Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus
Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was t...
Ausführliche Beschreibung
Autor*in: |
van der Meulen, Taco A. [verfasserIn] Harmsen, Hermie J.M. [verfasserIn] Vila, Arnau Vich [verfasserIn] Kurilshikov, Alexander [verfasserIn] Liefers, Silvia C. [verfasserIn] Zhernakova, Alexandra [verfasserIn] Fu, Jingyuan [verfasserIn] Wijmenga, Cisca [verfasserIn] Weersma, Rinse K. [verfasserIn] de Leeuw, Karina [verfasserIn] Bootsma, Hendrika [verfasserIn] Spijkervet, Fred K.L. [verfasserIn] Vissink, Arjan [verfasserIn] Kroese, Frans G.M. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
Enthalten in: Journal of autoimmunity - London : Academic Press, 1988, 97, Seite 77-87 |
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Übergeordnetes Werk: |
volume:97 ; pages:77-87 |
DOI / URN: |
10.1016/j.jaut.2018.10.009 |
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Katalog-ID: |
ELV001525786 |
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245 | 1 | 0 | |a Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
264 | 1 | |c 2018 | |
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520 | |a Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. | ||
700 | 1 | |a Harmsen, Hermie J.M. |e verfasserin |4 aut | |
700 | 1 | |a Vila, Arnau Vich |e verfasserin |4 aut | |
700 | 1 | |a Kurilshikov, Alexander |e verfasserin |4 aut | |
700 | 1 | |a Liefers, Silvia C. |e verfasserin |0 (orcid)0000-0002-7757-2053 |4 aut | |
700 | 1 | |a Zhernakova, Alexandra |e verfasserin |4 aut | |
700 | 1 | |a Fu, Jingyuan |e verfasserin |0 (orcid)0000-0001-5578-1236 |4 aut | |
700 | 1 | |a Wijmenga, Cisca |e verfasserin |0 (orcid)0000-0002-5635-1614 |4 aut | |
700 | 1 | |a Weersma, Rinse K. |e verfasserin |4 aut | |
700 | 1 | |a de Leeuw, Karina |e verfasserin |4 aut | |
700 | 1 | |a Bootsma, Hendrika |e verfasserin |4 aut | |
700 | 1 | |a Spijkervet, Fred K.L. |e verfasserin |4 aut | |
700 | 1 | |a Vissink, Arjan |e verfasserin |4 aut | |
700 | 1 | |a Kroese, Frans G.M. |e verfasserin |4 aut | |
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2018 |
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10.1016/j.jaut.2018.10.009 doi (DE-627)ELV001525786 (ELSEVIER)S0896-8411(18)30524-9 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl van der Meulen, Taco A. verfasserin aut Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. Harmsen, Hermie J.M. verfasserin aut Vila, Arnau Vich verfasserin aut Kurilshikov, Alexander verfasserin aut Liefers, Silvia C. verfasserin (orcid)0000-0002-7757-2053 aut Zhernakova, Alexandra verfasserin aut Fu, Jingyuan verfasserin (orcid)0000-0001-5578-1236 aut Wijmenga, Cisca verfasserin (orcid)0000-0002-5635-1614 aut Weersma, Rinse K. verfasserin aut de Leeuw, Karina verfasserin aut Bootsma, Hendrika verfasserin aut Spijkervet, Fred K.L. verfasserin aut Vissink, Arjan verfasserin aut Kroese, Frans G.M. verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 97, Seite 77-87 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:97 pages:77-87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 97 77-87 |
spelling |
10.1016/j.jaut.2018.10.009 doi (DE-627)ELV001525786 (ELSEVIER)S0896-8411(18)30524-9 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl van der Meulen, Taco A. verfasserin aut Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. Harmsen, Hermie J.M. verfasserin aut Vila, Arnau Vich verfasserin aut Kurilshikov, Alexander verfasserin aut Liefers, Silvia C. verfasserin (orcid)0000-0002-7757-2053 aut Zhernakova, Alexandra verfasserin aut Fu, Jingyuan verfasserin (orcid)0000-0001-5578-1236 aut Wijmenga, Cisca verfasserin (orcid)0000-0002-5635-1614 aut Weersma, Rinse K. verfasserin aut de Leeuw, Karina verfasserin aut Bootsma, Hendrika verfasserin aut Spijkervet, Fred K.L. verfasserin aut Vissink, Arjan verfasserin aut Kroese, Frans G.M. verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 97, Seite 77-87 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:97 pages:77-87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 97 77-87 |
allfields_unstemmed |
10.1016/j.jaut.2018.10.009 doi (DE-627)ELV001525786 (ELSEVIER)S0896-8411(18)30524-9 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl van der Meulen, Taco A. verfasserin aut Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. Harmsen, Hermie J.M. verfasserin aut Vila, Arnau Vich verfasserin aut Kurilshikov, Alexander verfasserin aut Liefers, Silvia C. verfasserin (orcid)0000-0002-7757-2053 aut Zhernakova, Alexandra verfasserin aut Fu, Jingyuan verfasserin (orcid)0000-0001-5578-1236 aut Wijmenga, Cisca verfasserin (orcid)0000-0002-5635-1614 aut Weersma, Rinse K. verfasserin aut de Leeuw, Karina verfasserin aut Bootsma, Hendrika verfasserin aut Spijkervet, Fred K.L. verfasserin aut Vissink, Arjan verfasserin aut Kroese, Frans G.M. verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 97, Seite 77-87 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:97 pages:77-87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 97 77-87 |
allfieldsGer |
10.1016/j.jaut.2018.10.009 doi (DE-627)ELV001525786 (ELSEVIER)S0896-8411(18)30524-9 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl van der Meulen, Taco A. verfasserin aut Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. Harmsen, Hermie J.M. verfasserin aut Vila, Arnau Vich verfasserin aut Kurilshikov, Alexander verfasserin aut Liefers, Silvia C. verfasserin (orcid)0000-0002-7757-2053 aut Zhernakova, Alexandra verfasserin aut Fu, Jingyuan verfasserin (orcid)0000-0001-5578-1236 aut Wijmenga, Cisca verfasserin (orcid)0000-0002-5635-1614 aut Weersma, Rinse K. verfasserin aut de Leeuw, Karina verfasserin aut Bootsma, Hendrika verfasserin aut Spijkervet, Fred K.L. verfasserin aut Vissink, Arjan verfasserin aut Kroese, Frans G.M. verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 97, Seite 77-87 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:97 pages:77-87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 97 77-87 |
allfieldsSound |
10.1016/j.jaut.2018.10.009 doi (DE-627)ELV001525786 (ELSEVIER)S0896-8411(18)30524-9 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl van der Meulen, Taco A. verfasserin aut Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. Harmsen, Hermie J.M. verfasserin aut Vila, Arnau Vich verfasserin aut Kurilshikov, Alexander verfasserin aut Liefers, Silvia C. verfasserin (orcid)0000-0002-7757-2053 aut Zhernakova, Alexandra verfasserin aut Fu, Jingyuan verfasserin (orcid)0000-0001-5578-1236 aut Wijmenga, Cisca verfasserin (orcid)0000-0002-5635-1614 aut Weersma, Rinse K. verfasserin aut de Leeuw, Karina verfasserin aut Bootsma, Hendrika verfasserin aut Spijkervet, Fred K.L. verfasserin aut Vissink, Arjan verfasserin aut Kroese, Frans G.M. verfasserin aut Enthalten in Journal of autoimmunity London : Academic Press, 1988 97, Seite 77-87 Online-Ressource (DE-627)266890822 (DE-600)1468989-3 (DE-576)104193786 1095-9157 nnns volume:97 pages:77-87 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 97 77-87 |
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van der Meulen, Taco A. @@aut@@ Harmsen, Hermie J.M. @@aut@@ Vila, Arnau Vich @@aut@@ Kurilshikov, Alexander @@aut@@ Liefers, Silvia C. @@aut@@ Zhernakova, Alexandra @@aut@@ Fu, Jingyuan @@aut@@ Wijmenga, Cisca @@aut@@ Weersma, Rinse K. @@aut@@ de Leeuw, Karina @@aut@@ Bootsma, Hendrika @@aut@@ Spijkervet, Fred K.L. @@aut@@ Vissink, Arjan @@aut@@ Kroese, Frans G.M. @@aut@@ |
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van der Meulen, Taco A. |
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van der Meulen, Taco A. ddc 610 bkl 44.45 Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
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610 DE-600 44.45 bkl Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
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Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
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Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
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van der Meulen, Taco A. |
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van der Meulen, Taco A. Harmsen, Hermie J.M. Vila, Arnau Vich Kurilshikov, Alexander Liefers, Silvia C. Zhernakova, Alexandra Fu, Jingyuan Wijmenga, Cisca Weersma, Rinse K. de Leeuw, Karina Bootsma, Hendrika Spijkervet, Fred K.L. Vissink, Arjan Kroese, Frans G.M. |
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shared gut, but distinct oral microbiota composition in primary sjögren's syndrome and systemic lupus erythematosus |
title_auth |
Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
abstract |
Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. |
abstractGer |
Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. |
abstract_unstemmed |
Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Alpha-diversity, beta-diversity and relative abundance of individual bacteria were used as outcome measures. Multivariate analyses were performed to test associations between individual bacteria and disease phenotype, taking age, sex, body-mass index, proton-pump inhibitor use and sequencing-depth into account as possible confounding factors.Results: Fecal microbiota composition from pSS and SLE patients differed significantly from population controls, but not between pSS and SLE. pSS and SLE patients were characterized by lower bacterial richness, lower Firmicutes/Bacteroidetes ratio and higher relative abundance of Bacteroides species in fecal samples compared with population controls. Oral microbiota composition differed significantly between pSS patients and SLE patients, which could partially be explained by oral dryness in pSS patients.Conclusions: pSS and SLE patients share similar alterations in gut microbiota composition, distinguishing patients from individuals in the general population, while oral microbiota composition shows disease-specific differences between pSS and SLE patients. |
collection_details |
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title_short |
Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus |
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Harmsen, Hermie J.M. Vila, Arnau Vich Kurilshikov, Alexander Liefers, Silvia C. Zhernakova, Alexandra Fu, Jingyuan Wijmenga, Cisca Weersma, Rinse K. de Leeuw, Karina Bootsma, Hendrika Spijkervet, Fred K.L. Vissink, Arjan Kroese, Frans G.M. |
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Harmsen, Hermie J.M. Vila, Arnau Vich Kurilshikov, Alexander Liefers, Silvia C. Zhernakova, Alexandra Fu, Jingyuan Wijmenga, Cisca Weersma, Rinse K. de Leeuw, Karina Bootsma, Hendrika Spijkervet, Fred K.L. Vissink, Arjan Kroese, Frans G.M. |
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up_date |
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