Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases
Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to...
Ausführliche Beschreibung
Autor*in: |
Bonifacio, Cristiana [verfasserIn] Viganò, Luca [verfasserIn] Felisaz, Paolo [verfasserIn] Lopci, Egesta [verfasserIn] Cimino, Matteo [verfasserIn] Poretti, Dario [verfasserIn] Donadon, Matteo [verfasserIn] Pedicini, Vittorio [verfasserIn] Procopio, Fabio [verfasserIn] Chiti, Arturo [verfasserIn] Balzarini, Luca [verfasserIn] Torzilli, Guido [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
Enthalten in: European journal of surgical oncology - Burlington, Mass. : Harcourt, 1995, 45 |
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Übergeordnetes Werk: |
volume:45 |
DOI / URN: |
10.1016/j.ejso.2018.11.018 |
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Katalog-ID: |
ELV001734741 |
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245 | 1 | 0 | |a Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases |
264 | 1 | |c 2018 | |
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520 | |a Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. | ||
650 | 4 | |a Colorectal liver metastases | |
650 | 4 | |a Lymph node metastases | |
650 | 4 | |a Diffusion-weighted MRI | |
650 | 4 | |a Staging of colorectal tumors | |
650 | 4 | |a N staging | |
650 | 4 | |a ADC measurement | |
700 | 1 | |a Viganò, Luca |e verfasserin |4 aut | |
700 | 1 | |a Felisaz, Paolo |e verfasserin |4 aut | |
700 | 1 | |a Lopci, Egesta |e verfasserin |4 aut | |
700 | 1 | |a Cimino, Matteo |e verfasserin |4 aut | |
700 | 1 | |a Poretti, Dario |e verfasserin |4 aut | |
700 | 1 | |a Donadon, Matteo |e verfasserin |4 aut | |
700 | 1 | |a Pedicini, Vittorio |e verfasserin |4 aut | |
700 | 1 | |a Procopio, Fabio |e verfasserin |4 aut | |
700 | 1 | |a Chiti, Arturo |e verfasserin |4 aut | |
700 | 1 | |a Balzarini, Luca |e verfasserin |4 aut | |
700 | 1 | |a Torzilli, Guido |e verfasserin |4 aut | |
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2018 |
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2018 |
allfields |
10.1016/j.ejso.2018.11.018 doi (DE-627)ELV001734741 (ELSEVIER)S0748-7983(18)32016-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Bonifacio, Cristiana verfasserin aut Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement Viganò, Luca verfasserin aut Felisaz, Paolo verfasserin aut Lopci, Egesta verfasserin aut Cimino, Matteo verfasserin aut Poretti, Dario verfasserin aut Donadon, Matteo verfasserin aut Pedicini, Vittorio verfasserin aut Procopio, Fabio verfasserin aut Chiti, Arturo verfasserin aut Balzarini, Luca verfasserin aut Torzilli, Guido verfasserin aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 45 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 45 |
spelling |
10.1016/j.ejso.2018.11.018 doi (DE-627)ELV001734741 (ELSEVIER)S0748-7983(18)32016-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Bonifacio, Cristiana verfasserin aut Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement Viganò, Luca verfasserin aut Felisaz, Paolo verfasserin aut Lopci, Egesta verfasserin aut Cimino, Matteo verfasserin aut Poretti, Dario verfasserin aut Donadon, Matteo verfasserin aut Pedicini, Vittorio verfasserin aut Procopio, Fabio verfasserin aut Chiti, Arturo verfasserin aut Balzarini, Luca verfasserin aut Torzilli, Guido verfasserin aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 45 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 45 |
allfields_unstemmed |
10.1016/j.ejso.2018.11.018 doi (DE-627)ELV001734741 (ELSEVIER)S0748-7983(18)32016-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Bonifacio, Cristiana verfasserin aut Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement Viganò, Luca verfasserin aut Felisaz, Paolo verfasserin aut Lopci, Egesta verfasserin aut Cimino, Matteo verfasserin aut Poretti, Dario verfasserin aut Donadon, Matteo verfasserin aut Pedicini, Vittorio verfasserin aut Procopio, Fabio verfasserin aut Chiti, Arturo verfasserin aut Balzarini, Luca verfasserin aut Torzilli, Guido verfasserin aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 45 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 45 |
allfieldsGer |
10.1016/j.ejso.2018.11.018 doi (DE-627)ELV001734741 (ELSEVIER)S0748-7983(18)32016-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Bonifacio, Cristiana verfasserin aut Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement Viganò, Luca verfasserin aut Felisaz, Paolo verfasserin aut Lopci, Egesta verfasserin aut Cimino, Matteo verfasserin aut Poretti, Dario verfasserin aut Donadon, Matteo verfasserin aut Pedicini, Vittorio verfasserin aut Procopio, Fabio verfasserin aut Chiti, Arturo verfasserin aut Balzarini, Luca verfasserin aut Torzilli, Guido verfasserin aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 45 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 45 |
allfieldsSound |
10.1016/j.ejso.2018.11.018 doi (DE-627)ELV001734741 (ELSEVIER)S0748-7983(18)32016-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.65 bkl Bonifacio, Cristiana verfasserin aut Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement Viganò, Luca verfasserin aut Felisaz, Paolo verfasserin aut Lopci, Egesta verfasserin aut Cimino, Matteo verfasserin aut Poretti, Dario verfasserin aut Donadon, Matteo verfasserin aut Pedicini, Vittorio verfasserin aut Procopio, Fabio verfasserin aut Chiti, Arturo verfasserin aut Balzarini, Luca verfasserin aut Torzilli, Guido verfasserin aut Enthalten in European journal of surgical oncology Burlington, Mass. : Harcourt, 1995 45 Online-Ressource (DE-627)320420361 (DE-600)2002481-2 (DE-576)103746862 1532-2157 nnns volume:45 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.65 Chirurgie AR 45 |
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Enthalten in European journal of surgical oncology 45 volume:45 |
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Enthalten in European journal of surgical oncology 45 volume:45 |
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Onkologie Chirurgie |
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Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement |
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European journal of surgical oncology |
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Bonifacio, Cristiana @@aut@@ Viganò, Luca @@aut@@ Felisaz, Paolo @@aut@@ Lopci, Egesta @@aut@@ Cimino, Matteo @@aut@@ Poretti, Dario @@aut@@ Donadon, Matteo @@aut@@ Pedicini, Vittorio @@aut@@ Procopio, Fabio @@aut@@ Chiti, Arturo @@aut@@ Balzarini, Luca @@aut@@ Torzilli, Guido @@aut@@ |
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2018-01-01T00:00:00Z |
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Bonifacio, Cristiana |
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Bonifacio, Cristiana ddc 610 bkl 44.81 bkl 44.65 misc Colorectal liver metastases misc Lymph node metastases misc Diffusion-weighted MRI misc Staging of colorectal tumors misc N staging misc ADC measurement Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases |
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610 DE-600 44.81 bkl 44.65 bkl Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases Colorectal liver metastases Lymph node metastases Diffusion-weighted MRI Staging of colorectal tumors N staging ADC measurement |
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ddc 610 bkl 44.81 bkl 44.65 misc Colorectal liver metastases misc Lymph node metastases misc Diffusion-weighted MRI misc Staging of colorectal tumors misc N staging misc ADC measurement |
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ddc 610 bkl 44.81 bkl 44.65 misc Colorectal liver metastases misc Lymph node metastases misc Diffusion-weighted MRI misc Staging of colorectal tumors misc N staging misc ADC measurement |
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European journal of surgical oncology |
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Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases |
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Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases |
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Bonifacio, Cristiana |
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European journal of surgical oncology |
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Bonifacio, Cristiana Viganò, Luca Felisaz, Paolo Lopci, Egesta Cimino, Matteo Poretti, Dario Donadon, Matteo Pedicini, Vittorio Procopio, Fabio Chiti, Arturo Balzarini, Luca Torzilli, Guido |
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Bonifacio, Cristiana |
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10.1016/j.ejso.2018.11.018 |
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diffusion-weighted imaging and loco-regional n staging of patients with colorectal liver metastases |
title_auth |
Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases |
abstract |
Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. |
abstractGer |
Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. |
abstract_unstemmed |
Introduction: Diffusion-weighted MRI (DWI) contributes to N staging of rectal cancers and diagnosis of colorectal liver metastases (CLM). About 15% of CLM patients have loco-regional lymph node (LN) metastases that impact prognosis and treatment strategy. This retrospective study is the first one to evaluate quantitative ADC measurement as a tool to identify metastatic LNs in patients with liver metastases from colorectal cancer.Methods: All consecutive patients undergoing surgery for CLM between 2008 and 2015 were considered. Inclusion criteria were: intraoperative retrieval of at least one LN; LN ≥ 5 mm; DWI performed ≤2 months before surgery. The ADC and ADCratio (ADCLN/ADCCLM) were computed by two radiologists for all the LNs.Results: Among 555 patients operated for CLM, 32 met the inclusion criteria. Fifty-six LNs were analyzed and 28 were metastatic. ADC and ADCratio in metastatic LNs were lower than in benign LNs (ADC = 1.37 vs. 1.83 × 10−3 mm2/s, p < 0.001; ADCratio = 1.26 vs. 1.73, p < 0.001). The optimal cut-off value for ADC was 1.48 x 10-3 mm2/s (AUC = 0.85, p < 0.001, sensitivity/specificity/accuracy 79%/93%/86% in per LN-analysis and 94%/86%/91% in per-patient analysis). The optimal cut-off for ADCratio was 1.15 (AUC = 0.80, p < 0.001, sensitivity/specificity/accuracy 69%/93%/81% and 76%,93%/84%). Excellent inter- and intra-operators’ agreements were observed.Conclusion: In patients with CLM, ADC values < 1.48 x 10-3 mm2/s can be postulated as a cut-off to distinguish metastatic LNs. |
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Diffusion-weighted imaging and loco-regional N staging of patients with colorectal liver metastases |
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Viganò, Luca Felisaz, Paolo Lopci, Egesta Cimino, Matteo Poretti, Dario Donadon, Matteo Pedicini, Vittorio Procopio, Fabio Chiti, Arturo Balzarini, Luca Torzilli, Guido |
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score |
7.400346 |