Involvement of ILR4α and TLR4 in miscarriages
Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyz...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kolben, Theresa Maria [verfasserIn] Rogatsch, Elisabeth [verfasserIn] Hester, Anna [verfasserIn] Kuhn, Christina [verfasserIn] Schmoeckel, Elisa [verfasserIn] Czogalla, Bastian [verfasserIn] Mahner, Sven [verfasserIn] Jeschke, Udo [verfasserIn] Kolben, Thomas [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of reproductive immunology - Oxford : Oxford University Press, 1979, 131, Seite 36-43 |
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| Übergeordnetes Werk: |
volume:131 ; pages:36-43 |
| DOI / URN: |
10.1016/j.jri.2018.12.001 |
|---|
| Katalog-ID: |
ELV001580531 |
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| 024 | 7 | |a 10.1016/j.jri.2018.12.001 |2 doi | |
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| 100 | 1 | |a Kolben, Theresa Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Involvement of ILR4α and TLR4 in miscarriages |
| 264 | 1 | |c 2019 | |
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| 520 | |a Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. | ||
| 650 | 4 | |a Habitual miscarriages | |
| 650 | 4 | |a Habitual abortions | |
| 650 | 4 | |a Spontaneous abortions | |
| 650 | 4 | |a IL4Rα | |
| 650 | 4 | |a TLR4 | |
| 700 | 1 | |a Rogatsch, Elisabeth |e verfasserin |0 (orcid)0000-0002-6402-0954 |4 aut | |
| 700 | 1 | |a Hester, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Kuhn, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Schmoeckel, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Czogalla, Bastian |e verfasserin |0 (orcid)0000-0001-6589-4736 |4 aut | |
| 700 | 1 | |a Mahner, Sven |e verfasserin |4 aut | |
| 700 | 1 | |a Jeschke, Udo |e verfasserin |0 (orcid)0000-0003-2623-3235 |4 aut | |
| 700 | 1 | |a Kolben, Thomas |e verfasserin |0 (orcid)0000-0003-1418-8588 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of reproductive immunology |d Oxford : Oxford University Press, 1979 |g 131, Seite 36-43 |h Online-Ressource |w (DE-627)320464458 |w (DE-600)2007694-0 |w (DE-576)095660186 |x 1872-7603 |7 nnns |
| 773 | 1 | 8 | |g volume:131 |g pages:36-43 |
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| 912 | |a GBV_ILN_2050 | ||
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| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
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| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4335 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
| 936 | b | k | |a 44.45 |j Immunologie |
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| 952 | |d 131 |h 36-43 | ||
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2019 |
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10.1016/j.jri.2018.12.001 doi (DE-627)ELV001580531 (ELSEVIER)S0165-0378(18)30075-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Kolben, Theresa Maria verfasserin aut Involvement of ILR4α and TLR4 in miscarriages 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 Rogatsch, Elisabeth verfasserin (orcid)0000-0002-6402-0954 aut Hester, Anna verfasserin aut Kuhn, Christina verfasserin aut Schmoeckel, Elisa verfasserin aut Czogalla, Bastian verfasserin (orcid)0000-0001-6589-4736 aut Mahner, Sven verfasserin aut Jeschke, Udo verfasserin (orcid)0000-0003-2623-3235 aut Kolben, Thomas verfasserin (orcid)0000-0003-1418-8588 aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 131, Seite 36-43 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:131 pages:36-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 131 36-43 |
| spelling |
10.1016/j.jri.2018.12.001 doi (DE-627)ELV001580531 (ELSEVIER)S0165-0378(18)30075-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Kolben, Theresa Maria verfasserin aut Involvement of ILR4α and TLR4 in miscarriages 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 Rogatsch, Elisabeth verfasserin (orcid)0000-0002-6402-0954 aut Hester, Anna verfasserin aut Kuhn, Christina verfasserin aut Schmoeckel, Elisa verfasserin aut Czogalla, Bastian verfasserin (orcid)0000-0001-6589-4736 aut Mahner, Sven verfasserin aut Jeschke, Udo verfasserin (orcid)0000-0003-2623-3235 aut Kolben, Thomas verfasserin (orcid)0000-0003-1418-8588 aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 131, Seite 36-43 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:131 pages:36-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 131 36-43 |
| allfields_unstemmed |
10.1016/j.jri.2018.12.001 doi (DE-627)ELV001580531 (ELSEVIER)S0165-0378(18)30075-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Kolben, Theresa Maria verfasserin aut Involvement of ILR4α and TLR4 in miscarriages 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 Rogatsch, Elisabeth verfasserin (orcid)0000-0002-6402-0954 aut Hester, Anna verfasserin aut Kuhn, Christina verfasserin aut Schmoeckel, Elisa verfasserin aut Czogalla, Bastian verfasserin (orcid)0000-0001-6589-4736 aut Mahner, Sven verfasserin aut Jeschke, Udo verfasserin (orcid)0000-0003-2623-3235 aut Kolben, Thomas verfasserin (orcid)0000-0003-1418-8588 aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 131, Seite 36-43 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:131 pages:36-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 131 36-43 |
| allfieldsGer |
10.1016/j.jri.2018.12.001 doi (DE-627)ELV001580531 (ELSEVIER)S0165-0378(18)30075-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Kolben, Theresa Maria verfasserin aut Involvement of ILR4α and TLR4 in miscarriages 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 Rogatsch, Elisabeth verfasserin (orcid)0000-0002-6402-0954 aut Hester, Anna verfasserin aut Kuhn, Christina verfasserin aut Schmoeckel, Elisa verfasserin aut Czogalla, Bastian verfasserin (orcid)0000-0001-6589-4736 aut Mahner, Sven verfasserin aut Jeschke, Udo verfasserin (orcid)0000-0003-2623-3235 aut Kolben, Thomas verfasserin (orcid)0000-0003-1418-8588 aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 131, Seite 36-43 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:131 pages:36-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 131 36-43 |
| allfieldsSound |
10.1016/j.jri.2018.12.001 doi (DE-627)ELV001580531 (ELSEVIER)S0165-0378(18)30075-5 DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl Kolben, Theresa Maria verfasserin aut Involvement of ILR4α and TLR4 in miscarriages 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 Rogatsch, Elisabeth verfasserin (orcid)0000-0002-6402-0954 aut Hester, Anna verfasserin aut Kuhn, Christina verfasserin aut Schmoeckel, Elisa verfasserin aut Czogalla, Bastian verfasserin (orcid)0000-0001-6589-4736 aut Mahner, Sven verfasserin aut Jeschke, Udo verfasserin (orcid)0000-0003-2623-3235 aut Kolben, Thomas verfasserin (orcid)0000-0003-1418-8588 aut Enthalten in Journal of reproductive immunology Oxford : Oxford University Press, 1979 131, Seite 36-43 Online-Ressource (DE-627)320464458 (DE-600)2007694-0 (DE-576)095660186 1872-7603 nnns volume:131 pages:36-43 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.45 Immunologie AR 131 36-43 |
| language |
English |
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Enthalten in Journal of reproductive immunology 131, Seite 36-43 volume:131 pages:36-43 |
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Enthalten in Journal of reproductive immunology 131, Seite 36-43 volume:131 pages:36-43 |
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Immunologie |
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findex.gbv.de |
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Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 |
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610 |
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Kolben, Theresa Maria @@aut@@ Rogatsch, Elisabeth @@aut@@ Hester, Anna @@aut@@ Kuhn, Christina @@aut@@ Schmoeckel, Elisa @@aut@@ Czogalla, Bastian @@aut@@ Mahner, Sven @@aut@@ Jeschke, Udo @@aut@@ Kolben, Thomas @@aut@@ |
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2019-01-01T00:00:00Z |
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3610 |
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Kolben, Theresa Maria |
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Kolben, Theresa Maria ddc 610 bkl 44.45 misc Habitual miscarriages misc Habitual abortions misc Spontaneous abortions misc IL4Rα misc TLR4 Involvement of ILR4α and TLR4 in miscarriages |
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610 DE-600 44.45 bkl Involvement of ILR4α and TLR4 in miscarriages Habitual miscarriages Habitual abortions Spontaneous abortions IL4Rα TLR4 |
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ddc 610 bkl 44.45 misc Habitual miscarriages misc Habitual abortions misc Spontaneous abortions misc IL4Rα misc TLR4 |
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ddc 610 bkl 44.45 misc Habitual miscarriages misc Habitual abortions misc Spontaneous abortions misc IL4Rα misc TLR4 |
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Involvement of ILR4α and TLR4 in miscarriages |
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Involvement of ILR4α and TLR4 in miscarriages |
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Kolben, Theresa Maria |
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Journal of reproductive immunology |
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Kolben, Theresa Maria Rogatsch, Elisabeth Hester, Anna Kuhn, Christina Schmoeckel, Elisa Czogalla, Bastian Mahner, Sven Jeschke, Udo Kolben, Thomas |
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involvement of ilr4α and tlr4 in miscarriages |
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Involvement of ILR4α and TLR4 in miscarriages |
| abstract |
Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. |
| abstractGer |
Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. |
| abstract_unstemmed |
Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Statistical analysis was carried out using SPSS 23 and Microsoft Excel.Results: IL4Rα could be detected in trophoblast cells of all groups. It was significantly downregulated in the syncytiotrophoblast of spontaneous and recurrent abortions (p = 0.001), and in decidual tissue of spontaneous abortions (p = 0.001). Expression of TLR4 was decreased in the intermediate villous trophoblast (IVT) and decidua of spontaneous abortions (p = 0.04 & 0.003, respectively). On mRNA level expression of IL4Rα and TLR4 was significantly decreased in the group of recurrent miscarriages (IL4Rα p = 0.002, TLR4 p = 0.004).Conclusion: This study contributes new findings to the understanding of the complex molecular interplay at the fetomaternal interface in normal pregnancy and miscarriages. For the first time signaling via IL4Rα being involved at the very beginning of the generation of new life could demonstrated. Moreover, new evidence was provided regarding TLR4 playing a pivotal role in early pregnancy. |
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| title_short |
Involvement of ILR4α and TLR4 in miscarriages |
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Rogatsch, Elisabeth Hester, Anna Kuhn, Christina Schmoeckel, Elisa Czogalla, Bastian Mahner, Sven Jeschke, Udo Kolben, Thomas |
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