Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial
Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Evald, Lars [verfasserIn] Brønnick, Kolbjørn [verfasserIn] Duez, Christophe Henri Valdemar [verfasserIn] Grejs, Anders Morten [verfasserIn] Jeppesen, Anni Nørgaard [verfasserIn] Søreide, Eldar [verfasserIn] Kirkegaard, Hans [verfasserIn] Nielsen, Jørgen Feldbæk [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
Out of Hospital Cardiac arrest |
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| Übergeordnetes Werk: |
Enthalten in: Resuscitation - Amsterdam [u.a.] : Elsevier Science, 1972, 134, Seite 1-9 |
|---|---|
| Übergeordnetes Werk: |
volume:134 ; pages:1-9 |
| DOI / URN: |
10.1016/j.resuscitation.2018.12.002 |
|---|
| Katalog-ID: |
ELV001674234 |
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| 100 | 1 | |a Evald, Lars |e verfasserin |0 (orcid)0000-0001-6255-2562 |4 aut | |
| 245 | 1 | 0 | |a Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial |
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| 520 | |a Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. | ||
| 650 | 4 | |a Out of Hospital Cardiac arrest | |
| 650 | 4 | |a OHCA | |
| 650 | 4 | |a Targeted Temperature Management | |
| 650 | 4 | |a TTM | |
| 650 | 4 | |a Outcome | |
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a Memory | |
| 650 | 4 | |a Randomised Controlled Trial | |
| 650 | 4 | |a RCT | |
| 700 | 1 | |a Brønnick, Kolbjørn |e verfasserin |4 aut | |
| 700 | 1 | |a Duez, Christophe Henri Valdemar |e verfasserin |0 (orcid)0000-0001-7560-9214 |4 aut | |
| 700 | 1 | |a Grejs, Anders Morten |e verfasserin |0 (orcid)0000-0002-8850-2982 |4 aut | |
| 700 | 1 | |a Jeppesen, Anni Nørgaard |e verfasserin |0 (orcid)0000-0003-2812-194X |4 aut | |
| 700 | 1 | |a Søreide, Eldar |e verfasserin |4 aut | |
| 700 | 1 | |a Kirkegaard, Hans |e verfasserin |0 (orcid)0000-0003-4853-8152 |4 aut | |
| 700 | 1 | |a Nielsen, Jørgen Feldbæk |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Resuscitation |d Amsterdam [u.a.] : Elsevier Science, 1972 |g 134, Seite 1-9 |h Online-Ressource |w (DE-627)320488543 |w (DE-600)2010733-X |w (DE-576)099879042 |x 1873-1570 |7 nnns |
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10.1016/j.resuscitation.2018.12.002 doi (DE-627)ELV001674234 (ELSEVIER)S0300-9572(18)30764-0 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Evald, Lars verfasserin (orcid)0000-0001-6255-2562 aut Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. Out of Hospital Cardiac arrest OHCA Targeted Temperature Management TTM Outcome Cognition Memory Randomised Controlled Trial RCT Brønnick, Kolbjørn verfasserin aut Duez, Christophe Henri Valdemar verfasserin (orcid)0000-0001-7560-9214 aut Grejs, Anders Morten verfasserin (orcid)0000-0002-8850-2982 aut Jeppesen, Anni Nørgaard verfasserin (orcid)0000-0003-2812-194X aut Søreide, Eldar verfasserin aut Kirkegaard, Hans verfasserin (orcid)0000-0003-4853-8152 aut Nielsen, Jørgen Feldbæk verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 134, Seite 1-9 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:134 pages:1-9 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 134 1-9 |
| spelling |
10.1016/j.resuscitation.2018.12.002 doi (DE-627)ELV001674234 (ELSEVIER)S0300-9572(18)30764-0 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Evald, Lars verfasserin (orcid)0000-0001-6255-2562 aut Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. Out of Hospital Cardiac arrest OHCA Targeted Temperature Management TTM Outcome Cognition Memory Randomised Controlled Trial RCT Brønnick, Kolbjørn verfasserin aut Duez, Christophe Henri Valdemar verfasserin (orcid)0000-0001-7560-9214 aut Grejs, Anders Morten verfasserin (orcid)0000-0002-8850-2982 aut Jeppesen, Anni Nørgaard verfasserin (orcid)0000-0003-2812-194X aut Søreide, Eldar verfasserin aut Kirkegaard, Hans verfasserin (orcid)0000-0003-4853-8152 aut Nielsen, Jørgen Feldbæk verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 134, Seite 1-9 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:134 pages:1-9 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 134 1-9 |
| allfields_unstemmed |
10.1016/j.resuscitation.2018.12.002 doi (DE-627)ELV001674234 (ELSEVIER)S0300-9572(18)30764-0 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Evald, Lars verfasserin (orcid)0000-0001-6255-2562 aut Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. Out of Hospital Cardiac arrest OHCA Targeted Temperature Management TTM Outcome Cognition Memory Randomised Controlled Trial RCT Brønnick, Kolbjørn verfasserin aut Duez, Christophe Henri Valdemar verfasserin (orcid)0000-0001-7560-9214 aut Grejs, Anders Morten verfasserin (orcid)0000-0002-8850-2982 aut Jeppesen, Anni Nørgaard verfasserin (orcid)0000-0003-2812-194X aut Søreide, Eldar verfasserin aut Kirkegaard, Hans verfasserin (orcid)0000-0003-4853-8152 aut Nielsen, Jørgen Feldbæk verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 134, Seite 1-9 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:134 pages:1-9 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 134 1-9 |
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10.1016/j.resuscitation.2018.12.002 doi (DE-627)ELV001674234 (ELSEVIER)S0300-9572(18)30764-0 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Evald, Lars verfasserin (orcid)0000-0001-6255-2562 aut Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. Out of Hospital Cardiac arrest OHCA Targeted Temperature Management TTM Outcome Cognition Memory Randomised Controlled Trial RCT Brønnick, Kolbjørn verfasserin aut Duez, Christophe Henri Valdemar verfasserin (orcid)0000-0001-7560-9214 aut Grejs, Anders Morten verfasserin (orcid)0000-0002-8850-2982 aut Jeppesen, Anni Nørgaard verfasserin (orcid)0000-0003-2812-194X aut Søreide, Eldar verfasserin aut Kirkegaard, Hans verfasserin (orcid)0000-0003-4853-8152 aut Nielsen, Jørgen Feldbæk verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 134, Seite 1-9 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:134 pages:1-9 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 134 1-9 |
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10.1016/j.resuscitation.2018.12.002 doi (DE-627)ELV001674234 (ELSEVIER)S0300-9572(18)30764-0 DE-627 ger DE-627 rda eng 610 DE-600 44.80 bkl Evald, Lars verfasserin (orcid)0000-0001-6255-2562 aut Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. Out of Hospital Cardiac arrest OHCA Targeted Temperature Management TTM Outcome Cognition Memory Randomised Controlled Trial RCT Brønnick, Kolbjørn verfasserin aut Duez, Christophe Henri Valdemar verfasserin (orcid)0000-0001-7560-9214 aut Grejs, Anders Morten verfasserin (orcid)0000-0002-8850-2982 aut Jeppesen, Anni Nørgaard verfasserin (orcid)0000-0003-2812-194X aut Søreide, Eldar verfasserin aut Kirkegaard, Hans verfasserin (orcid)0000-0003-4853-8152 aut Nielsen, Jørgen Feldbæk verfasserin aut Enthalten in Resuscitation Amsterdam [u.a.] : Elsevier Science, 1972 134, Seite 1-9 Online-Ressource (DE-627)320488543 (DE-600)2010733-X (DE-576)099879042 1873-1570 nnns volume:134 pages:1-9 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.80 Unfallmedizin Notfallmedizin AR 134 1-9 |
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Evald, Lars @@aut@@ Brønnick, Kolbjørn @@aut@@ Duez, Christophe Henri Valdemar @@aut@@ Grejs, Anders Morten @@aut@@ Jeppesen, Anni Nørgaard @@aut@@ Søreide, Eldar @@aut@@ Kirkegaard, Hans @@aut@@ Nielsen, Jørgen Feldbæk @@aut@@ |
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Evald, Lars ddc 610 bkl 44.80 misc Out of Hospital Cardiac arrest misc OHCA misc Targeted Temperature Management misc TTM misc Outcome misc Cognition misc Memory misc Randomised Controlled Trial misc RCT Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial |
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610 DE-600 44.80 bkl Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial Out of Hospital Cardiac arrest OHCA Targeted Temperature Management TTM Outcome Cognition Memory Randomised Controlled Trial RCT |
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Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial |
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Evald, Lars Brønnick, Kolbjørn Duez, Christophe Henri Valdemar Grejs, Anders Morten Jeppesen, Anni Nørgaard Søreide, Eldar Kirkegaard, Hans Nielsen, Jørgen Feldbæk |
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prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: a randomised controlled trial |
| title_auth |
Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial |
| abstract |
Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. |
| abstractGer |
Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. |
| abstract_unstemmed |
Background: Cognitive sequelae, most frequently memory, attention, and executive dysfunctions, occur commonly in out-of-hospital cardiac arrest (OHCA) survivors. Targeted temperature management (TTM) following OHCA is associated with improved cognitive function. However, the relationship between the duration of TTM and cognitive outcome remains unclear. We hypothesised that OHCA survivors that were subjected to prolonged TTM of 48 h (TTM48) would exhibit better cognitive functions compared to those subjected to standard TTM of 24 h (TTM24) six months post-OHCA.Methods: A predefined, cognitive post-hoc sub-study was conducted on the multicentre clinical trial: “Target Temperature Management for 48 vs. 24 h and Neurologic Outcome after out-of-hospital cardiac arrest: A Randomised Clinical Trial” (the TTH48 trial). OHCA survivors with perceived good cognitive outcome (CPC score ≤ 2) were invited to a neuropsychological assessment of memory, attention, and executive functions six months post-OHCA.Results: In total, 79 patients were included in the study. Multivariate regression analysis revealed that TTM48 was associated with a significant better performance on three of 13 cognitive tests specific to memory retrieval after adjusting for age at follow-up and time to return of spontaneous circulation. Overall, patients in the TTM24 group were almost three times more likely (RR = 2.9 (95% CI 1.1–7.4)), p = 0.02) to be cognitively impaired.Conclusions: This study reports an association between the duration of TTM and cognitive outcome. In OHCA survivors with perceived good cognitive outcome (CPC ≤ 2), TTM48 was associated with reduced memory retrieval deficits and lower relative risk of cognitive impairment six months after OHCA compared to standard TTM24. |
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Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial |
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Brønnick, Kolbjørn Duez, Christophe Henri Valdemar Grejs, Anders Morten Jeppesen, Anni Nørgaard Søreide, Eldar Kirkegaard, Hans Nielsen, Jørgen Feldbæk |
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