Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time

Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule gr...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Farber, Leon [verfasserIn] Michaels, James N. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation

Übergeordnetes Werk:	Enthalten in: Chemical engineering research and design - Amsterdam : Elsevier, 1983, 132, Seite 1054-1059
Übergeordnetes Werk:	volume:132 ; pages:1054-1059

DOI / URN:	10.1016/j.cherd.2017.12.025

Katalog-ID:	ELV001870513

Internformat


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100	1		\|a Farber, Leon \|e verfasserin \|4 aut
245	1	0	\|a Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
264		1	\|c 2018
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520			\|a Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times.
650		4	\|a High shear wet granulation
650		4	\|a Granule structure
650		4	\|a Lactose- Micro-crystalline cellulose based granulation
700	1		\|a Michaels, James N. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Chemical engineering research and design \|d Amsterdam : Elsevier, 1983 \|g 132, Seite 1054-1059 \|h Online-Ressource \|w (DE-627)312841965 \|w (DE-600)2008006-2 \|w (DE-576)090893190 \|x 1744-3563 \|7 nnns
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936	b	k	\|a 58.10 \|j Verfahrenstechnik: Allgemeines
951			\|a AR
952			\|d 132 \|h 1054-1059

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matchkey_str	article:17443563:2018----::irsrcuefircytlieellsbsdrnlsrdcdyihhawtrn
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publishDate	2018
allfields	10.1016/j.cherd.2017.12.025 doi (DE-627)ELV001870513 (ELSEVIER)S0263-8762(17)30698-6 DE-627 ger DE-627 rda eng 540 660 DE-600 58.10 bkl Farber, Leon verfasserin aut Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times. High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation Michaels, James N. verfasserin aut Enthalten in Chemical engineering research and design Amsterdam : Elsevier, 1983 132, Seite 1054-1059 Online-Ressource (DE-627)312841965 (DE-600)2008006-2 (DE-576)090893190 1744-3563 nnns volume:132 pages:1054-1059 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_206 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.10 Verfahrenstechnik: Allgemeines AR 132 1054-1059
spelling	10.1016/j.cherd.2017.12.025 doi (DE-627)ELV001870513 (ELSEVIER)S0263-8762(17)30698-6 DE-627 ger DE-627 rda eng 540 660 DE-600 58.10 bkl Farber, Leon verfasserin aut Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times. High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation Michaels, James N. verfasserin aut Enthalten in Chemical engineering research and design Amsterdam : Elsevier, 1983 132, Seite 1054-1059 Online-Ressource (DE-627)312841965 (DE-600)2008006-2 (DE-576)090893190 1744-3563 nnns volume:132 pages:1054-1059 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_206 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.10 Verfahrenstechnik: Allgemeines AR 132 1054-1059
allfields_unstemmed	10.1016/j.cherd.2017.12.025 doi (DE-627)ELV001870513 (ELSEVIER)S0263-8762(17)30698-6 DE-627 ger DE-627 rda eng 540 660 DE-600 58.10 bkl Farber, Leon verfasserin aut Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times. High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation Michaels, James N. verfasserin aut Enthalten in Chemical engineering research and design Amsterdam : Elsevier, 1983 132, Seite 1054-1059 Online-Ressource (DE-627)312841965 (DE-600)2008006-2 (DE-576)090893190 1744-3563 nnns volume:132 pages:1054-1059 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_206 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.10 Verfahrenstechnik: Allgemeines AR 132 1054-1059
allfieldsGer	10.1016/j.cherd.2017.12.025 doi (DE-627)ELV001870513 (ELSEVIER)S0263-8762(17)30698-6 DE-627 ger DE-627 rda eng 540 660 DE-600 58.10 bkl Farber, Leon verfasserin aut Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times. High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation Michaels, James N. verfasserin aut Enthalten in Chemical engineering research and design Amsterdam : Elsevier, 1983 132, Seite 1054-1059 Online-Ressource (DE-627)312841965 (DE-600)2008006-2 (DE-576)090893190 1744-3563 nnns volume:132 pages:1054-1059 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_206 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.10 Verfahrenstechnik: Allgemeines AR 132 1054-1059
allfieldsSound	10.1016/j.cherd.2017.12.025 doi (DE-627)ELV001870513 (ELSEVIER)S0263-8762(17)30698-6 DE-627 ger DE-627 rda eng 540 660 DE-600 58.10 bkl Farber, Leon verfasserin aut Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times. High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation Michaels, James N. verfasserin aut Enthalten in Chemical engineering research and design Amsterdam : Elsevier, 1983 132, Seite 1054-1059 Online-Ressource (DE-627)312841965 (DE-600)2008006-2 (DE-576)090893190 1744-3563 nnns volume:132 pages:1054-1059 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_206 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.10 Verfahrenstechnik: Allgemeines AR 132 1054-1059
language	English
source	Enthalten in Chemical engineering research and design 132, Seite 1054-1059 volume:132 pages:1054-1059
sourceStr	Enthalten in Chemical engineering research and design 132, Seite 1054-1059 volume:132 pages:1054-1059
format_phy_str_mv	Article
bklname	Verfahrenstechnik: Allgemeines
institution	findex.gbv.de
topic_facet	High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation
dewey-raw	540
isfreeaccess_bool	false
container_title	Chemical engineering research and design
authorswithroles_txt_mv	Farber, Leon @@aut@@ Michaels, James N. @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	312841965
dewey-sort	3540
id	ELV001870513
language_de	englisch
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author	Farber, Leon
spellingShingle	Farber, Leon ddc 540 bkl 58.10 misc High shear wet granulation misc Granule structure misc Lactose- Micro-crystalline cellulose based granulation Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
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topic_title	540 660 DE-600 58.10 bkl Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time High shear wet granulation Granule structure Lactose- Micro-crystalline cellulose based granulation
topic	ddc 540 bkl 58.10 misc High shear wet granulation misc Granule structure misc Lactose- Micro-crystalline cellulose based granulation
topic_unstemmed	ddc 540 bkl 58.10 misc High shear wet granulation misc Granule structure misc Lactose- Micro-crystalline cellulose based granulation
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title	Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
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title_full	Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
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title_sort	microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
title_auth	Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
abstract	Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times.
abstractGer	Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times.
abstract_unstemmed	Design and scale-up of batch high-shear granulation is complicated by the interplay of granule nucleation, growth, and breakage and their non-linear dependence on liquid binder addition rate and granulation time. In an earlier paper, we demonstrated that during extended wet massing times, granule growth and breakage rates become equal (pseudo-steady-state granulation), and the ultimate granule size distribution depends only on agitation intensity and granulating fluid level. This significantly simplifies scale-up. The granule size distributions produced in these long granulation times were quite narrow compared to those produced in more typical granulation times.
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title_short	Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time
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up_date	2024-07-06T22:50:48.268Z
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Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time

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