Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates

The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramo...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Otter, Ronja [verfasserIn] Berac, Christian Marijan [verfasserIn] Seiffert, Sebastian [verfasserIn] Besenius, Pol [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control

Übergeordnetes Werk:	Enthalten in: European polymer journal - New York, NY [u.a.] : Elsevier, 1965, 110, Seite 90-96
Übergeordnetes Werk:	volume:110 ; pages:90-96

DOI / URN:	10.1016/j.eurpolymj.2018.11.019

Katalog-ID:	ELV001265865

Internformat


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245	1	0	\|a Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates
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520			\|a The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments.
650		4	\|a Supramolecular chemistry
650		4	\|a Peptide-polymer conjugation
650		4	\|a Self-assembly
650		4	\|a Redox-regulation
650		4	\|a Kinetic control
700	1		\|a Berac, Christian Marijan \|e verfasserin \|4 aut
700	1		\|a Seiffert, Sebastian \|e verfasserin \|4 aut
700	1		\|a Besenius, Pol \|e verfasserin \|0 (orcid)0000-0001-7478-4459 \|4 aut
773	0	8	\|i Enthalten in \|t European polymer journal \|d New York, NY [u.a.] : Elsevier, 1965 \|g 110, Seite 90-96 \|h Online-Ressource \|w (DE-627)300897375 \|w (DE-600)1483529-0 \|w (DE-576)259270830 \|7 nnns
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912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_224
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2411
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 35.80 \|j Makromolekulare Chemie
951			\|a AR
952			\|d 110 \|h 90-96

Indexfelder

author_variant	r o ro c m b cm cmb s s ss p b pb
matchkey_str	otterronjaberacchristianmarijanseifferts:2018----:uighlftmospaoeuahdoessnrsepnieeehl
hierarchy_sort_str	2018
bklnumber	35.80
publishDate	2018
allfields	10.1016/j.eurpolymj.2018.11.019 doi (DE-627)ELV001265865 (ELSEVIER)S0014-3057(18)32026-3 DE-627 ger DE-627 rda eng 670 DE-600 35.80 bkl Otter, Ronja verfasserin aut Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments. Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control Berac, Christian Marijan verfasserin aut Seiffert, Sebastian verfasserin aut Besenius, Pol verfasserin (orcid)0000-0001-7478-4459 aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 110, Seite 90-96 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:110 pages:90-96 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie AR 110 90-96
spelling	10.1016/j.eurpolymj.2018.11.019 doi (DE-627)ELV001265865 (ELSEVIER)S0014-3057(18)32026-3 DE-627 ger DE-627 rda eng 670 DE-600 35.80 bkl Otter, Ronja verfasserin aut Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments. Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control Berac, Christian Marijan verfasserin aut Seiffert, Sebastian verfasserin aut Besenius, Pol verfasserin (orcid)0000-0001-7478-4459 aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 110, Seite 90-96 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:110 pages:90-96 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie AR 110 90-96
allfields_unstemmed	10.1016/j.eurpolymj.2018.11.019 doi (DE-627)ELV001265865 (ELSEVIER)S0014-3057(18)32026-3 DE-627 ger DE-627 rda eng 670 DE-600 35.80 bkl Otter, Ronja verfasserin aut Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments. Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control Berac, Christian Marijan verfasserin aut Seiffert, Sebastian verfasserin aut Besenius, Pol verfasserin (orcid)0000-0001-7478-4459 aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 110, Seite 90-96 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:110 pages:90-96 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie AR 110 90-96
allfieldsGer	10.1016/j.eurpolymj.2018.11.019 doi (DE-627)ELV001265865 (ELSEVIER)S0014-3057(18)32026-3 DE-627 ger DE-627 rda eng 670 DE-600 35.80 bkl Otter, Ronja verfasserin aut Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments. Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control Berac, Christian Marijan verfasserin aut Seiffert, Sebastian verfasserin aut Besenius, Pol verfasserin (orcid)0000-0001-7478-4459 aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 110, Seite 90-96 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:110 pages:90-96 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie AR 110 90-96
allfieldsSound	10.1016/j.eurpolymj.2018.11.019 doi (DE-627)ELV001265865 (ELSEVIER)S0014-3057(18)32026-3 DE-627 ger DE-627 rda eng 670 DE-600 35.80 bkl Otter, Ronja verfasserin aut Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments. Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control Berac, Christian Marijan verfasserin aut Seiffert, Sebastian verfasserin aut Besenius, Pol verfasserin (orcid)0000-0001-7478-4459 aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 110, Seite 90-96 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:110 pages:90-96 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.80 Makromolekulare Chemie AR 110 90-96
language	English
source	Enthalten in European polymer journal 110, Seite 90-96 volume:110 pages:90-96
sourceStr	Enthalten in European polymer journal 110, Seite 90-96 volume:110 pages:90-96
format_phy_str_mv	Article
bklname	Makromolekulare Chemie
institution	findex.gbv.de
topic_facet	Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control
dewey-raw	670
isfreeaccess_bool	false
container_title	European polymer journal
authorswithroles_txt_mv	Otter, Ronja @@aut@@ Berac, Christian Marijan @@aut@@ Seiffert, Sebastian @@aut@@ Besenius, Pol @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	300897375
dewey-sort	3670
id	ELV001265865
language_de	englisch
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author	Otter, Ronja
spellingShingle	Otter, Ronja ddc 670 bkl 35.80 misc Supramolecular chemistry misc Peptide-polymer conjugation misc Self-assembly misc Redox-regulation misc Kinetic control Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates
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topic_title	670 DE-600 35.80 bkl Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates Supramolecular chemistry Peptide-polymer conjugation Self-assembly Redox-regulation Kinetic control
topic	ddc 670 bkl 35.80 misc Supramolecular chemistry misc Peptide-polymer conjugation misc Self-assembly misc Redox-regulation misc Kinetic control
topic_unstemmed	ddc 670 bkl 35.80 misc Supramolecular chemistry misc Peptide-polymer conjugation misc Self-assembly misc Redox-regulation misc Kinetic control
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title	Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates
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title_full	Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates
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author_browse	Otter, Ronja Berac, Christian Marijan Seiffert, Sebastian Besenius, Pol
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title_sort	tuning the life-time of supramolecular hydrogels using ros-responsive telechelic peptide-polymer conjugates
title_auth	Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates
abstract	The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments.
abstractGer	The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments.
abstract_unstemmed	The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments.
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title_short	Tuning the life-time of supramolecular hydrogels using ROS-responsive telechelic peptide-polymer conjugates
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author2	Berac, Christian Marijan Seiffert, Sebastian Besenius, Pol
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up_date	2024-07-06T20:47:25.329Z
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