Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study

Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascul...
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Autor*in:	Vargas-Alarcón, Gilberto [verfasserIn] Pérez-Hernández, Nonanzit [verfasserIn] Rodríguez-Pérez, José Manuel [verfasserIn] Fragoso, José Manuel [verfasserIn] Posadas-Romero, Carlos [verfasserIn] López-Bautista, Fabiola [verfasserIn] Vázquez-Vázquez, Christian [verfasserIn] Posadas-Sánchez, Rosalinda [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis

Übergeordnetes Werk:	Enthalten in: Cytokine - Oxford [u.a.] : Elsevier, 1989, 114, Seite 32-37
Übergeordnetes Werk:	volume:114 ; pages:32-37

DOI / URN:	10.1016/j.cyto.2018.11.028

Katalog-ID:	ELV001855697

Internformat


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245	1	0	\|a Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study
264		1	\|c 2018
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat.
650		4	\|a Insulin resistance
650		4	\|a Interleukin 27
650		4	\|a Hypertension
650		4	\|a Hypoadiponectinemia
650		4	\|a Polymorphisms
650		4	\|a Subclinical atherosclerosis
700	1		\|a Pérez-Hernández, Nonanzit \|e verfasserin \|4 aut
700	1		\|a Rodríguez-Pérez, José Manuel \|e verfasserin \|4 aut
700	1		\|a Fragoso, José Manuel \|e verfasserin \|4 aut
700	1		\|a Posadas-Romero, Carlos \|e verfasserin \|4 aut
700	1		\|a López-Bautista, Fabiola \|e verfasserin \|0 (orcid)0000-0001-9607-6090 \|4 aut
700	1		\|a Vázquez-Vázquez, Christian \|e verfasserin \|4 aut
700	1		\|a Posadas-Sánchez, Rosalinda \|e verfasserin \|0 (orcid)0000-0001-8467-3488 \|4 aut
773	0	8	\|i Enthalten in \|t Cytokine \|d Oxford [u.a.] : Elsevier, 1989 \|g 114, Seite 32-37 \|h Online-Ressource \|w (DE-627)254909884 \|w (DE-600)1463198-2 \|w (DE-576)106801759 \|x 1096-0023 \|7 nnns
773	1	8	\|g volume:114 \|g pages:32-37
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912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
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912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
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912			\|a GBV_ILN_2059
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912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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936	b	k	\|a 44.00 \|j Medizin: Allgemeines
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Indexfelder

author_variant	g v a gva n p h nph j m r p jmr jmrp j m f jm jmf c p r cpr f l b flb c v v cvv r p s rps
matchkey_str	article:10960023:2018----::nelui2plmrhsshiascainihnuirssacadhicnrbtotsblncl
hierarchy_sort_str	2018
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publishDate	2018
allfields	10.1016/j.cyto.2018.11.028 doi (DE-627)ELV001855697 (ELSEVIER)S1043-4666(18)30470-8 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.00 bkl Vargas-Alarcón, Gilberto verfasserin aut Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat. Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis Pérez-Hernández, Nonanzit verfasserin aut Rodríguez-Pérez, José Manuel verfasserin aut Fragoso, José Manuel verfasserin aut Posadas-Romero, Carlos verfasserin aut López-Bautista, Fabiola verfasserin (orcid)0000-0001-9607-6090 aut Vázquez-Vázquez, Christian verfasserin aut Posadas-Sánchez, Rosalinda verfasserin (orcid)0000-0001-8467-3488 aut Enthalten in Cytokine Oxford [u.a.] : Elsevier, 1989 114, Seite 32-37 Online-Ressource (DE-627)254909884 (DE-600)1463198-2 (DE-576)106801759 1096-0023 nnns volume:114 pages:32-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.00 Medizin: Allgemeines AR 114 32-37
spelling	10.1016/j.cyto.2018.11.028 doi (DE-627)ELV001855697 (ELSEVIER)S1043-4666(18)30470-8 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.00 bkl Vargas-Alarcón, Gilberto verfasserin aut Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat. Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis Pérez-Hernández, Nonanzit verfasserin aut Rodríguez-Pérez, José Manuel verfasserin aut Fragoso, José Manuel verfasserin aut Posadas-Romero, Carlos verfasserin aut López-Bautista, Fabiola verfasserin (orcid)0000-0001-9607-6090 aut Vázquez-Vázquez, Christian verfasserin aut Posadas-Sánchez, Rosalinda verfasserin (orcid)0000-0001-8467-3488 aut Enthalten in Cytokine Oxford [u.a.] : Elsevier, 1989 114, Seite 32-37 Online-Ressource (DE-627)254909884 (DE-600)1463198-2 (DE-576)106801759 1096-0023 nnns volume:114 pages:32-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.00 Medizin: Allgemeines AR 114 32-37
allfields_unstemmed	10.1016/j.cyto.2018.11.028 doi (DE-627)ELV001855697 (ELSEVIER)S1043-4666(18)30470-8 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.00 bkl Vargas-Alarcón, Gilberto verfasserin aut Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat. Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis Pérez-Hernández, Nonanzit verfasserin aut Rodríguez-Pérez, José Manuel verfasserin aut Fragoso, José Manuel verfasserin aut Posadas-Romero, Carlos verfasserin aut López-Bautista, Fabiola verfasserin (orcid)0000-0001-9607-6090 aut Vázquez-Vázquez, Christian verfasserin aut Posadas-Sánchez, Rosalinda verfasserin (orcid)0000-0001-8467-3488 aut Enthalten in Cytokine Oxford [u.a.] : Elsevier, 1989 114, Seite 32-37 Online-Ressource (DE-627)254909884 (DE-600)1463198-2 (DE-576)106801759 1096-0023 nnns volume:114 pages:32-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.00 Medizin: Allgemeines AR 114 32-37
allfieldsGer	10.1016/j.cyto.2018.11.028 doi (DE-627)ELV001855697 (ELSEVIER)S1043-4666(18)30470-8 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.00 bkl Vargas-Alarcón, Gilberto verfasserin aut Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat. Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis Pérez-Hernández, Nonanzit verfasserin aut Rodríguez-Pérez, José Manuel verfasserin aut Fragoso, José Manuel verfasserin aut Posadas-Romero, Carlos verfasserin aut López-Bautista, Fabiola verfasserin (orcid)0000-0001-9607-6090 aut Vázquez-Vázquez, Christian verfasserin aut Posadas-Sánchez, Rosalinda verfasserin (orcid)0000-0001-8467-3488 aut Enthalten in Cytokine Oxford [u.a.] : Elsevier, 1989 114, Seite 32-37 Online-Ressource (DE-627)254909884 (DE-600)1463198-2 (DE-576)106801759 1096-0023 nnns volume:114 pages:32-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.00 Medizin: Allgemeines AR 114 32-37
allfieldsSound	10.1016/j.cyto.2018.11.028 doi (DE-627)ELV001855697 (ELSEVIER)S1043-4666(18)30470-8 DE-627 ger DE-627 rda eng 570 DE-600 BIODIV DE-30 fid 44.00 bkl Vargas-Alarcón, Gilberto verfasserin aut Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat. Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis Pérez-Hernández, Nonanzit verfasserin aut Rodríguez-Pérez, José Manuel verfasserin aut Fragoso, José Manuel verfasserin aut Posadas-Romero, Carlos verfasserin aut López-Bautista, Fabiola verfasserin (orcid)0000-0001-9607-6090 aut Vázquez-Vázquez, Christian verfasserin aut Posadas-Sánchez, Rosalinda verfasserin (orcid)0000-0001-8467-3488 aut Enthalten in Cytokine Oxford [u.a.] : Elsevier, 1989 114, Seite 32-37 Online-Ressource (DE-627)254909884 (DE-600)1463198-2 (DE-576)106801759 1096-0023 nnns volume:114 pages:32-37 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.00 Medizin: Allgemeines AR 114 32-37
language	English
source	Enthalten in Cytokine 114, Seite 32-37 volume:114 pages:32-37
sourceStr	Enthalten in Cytokine 114, Seite 32-37 volume:114 pages:32-37
format_phy_str_mv	Article
bklname	Medizin: Allgemeines
institution	findex.gbv.de
topic_facet	Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis
dewey-raw	570
isfreeaccess_bool	false
container_title	Cytokine
authorswithroles_txt_mv	Vargas-Alarcón, Gilberto @@aut@@ Pérez-Hernández, Nonanzit @@aut@@ Rodríguez-Pérez, José Manuel @@aut@@ Fragoso, José Manuel @@aut@@ Posadas-Romero, Carlos @@aut@@ López-Bautista, Fabiola @@aut@@ Vázquez-Vázquez, Christian @@aut@@ Posadas-Sánchez, Rosalinda @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	254909884
dewey-sort	3570
id	ELV001855697
language_de	englisch
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The GEA Mexican study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. 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author	Vargas-Alarcón, Gilberto
spellingShingle	Vargas-Alarcón, Gilberto ddc 570 fid BIODIV bkl 44.00 misc Insulin resistance misc Interleukin 27 misc Hypertension misc Hypoadiponectinemia misc Polymorphisms misc Subclinical atherosclerosis Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study
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topic_title	570 DE-600 BIODIV DE-30 fid 44.00 bkl Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study Insulin resistance Interleukin 27 Hypertension Hypoadiponectinemia Polymorphisms Subclinical atherosclerosis
topic	ddc 570 fid BIODIV bkl 44.00 misc Insulin resistance misc Interleukin 27 misc Hypertension misc Hypoadiponectinemia misc Polymorphisms misc Subclinical atherosclerosis
topic_unstemmed	ddc 570 fid BIODIV bkl 44.00 misc Insulin resistance misc Interleukin 27 misc Hypertension misc Hypoadiponectinemia misc Polymorphisms misc Subclinical atherosclerosis
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title	Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study
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title_full	Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study
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author_browse	Vargas-Alarcón, Gilberto Pérez-Hernández, Nonanzit Rodríguez-Pérez, José Manuel Fragoso, José Manuel Posadas-Romero, Carlos López-Bautista, Fabiola Vázquez-Vázquez, Christian Posadas-Sánchez, Rosalinda
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title_sort	interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. the gea mexican study
title_auth	Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study
abstract	Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat.
abstractGer	Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat.
abstract_unstemmed	Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat.
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title_short	Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study
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author2	Pérez-Hernández, Nonanzit Rodríguez-Pérez, José Manuel Fragoso, José Manuel Posadas-Romero, Carlos López-Bautista, Fabiola Vázquez-Vázquez, Christian Posadas-Sánchez, Rosalinda
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up_date	2024-07-06T22:47:43.031Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV001855697</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524135200.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230428s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.cyto.2018.11.028</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV001855697</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1043-4666(18)30470-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Vargas-Alarcón, Gilberto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Under inheritance models adjusted for confounding factors, the rs153109A (0.78[0.64–0.94] Padditive = 0.008, 0.58[0.41–0.82] Precessive = 0.002, 0.57[0.38–0.83] Pcodominant2 = 0.004), rs26528T (0.78[0.64–0.94] Padditive = 0.008, 0.61[0.43–0.88] Precessive = 0.007, 0.57[0.38–0.84] Pcodominant2 = 0.004) and rs40837A (0.76[0.63–0.92] Padditive = 0.004; 0.60[0.42–0.86] Precessive = 0.005; 0.54[0.37–0.80] Pcodominant2 = 0.002) alleles were related with a decreased risk of IR. Moreover, AAATA haplotype that contains the protector alleles was related with 17% lower risk of presenting IR (0.83 [0.71–0.98], P = 0.023). After adjusting for potential confounding variables, IL-27p28 SNPs were not associated with SA. However, some SNPs were associated with hypertension (rs26528 and rs40837) and increased total abdominal fat (rs17855750) in non-IR individuals, whereas in IR subjects we observed an association of rs26528 and rs40837 with hypoadiponectinemia. Our evidence suggests that rs40837A, rs153109A, and rs26528T alleles could be envisaged as protective markers for IR. Some polymorphisms showed an association with hypertension, low adiponectin levels, and increased total abdominal fat.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Insulin resistance</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin 27</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypertension</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypoadiponectinemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polymorphisms</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Subclinical atherosclerosis</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pérez-Hernández, Nonanzit</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rodríguez-Pérez, José Manuel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fragoso, José Manuel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Posadas-Romero, Carlos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">López-Bautista, Fabiola</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-9607-6090</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vázquez-Vázquez, Christian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Posadas-Sánchez, Rosalinda</subfield><subfield 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Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study

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