Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study

There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly v...
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Autor*in:	Ohene, Yolanda [verfasserIn] Harrison, Ian F. [verfasserIn] Nahavandi, Payam [verfasserIn] Ismail, Ozama [verfasserIn] Bird, Eleanor V. [verfasserIn] Ottersen, Ole P. [verfasserIn] Nagelhus, Erlend A. [verfasserIn] Thomas, David L. [verfasserIn] Lythgoe, Mark F. [verfasserIn] Wells, Jack A. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system

Übergeordnetes Werk:	Enthalten in: NeuroImage - Orlando, Fla. : Academic Press, 1992, 188, Seite 515-523
Übergeordnetes Werk:	volume:188 ; pages:515-523

DOI / URN:	10.1016/j.neuroimage.2018.12.026

Katalog-ID:	ELV001807242

Internformat


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245	1	0	\|a Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
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520			\|a There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease.
650		4	\|a Aquaporin-4
650		4	\|a Multiple echo-time
650		4	\|a ASL
650		4	\|a Blood-brain interface
650		4	\|a Blood-brain barrier
650		4	\|a Water permeability
650		4	\|a Glymphatic system
700	1		\|a Harrison, Ian F. \|e verfasserin \|4 aut
700	1		\|a Nahavandi, Payam \|e verfasserin \|4 aut
700	1		\|a Ismail, Ozama \|e verfasserin \|4 aut
700	1		\|a Bird, Eleanor V. \|e verfasserin \|4 aut
700	1		\|a Ottersen, Ole P. \|e verfasserin \|4 aut
700	1		\|a Nagelhus, Erlend A. \|e verfasserin \|4 aut
700	1		\|a Thomas, David L. \|e verfasserin \|4 aut
700	1		\|a Lythgoe, Mark F. \|e verfasserin \|4 aut
700	1		\|a Wells, Jack A. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t NeuroImage \|d Orlando, Fla. : Academic Press, 1992 \|g 188, Seite 515-523 \|h Online-Ressource \|w (DE-627)268125503 \|w (DE-600)1471418-8 \|w (DE-576)106869507 \|x 1095-9572 \|7 nnns
773	1	8	\|g volume:188 \|g pages:515-523
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936	b	k	\|a 44.64 \|j Radiologie
936	b	k	\|a 44.90 \|j Neurologie
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Indexfelder

author_variant	y o yo i f h if ifh p n pn o i oi e v b ev evb o p o op opo e a n ea ean d l t dl dlt m f l mf mfl j a w ja jaw
matchkey_str	article:10959572:2019----::oivsvmifricerneahassnmlilehtmatrasil
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bklnumber	44.64 44.90
publishDate	2019
allfields	10.1016/j.neuroimage.2018.12.026 doi (DE-627)ELV001807242 (ELSEVIER)S1053-8119(18)32170-0 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 44.64 bkl 44.90 bkl Ohene, Yolanda verfasserin aut Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease. Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system Harrison, Ian F. verfasserin aut Nahavandi, Payam verfasserin aut Ismail, Ozama verfasserin aut Bird, Eleanor V. verfasserin aut Ottersen, Ole P. verfasserin aut Nagelhus, Erlend A. verfasserin aut Thomas, David L. verfasserin aut Lythgoe, Mark F. verfasserin aut Wells, Jack A. verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 188, Seite 515-523 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:188 pages:515-523 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 Radiologie 44.90 Neurologie AR 188 515-523
spelling	10.1016/j.neuroimage.2018.12.026 doi (DE-627)ELV001807242 (ELSEVIER)S1053-8119(18)32170-0 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 44.64 bkl 44.90 bkl Ohene, Yolanda verfasserin aut Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease. Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system Harrison, Ian F. verfasserin aut Nahavandi, Payam verfasserin aut Ismail, Ozama verfasserin aut Bird, Eleanor V. verfasserin aut Ottersen, Ole P. verfasserin aut Nagelhus, Erlend A. verfasserin aut Thomas, David L. verfasserin aut Lythgoe, Mark F. verfasserin aut Wells, Jack A. verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 188, Seite 515-523 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:188 pages:515-523 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 Radiologie 44.90 Neurologie AR 188 515-523
allfields_unstemmed	10.1016/j.neuroimage.2018.12.026 doi (DE-627)ELV001807242 (ELSEVIER)S1053-8119(18)32170-0 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 44.64 bkl 44.90 bkl Ohene, Yolanda verfasserin aut Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease. Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system Harrison, Ian F. verfasserin aut Nahavandi, Payam verfasserin aut Ismail, Ozama verfasserin aut Bird, Eleanor V. verfasserin aut Ottersen, Ole P. verfasserin aut Nagelhus, Erlend A. verfasserin aut Thomas, David L. verfasserin aut Lythgoe, Mark F. verfasserin aut Wells, Jack A. verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 188, Seite 515-523 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:188 pages:515-523 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 Radiologie 44.90 Neurologie AR 188 515-523
allfieldsGer	10.1016/j.neuroimage.2018.12.026 doi (DE-627)ELV001807242 (ELSEVIER)S1053-8119(18)32170-0 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 44.64 bkl 44.90 bkl Ohene, Yolanda verfasserin aut Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease. Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system Harrison, Ian F. verfasserin aut Nahavandi, Payam verfasserin aut Ismail, Ozama verfasserin aut Bird, Eleanor V. verfasserin aut Ottersen, Ole P. verfasserin aut Nagelhus, Erlend A. verfasserin aut Thomas, David L. verfasserin aut Lythgoe, Mark F. verfasserin aut Wells, Jack A. verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 188, Seite 515-523 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:188 pages:515-523 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 Radiologie 44.90 Neurologie AR 188 515-523
allfieldsSound	10.1016/j.neuroimage.2018.12.026 doi (DE-627)ELV001807242 (ELSEVIER)S1053-8119(18)32170-0 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 44.64 bkl 44.90 bkl Ohene, Yolanda verfasserin aut Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease. Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system Harrison, Ian F. verfasserin aut Nahavandi, Payam verfasserin aut Ismail, Ozama verfasserin aut Bird, Eleanor V. verfasserin aut Ottersen, Ole P. verfasserin aut Nagelhus, Erlend A. verfasserin aut Thomas, David L. verfasserin aut Lythgoe, Mark F. verfasserin aut Wells, Jack A. verfasserin aut Enthalten in NeuroImage Orlando, Fla. : Academic Press, 1992 188, Seite 515-523 Online-Ressource (DE-627)268125503 (DE-600)1471418-8 (DE-576)106869507 1095-9572 nnns volume:188 pages:515-523 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 Radiologie 44.90 Neurologie AR 188 515-523
language	English
source	Enthalten in NeuroImage 188, Seite 515-523 volume:188 pages:515-523
sourceStr	Enthalten in NeuroImage 188, Seite 515-523 volume:188 pages:515-523
format_phy_str_mv	Article
bklname	Radiologie Neurologie
institution	findex.gbv.de
topic_facet	Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system
dewey-raw	610
isfreeaccess_bool	false
container_title	NeuroImage
authorswithroles_txt_mv	Ohene, Yolanda @@aut@@ Harrison, Ian F. @@aut@@ Nahavandi, Payam @@aut@@ Ismail, Ozama @@aut@@ Bird, Eleanor V. @@aut@@ Ottersen, Ole P. @@aut@@ Nagelhus, Erlend A. @@aut@@ Thomas, David L. @@aut@@ Lythgoe, Mark F. @@aut@@ Wells, Jack A. @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	268125503
dewey-sort	3610
id	ELV001807242
language_de	englisch
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author	Ohene, Yolanda
spellingShingle	Ohene, Yolanda ddc 610 fid LING bkl 44.64 bkl 44.90 misc Aquaporin-4 misc Multiple echo-time misc ASL misc Blood-brain interface misc Blood-brain barrier misc Water permeability misc Glymphatic system Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
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topic_title	610 DE-600 LING DE-30 fid 44.64 bkl 44.90 bkl Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study Aquaporin-4 Multiple echo-time ASL Blood-brain interface Blood-brain barrier Water permeability Glymphatic system
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title	Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
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title_full	Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
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author_browse	Ohene, Yolanda Harrison, Ian F. Nahavandi, Payam Ismail, Ozama Bird, Eleanor V. Ottersen, Ole P. Nagelhus, Erlend A. Thomas, David L. Lythgoe, Mark F. Wells, Jack A.
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title_sort	non-invasive mri of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
title_auth	Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
abstract	There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease.
abstractGer	There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease.
abstract_unstemmed	There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. This clinically relevant tool may be crucial to better understand the role of AQP4 in water transport across the BBI, as well as clearance of proteins in neurodegenerative conditions such as Alzheimer's disease.
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title_short	Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
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author2	Harrison, Ian F. Nahavandi, Payam Ismail, Ozama Bird, Eleanor V. Ottersen, Ole P. Nagelhus, Erlend A. Thomas, David L. Lythgoe, Mark F. Wells, Jack A.
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up_date	2024-07-06T22:38:26.822Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV001807242</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524144036.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230428s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.neuroimage.2018.12.026</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV001807242</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1053-8119(18)32170-0</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">LING</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.64</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ohene, Yolanda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">There is currently a lack of non-invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin-4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests that AQP4 plays a key role in amyloid-β (Aβ) clearance, possibly via the glymphatic system. Here, we present the first non-invasive technique sensitive to AQP4 channels polarised at the blood-brain interface (BBI). We apply a multiple echo time (multi-TE) arterial spin labelling (ASL) MRI technique to the mouse brain to assess BBI water permeability via calculation of the exchange time ( T e x w ) , the time for magnetically labelled intravascular water to exchange across the BBI. We observed a 31% increase in exchange time in AQP4-deficient (Aqp4 −/− ) mice (452 ± 90 ms) compared to their wild-type counterparts (343 ± 91 ms) (p = 0.01), demonstrating the sensitivity of the technique to the lack of AQP4 water channels. More established, quantitative MRI parameters: arterial transit time (δa), cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) detected no significant changes with the removal of AQP4. 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Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study

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