Effect of

This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Oliveira, D.E. [verfasserIn] Urio, M. [verfasserIn] Sandri, E.C. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Fatty acid synthesis Milk fat depression Milk fat synthesis

Übergeordnetes Werk:	Enthalten in: Small ruminant research - Amsterdam [u.a.] : Elsevier Science, 1988, 169, Seite 42-45
Übergeordnetes Werk:	volume:169 ; pages:42-45

DOI / URN:	10.1016/j.smallrumres.2018.10.009

Katalog-ID:	ELV001230158

Internformat


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520			\|a This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent.
650		4	\|a Fatty acid synthesis
650		4	\|a Milk fat depression
650		4	\|a Milk fat synthesis
700	1		\|a Urio, M. \|e verfasserin \|4 aut
700	1		\|a Sandri, E.C. \|e verfasserin \|4 aut
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912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
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912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
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912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
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912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
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912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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912			\|a GBV_ILN_4393
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952			\|d 169 \|h 42-45

Indexfelder

author_variant	d o do m u mu e s es
matchkey_str	article:09214488:2018----::fet
hierarchy_sort_str	2018
publishDate	2018
allfields	10.1016/j.smallrumres.2018.10.009 doi (DE-627)ELV001230158 (ELSEVIER)S0921-4488(18)30664-3 DE-627 ger DE-627 rda eng 630 640 DE-600 Oliveira, D.E. verfasserin aut Effect of 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent. Fatty acid synthesis Milk fat depression Milk fat synthesis Urio, M. verfasserin aut Sandri, E.C. verfasserin aut Enthalten in Small ruminant research Amsterdam [u.a.] : Elsevier Science, 1988 169, Seite 42-45 Online-Ressource (DE-627)306591537 (DE-600)1498734-X (DE-576)090954483 0921-4488 nnns volume:169 pages:42-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 169 42-45
spelling	10.1016/j.smallrumres.2018.10.009 doi (DE-627)ELV001230158 (ELSEVIER)S0921-4488(18)30664-3 DE-627 ger DE-627 rda eng 630 640 DE-600 Oliveira, D.E. verfasserin aut Effect of 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent. Fatty acid synthesis Milk fat depression Milk fat synthesis Urio, M. verfasserin aut Sandri, E.C. verfasserin aut Enthalten in Small ruminant research Amsterdam [u.a.] : Elsevier Science, 1988 169, Seite 42-45 Online-Ressource (DE-627)306591537 (DE-600)1498734-X (DE-576)090954483 0921-4488 nnns volume:169 pages:42-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 169 42-45
allfields_unstemmed	10.1016/j.smallrumres.2018.10.009 doi (DE-627)ELV001230158 (ELSEVIER)S0921-4488(18)30664-3 DE-627 ger DE-627 rda eng 630 640 DE-600 Oliveira, D.E. verfasserin aut Effect of 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent. Fatty acid synthesis Milk fat depression Milk fat synthesis Urio, M. verfasserin aut Sandri, E.C. verfasserin aut Enthalten in Small ruminant research Amsterdam [u.a.] : Elsevier Science, 1988 169, Seite 42-45 Online-Ressource (DE-627)306591537 (DE-600)1498734-X (DE-576)090954483 0921-4488 nnns volume:169 pages:42-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 169 42-45
allfieldsGer	10.1016/j.smallrumres.2018.10.009 doi (DE-627)ELV001230158 (ELSEVIER)S0921-4488(18)30664-3 DE-627 ger DE-627 rda eng 630 640 DE-600 Oliveira, D.E. verfasserin aut Effect of 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent. Fatty acid synthesis Milk fat depression Milk fat synthesis Urio, M. verfasserin aut Sandri, E.C. verfasserin aut Enthalten in Small ruminant research Amsterdam [u.a.] : Elsevier Science, 1988 169, Seite 42-45 Online-Ressource (DE-627)306591537 (DE-600)1498734-X (DE-576)090954483 0921-4488 nnns volume:169 pages:42-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 169 42-45
allfieldsSound	10.1016/j.smallrumres.2018.10.009 doi (DE-627)ELV001230158 (ELSEVIER)S0921-4488(18)30664-3 DE-627 ger DE-627 rda eng 630 640 DE-600 Oliveira, D.E. verfasserin aut Effect of 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent. Fatty acid synthesis Milk fat depression Milk fat synthesis Urio, M. verfasserin aut Sandri, E.C. verfasserin aut Enthalten in Small ruminant research Amsterdam [u.a.] : Elsevier Science, 1988 169, Seite 42-45 Online-Ressource (DE-627)306591537 (DE-600)1498734-X (DE-576)090954483 0921-4488 nnns volume:169 pages:42-45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 169 42-45
language	English
source	Enthalten in Small ruminant research 169, Seite 42-45 volume:169 pages:42-45
sourceStr	Enthalten in Small ruminant research 169, Seite 42-45 volume:169 pages:42-45
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Fatty acid synthesis Milk fat depression Milk fat synthesis
dewey-raw	630
isfreeaccess_bool	false
container_title	Small ruminant research
authorswithroles_txt_mv	Oliveira, D.E. @@aut@@ Urio, M. @@aut@@ Sandri, E.C. @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	306591537
dewey-sort	3630
id	ELV001230158
language_de	englisch
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author	Oliveira, D.E.
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topic	ddc 630 misc Fatty acid synthesis misc Milk fat depression misc Milk fat synthesis
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abstract	This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent.
abstractGer	This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent.
abstract_unstemmed	This study evaluated the effect of trans-10, cis-12 CLA on the expression of genes involved in decreasing milk fat synthesis in two groups of lactating ewes with different metabolic weights. Twelve Lacaune ewes were alloted, according to metabolic weight (MW), into a Light Metabolic Weight (LMW) and Heavy Metabolic Weigth (HMW) groups, both of which were orally fed 30 g/d of rumen-unprotected CLA supplement containing 29.9% trans-10, cis-12. Milk samples were collected on days 0, 3 and 10 and mammary and adipose tissue biopsies were taken on days 3 and 10. RNA extraction, cDNA synthesis and RT-qPCR were performed and data were analyzed using the MIXED procedure of SAS as repeated measure in a completely randomized design. The trans-10, cis-12 CLA reduced milk fat synthesis between days 3 and 10 (P = 0.001), and the HMW group had a greater expression (P < 0.05) of the genes acetyl-CoA carboxylase alpha - promoter III (ACACA-α PIII), fatty acid synthase (FASN), stearoil CoA desaturase 1 (SCD1) and thyroid hormone responsive spot14 (THRSP) in the mammary gland and of acetyl-CoA carboxylase alpha - promoter I (ACACA-α PI) and leptin (P < 0.05) in adipose tissue. Our findings indicate that the response of animals to trans-10, cis-12 CLA appears to be metabolic weight dependent.
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title_short	Effect of
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doi_str	10.1016/j.smallrumres.2018.10.009
up_date	2024-07-06T20:40:00.618Z
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