Improved radiosynthesis and preliminary in vivo evaluation of the
Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Stéen, E. Johanna L. [verfasserIn] Jørgensen, Jesper T. [verfasserIn] Petersen, Ida N. [verfasserIn] Nørregaard, Kamilla [verfasserIn] Lehel, Szabolcs [verfasserIn] Shalgunov, Vladimir [verfasserIn] Birke, Alexander [verfasserIn] Edem, Patricia E. [verfasserIn] L'Estrade, Elina T. [verfasserIn] Hansen, Hanne D. [verfasserIn] Villadsen, Jonas [verfasserIn] Erlandsson, Maria [verfasserIn] Ohlsson, Tomas [verfasserIn] Yazdani, Abdolreza [verfasserIn] Valliant, John F. [verfasserIn] Kristensen, Jesper L. [verfasserIn] Barz, Matthias [verfasserIn] Knudsen, Gitte M. [verfasserIn] Kjær, Andreas [verfasserIn] Herth, Matthias M. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Bioorganic & medicinal chemistry letters - Amsterdam [u.a.] : Elsevier Science, 1991, 29, Seite 986-990 |
|---|---|
| Übergeordnetes Werk: |
volume:29 ; pages:986-990 |
| DOI / URN: |
10.1016/j.bmcl.2019.02.014 |
|---|
| Katalog-ID: |
ELV001836625 |
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| 245 | 1 | 0 | |a Improved radiosynthesis and preliminary in vivo evaluation of the |
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| 520 | |a Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. | ||
| 650 | 4 | |a PET imaging | |
| 650 | 4 | |a Pretargeting | |
| 650 | 4 | |a Carbon-11 | |
| 650 | 4 | |a Tetrazine | |
| 650 | 4 | |a Trans-cyclooctene | |
| 700 | 1 | |a Jørgensen, Jesper T. |e verfasserin |4 aut | |
| 700 | 1 | |a Petersen, Ida N. |e verfasserin |4 aut | |
| 700 | 1 | |a Nørregaard, Kamilla |e verfasserin |4 aut | |
| 700 | 1 | |a Lehel, Szabolcs |e verfasserin |4 aut | |
| 700 | 1 | |a Shalgunov, Vladimir |e verfasserin |4 aut | |
| 700 | 1 | |a Birke, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Edem, Patricia E. |e verfasserin |4 aut | |
| 700 | 1 | |a L'Estrade, Elina T. |e verfasserin |4 aut | |
| 700 | 1 | |a Hansen, Hanne D. |e verfasserin |4 aut | |
| 700 | 1 | |a Villadsen, Jonas |e verfasserin |4 aut | |
| 700 | 1 | |a Erlandsson, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Ohlsson, Tomas |e verfasserin |4 aut | |
| 700 | 1 | |a Yazdani, Abdolreza |e verfasserin |0 (orcid)0000-0002-5613-1267 |4 aut | |
| 700 | 1 | |a Valliant, John F. |e verfasserin |4 aut | |
| 700 | 1 | |a Kristensen, Jesper L. |e verfasserin |4 aut | |
| 700 | 1 | |a Barz, Matthias |e verfasserin |0 (orcid)0000-0001-5564-7627 |4 aut | |
| 700 | 1 | |a Knudsen, Gitte M. |e verfasserin |4 aut | |
| 700 | 1 | |a Kjær, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Herth, Matthias M. |e verfasserin |4 aut | |
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10.1016/j.bmcl.2019.02.014 doi (DE-627)ELV001836625 (ELSEVIER)S0960-894X(19)30085-X DE-627 ger DE-627 rda eng 540 610 DE-600 15,3 ssgn PHARM DE-84 fid 35.70 bkl 44.33 bkl 44.42 bkl Stéen, E. Johanna L. verfasserin aut Improved radiosynthesis and preliminary in vivo evaluation of the 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene Jørgensen, Jesper T. verfasserin aut Petersen, Ida N. verfasserin aut Nørregaard, Kamilla verfasserin aut Lehel, Szabolcs verfasserin aut Shalgunov, Vladimir verfasserin aut Birke, Alexander verfasserin aut Edem, Patricia E. verfasserin aut L'Estrade, Elina T. verfasserin aut Hansen, Hanne D. verfasserin aut Villadsen, Jonas verfasserin aut Erlandsson, Maria verfasserin aut Ohlsson, Tomas verfasserin aut Yazdani, Abdolreza verfasserin (orcid)0000-0002-5613-1267 aut Valliant, John F. verfasserin aut Kristensen, Jesper L. verfasserin aut Barz, Matthias verfasserin (orcid)0000-0001-5564-7627 aut Knudsen, Gitte M. verfasserin aut Kjær, Andreas verfasserin aut Herth, Matthias M. verfasserin aut Enthalten in Bioorganic & medicinal chemistry letters Amsterdam [u.a.] : Elsevier Science, 1991 29, Seite 986-990 Online-Ressource (DE-627)306717522 (DE-600)1501505-1 (DE-576)110916573 1464-3405 nnns volume:29 pages:986-990 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines 44.33 Physiologische Chemie 44.42 Pharmazeutische Chemie AR 29 986-990 |
| spelling |
10.1016/j.bmcl.2019.02.014 doi (DE-627)ELV001836625 (ELSEVIER)S0960-894X(19)30085-X DE-627 ger DE-627 rda eng 540 610 DE-600 15,3 ssgn PHARM DE-84 fid 35.70 bkl 44.33 bkl 44.42 bkl Stéen, E. Johanna L. verfasserin aut Improved radiosynthesis and preliminary in vivo evaluation of the 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene Jørgensen, Jesper T. verfasserin aut Petersen, Ida N. verfasserin aut Nørregaard, Kamilla verfasserin aut Lehel, Szabolcs verfasserin aut Shalgunov, Vladimir verfasserin aut Birke, Alexander verfasserin aut Edem, Patricia E. verfasserin aut L'Estrade, Elina T. verfasserin aut Hansen, Hanne D. verfasserin aut Villadsen, Jonas verfasserin aut Erlandsson, Maria verfasserin aut Ohlsson, Tomas verfasserin aut Yazdani, Abdolreza verfasserin (orcid)0000-0002-5613-1267 aut Valliant, John F. verfasserin aut Kristensen, Jesper L. verfasserin aut Barz, Matthias verfasserin (orcid)0000-0001-5564-7627 aut Knudsen, Gitte M. verfasserin aut Kjær, Andreas verfasserin aut Herth, Matthias M. verfasserin aut Enthalten in Bioorganic & medicinal chemistry letters Amsterdam [u.a.] : Elsevier Science, 1991 29, Seite 986-990 Online-Ressource (DE-627)306717522 (DE-600)1501505-1 (DE-576)110916573 1464-3405 nnns volume:29 pages:986-990 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines 44.33 Physiologische Chemie 44.42 Pharmazeutische Chemie AR 29 986-990 |
| allfields_unstemmed |
10.1016/j.bmcl.2019.02.014 doi (DE-627)ELV001836625 (ELSEVIER)S0960-894X(19)30085-X DE-627 ger DE-627 rda eng 540 610 DE-600 15,3 ssgn PHARM DE-84 fid 35.70 bkl 44.33 bkl 44.42 bkl Stéen, E. Johanna L. verfasserin aut Improved radiosynthesis and preliminary in vivo evaluation of the 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene Jørgensen, Jesper T. verfasserin aut Petersen, Ida N. verfasserin aut Nørregaard, Kamilla verfasserin aut Lehel, Szabolcs verfasserin aut Shalgunov, Vladimir verfasserin aut Birke, Alexander verfasserin aut Edem, Patricia E. verfasserin aut L'Estrade, Elina T. verfasserin aut Hansen, Hanne D. verfasserin aut Villadsen, Jonas verfasserin aut Erlandsson, Maria verfasserin aut Ohlsson, Tomas verfasserin aut Yazdani, Abdolreza verfasserin (orcid)0000-0002-5613-1267 aut Valliant, John F. verfasserin aut Kristensen, Jesper L. verfasserin aut Barz, Matthias verfasserin (orcid)0000-0001-5564-7627 aut Knudsen, Gitte M. verfasserin aut Kjær, Andreas verfasserin aut Herth, Matthias M. verfasserin aut Enthalten in Bioorganic & medicinal chemistry letters Amsterdam [u.a.] : Elsevier Science, 1991 29, Seite 986-990 Online-Ressource (DE-627)306717522 (DE-600)1501505-1 (DE-576)110916573 1464-3405 nnns volume:29 pages:986-990 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines 44.33 Physiologische Chemie 44.42 Pharmazeutische Chemie AR 29 986-990 |
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10.1016/j.bmcl.2019.02.014 doi (DE-627)ELV001836625 (ELSEVIER)S0960-894X(19)30085-X DE-627 ger DE-627 rda eng 540 610 DE-600 15,3 ssgn PHARM DE-84 fid 35.70 bkl 44.33 bkl 44.42 bkl Stéen, E. Johanna L. verfasserin aut Improved radiosynthesis and preliminary in vivo evaluation of the 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene Jørgensen, Jesper T. verfasserin aut Petersen, Ida N. verfasserin aut Nørregaard, Kamilla verfasserin aut Lehel, Szabolcs verfasserin aut Shalgunov, Vladimir verfasserin aut Birke, Alexander verfasserin aut Edem, Patricia E. verfasserin aut L'Estrade, Elina T. verfasserin aut Hansen, Hanne D. verfasserin aut Villadsen, Jonas verfasserin aut Erlandsson, Maria verfasserin aut Ohlsson, Tomas verfasserin aut Yazdani, Abdolreza verfasserin (orcid)0000-0002-5613-1267 aut Valliant, John F. verfasserin aut Kristensen, Jesper L. verfasserin aut Barz, Matthias verfasserin (orcid)0000-0001-5564-7627 aut Knudsen, Gitte M. verfasserin aut Kjær, Andreas verfasserin aut Herth, Matthias M. verfasserin aut Enthalten in Bioorganic & medicinal chemistry letters Amsterdam [u.a.] : Elsevier Science, 1991 29, Seite 986-990 Online-Ressource (DE-627)306717522 (DE-600)1501505-1 (DE-576)110916573 1464-3405 nnns volume:29 pages:986-990 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines 44.33 Physiologische Chemie 44.42 Pharmazeutische Chemie AR 29 986-990 |
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10.1016/j.bmcl.2019.02.014 doi (DE-627)ELV001836625 (ELSEVIER)S0960-894X(19)30085-X DE-627 ger DE-627 rda eng 540 610 DE-600 15,3 ssgn PHARM DE-84 fid 35.70 bkl 44.33 bkl 44.42 bkl Stéen, E. Johanna L. verfasserin aut Improved radiosynthesis and preliminary in vivo evaluation of the 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene Jørgensen, Jesper T. verfasserin aut Petersen, Ida N. verfasserin aut Nørregaard, Kamilla verfasserin aut Lehel, Szabolcs verfasserin aut Shalgunov, Vladimir verfasserin aut Birke, Alexander verfasserin aut Edem, Patricia E. verfasserin aut L'Estrade, Elina T. verfasserin aut Hansen, Hanne D. verfasserin aut Villadsen, Jonas verfasserin aut Erlandsson, Maria verfasserin aut Ohlsson, Tomas verfasserin aut Yazdani, Abdolreza verfasserin (orcid)0000-0002-5613-1267 aut Valliant, John F. verfasserin aut Kristensen, Jesper L. verfasserin aut Barz, Matthias verfasserin (orcid)0000-0001-5564-7627 aut Knudsen, Gitte M. verfasserin aut Kjær, Andreas verfasserin aut Herth, Matthias M. verfasserin aut Enthalten in Bioorganic & medicinal chemistry letters Amsterdam [u.a.] : Elsevier Science, 1991 29, Seite 986-990 Online-Ressource (DE-627)306717522 (DE-600)1501505-1 (DE-576)110916573 1464-3405 nnns volume:29 pages:986-990 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.70 Biochemie: Allgemeines 44.33 Physiologische Chemie 44.42 Pharmazeutische Chemie AR 29 986-990 |
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Enthalten in Bioorganic & medicinal chemistry letters 29, Seite 986-990 volume:29 pages:986-990 |
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PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene |
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Stéen, E. Johanna L. @@aut@@ Jørgensen, Jesper T. @@aut@@ Petersen, Ida N. @@aut@@ Nørregaard, Kamilla @@aut@@ Lehel, Szabolcs @@aut@@ Shalgunov, Vladimir @@aut@@ Birke, Alexander @@aut@@ Edem, Patricia E. @@aut@@ L'Estrade, Elina T. @@aut@@ Hansen, Hanne D. @@aut@@ Villadsen, Jonas @@aut@@ Erlandsson, Maria @@aut@@ Ohlsson, Tomas @@aut@@ Yazdani, Abdolreza @@aut@@ Valliant, John F. @@aut@@ Kristensen, Jesper L. @@aut@@ Barz, Matthias @@aut@@ Knudsen, Gitte M. @@aut@@ Kjær, Andreas @@aut@@ Herth, Matthias M. @@aut@@ |
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540 610 DE-600 15,3 ssgn PHARM DE-84 fid 35.70 bkl 44.33 bkl 44.42 bkl Improved radiosynthesis and preliminary in vivo evaluation of the PET imaging Pretargeting Carbon-11 Tetrazine Trans-cyclooctene |
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Stéen, E. Johanna L. Jørgensen, Jesper T. Petersen, Ida N. Nørregaard, Kamilla Lehel, Szabolcs Shalgunov, Vladimir Birke, Alexander Edem, Patricia E. L'Estrade, Elina T. Hansen, Hanne D. Villadsen, Jonas Erlandsson, Maria Ohlsson, Tomas Yazdani, Abdolreza Valliant, John F. Kristensen, Jesper L. Barz, Matthias Knudsen, Gitte M. Kjær, Andreas Herth, Matthias M. |
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improved radiosynthesis and preliminary in vivo evaluation of the |
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Improved radiosynthesis and preliminary in vivo evaluation of the |
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Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. |
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Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. |
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Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently been shown to improve both imaging contrast and dosimetry in nuclear imaging of nanomedicines. Herein, we describe the improved radiosynthesis of a 11C-labeled tetrazine ([11C]AE-1) and its preliminary evaluation in both mice and pigs. Pretargeted imaging in mice was carried out using both a new TCO-functionalized polyglutamic acid and a previously reported TCO-functionalized bisphosphonate system as targeting agents. Unfortunately, pretargeted imaging was not successful using these targeting agents in pair with [11C]AE-1. However, brain imaging in pig indicated that the tracer crossed the blood-brain-barrier. Hence, we suggest that this tetrazine scaffold could be used as a starting point for the development of pretargeted brain imaging, which has so far been a challenging task. |
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