The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project
Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormal...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Schizophrenia research - Amsterdam [u.a.] : Elsevier Science, 1988, 195, Seite 306-317 |
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| Übergeordnetes Werk: |
volume:195 ; pages:306-317 |
| DOI / URN: |
10.1016/j.schres.2017.09.024 |
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ELV001623192 |
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| 024 | 7 | |a 10.1016/j.schres.2017.09.024 |2 doi | |
| 035 | |a (DE-627)ELV001623192 | ||
| 035 | |a (ELSEVIER)S0920-9964(17)30586-8 | ||
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| 041 | |a eng | ||
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| 100 | 1 | |a Blokland, Gabriëlla A.M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project |
| 264 | 1 | |c 2017 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. | ||
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Neuropsychology | |
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a Neuroimaging | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Genetics | |
| 700 | 1 | |a del Re, Elisabetta C. |e verfasserin |4 aut | |
| 700 | 1 | |a Mesholam-Gately, Raquelle I. |e verfasserin |4 aut | |
| 700 | 1 | |a Jovicich, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Trampush, Joey W. |e verfasserin |4 aut | |
| 700 | 1 | |a Keshavan, Matcheri S. |e verfasserin |4 aut | |
| 700 | 1 | |a DeLisi, Lynn E. |e verfasserin |4 aut | |
| 700 | 1 | |a Walters, James T.R. |e verfasserin |4 aut | |
| 700 | 1 | |a Turner, Jessica A. |e verfasserin |4 aut | |
| 700 | 1 | |a Malhotra, Anil K. |e verfasserin |4 aut | |
| 700 | 1 | |a Lencz, Todd |e verfasserin |0 (orcid)0000-0001-8586-338X |4 aut | |
| 700 | 1 | |a Shenton, Martha E. |e verfasserin |4 aut | |
| 700 | 1 | |a Voineskos, Aristotle N. |e verfasserin |4 aut | |
| 700 | 1 | |a Rujescu, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Giegling, Ina |e verfasserin |4 aut | |
| 700 | 1 | |a Kahn, René S. |e verfasserin |4 aut | |
| 700 | 1 | |a Roffman, Joshua L. |e verfasserin |4 aut | |
| 700 | 1 | |a Holt, Daphne J. |e verfasserin |4 aut | |
| 700 | 1 | |a Ehrlich, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Kikinis, Zora |e verfasserin |4 aut | |
| 700 | 1 | |a Dazzan, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Murray, Robin M. |e verfasserin |4 aut | |
| 700 | 1 | |a Di Forti, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jimmy |e verfasserin |4 aut | |
| 700 | 1 | |a Sim, Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Lam, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Wolthusen, Rick P.F. |e verfasserin |4 aut | |
| 700 | 1 | |a de Zwarte, Sonja M.C. |e verfasserin |4 aut | |
| 700 | 1 | |a Walton, Esther |e verfasserin |4 aut | |
| 700 | 1 | |a Cosgrove, Donna |e verfasserin |4 aut | |
| 700 | 1 | |a Kelly, Sinead |e verfasserin |4 aut | |
| 700 | 1 | |a Maleki, Nasim |e verfasserin |4 aut | |
| 700 | 1 | |a Osiecki, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Picchioni, Marco M. |e verfasserin |4 aut | |
| 700 | 1 | |a Bramon, Elvira |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a David, Anthony S. |e verfasserin |4 aut | |
| 700 | 1 | |a Mondelli, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Reinders, Antje A.T.S. |e verfasserin |4 aut | |
| 700 | 1 | |a Falcone, M. Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Hartmann, Annette M. |e verfasserin |4 aut | |
| 700 | 1 | |a Konte, Bettina |e verfasserin |4 aut | |
| 700 | 1 | |a Morris, Derek W. |e verfasserin |4 aut | |
| 700 | 1 | |a Gill, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Corvin, Aiden P. |e verfasserin |4 aut | |
| 700 | 1 | |a Cahn, Wiepke |e verfasserin |4 aut | |
| 700 | 1 | |a Ho, New Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jian Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Keefe, Richard S.E. |e verfasserin |4 aut | |
| 700 | 1 | |a Gollub, Randy L. |e verfasserin |4 aut | |
| 700 | 1 | |a Manoach, Dara S. |e verfasserin |4 aut | |
| 700 | 1 | |a Calhoun, Vince D. |e verfasserin |4 aut | |
| 700 | 1 | |a Schulz, S. Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Sponheim, Scott R. |e verfasserin |4 aut | |
| 700 | 1 | |a Goff, Donald C. |e verfasserin |4 aut | |
| 700 | 1 | |a Buka, Stephen L. |e verfasserin |4 aut | |
| 700 | 1 | |a Cherkerzian, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Thermenos, Heidi W. |e verfasserin |4 aut | |
| 700 | 1 | |a Kubicki, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Nestor, Paul G. |e verfasserin |4 aut | |
| 700 | 1 | |a Dickie, Erin W. |e verfasserin |4 aut | |
| 700 | 1 | |a Vassos, Evangelos |e verfasserin |4 aut | |
| 700 | 1 | |a Ciufolini, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Reis Marques, Tiago |e verfasserin |4 aut | |
| 700 | 1 | |a Crossley, Nicolas A. |e verfasserin |4 aut | |
| 700 | 1 | |a Purcell, Shaun M. |e verfasserin |4 aut | |
| 700 | 1 | |a Smoller, Jordan W. |e verfasserin |4 aut | |
| 700 | 1 | |a van Haren, Neeltje E.M. |e verfasserin |4 aut | |
| 700 | 1 | |a Toulopoulou, Timothea |e verfasserin |4 aut | |
| 700 | 1 | |a Donohoe, Gary |e verfasserin |4 aut | |
| 700 | 1 | |a Goldstein, Jill M. |e verfasserin |4 aut | |
| 700 | 1 | |a Seidman, Larry J. |e verfasserin |4 aut | |
| 700 | 1 | |a McCarley, Robert W. |e verfasserin |4 aut | |
| 700 | 1 | |a Petryshen, Tracey L. |e verfasserin |4 aut | |
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10.1016/j.schres.2017.09.024 doi (DE-627)ELV001623192 (ELSEVIER)S0920-9964(17)30586-8 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Blokland, Gabriëlla A.M. verfasserin aut The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. Schizophrenia Neuropsychology Cognition Neuroimaging MRI Genetics del Re, Elisabetta C. verfasserin aut Mesholam-Gately, Raquelle I. verfasserin aut Jovicich, Jorge verfasserin aut Trampush, Joey W. verfasserin aut Keshavan, Matcheri S. verfasserin aut DeLisi, Lynn E. verfasserin aut Walters, James T.R. verfasserin aut Turner, Jessica A. verfasserin aut Malhotra, Anil K. verfasserin aut Lencz, Todd verfasserin (orcid)0000-0001-8586-338X aut Shenton, Martha E. verfasserin aut Voineskos, Aristotle N. verfasserin aut Rujescu, Dan verfasserin aut Giegling, Ina verfasserin aut Kahn, René S. verfasserin aut Roffman, Joshua L. verfasserin aut Holt, Daphne J. verfasserin aut Ehrlich, Stefan verfasserin aut Kikinis, Zora verfasserin aut Dazzan, Paola verfasserin aut Murray, Robin M. verfasserin aut Di Forti, Marta verfasserin aut Lee, Jimmy verfasserin aut Sim, Kang verfasserin aut Lam, Max verfasserin aut Wolthusen, Rick P.F. verfasserin aut de Zwarte, Sonja M.C. verfasserin aut Walton, Esther verfasserin aut Cosgrove, Donna verfasserin aut Kelly, Sinead verfasserin aut Maleki, Nasim verfasserin aut Osiecki, Lisa verfasserin aut Picchioni, Marco M. verfasserin aut Bramon, Elvira verfasserin aut Russo, Manuela verfasserin aut David, Anthony S. verfasserin aut Mondelli, Valeria verfasserin aut Reinders, Antje A.T.S. verfasserin aut Falcone, M. Aurora verfasserin aut Hartmann, Annette M. verfasserin aut Konte, Bettina verfasserin aut Morris, Derek W. verfasserin aut Gill, Michael verfasserin aut Corvin, Aiden P. verfasserin aut Cahn, Wiepke verfasserin aut Ho, New Fei verfasserin aut Liu, Jian Jun verfasserin aut Keefe, Richard S.E. verfasserin aut Gollub, Randy L. verfasserin aut Manoach, Dara S. verfasserin aut Calhoun, Vince D. verfasserin aut Schulz, S. Charles verfasserin aut Sponheim, Scott R. verfasserin aut Goff, Donald C. verfasserin aut Buka, Stephen L. verfasserin aut Cherkerzian, Sara verfasserin aut Thermenos, Heidi W. verfasserin aut Kubicki, Marek verfasserin aut Nestor, Paul G. verfasserin aut Dickie, Erin W. verfasserin aut Vassos, Evangelos verfasserin aut Ciufolini, Simone verfasserin aut Reis Marques, Tiago verfasserin aut Crossley, Nicolas A. verfasserin aut Purcell, Shaun M. verfasserin aut Smoller, Jordan W. verfasserin aut van Haren, Neeltje E.M. verfasserin aut Toulopoulou, Timothea verfasserin aut Donohoe, Gary verfasserin aut Goldstein, Jill M. verfasserin aut Seidman, Larry J. verfasserin aut McCarley, Robert W. verfasserin aut Petryshen, Tracey L. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 195, Seite 306-317 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:195 pages:306-317 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 195 306-317 |
| spelling |
10.1016/j.schres.2017.09.024 doi (DE-627)ELV001623192 (ELSEVIER)S0920-9964(17)30586-8 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Blokland, Gabriëlla A.M. verfasserin aut The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. Schizophrenia Neuropsychology Cognition Neuroimaging MRI Genetics del Re, Elisabetta C. verfasserin aut Mesholam-Gately, Raquelle I. verfasserin aut Jovicich, Jorge verfasserin aut Trampush, Joey W. verfasserin aut Keshavan, Matcheri S. verfasserin aut DeLisi, Lynn E. verfasserin aut Walters, James T.R. verfasserin aut Turner, Jessica A. verfasserin aut Malhotra, Anil K. verfasserin aut Lencz, Todd verfasserin (orcid)0000-0001-8586-338X aut Shenton, Martha E. verfasserin aut Voineskos, Aristotle N. verfasserin aut Rujescu, Dan verfasserin aut Giegling, Ina verfasserin aut Kahn, René S. verfasserin aut Roffman, Joshua L. verfasserin aut Holt, Daphne J. verfasserin aut Ehrlich, Stefan verfasserin aut Kikinis, Zora verfasserin aut Dazzan, Paola verfasserin aut Murray, Robin M. verfasserin aut Di Forti, Marta verfasserin aut Lee, Jimmy verfasserin aut Sim, Kang verfasserin aut Lam, Max verfasserin aut Wolthusen, Rick P.F. verfasserin aut de Zwarte, Sonja M.C. verfasserin aut Walton, Esther verfasserin aut Cosgrove, Donna verfasserin aut Kelly, Sinead verfasserin aut Maleki, Nasim verfasserin aut Osiecki, Lisa verfasserin aut Picchioni, Marco M. verfasserin aut Bramon, Elvira verfasserin aut Russo, Manuela verfasserin aut David, Anthony S. verfasserin aut Mondelli, Valeria verfasserin aut Reinders, Antje A.T.S. verfasserin aut Falcone, M. Aurora verfasserin aut Hartmann, Annette M. verfasserin aut Konte, Bettina verfasserin aut Morris, Derek W. verfasserin aut Gill, Michael verfasserin aut Corvin, Aiden P. verfasserin aut Cahn, Wiepke verfasserin aut Ho, New Fei verfasserin aut Liu, Jian Jun verfasserin aut Keefe, Richard S.E. verfasserin aut Gollub, Randy L. verfasserin aut Manoach, Dara S. verfasserin aut Calhoun, Vince D. verfasserin aut Schulz, S. Charles verfasserin aut Sponheim, Scott R. verfasserin aut Goff, Donald C. verfasserin aut Buka, Stephen L. verfasserin aut Cherkerzian, Sara verfasserin aut Thermenos, Heidi W. verfasserin aut Kubicki, Marek verfasserin aut Nestor, Paul G. verfasserin aut Dickie, Erin W. verfasserin aut Vassos, Evangelos verfasserin aut Ciufolini, Simone verfasserin aut Reis Marques, Tiago verfasserin aut Crossley, Nicolas A. verfasserin aut Purcell, Shaun M. verfasserin aut Smoller, Jordan W. verfasserin aut van Haren, Neeltje E.M. verfasserin aut Toulopoulou, Timothea verfasserin aut Donohoe, Gary verfasserin aut Goldstein, Jill M. verfasserin aut Seidman, Larry J. verfasserin aut McCarley, Robert W. verfasserin aut Petryshen, Tracey L. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 195, Seite 306-317 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:195 pages:306-317 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 195 306-317 |
| allfields_unstemmed |
10.1016/j.schres.2017.09.024 doi (DE-627)ELV001623192 (ELSEVIER)S0920-9964(17)30586-8 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Blokland, Gabriëlla A.M. verfasserin aut The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. Schizophrenia Neuropsychology Cognition Neuroimaging MRI Genetics del Re, Elisabetta C. verfasserin aut Mesholam-Gately, Raquelle I. verfasserin aut Jovicich, Jorge verfasserin aut Trampush, Joey W. verfasserin aut Keshavan, Matcheri S. verfasserin aut DeLisi, Lynn E. verfasserin aut Walters, James T.R. verfasserin aut Turner, Jessica A. verfasserin aut Malhotra, Anil K. verfasserin aut Lencz, Todd verfasserin (orcid)0000-0001-8586-338X aut Shenton, Martha E. verfasserin aut Voineskos, Aristotle N. verfasserin aut Rujescu, Dan verfasserin aut Giegling, Ina verfasserin aut Kahn, René S. verfasserin aut Roffman, Joshua L. verfasserin aut Holt, Daphne J. verfasserin aut Ehrlich, Stefan verfasserin aut Kikinis, Zora verfasserin aut Dazzan, Paola verfasserin aut Murray, Robin M. verfasserin aut Di Forti, Marta verfasserin aut Lee, Jimmy verfasserin aut Sim, Kang verfasserin aut Lam, Max verfasserin aut Wolthusen, Rick P.F. verfasserin aut de Zwarte, Sonja M.C. verfasserin aut Walton, Esther verfasserin aut Cosgrove, Donna verfasserin aut Kelly, Sinead verfasserin aut Maleki, Nasim verfasserin aut Osiecki, Lisa verfasserin aut Picchioni, Marco M. verfasserin aut Bramon, Elvira verfasserin aut Russo, Manuela verfasserin aut David, Anthony S. verfasserin aut Mondelli, Valeria verfasserin aut Reinders, Antje A.T.S. verfasserin aut Falcone, M. Aurora verfasserin aut Hartmann, Annette M. verfasserin aut Konte, Bettina verfasserin aut Morris, Derek W. verfasserin aut Gill, Michael verfasserin aut Corvin, Aiden P. verfasserin aut Cahn, Wiepke verfasserin aut Ho, New Fei verfasserin aut Liu, Jian Jun verfasserin aut Keefe, Richard S.E. verfasserin aut Gollub, Randy L. verfasserin aut Manoach, Dara S. verfasserin aut Calhoun, Vince D. verfasserin aut Schulz, S. Charles verfasserin aut Sponheim, Scott R. verfasserin aut Goff, Donald C. verfasserin aut Buka, Stephen L. verfasserin aut Cherkerzian, Sara verfasserin aut Thermenos, Heidi W. verfasserin aut Kubicki, Marek verfasserin aut Nestor, Paul G. verfasserin aut Dickie, Erin W. verfasserin aut Vassos, Evangelos verfasserin aut Ciufolini, Simone verfasserin aut Reis Marques, Tiago verfasserin aut Crossley, Nicolas A. verfasserin aut Purcell, Shaun M. verfasserin aut Smoller, Jordan W. verfasserin aut van Haren, Neeltje E.M. verfasserin aut Toulopoulou, Timothea verfasserin aut Donohoe, Gary verfasserin aut Goldstein, Jill M. verfasserin aut Seidman, Larry J. verfasserin aut McCarley, Robert W. verfasserin aut Petryshen, Tracey L. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 195, Seite 306-317 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:195 pages:306-317 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 195 306-317 |
| allfieldsGer |
10.1016/j.schres.2017.09.024 doi (DE-627)ELV001623192 (ELSEVIER)S0920-9964(17)30586-8 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Blokland, Gabriëlla A.M. verfasserin aut The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. Schizophrenia Neuropsychology Cognition Neuroimaging MRI Genetics del Re, Elisabetta C. verfasserin aut Mesholam-Gately, Raquelle I. verfasserin aut Jovicich, Jorge verfasserin aut Trampush, Joey W. verfasserin aut Keshavan, Matcheri S. verfasserin aut DeLisi, Lynn E. verfasserin aut Walters, James T.R. verfasserin aut Turner, Jessica A. verfasserin aut Malhotra, Anil K. verfasserin aut Lencz, Todd verfasserin (orcid)0000-0001-8586-338X aut Shenton, Martha E. verfasserin aut Voineskos, Aristotle N. verfasserin aut Rujescu, Dan verfasserin aut Giegling, Ina verfasserin aut Kahn, René S. verfasserin aut Roffman, Joshua L. verfasserin aut Holt, Daphne J. verfasserin aut Ehrlich, Stefan verfasserin aut Kikinis, Zora verfasserin aut Dazzan, Paola verfasserin aut Murray, Robin M. verfasserin aut Di Forti, Marta verfasserin aut Lee, Jimmy verfasserin aut Sim, Kang verfasserin aut Lam, Max verfasserin aut Wolthusen, Rick P.F. verfasserin aut de Zwarte, Sonja M.C. verfasserin aut Walton, Esther verfasserin aut Cosgrove, Donna verfasserin aut Kelly, Sinead verfasserin aut Maleki, Nasim verfasserin aut Osiecki, Lisa verfasserin aut Picchioni, Marco M. verfasserin aut Bramon, Elvira verfasserin aut Russo, Manuela verfasserin aut David, Anthony S. verfasserin aut Mondelli, Valeria verfasserin aut Reinders, Antje A.T.S. verfasserin aut Falcone, M. Aurora verfasserin aut Hartmann, Annette M. verfasserin aut Konte, Bettina verfasserin aut Morris, Derek W. verfasserin aut Gill, Michael verfasserin aut Corvin, Aiden P. verfasserin aut Cahn, Wiepke verfasserin aut Ho, New Fei verfasserin aut Liu, Jian Jun verfasserin aut Keefe, Richard S.E. verfasserin aut Gollub, Randy L. verfasserin aut Manoach, Dara S. verfasserin aut Calhoun, Vince D. verfasserin aut Schulz, S. Charles verfasserin aut Sponheim, Scott R. verfasserin aut Goff, Donald C. verfasserin aut Buka, Stephen L. verfasserin aut Cherkerzian, Sara verfasserin aut Thermenos, Heidi W. verfasserin aut Kubicki, Marek verfasserin aut Nestor, Paul G. verfasserin aut Dickie, Erin W. verfasserin aut Vassos, Evangelos verfasserin aut Ciufolini, Simone verfasserin aut Reis Marques, Tiago verfasserin aut Crossley, Nicolas A. verfasserin aut Purcell, Shaun M. verfasserin aut Smoller, Jordan W. verfasserin aut van Haren, Neeltje E.M. verfasserin aut Toulopoulou, Timothea verfasserin aut Donohoe, Gary verfasserin aut Goldstein, Jill M. verfasserin aut Seidman, Larry J. verfasserin aut McCarley, Robert W. verfasserin aut Petryshen, Tracey L. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 195, Seite 306-317 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:195 pages:306-317 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 195 306-317 |
| allfieldsSound |
10.1016/j.schres.2017.09.024 doi (DE-627)ELV001623192 (ELSEVIER)S0920-9964(17)30586-8 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Blokland, Gabriëlla A.M. verfasserin aut The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. Schizophrenia Neuropsychology Cognition Neuroimaging MRI Genetics del Re, Elisabetta C. verfasserin aut Mesholam-Gately, Raquelle I. verfasserin aut Jovicich, Jorge verfasserin aut Trampush, Joey W. verfasserin aut Keshavan, Matcheri S. verfasserin aut DeLisi, Lynn E. verfasserin aut Walters, James T.R. verfasserin aut Turner, Jessica A. verfasserin aut Malhotra, Anil K. verfasserin aut Lencz, Todd verfasserin (orcid)0000-0001-8586-338X aut Shenton, Martha E. verfasserin aut Voineskos, Aristotle N. verfasserin aut Rujescu, Dan verfasserin aut Giegling, Ina verfasserin aut Kahn, René S. verfasserin aut Roffman, Joshua L. verfasserin aut Holt, Daphne J. verfasserin aut Ehrlich, Stefan verfasserin aut Kikinis, Zora verfasserin aut Dazzan, Paola verfasserin aut Murray, Robin M. verfasserin aut Di Forti, Marta verfasserin aut Lee, Jimmy verfasserin aut Sim, Kang verfasserin aut Lam, Max verfasserin aut Wolthusen, Rick P.F. verfasserin aut de Zwarte, Sonja M.C. verfasserin aut Walton, Esther verfasserin aut Cosgrove, Donna verfasserin aut Kelly, Sinead verfasserin aut Maleki, Nasim verfasserin aut Osiecki, Lisa verfasserin aut Picchioni, Marco M. verfasserin aut Bramon, Elvira verfasserin aut Russo, Manuela verfasserin aut David, Anthony S. verfasserin aut Mondelli, Valeria verfasserin aut Reinders, Antje A.T.S. verfasserin aut Falcone, M. Aurora verfasserin aut Hartmann, Annette M. verfasserin aut Konte, Bettina verfasserin aut Morris, Derek W. verfasserin aut Gill, Michael verfasserin aut Corvin, Aiden P. verfasserin aut Cahn, Wiepke verfasserin aut Ho, New Fei verfasserin aut Liu, Jian Jun verfasserin aut Keefe, Richard S.E. verfasserin aut Gollub, Randy L. verfasserin aut Manoach, Dara S. verfasserin aut Calhoun, Vince D. verfasserin aut Schulz, S. Charles verfasserin aut Sponheim, Scott R. verfasserin aut Goff, Donald C. verfasserin aut Buka, Stephen L. verfasserin aut Cherkerzian, Sara verfasserin aut Thermenos, Heidi W. verfasserin aut Kubicki, Marek verfasserin aut Nestor, Paul G. verfasserin aut Dickie, Erin W. verfasserin aut Vassos, Evangelos verfasserin aut Ciufolini, Simone verfasserin aut Reis Marques, Tiago verfasserin aut Crossley, Nicolas A. verfasserin aut Purcell, Shaun M. verfasserin aut Smoller, Jordan W. verfasserin aut van Haren, Neeltje E.M. verfasserin aut Toulopoulou, Timothea verfasserin aut Donohoe, Gary verfasserin aut Goldstein, Jill M. verfasserin aut Seidman, Larry J. verfasserin aut McCarley, Robert W. verfasserin aut Petryshen, Tracey L. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 195, Seite 306-317 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:195 pages:306-317 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 195 306-317 |
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Enthalten in Schizophrenia research 195, Seite 306-317 volume:195 pages:306-317 |
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Blokland, Gabriëlla A.M. @@aut@@ del Re, Elisabetta C. @@aut@@ Mesholam-Gately, Raquelle I. @@aut@@ Jovicich, Jorge @@aut@@ Trampush, Joey W. @@aut@@ Keshavan, Matcheri S. @@aut@@ DeLisi, Lynn E. @@aut@@ Walters, James T.R. @@aut@@ Turner, Jessica A. @@aut@@ Malhotra, Anil K. @@aut@@ Lencz, Todd @@aut@@ Shenton, Martha E. @@aut@@ Voineskos, Aristotle N. @@aut@@ Rujescu, Dan @@aut@@ Giegling, Ina @@aut@@ Kahn, René S. @@aut@@ Roffman, Joshua L. @@aut@@ Holt, Daphne J. @@aut@@ Ehrlich, Stefan @@aut@@ Kikinis, Zora @@aut@@ Dazzan, Paola @@aut@@ Murray, Robin M. @@aut@@ Di Forti, Marta @@aut@@ Lee, Jimmy @@aut@@ Sim, Kang @@aut@@ Lam, Max @@aut@@ Wolthusen, Rick P.F. @@aut@@ de Zwarte, Sonja M.C. @@aut@@ Walton, Esther @@aut@@ Cosgrove, Donna @@aut@@ Kelly, Sinead @@aut@@ Maleki, Nasim @@aut@@ Osiecki, Lisa @@aut@@ Picchioni, Marco M. @@aut@@ Bramon, Elvira @@aut@@ Russo, Manuela @@aut@@ David, Anthony S. @@aut@@ Mondelli, Valeria @@aut@@ Reinders, Antje A.T.S. @@aut@@ Falcone, M. Aurora @@aut@@ Hartmann, Annette M. @@aut@@ Konte, Bettina @@aut@@ Morris, Derek W. @@aut@@ Gill, Michael @@aut@@ Corvin, Aiden P. @@aut@@ Cahn, Wiepke @@aut@@ Ho, New Fei @@aut@@ Liu, Jian Jun @@aut@@ Keefe, Richard S.E. @@aut@@ Gollub, Randy L. @@aut@@ Manoach, Dara S. @@aut@@ Calhoun, Vince D. @@aut@@ Schulz, S. Charles @@aut@@ Sponheim, Scott R. @@aut@@ Goff, Donald C. @@aut@@ Buka, Stephen L. @@aut@@ Cherkerzian, Sara @@aut@@ Thermenos, Heidi W. @@aut@@ Kubicki, Marek @@aut@@ Nestor, Paul G. @@aut@@ Dickie, Erin W. @@aut@@ Vassos, Evangelos @@aut@@ Ciufolini, Simone @@aut@@ Reis Marques, Tiago @@aut@@ Crossley, Nicolas A. @@aut@@ Purcell, Shaun M. @@aut@@ Smoller, Jordan W. @@aut@@ van Haren, Neeltje E.M. @@aut@@ Toulopoulou, Timothea @@aut@@ Donohoe, Gary @@aut@@ Goldstein, Jill M. @@aut@@ Seidman, Larry J. @@aut@@ McCarley, Robert W. @@aut@@ Petryshen, Tracey L. @@aut@@ |
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2017-01-01T00:00:00Z |
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The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. 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Blokland, Gabriëlla A.M. |
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Blokland, Gabriëlla A.M. ddc 610 bkl 44.91 misc Schizophrenia misc Neuropsychology misc Cognition misc Neuroimaging misc MRI misc Genetics The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project |
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610 DE-600 44.91 bkl The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project Schizophrenia Neuropsychology Cognition Neuroimaging MRI Genetics |
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ddc 610 bkl 44.91 misc Schizophrenia misc Neuropsychology misc Cognition misc Neuroimaging misc MRI misc Genetics |
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The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project |
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The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project |
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Blokland, Gabriëlla A.M. |
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Blokland, Gabriëlla A.M. del Re, Elisabetta C. Mesholam-Gately, Raquelle I. Jovicich, Jorge Trampush, Joey W. Keshavan, Matcheri S. DeLisi, Lynn E. Walters, James T.R. Turner, Jessica A. Malhotra, Anil K. Lencz, Todd Shenton, Martha E. Voineskos, Aristotle N. Rujescu, Dan Giegling, Ina Kahn, René S. Roffman, Joshua L. Holt, Daphne J. Ehrlich, Stefan Kikinis, Zora Dazzan, Paola Murray, Robin M. Di Forti, Marta Lee, Jimmy Sim, Kang Lam, Max Wolthusen, Rick P.F. de Zwarte, Sonja M.C. Walton, Esther Cosgrove, Donna Kelly, Sinead Maleki, Nasim Osiecki, Lisa Picchioni, Marco M. Bramon, Elvira Russo, Manuela David, Anthony S. Mondelli, Valeria Reinders, Antje A.T.S. Falcone, M. Aurora Hartmann, Annette M. Konte, Bettina Morris, Derek W. Gill, Michael Corvin, Aiden P. Cahn, Wiepke Ho, New Fei Liu, Jian Jun Keefe, Richard S.E. Gollub, Randy L. Manoach, Dara S. Calhoun, Vince D. Schulz, S. Charles Sponheim, Scott R. Goff, Donald C. Buka, Stephen L. Cherkerzian, Sara Thermenos, Heidi W. Kubicki, Marek Nestor, Paul G. Dickie, Erin W. Vassos, Evangelos Ciufolini, Simone Reis Marques, Tiago Crossley, Nicolas A. Purcell, Shaun M. Smoller, Jordan W. van Haren, Neeltje E.M. Toulopoulou, Timothea Donohoe, Gary Goldstein, Jill M. Seidman, Larry J. McCarley, Robert W. Petryshen, Tracey L. |
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Blokland, Gabriëlla A.M. |
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10.1016/j.schres.2017.09.024 |
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the genetics of endophenotypes of neurofunction to understand schizophrenia (genus) consortium: a collaborative cognitive and neuroimaging genetics project |
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The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project |
| abstract |
Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. |
| abstractGer |
Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. |
| abstract_unstemmed |
Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.Methods: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.Results: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p <1×10−10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other.Conclusions: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia. |
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| title_short |
The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project |
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del Re, Elisabetta C. Mesholam-Gately, Raquelle I. Jovicich, Jorge Trampush, Joey W. Keshavan, Matcheri S. DeLisi, Lynn E. Walters, James T.R. Turner, Jessica A. Malhotra, Anil K. Lencz, Todd Shenton, Martha E. Voineskos, Aristotle N. Rujescu, Dan Giegling, Ina Kahn, René S. Roffman, Joshua L. Holt, Daphne J. Ehrlich, Stefan Kikinis, Zora Dazzan, Paola Murray, Robin M. Di Forti, Marta Lee, Jimmy Sim, Kang Lam, Max Wolthusen, Rick P.F. de Zwarte, Sonja M.C. Walton, Esther Cosgrove, Donna Kelly, Sinead Maleki, Nasim Osiecki, Lisa Picchioni, Marco M. Bramon, Elvira Russo, Manuela David, Anthony S. Mondelli, Valeria Reinders, Antje A.T.S. Falcone, M. Aurora Hartmann, Annette M. Konte, Bettina Morris, Derek W. Gill, Michael Corvin, Aiden P. Cahn, Wiepke Ho, New Fei Liu, Jian Jun Keefe, Richard S.E. Gollub, Randy L. Manoach, Dara S. Calhoun, Vince D. Schulz, S. Charles Sponheim, Scott R. Goff, Donald C. Buka, Stephen L. Cherkerzian, Sara Thermenos, Heidi W. Kubicki, Marek Nestor, Paul G. Dickie, Erin W. Vassos, Evangelos Ciufolini, Simone Reis Marques, Tiago Crossley, Nicolas A. Purcell, Shaun M. Smoller, Jordan W. van Haren, Neeltje E.M. Toulopoulou, Timothea Donohoe, Gary Goldstein, Jill M. Seidman, Larry J. McCarley, Robert W. Petryshen, Tracey L. |
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del Re, Elisabetta C. Mesholam-Gately, Raquelle I. Jovicich, Jorge Trampush, Joey W. Keshavan, Matcheri S. DeLisi, Lynn E. Walters, James T.R. Turner, Jessica A. Malhotra, Anil K. Lencz, Todd Shenton, Martha E. Voineskos, Aristotle N. Rujescu, Dan Giegling, Ina Kahn, René S. Roffman, Joshua L. Holt, Daphne J. Ehrlich, Stefan Kikinis, Zora Dazzan, Paola Murray, Robin M. Di Forti, Marta Lee, Jimmy Sim, Kang Lam, Max Wolthusen, Rick P.F. de Zwarte, Sonja M.C. Walton, Esther Cosgrove, Donna Kelly, Sinead Maleki, Nasim Osiecki, Lisa Picchioni, Marco M. Bramon, Elvira Russo, Manuela David, Anthony S. Mondelli, Valeria Reinders, Antje A.T.S. Falcone, M. Aurora Hartmann, Annette M. Konte, Bettina Morris, Derek W. Gill, Michael Corvin, Aiden P. Cahn, Wiepke Ho, New Fei Liu, Jian Jun Keefe, Richard S.E. Gollub, Randy L. Manoach, Dara S. Calhoun, Vince D. Schulz, S. Charles Sponheim, Scott R. Goff, Donald C. Buka, Stephen L. Cherkerzian, Sara Thermenos, Heidi W. Kubicki, Marek Nestor, Paul G. Dickie, Erin W. Vassos, Evangelos Ciufolini, Simone Reis Marques, Tiago Crossley, Nicolas A. Purcell, Shaun M. Smoller, Jordan W. van Haren, Neeltje E.M. Toulopoulou, Timothea Donohoe, Gary Goldstein, Jill M. Seidman, Larry J. McCarley, Robert W. Petryshen, Tracey L. |
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| doi_str |
10.1016/j.schres.2017.09.024 |
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2024-07-06T22:00:34.456Z |
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