@aut@@ Gordon, Joshua @@aut@@ Farabough, Michelle @@aut@@ Vassar, Matt @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	326646221
dewey-sort	3610
id	ELV001171232
language_de	englisch
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author	Manquen, Jack
spellingShingle	Manquen, Jack ddc 610 bkl 44.80 misc Traumatic brain injury misc Research gaps misc Clinical practice guidelines misc Emergency medicine A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury
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topic_title	610 DE-600 44.80 bkl A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury Traumatic brain injury Research gaps Clinical practice guidelines Emergency medicine
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title	A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury
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title_full	A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury
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title_sort	a review of research efforts to address the 2008 acep guideline for mild traumatic brain injury
title_auth	A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury
abstract	Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors.
abstractGer	Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors.
abstract_unstemmed	Background: The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations. We aimed to assess the quality of current research efforts to address the American College of Emergency Physicians guideline and to provide suggestions for future research of mild traumatic brain injury.Methods: We identified clinical practice guideline recommendations with low levels of underlying evidence and searched ClinicalTrials.gov and the World Health Organization's International Clinical Trial Registry Portal to determine whether subsequent research has reflected an effort to address guideline recommendations.Results: Few currently registered clinical trials attempt to focus on clinical practice guideline recommendations where the basis of evidence is weak, and even fewer might benefit future iterations of the guideline due to multiple problems in study design and reporting.Conclusions: The amount of research dedicated to investigation of mild traumatic brain injury continues to be sparse and of poor quality. Study results should always be posted, even if the null hypothesis is confirmed. Efforts to improve the evidence base of a guideline should be realized by designing studies that directly assess and speak to the questions posed by guideline authors.
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title_short	A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury
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author2	Combs, Tyler Mazur-Mosiewicz, Anya Sanders, Donald Schiesel, Michael Gordon, Joshua Farabough, Michelle Vassar, Matt
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up_date	2024-07-06T20:28:02.900Z
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A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury

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