Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias
Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presen...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Schupp, Tobias [verfasserIn] Behnes, Michael [verfasserIn] Reiser, Linda [verfasserIn] Bollow, Armin [verfasserIn] Taton, Gabriel [verfasserIn] Reichelt, Thomas [verfasserIn] Ellguth, Dominik [verfasserIn] Engelke, Niko [verfasserIn] Ansari, Uzair [verfasserIn] El-Battrawy, Ibrahim [verfasserIn] Bertsch, Thomas [verfasserIn] Weiß, Christel [verfasserIn] Nienaber, Christoph [verfasserIn] Lang, Siegfried [verfasserIn] Akin, Muharrem [verfasserIn] Mashayekhi, Kambis [verfasserIn] Borggrefe, Martin [verfasserIn] Akin, Ibrahim [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of cardiology - Amsterdam [u.a.] : Elsevier Science, 1981, 277 |
|---|---|
| Übergeordnetes Werk: |
volume:277 |
| DOI / URN: |
10.1016/j.ijcard.2018.11.030 |
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| Katalog-ID: |
ELV001443747 |
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| 100 | 1 | |a Schupp, Tobias |e verfasserin |0 (orcid)0000-0001-8171-7617 |4 aut | |
| 245 | 1 | 0 | |a Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
| 264 | 1 | |c 2018 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. | ||
| 650 | 4 | |a Ventricular tachycardia | |
| 650 | 4 | |a Ventricular fibrillation | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Amiodarone | |
| 650 | 4 | |a Beta-blocker | |
| 650 | 4 | |a ICD | |
| 700 | 1 | |a Behnes, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Reiser, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Bollow, Armin |e verfasserin |4 aut | |
| 700 | 1 | |a Taton, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Reichelt, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Ellguth, Dominik |e verfasserin |4 aut | |
| 700 | 1 | |a Engelke, Niko |e verfasserin |4 aut | |
| 700 | 1 | |a Ansari, Uzair |e verfasserin |4 aut | |
| 700 | 1 | |a El-Battrawy, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Bertsch, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Weiß, Christel |e verfasserin |4 aut | |
| 700 | 1 | |a Nienaber, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Siegfried |e verfasserin |4 aut | |
| 700 | 1 | |a Akin, Muharrem |e verfasserin |4 aut | |
| 700 | 1 | |a Mashayekhi, Kambis |e verfasserin |4 aut | |
| 700 | 1 | |a Borggrefe, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Akin, Ibrahim |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cardiology |d Amsterdam [u.a.] : Elsevier Science, 1981 |g 277 |h Online-Ressource |w (DE-627)306659581 |w (DE-600)1500478-8 |w (DE-576)081986270 |x 1874-1754 |7 nnns |
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2018 |
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44.85 |
| publishDate |
2018 |
| allfields |
10.1016/j.ijcard.2018.11.030 doi (DE-627)ELV001443747 (ELSEVIER)S0167-5273(18)34572-8 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Schupp, Tobias verfasserin (orcid)0000-0001-8171-7617 aut Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD Behnes, Michael verfasserin aut Reiser, Linda verfasserin aut Bollow, Armin verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Ansari, Uzair verfasserin aut El-Battrawy, Ibrahim verfasserin aut Bertsch, Thomas verfasserin aut Weiß, Christel verfasserin aut Nienaber, Christoph verfasserin aut Lang, Siegfried verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in International journal of cardiology Amsterdam [u.a.] : Elsevier Science, 1981 277 Online-Ressource (DE-627)306659581 (DE-600)1500478-8 (DE-576)081986270 1874-1754 nnns volume:277 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.85 Kardiologie Angiologie AR 277 |
| spelling |
10.1016/j.ijcard.2018.11.030 doi (DE-627)ELV001443747 (ELSEVIER)S0167-5273(18)34572-8 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Schupp, Tobias verfasserin (orcid)0000-0001-8171-7617 aut Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD Behnes, Michael verfasserin aut Reiser, Linda verfasserin aut Bollow, Armin verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Ansari, Uzair verfasserin aut El-Battrawy, Ibrahim verfasserin aut Bertsch, Thomas verfasserin aut Weiß, Christel verfasserin aut Nienaber, Christoph verfasserin aut Lang, Siegfried verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in International journal of cardiology Amsterdam [u.a.] : Elsevier Science, 1981 277 Online-Ressource (DE-627)306659581 (DE-600)1500478-8 (DE-576)081986270 1874-1754 nnns volume:277 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.85 Kardiologie Angiologie AR 277 |
| allfields_unstemmed |
10.1016/j.ijcard.2018.11.030 doi (DE-627)ELV001443747 (ELSEVIER)S0167-5273(18)34572-8 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Schupp, Tobias verfasserin (orcid)0000-0001-8171-7617 aut Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD Behnes, Michael verfasserin aut Reiser, Linda verfasserin aut Bollow, Armin verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Ansari, Uzair verfasserin aut El-Battrawy, Ibrahim verfasserin aut Bertsch, Thomas verfasserin aut Weiß, Christel verfasserin aut Nienaber, Christoph verfasserin aut Lang, Siegfried verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in International journal of cardiology Amsterdam [u.a.] : Elsevier Science, 1981 277 Online-Ressource (DE-627)306659581 (DE-600)1500478-8 (DE-576)081986270 1874-1754 nnns volume:277 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.85 Kardiologie Angiologie AR 277 |
| allfieldsGer |
10.1016/j.ijcard.2018.11.030 doi (DE-627)ELV001443747 (ELSEVIER)S0167-5273(18)34572-8 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Schupp, Tobias verfasserin (orcid)0000-0001-8171-7617 aut Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD Behnes, Michael verfasserin aut Reiser, Linda verfasserin aut Bollow, Armin verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Ansari, Uzair verfasserin aut El-Battrawy, Ibrahim verfasserin aut Bertsch, Thomas verfasserin aut Weiß, Christel verfasserin aut Nienaber, Christoph verfasserin aut Lang, Siegfried verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in International journal of cardiology Amsterdam [u.a.] : Elsevier Science, 1981 277 Online-Ressource (DE-627)306659581 (DE-600)1500478-8 (DE-576)081986270 1874-1754 nnns volume:277 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.85 Kardiologie Angiologie AR 277 |
| allfieldsSound |
10.1016/j.ijcard.2018.11.030 doi (DE-627)ELV001443747 (ELSEVIER)S0167-5273(18)34572-8 DE-627 ger DE-627 rda eng 610 DE-600 44.85 bkl Schupp, Tobias verfasserin (orcid)0000-0001-8171-7617 aut Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD Behnes, Michael verfasserin aut Reiser, Linda verfasserin aut Bollow, Armin verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Ansari, Uzair verfasserin aut El-Battrawy, Ibrahim verfasserin aut Bertsch, Thomas verfasserin aut Weiß, Christel verfasserin aut Nienaber, Christoph verfasserin aut Lang, Siegfried verfasserin aut Akin, Muharrem verfasserin aut Mashayekhi, Kambis verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in International journal of cardiology Amsterdam [u.a.] : Elsevier Science, 1981 277 Online-Ressource (DE-627)306659581 (DE-600)1500478-8 (DE-576)081986270 1874-1754 nnns volume:277 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.85 Kardiologie Angiologie AR 277 |
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English |
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Enthalten in International journal of cardiology 277 volume:277 |
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Enthalten in International journal of cardiology 277 volume:277 |
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Kardiologie Angiologie |
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findex.gbv.de |
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Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD |
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610 |
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false |
| container_title |
International journal of cardiology |
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Schupp, Tobias @@aut@@ Behnes, Michael @@aut@@ Reiser, Linda @@aut@@ Bollow, Armin @@aut@@ Taton, Gabriel @@aut@@ Reichelt, Thomas @@aut@@ Ellguth, Dominik @@aut@@ Engelke, Niko @@aut@@ Ansari, Uzair @@aut@@ El-Battrawy, Ibrahim @@aut@@ Bertsch, Thomas @@aut@@ Weiß, Christel @@aut@@ Nienaber, Christoph @@aut@@ Lang, Siegfried @@aut@@ Akin, Muharrem @@aut@@ Mashayekhi, Kambis @@aut@@ Borggrefe, Martin @@aut@@ Akin, Ibrahim @@aut@@ |
| publishDateDaySort_date |
2018-01-01T00:00:00Z |
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306659581 |
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3610 |
| id |
ELV001443747 |
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englisch |
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Schupp, Tobias |
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Schupp, Tobias ddc 610 bkl 44.85 misc Ventricular tachycardia misc Ventricular fibrillation misc Mortality misc Amiodarone misc Beta-blocker misc ICD Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
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610 DE-600 44.85 bkl Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias Ventricular tachycardia Ventricular fibrillation Mortality Amiodarone Beta-blocker ICD |
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ddc 610 bkl 44.85 misc Ventricular tachycardia misc Ventricular fibrillation misc Mortality misc Amiodarone misc Beta-blocker misc ICD |
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Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
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Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
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Schupp, Tobias |
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Schupp, Tobias Behnes, Michael Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Ansari, Uzair El-Battrawy, Ibrahim Bertsch, Thomas Weiß, Christel Nienaber, Christoph Lang, Siegfried Akin, Muharrem Mashayekhi, Kambis Borggrefe, Martin Akin, Ibrahim |
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prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
| title_auth |
Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
| abstract |
Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. |
| abstractGer |
Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. |
| abstract_unstemmed |
Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. |
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Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |
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Behnes, Michael Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Ansari, Uzair El-Battrawy, Ibrahim Bertsch, Thomas Weiß, Christel Nienaber, Christoph Lang, Siegfried Akin, Muharrem Mashayekhi, Kambis Borggrefe, Martin Akin, Ibrahim |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV001443747</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524141924.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230428s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijcard.2018.11.030</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV001443747</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0167-5273(18)34572-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.85</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Schupp, Tobias</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-8171-7617</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective: The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission.Background: Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited.Methods: A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3 years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied.Results: A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR = 0.550; p = 0.001, multivariable: HR = 0.712; statistical trend, p = 0.052). After propensity-score matching (n = 186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p = 0.042; HR = 0.634; 95% CI = 0.407–0.988; p = 0.044). Prognostic superiority of BB was mainly observed in patients with LVEF ≥ 35% (HR = 0.463; 95% CI = 0.215–0.997; p = 0.049) and in those without atrial fibrillation (non-AF) (HR = 0.415; 95% CI = 0.202–0.852; p = 0.017).Conclusion: BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventricular tachycardia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventricular fibrillation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mortality</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Amiodarone</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Beta-blocker</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ICD</subfield></datafield><datafield tag="700" 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