Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group
Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential ra...
Ausführliche Beschreibung
Gespeichert in:
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
Enthalten in: The lancet |
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| Übergeordnetes Werk: |
volume:20 ; pages:e155-e166 |
| DOI / URN: |
10.1016/S1470-2045(19)30034-8 |
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ELV001808508 |
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| 520 | |a Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. | ||
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| 700 | 1 | |a Mandeville, Henry C |e verfasserin |4 aut | |
| 700 | 1 | |a Gandola, Lorenza |e verfasserin |4 aut | |
| 700 | 1 | |a Dieckmann, Karin |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos Albiac, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Magelssen, Henriette |e verfasserin |4 aut | |
| 700 | 1 | |a Lassen-Ramshad, Yasmin |e verfasserin |4 aut | |
| 700 | 1 | |a Ondrová, Barbora |e verfasserin |4 aut | |
| 700 | 1 | |a Ajithkumar, Thankamma |e verfasserin |4 aut | |
| 700 | 1 | |a Alapetite, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Balgobind, Brian V |e verfasserin |4 aut | |
| 700 | 1 | |a Bolle, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Cameron, Alison L |e verfasserin |4 aut | |
| 700 | 1 | |a Davila Fajardo, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Dietzsch, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Dumont Lecomte, Delphine |e verfasserin |4 aut | |
| 700 | 1 | |a van den Heuvel-Eibrink, Marry M |e verfasserin |4 aut | |
| 700 | 1 | |a Kortmann, Rolf D |e verfasserin |4 aut | |
| 700 | 1 | |a Laprie, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Melchior, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Laetitia |e verfasserin |4 aut | |
| 700 | 1 | |a Rombi, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Scarzello, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Schwarz, Rudolf |e verfasserin |4 aut | |
| 700 | 1 | |a Seiersen, Klaus |e verfasserin |4 aut | |
| 700 | 1 | |a Seravalli, Enrica |e verfasserin |4 aut | |
| 700 | 1 | |a Thorp, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Whitfield, Gillian A |e verfasserin |4 aut | |
| 700 | 1 | |a Boterberg, Tom |e verfasserin |4 aut | |
| 700 | 1 | |a Janssens, Geert O |e verfasserin |4 aut | |
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10.1016/S1470-2045(19)30034-8 doi (DE-627)ELV001808508 (ELSEVIER)S1470-2045(19)30034-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Hoeben, Bianca A verfasserin aut Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. Carrie, Christian verfasserin aut Timmermann, Beate verfasserin aut Mandeville, Henry C verfasserin aut Gandola, Lorenza verfasserin aut Dieckmann, Karin verfasserin aut Ramos Albiac, Monica verfasserin aut Magelssen, Henriette verfasserin aut Lassen-Ramshad, Yasmin verfasserin aut Ondrová, Barbora verfasserin aut Ajithkumar, Thankamma verfasserin aut Alapetite, Claire verfasserin aut Balgobind, Brian V verfasserin aut Bolle, Stephanie verfasserin aut Cameron, Alison L verfasserin aut Davila Fajardo, Raquel verfasserin aut Dietzsch, Stefan verfasserin aut Dumont Lecomte, Delphine verfasserin aut van den Heuvel-Eibrink, Marry M verfasserin aut Kortmann, Rolf D verfasserin aut Laprie, Anne verfasserin aut Melchior, Patrick verfasserin aut Padovani, Laetitia verfasserin aut Rombi, Barbara verfasserin aut Scarzello, Giovanni verfasserin aut Schwarz, Rudolf verfasserin aut Seiersen, Klaus verfasserin aut Seravalli, Enrica verfasserin aut Thorp, Nicola verfasserin aut Whitfield, Gillian A verfasserin aut Boterberg, Tom verfasserin aut Janssens, Geert O verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 20, Seite e155-e166 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:20 pages:e155-e166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 20 e155-e166 |
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10.1016/S1470-2045(19)30034-8 doi (DE-627)ELV001808508 (ELSEVIER)S1470-2045(19)30034-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Hoeben, Bianca A verfasserin aut Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. Carrie, Christian verfasserin aut Timmermann, Beate verfasserin aut Mandeville, Henry C verfasserin aut Gandola, Lorenza verfasserin aut Dieckmann, Karin verfasserin aut Ramos Albiac, Monica verfasserin aut Magelssen, Henriette verfasserin aut Lassen-Ramshad, Yasmin verfasserin aut Ondrová, Barbora verfasserin aut Ajithkumar, Thankamma verfasserin aut Alapetite, Claire verfasserin aut Balgobind, Brian V verfasserin aut Bolle, Stephanie verfasserin aut Cameron, Alison L verfasserin aut Davila Fajardo, Raquel verfasserin aut Dietzsch, Stefan verfasserin aut Dumont Lecomte, Delphine verfasserin aut van den Heuvel-Eibrink, Marry M verfasserin aut Kortmann, Rolf D verfasserin aut Laprie, Anne verfasserin aut Melchior, Patrick verfasserin aut Padovani, Laetitia verfasserin aut Rombi, Barbara verfasserin aut Scarzello, Giovanni verfasserin aut Schwarz, Rudolf verfasserin aut Seiersen, Klaus verfasserin aut Seravalli, Enrica verfasserin aut Thorp, Nicola verfasserin aut Whitfield, Gillian A verfasserin aut Boterberg, Tom verfasserin aut Janssens, Geert O verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 20, Seite e155-e166 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:20 pages:e155-e166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 20 e155-e166 |
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10.1016/S1470-2045(19)30034-8 doi (DE-627)ELV001808508 (ELSEVIER)S1470-2045(19)30034-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Hoeben, Bianca A verfasserin aut Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. Carrie, Christian verfasserin aut Timmermann, Beate verfasserin aut Mandeville, Henry C verfasserin aut Gandola, Lorenza verfasserin aut Dieckmann, Karin verfasserin aut Ramos Albiac, Monica verfasserin aut Magelssen, Henriette verfasserin aut Lassen-Ramshad, Yasmin verfasserin aut Ondrová, Barbora verfasserin aut Ajithkumar, Thankamma verfasserin aut Alapetite, Claire verfasserin aut Balgobind, Brian V verfasserin aut Bolle, Stephanie verfasserin aut Cameron, Alison L verfasserin aut Davila Fajardo, Raquel verfasserin aut Dietzsch, Stefan verfasserin aut Dumont Lecomte, Delphine verfasserin aut van den Heuvel-Eibrink, Marry M verfasserin aut Kortmann, Rolf D verfasserin aut Laprie, Anne verfasserin aut Melchior, Patrick verfasserin aut Padovani, Laetitia verfasserin aut Rombi, Barbara verfasserin aut Scarzello, Giovanni verfasserin aut Schwarz, Rudolf verfasserin aut Seiersen, Klaus verfasserin aut Seravalli, Enrica verfasserin aut Thorp, Nicola verfasserin aut Whitfield, Gillian A verfasserin aut Boterberg, Tom verfasserin aut Janssens, Geert O verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 20, Seite e155-e166 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:20 pages:e155-e166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 20 e155-e166 |
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10.1016/S1470-2045(19)30034-8 doi (DE-627)ELV001808508 (ELSEVIER)S1470-2045(19)30034-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Hoeben, Bianca A verfasserin aut Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. Carrie, Christian verfasserin aut Timmermann, Beate verfasserin aut Mandeville, Henry C verfasserin aut Gandola, Lorenza verfasserin aut Dieckmann, Karin verfasserin aut Ramos Albiac, Monica verfasserin aut Magelssen, Henriette verfasserin aut Lassen-Ramshad, Yasmin verfasserin aut Ondrová, Barbora verfasserin aut Ajithkumar, Thankamma verfasserin aut Alapetite, Claire verfasserin aut Balgobind, Brian V verfasserin aut Bolle, Stephanie verfasserin aut Cameron, Alison L verfasserin aut Davila Fajardo, Raquel verfasserin aut Dietzsch, Stefan verfasserin aut Dumont Lecomte, Delphine verfasserin aut van den Heuvel-Eibrink, Marry M verfasserin aut Kortmann, Rolf D verfasserin aut Laprie, Anne verfasserin aut Melchior, Patrick verfasserin aut Padovani, Laetitia verfasserin aut Rombi, Barbara verfasserin aut Scarzello, Giovanni verfasserin aut Schwarz, Rudolf verfasserin aut Seiersen, Klaus verfasserin aut Seravalli, Enrica verfasserin aut Thorp, Nicola verfasserin aut Whitfield, Gillian A verfasserin aut Boterberg, Tom verfasserin aut Janssens, Geert O verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 20, Seite e155-e166 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:20 pages:e155-e166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 20 e155-e166 |
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10.1016/S1470-2045(19)30034-8 doi (DE-627)ELV001808508 (ELSEVIER)S1470-2045(19)30034-8 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl Hoeben, Bianca A verfasserin aut Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. Carrie, Christian verfasserin aut Timmermann, Beate verfasserin aut Mandeville, Henry C verfasserin aut Gandola, Lorenza verfasserin aut Dieckmann, Karin verfasserin aut Ramos Albiac, Monica verfasserin aut Magelssen, Henriette verfasserin aut Lassen-Ramshad, Yasmin verfasserin aut Ondrová, Barbora verfasserin aut Ajithkumar, Thankamma verfasserin aut Alapetite, Claire verfasserin aut Balgobind, Brian V verfasserin aut Bolle, Stephanie verfasserin aut Cameron, Alison L verfasserin aut Davila Fajardo, Raquel verfasserin aut Dietzsch, Stefan verfasserin aut Dumont Lecomte, Delphine verfasserin aut van den Heuvel-Eibrink, Marry M verfasserin aut Kortmann, Rolf D verfasserin aut Laprie, Anne verfasserin aut Melchior, Patrick verfasserin aut Padovani, Laetitia verfasserin aut Rombi, Barbara verfasserin aut Scarzello, Giovanni verfasserin aut Schwarz, Rudolf verfasserin aut Seiersen, Klaus verfasserin aut Seravalli, Enrica verfasserin aut Thorp, Nicola verfasserin aut Whitfield, Gillian A verfasserin aut Boterberg, Tom verfasserin aut Janssens, Geert O verfasserin aut Enthalten in The lancet <London> / Oncology London : The Lancet Publ. Group, 2000 20, Seite e155-e166 Online-Ressource (DE-627)325349770 (DE-600)2035574-9 (DE-576)100517544 1474-5488 nnns volume:20 pages:e155-e166 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 Onkologie AR 20 e155-e166 |
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Hoeben, Bianca A @@aut@@ Carrie, Christian @@aut@@ Timmermann, Beate @@aut@@ Mandeville, Henry C @@aut@@ Gandola, Lorenza @@aut@@ Dieckmann, Karin @@aut@@ Ramos Albiac, Monica @@aut@@ Magelssen, Henriette @@aut@@ Lassen-Ramshad, Yasmin @@aut@@ Ondrová, Barbora @@aut@@ Ajithkumar, Thankamma @@aut@@ Alapetite, Claire @@aut@@ Balgobind, Brian V @@aut@@ Bolle, Stephanie @@aut@@ Cameron, Alison L @@aut@@ Davila Fajardo, Raquel @@aut@@ Dietzsch, Stefan @@aut@@ Dumont Lecomte, Delphine @@aut@@ van den Heuvel-Eibrink, Marry M @@aut@@ Kortmann, Rolf D @@aut@@ Laprie, Anne @@aut@@ Melchior, Patrick @@aut@@ Padovani, Laetitia @@aut@@ Rombi, Barbara @@aut@@ Scarzello, Giovanni @@aut@@ Schwarz, Rudolf @@aut@@ Seiersen, Klaus @@aut@@ Seravalli, Enrica @@aut@@ Thorp, Nicola @@aut@@ Whitfield, Gillian A @@aut@@ Boterberg, Tom @@aut@@ Janssens, Geert O @@aut@@ |
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In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). 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610 DE-600 44.81 bkl Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group |
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Hoeben, Bianca A Carrie, Christian Timmermann, Beate Mandeville, Henry C Gandola, Lorenza Dieckmann, Karin Ramos Albiac, Monica Magelssen, Henriette Lassen-Ramshad, Yasmin Ondrová, Barbora Ajithkumar, Thankamma Alapetite, Claire Balgobind, Brian V Bolle, Stephanie Cameron, Alison L Davila Fajardo, Raquel Dietzsch, Stefan Dumont Lecomte, Delphine van den Heuvel-Eibrink, Marry M Kortmann, Rolf D Laprie, Anne Melchior, Patrick Padovani, Laetitia Rombi, Barbara Scarzello, Giovanni Schwarz, Rudolf Seiersen, Klaus Seravalli, Enrica Thorp, Nicola Whitfield, Gillian A Boterberg, Tom Janssens, Geert O |
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management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the siope radiotherapy working group |
| title_auth |
Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group |
| abstract |
Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. |
| abstractGer |
Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. |
| abstract_unstemmed |
Inhomogeneities in radiotherapy dose distributions covering the vertebrae in children can produce long-term spinal problems, including kyphosis, lordosis, scoliosis, and hypoplasia. In the published literature, many often interrelated variables have been reported to affect the extent of potential radiotherapy damage to the spine. Articles published in the 2D and 3D radiotherapy era instructed radiation oncologists to avoid dose inhomogeneity over growing vertebrae. However, in the present era of highly conformal radiotherapy, steep dose gradients over at-risk structures can be generated and thus less harm is caused to patients. In this report, paediatric radiation oncologists from leading centres in 11 European countries have produced recommendations on how to approach dose coverage for target volumes that are adjacent to vertebrae to minimise the risk of long-term spinal problems. Based on available information, it is advised that homogeneous vertebral radiotherapy doses should be delivered in children who have not yet finished the pubertal growth spurt. If dose fall-off within vertebrae cannot be avoided, acceptable dose gradients for different age groups are detailed here. Vertebral delineation should include all primary ossification centres and growth plates, and therefore include at least the vertebral body and arch. For partial spinal radiotherapy, the number of irradiated vertebrae should be restricted as much as achievable, particularly at the thoracic level in young children (<6 years old). There is a need for multicentre research on vertebral radiotherapy dose distributions for children, but until more valid data become available, these recommendations can provide a basis for daily practice for radiation oncologists who have patients that require vertebral radiotherapy. |
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| title_short |
Management of vertebral radiotherapy dose in paediatric patients with cancer: consensus recommendations from the SIOPE radiotherapy working group |
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Carrie, Christian Timmermann, Beate Mandeville, Henry C Gandola, Lorenza Dieckmann, Karin Ramos Albiac, Monica Magelssen, Henriette Lassen-Ramshad, Yasmin Ondrová, Barbora Ajithkumar, Thankamma Alapetite, Claire Balgobind, Brian V Bolle, Stephanie Cameron, Alison L Davila Fajardo, Raquel Dietzsch, Stefan Dumont Lecomte, Delphine van den Heuvel-Eibrink, Marry M Kortmann, Rolf D Laprie, Anne Melchior, Patrick Padovani, Laetitia Rombi, Barbara Scarzello, Giovanni Schwarz, Rudolf Seiersen, Klaus Seravalli, Enrica Thorp, Nicola Whitfield, Gillian A Boterberg, Tom Janssens, Geert O |
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Carrie, Christian Timmermann, Beate Mandeville, Henry C Gandola, Lorenza Dieckmann, Karin Ramos Albiac, Monica Magelssen, Henriette Lassen-Ramshad, Yasmin Ondrová, Barbora Ajithkumar, Thankamma Alapetite, Claire Balgobind, Brian V Bolle, Stephanie Cameron, Alison L Davila Fajardo, Raquel Dietzsch, Stefan Dumont Lecomte, Delphine van den Heuvel-Eibrink, Marry M Kortmann, Rolf D Laprie, Anne Melchior, Patrick Padovani, Laetitia Rombi, Barbara Scarzello, Giovanni Schwarz, Rudolf Seiersen, Klaus Seravalli, Enrica Thorp, Nicola Whitfield, Gillian A Boterberg, Tom Janssens, Geert O |
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10.1016/S1470-2045(19)30034-8 |
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2024-07-06T22:38:42.010Z |
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|
| score |
7.39999 |