Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials

Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related qual...
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Autor*in:	Ghislain, Irina [verfasserIn] Zikos, Efstathios [verfasserIn] Coens, Corneel [verfasserIn] Quinten, Chantal [verfasserIn] Balta, Vasiliki [verfasserIn] Tryfonidis, Konstantinos [verfasserIn] Piccart, Martine [verfasserIn] Zardavas, Dimitrios [verfasserIn] Nagele, Eva [verfasserIn] Bjelic-Radisic, Vesna [verfasserIn] Cardoso, Fatima [verfasserIn] Sprangers, Mirjam A G [verfasserIn] Velikova, Galina [verfasserIn] Bottomley, Andrew [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	Enthalten in: The lancet / Oncology - London : The Lancet Publ. Group, 2000, 17, Seite e294-e304
Übergeordnetes Werk:	volume:17 ; pages:e294-e304

DOI / URN:	10.1016/S1470-2045(16)30099-7

Katalog-ID:	ELV001590731

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520			\|a Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies.
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700	1		\|a Coens, Corneel \|e verfasserin \|4 aut
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700	1		\|a Balta, Vasiliki \|e verfasserin \|4 aut
700	1		\|a Tryfonidis, Konstantinos \|e verfasserin \|4 aut
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700	1		\|a Zardavas, Dimitrios \|e verfasserin \|4 aut
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700	1		\|a Bjelic-Radisic, Vesna \|e verfasserin \|4 aut
700	1		\|a Cardoso, Fatima \|e verfasserin \|4 aut
700	1		\|a Sprangers, Mirjam A G \|e verfasserin \|4 aut
700	1		\|a Velikova, Galina \|e verfasserin \|4 aut
700	1		\|a Bottomley, Andrew \|e verfasserin \|4 aut
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936	b	k	\|a 44.81 \|j Onkologie
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allfields	10.1016/S1470-2045(16)30099-7 doi (DE-627)ELV001590731 (ELSEVIER)S1470-2045(16)30099-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Ghislain, Irina verfasserin aut Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies. Zikos, Efstathios verfasserin aut Coens, Corneel verfasserin aut Quinten, Chantal verfasserin aut Balta, Vasiliki verfasserin aut Tryfonidis, Konstantinos verfasserin aut Piccart, Martine verfasserin aut Zardavas, Dimitrios verfasserin aut Nagele, Eva verfasserin aut Bjelic-Radisic, Vesna verfasserin aut Cardoso, Fatima verfasserin aut Sprangers, Mirjam A G verfasserin aut Velikova, Galina verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 17, Seite e294-e304 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:17 pages:e294-e304 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 17 e294-e304
spelling	10.1016/S1470-2045(16)30099-7 doi (DE-627)ELV001590731 (ELSEVIER)S1470-2045(16)30099-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Ghislain, Irina verfasserin aut Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies. Zikos, Efstathios verfasserin aut Coens, Corneel verfasserin aut Quinten, Chantal verfasserin aut Balta, Vasiliki verfasserin aut Tryfonidis, Konstantinos verfasserin aut Piccart, Martine verfasserin aut Zardavas, Dimitrios verfasserin aut Nagele, Eva verfasserin aut Bjelic-Radisic, Vesna verfasserin aut Cardoso, Fatima verfasserin aut Sprangers, Mirjam A G verfasserin aut Velikova, Galina verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 17, Seite e294-e304 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:17 pages:e294-e304 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 17 e294-e304
allfields_unstemmed	10.1016/S1470-2045(16)30099-7 doi (DE-627)ELV001590731 (ELSEVIER)S1470-2045(16)30099-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Ghislain, Irina verfasserin aut Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies. Zikos, Efstathios verfasserin aut Coens, Corneel verfasserin aut Quinten, Chantal verfasserin aut Balta, Vasiliki verfasserin aut Tryfonidis, Konstantinos verfasserin aut Piccart, Martine verfasserin aut Zardavas, Dimitrios verfasserin aut Nagele, Eva verfasserin aut Bjelic-Radisic, Vesna verfasserin aut Cardoso, Fatima verfasserin aut Sprangers, Mirjam A G verfasserin aut Velikova, Galina verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 17, Seite e294-e304 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:17 pages:e294-e304 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 17 e294-e304
allfieldsGer	10.1016/S1470-2045(16)30099-7 doi (DE-627)ELV001590731 (ELSEVIER)S1470-2045(16)30099-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Ghislain, Irina verfasserin aut Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies. Zikos, Efstathios verfasserin aut Coens, Corneel verfasserin aut Quinten, Chantal verfasserin aut Balta, Vasiliki verfasserin aut Tryfonidis, Konstantinos verfasserin aut Piccart, Martine verfasserin aut Zardavas, Dimitrios verfasserin aut Nagele, Eva verfasserin aut Bjelic-Radisic, Vesna verfasserin aut Cardoso, Fatima verfasserin aut Sprangers, Mirjam A G verfasserin aut Velikova, Galina verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 17, Seite e294-e304 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:17 pages:e294-e304 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 17 e294-e304
allfieldsSound	10.1016/S1470-2045(16)30099-7 doi (DE-627)ELV001590731 (ELSEVIER)S1470-2045(16)30099-7 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Ghislain, Irina verfasserin aut Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials 2016 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies. Zikos, Efstathios verfasserin aut Coens, Corneel verfasserin aut Quinten, Chantal verfasserin aut Balta, Vasiliki verfasserin aut Tryfonidis, Konstantinos verfasserin aut Piccart, Martine verfasserin aut Zardavas, Dimitrios verfasserin aut Nagele, Eva verfasserin aut Bjelic-Radisic, Vesna verfasserin aut Cardoso, Fatima verfasserin aut Sprangers, Mirjam A G verfasserin aut Velikova, Galina verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 17, Seite e294-e304 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:17 pages:e294-e304 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 17 e294-e304
language	English
source	Enthalten in The lancet <London> / Oncology 17, Seite e294-e304 volume:17 pages:e294-e304
sourceStr	Enthalten in The lancet <London> / Oncology 17, Seite e294-e304 volume:17 pages:e294-e304
format_phy_str_mv	Article
bklname	Onkologie
institution	findex.gbv.de
dewey-raw	610
isfreeaccess_bool	false
container_title	The lancet <London> / Oncology
authorswithroles_txt_mv	Ghislain, Irina @@aut@@ Zikos, Efstathios @@aut@@ Coens, Corneel @@aut@@ Quinten, Chantal @@aut@@ Balta, Vasiliki @@aut@@ Tryfonidis, Konstantinos @@aut@@ Piccart, Martine @@aut@@ Zardavas, Dimitrios @@aut@@ Nagele, Eva @@aut@@ Bjelic-Radisic, Vesna @@aut@@ Cardoso, Fatima @@aut@@ Sprangers, Mirjam A G @@aut@@ Velikova, Galina @@aut@@ Bottomley, Andrew @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	325349770
dewey-sort	3610
id	ELV001590731
language_de	englisch
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spellingShingle	Ghislain, Irina ddc 610 bkl 44.81 Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
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topic_title	610 DE-600 44.81 bkl Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
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title	Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
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title_full	Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
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author_browse	Ghislain, Irina Zikos, Efstathios Coens, Corneel Quinten, Chantal Balta, Vasiliki Tryfonidis, Konstantinos Piccart, Martine Zardavas, Dimitrios Nagele, Eva Bjelic-Radisic, Vesna Cardoso, Fatima Sprangers, Mirjam A G Velikova, Galina Bottomley, Andrew
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title_sort	health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
title_auth	Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
abstract	Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies.
abstractGer	Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies.
abstract_unstemmed	Breast cancer is the leading cause of cancer death among women worldwide, and increasingly, randomised controlled trials of this disease are measuring the health-related quality of life of these patients. In this systematic Review, we assess the adequacy of methods used to report health-related quality of life (HRQOL) from 49 eligible randomised controlled trials of advanced breast cancer. We compare our findings with those from the literature to investigate whether the standard of HRQOL reporting in this field has changed. We conclude that the overall reporting of HRQOL has improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypotheses and the overemphasis on statistical rather than clinical significance. Additionally, new challenges are arising with the emergence of novel treatments and the advent of personalised medicine, and improved HRQOL tools are required to cover the range of side-effects of newer therapies.
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title_short	Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials
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up_date	2024-07-06T21:53:50.947Z
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Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials

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