Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats

Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the...
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Autor*in:	Zhao, Ming [verfasserIn] Cheng, Xiang [verfasserIn] Lin, Xiao [verfasserIn] Han, Ying [verfasserIn] Zhou, Yanzhao [verfasserIn] Zhao, Tong [verfasserIn] He, Yunling [verfasserIn] Wu, Liying [verfasserIn] Zhao, Yongqi [verfasserIn] Fan, Ming [verfasserIn] Zhu, Lingling [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Metformin Hypobaric hypoxia Memory impairment

Übergeordnetes Werk:	Enthalten in: Behavioural brain research - Amsterdam : Elsevier, 1980, 363, Seite 30-37
Übergeordnetes Werk:	volume:363 ; pages:30-37

DOI / URN:	10.1016/j.bbr.2019.01.048

Katalog-ID:	ELV001700723

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245	1	0	\|a Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
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520			\|a Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia.
650		4	\|a Metformin
650		4	\|a Hypobaric hypoxia
650		4	\|a Memory impairment
700	1		\|a Cheng, Xiang \|e verfasserin \|4 aut
700	1		\|a Lin, Xiao \|e verfasserin \|4 aut
700	1		\|a Han, Ying \|e verfasserin \|4 aut
700	1		\|a Zhou, Yanzhao \|e verfasserin \|4 aut
700	1		\|a Zhao, Tong \|e verfasserin \|4 aut
700	1		\|a He, Yunling \|e verfasserin \|4 aut
700	1		\|a Wu, Liying \|e verfasserin \|4 aut
700	1		\|a Zhao, Yongqi \|e verfasserin \|4 aut
700	1		\|a Fan, Ming \|e verfasserin \|4 aut
700	1		\|a Zhu, Lingling \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Behavioural brain research \|d Amsterdam : Elsevier, 1980 \|g 363, Seite 30-37 \|h Online-Ressource \|w (DE-627)320512746 \|w (DE-600)2013604-3 \|w (DE-576)094085714 \|x 1872-7549 \|7 nnns
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912			\|a GBV_ILN_4393
936	b	k	\|a 44.90 \|j Neurologie
951			\|a AR
952			\|d 363 \|h 30-37

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author_variant	m z mz x c xc x l xl y h yh y z yz t z tz y h yh l w lw y z yz m f mf l z lz
matchkey_str	article:18727549:2019----::efriamnsrtopeetmmripimnidcdy
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publishDate	2019
allfields	10.1016/j.bbr.2019.01.048 doi (DE-627)ELV001700723 (ELSEVIER)S0166-4328(18)31414-1 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Zhao, Ming verfasserin aut Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia. Metformin Hypobaric hypoxia Memory impairment Cheng, Xiang verfasserin aut Lin, Xiao verfasserin aut Han, Ying verfasserin aut Zhou, Yanzhao verfasserin aut Zhao, Tong verfasserin aut He, Yunling verfasserin aut Wu, Liying verfasserin aut Zhao, Yongqi verfasserin aut Fan, Ming verfasserin aut Zhu, Lingling verfasserin aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 363, Seite 30-37 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:363 pages:30-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 363 30-37
spelling	10.1016/j.bbr.2019.01.048 doi (DE-627)ELV001700723 (ELSEVIER)S0166-4328(18)31414-1 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Zhao, Ming verfasserin aut Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia. Metformin Hypobaric hypoxia Memory impairment Cheng, Xiang verfasserin aut Lin, Xiao verfasserin aut Han, Ying verfasserin aut Zhou, Yanzhao verfasserin aut Zhao, Tong verfasserin aut He, Yunling verfasserin aut Wu, Liying verfasserin aut Zhao, Yongqi verfasserin aut Fan, Ming verfasserin aut Zhu, Lingling verfasserin aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 363, Seite 30-37 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:363 pages:30-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 363 30-37
allfields_unstemmed	10.1016/j.bbr.2019.01.048 doi (DE-627)ELV001700723 (ELSEVIER)S0166-4328(18)31414-1 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Zhao, Ming verfasserin aut Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia. Metformin Hypobaric hypoxia Memory impairment Cheng, Xiang verfasserin aut Lin, Xiao verfasserin aut Han, Ying verfasserin aut Zhou, Yanzhao verfasserin aut Zhao, Tong verfasserin aut He, Yunling verfasserin aut Wu, Liying verfasserin aut Zhao, Yongqi verfasserin aut Fan, Ming verfasserin aut Zhu, Lingling verfasserin aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 363, Seite 30-37 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:363 pages:30-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 363 30-37
allfieldsGer	10.1016/j.bbr.2019.01.048 doi (DE-627)ELV001700723 (ELSEVIER)S0166-4328(18)31414-1 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Zhao, Ming verfasserin aut Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia. Metformin Hypobaric hypoxia Memory impairment Cheng, Xiang verfasserin aut Lin, Xiao verfasserin aut Han, Ying verfasserin aut Zhou, Yanzhao verfasserin aut Zhao, Tong verfasserin aut He, Yunling verfasserin aut Wu, Liying verfasserin aut Zhao, Yongqi verfasserin aut Fan, Ming verfasserin aut Zhu, Lingling verfasserin aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 363, Seite 30-37 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:363 pages:30-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 363 30-37
allfieldsSound	10.1016/j.bbr.2019.01.048 doi (DE-627)ELV001700723 (ELSEVIER)S0166-4328(18)31414-1 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Zhao, Ming verfasserin aut Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia. Metformin Hypobaric hypoxia Memory impairment Cheng, Xiang verfasserin aut Lin, Xiao verfasserin aut Han, Ying verfasserin aut Zhou, Yanzhao verfasserin aut Zhao, Tong verfasserin aut He, Yunling verfasserin aut Wu, Liying verfasserin aut Zhao, Yongqi verfasserin aut Fan, Ming verfasserin aut Zhu, Lingling verfasserin aut Enthalten in Behavioural brain research Amsterdam : Elsevier, 1980 363, Seite 30-37 Online-Ressource (DE-627)320512746 (DE-600)2013604-3 (DE-576)094085714 1872-7549 nnns volume:363 pages:30-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 363 30-37
language	English
source	Enthalten in Behavioural brain research 363, Seite 30-37 volume:363 pages:30-37
sourceStr	Enthalten in Behavioural brain research 363, Seite 30-37 volume:363 pages:30-37
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	Metformin Hypobaric hypoxia Memory impairment
dewey-raw	610
isfreeaccess_bool	false
container_title	Behavioural brain research
authorswithroles_txt_mv	Zhao, Ming @@aut@@ Cheng, Xiang @@aut@@ Lin, Xiao @@aut@@ Han, Ying @@aut@@ Zhou, Yanzhao @@aut@@ Zhao, Tong @@aut@@ He, Yunling @@aut@@ Wu, Liying @@aut@@ Zhao, Yongqi @@aut@@ Fan, Ming @@aut@@ Zhu, Lingling @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	320512746
dewey-sort	3610
id	ELV001700723
language_de	englisch
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author	Zhao, Ming
spellingShingle	Zhao, Ming ddc 610 bkl 44.90 misc Metformin misc Hypobaric hypoxia misc Memory impairment Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
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topic_title	610 DE-600 44.90 bkl Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats Metformin Hypobaric hypoxia Memory impairment
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title	Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
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title_full	Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
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title_sort	metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
title_auth	Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
abstract	Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia.
abstractGer	Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia.
abstract_unstemmed	Metformin, an antidiabetic biguanide, reduces hyperglycemia by improving glucose utilization and reducing gluconeogenesis. Recently, an increasing number of studies have shown that metformin also led to a significant clinical improvement in memory and cognition in different clinical settings. In the present study, we investigated whether metformin administration protects against memory impairment and neuron damage caused by acute exposure to hypobaric hypoxia and screened the possible molecular mechanisms with a focused gene array. We found that metformin treatment obviously attenuated spatial memory and recognition memory impairment resulting from acute hypobaric hypoxia exposure but had no effect on general locomotor and behavioral activity. Moreover, the results of Nissl and TUNEL staining showed that neuron damage and cell apoptosis caused by hypobaric hypoxia exposure was also inhibited by metformin pretreatment. At the molecular level, we found that metformin pretreatment not only prevented the changes of FOS, JUNB and BDNF at both mRNA and protein levels, but also increased the expression of the postsynaptic scaffold genes HOMER and PSD95 after exposure to hypobaric hypoxia. These data suggested that metformin pretreatment is a feasible strategy for preventing memory impairment under hypobaric hypoxia.
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title_short	Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats
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author2	Cheng, Xiang Lin, Xiao Han, Ying Zhou, Yanzhao Zhao, Tong He, Yunling Wu, Liying Zhao, Yongqi Fan, Ming Zhu, Lingling
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up_date	2024-07-06T22:16:38.281Z
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