Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab
Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Blumenthal, Deborah T. [verfasserIn] Kanner, Andrew A. [verfasserIn] Aizenstein, Orna [verfasserIn] Cagnano, Emanuela [verfasserIn] Greenberg, Ariel [verfasserIn] Hershkovitz, Dov [verfasserIn] Ram, Zvi [verfasserIn] Bokstein, Felix [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: World neurosurgery - Amsterdam : Elsevier, 2010, 110, Seite e727-e737 |
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| Übergeordnetes Werk: |
volume:110 ; pages:e727-e737 |
| DOI / URN: |
10.1016/j.wneu.2017.11.105 |
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ELV001947362 |
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| 520 | |a Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. | ||
| 650 | 4 | |a Bevacizumab | |
| 650 | 4 | |a Mean vessel density | |
| 650 | 4 | |a Postoperative complication | |
| 650 | 4 | |a Recurrent high-grade glioma | |
| 650 | 4 | |a Surgical resection | |
| 700 | 1 | |a Kanner, Andrew A. |e verfasserin |4 aut | |
| 700 | 1 | |a Aizenstein, Orna |e verfasserin |4 aut | |
| 700 | 1 | |a Cagnano, Emanuela |e verfasserin |4 aut | |
| 700 | 1 | |a Greenberg, Ariel |e verfasserin |4 aut | |
| 700 | 1 | |a Hershkovitz, Dov |e verfasserin |4 aut | |
| 700 | 1 | |a Ram, Zvi |e verfasserin |4 aut | |
| 700 | 1 | |a Bokstein, Felix |e verfasserin |0 (orcid)0000-0002-5870-9499 |4 aut | |
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10.1016/j.wneu.2017.11.105 doi (DE-627)ELV001947362 (ELSEVIER)S1878-8750(17)32028-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Blumenthal, Deborah T. verfasserin aut Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. Bevacizumab Mean vessel density Postoperative complication Recurrent high-grade glioma Surgical resection Kanner, Andrew A. verfasserin aut Aizenstein, Orna verfasserin aut Cagnano, Emanuela verfasserin aut Greenberg, Ariel verfasserin aut Hershkovitz, Dov verfasserin aut Ram, Zvi verfasserin aut Bokstein, Felix verfasserin (orcid)0000-0002-5870-9499 aut Enthalten in World neurosurgery Amsterdam : Elsevier, 2010 110, Seite e727-e737 Online-Ressource (DE-627)615134904 (DE-600)2530041-6 (DE-576)321461150 1878-8769 nnns volume:110 pages:e727-e737 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 110 e727-e737 |
| spelling |
10.1016/j.wneu.2017.11.105 doi (DE-627)ELV001947362 (ELSEVIER)S1878-8750(17)32028-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Blumenthal, Deborah T. verfasserin aut Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. Bevacizumab Mean vessel density Postoperative complication Recurrent high-grade glioma Surgical resection Kanner, Andrew A. verfasserin aut Aizenstein, Orna verfasserin aut Cagnano, Emanuela verfasserin aut Greenberg, Ariel verfasserin aut Hershkovitz, Dov verfasserin aut Ram, Zvi verfasserin aut Bokstein, Felix verfasserin (orcid)0000-0002-5870-9499 aut Enthalten in World neurosurgery Amsterdam : Elsevier, 2010 110, Seite e727-e737 Online-Ressource (DE-627)615134904 (DE-600)2530041-6 (DE-576)321461150 1878-8769 nnns volume:110 pages:e727-e737 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 110 e727-e737 |
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10.1016/j.wneu.2017.11.105 doi (DE-627)ELV001947362 (ELSEVIER)S1878-8750(17)32028-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Blumenthal, Deborah T. verfasserin aut Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. Bevacizumab Mean vessel density Postoperative complication Recurrent high-grade glioma Surgical resection Kanner, Andrew A. verfasserin aut Aizenstein, Orna verfasserin aut Cagnano, Emanuela verfasserin aut Greenberg, Ariel verfasserin aut Hershkovitz, Dov verfasserin aut Ram, Zvi verfasserin aut Bokstein, Felix verfasserin (orcid)0000-0002-5870-9499 aut Enthalten in World neurosurgery Amsterdam : Elsevier, 2010 110, Seite e727-e737 Online-Ressource (DE-627)615134904 (DE-600)2530041-6 (DE-576)321461150 1878-8769 nnns volume:110 pages:e727-e737 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 110 e727-e737 |
| allfieldsGer |
10.1016/j.wneu.2017.11.105 doi (DE-627)ELV001947362 (ELSEVIER)S1878-8750(17)32028-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Blumenthal, Deborah T. verfasserin aut Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. Bevacizumab Mean vessel density Postoperative complication Recurrent high-grade glioma Surgical resection Kanner, Andrew A. verfasserin aut Aizenstein, Orna verfasserin aut Cagnano, Emanuela verfasserin aut Greenberg, Ariel verfasserin aut Hershkovitz, Dov verfasserin aut Ram, Zvi verfasserin aut Bokstein, Felix verfasserin (orcid)0000-0002-5870-9499 aut Enthalten in World neurosurgery Amsterdam : Elsevier, 2010 110, Seite e727-e737 Online-Ressource (DE-627)615134904 (DE-600)2530041-6 (DE-576)321461150 1878-8769 nnns volume:110 pages:e727-e737 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 110 e727-e737 |
| allfieldsSound |
10.1016/j.wneu.2017.11.105 doi (DE-627)ELV001947362 (ELSEVIER)S1878-8750(17)32028-4 DE-627 ger DE-627 rda eng 610 DE-600 44.90 bkl Blumenthal, Deborah T. verfasserin aut Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab 2017 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. Bevacizumab Mean vessel density Postoperative complication Recurrent high-grade glioma Surgical resection Kanner, Andrew A. verfasserin aut Aizenstein, Orna verfasserin aut Cagnano, Emanuela verfasserin aut Greenberg, Ariel verfasserin aut Hershkovitz, Dov verfasserin aut Ram, Zvi verfasserin aut Bokstein, Felix verfasserin (orcid)0000-0002-5870-9499 aut Enthalten in World neurosurgery Amsterdam : Elsevier, 2010 110, Seite e727-e737 Online-Ressource (DE-627)615134904 (DE-600)2530041-6 (DE-576)321461150 1878-8769 nnns volume:110 pages:e727-e737 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_151 GBV_ILN_165 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie AR 110 e727-e737 |
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Blumenthal, Deborah T. @@aut@@ Kanner, Andrew A. @@aut@@ Aizenstein, Orna @@aut@@ Cagnano, Emanuela @@aut@@ Greenberg, Ariel @@aut@@ Hershkovitz, Dov @@aut@@ Ram, Zvi @@aut@@ Bokstein, Felix @@aut@@ |
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Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. 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Blumenthal, Deborah T. |
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Blumenthal, Deborah T. ddc 610 bkl 44.90 misc Bevacizumab misc Mean vessel density misc Postoperative complication misc Recurrent high-grade glioma misc Surgical resection Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab |
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610 DE-600 44.90 bkl Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab Bevacizumab Mean vessel density Postoperative complication Recurrent high-grade glioma Surgical resection |
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ddc 610 bkl 44.90 misc Bevacizumab misc Mean vessel density misc Postoperative complication misc Recurrent high-grade glioma misc Surgical resection |
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Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab |
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Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab |
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Blumenthal, Deborah T. Kanner, Andrew A. Aizenstein, Orna Cagnano, Emanuela Greenberg, Ariel Hershkovitz, Dov Ram, Zvi Bokstein, Felix |
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10.1016/j.wneu.2017.11.105 |
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surgery for recurrent high-grade glioma after treatment with bevacizumab |
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Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab |
| abstract |
Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. |
| abstractGer |
Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. |
| abstract_unstemmed |
Background: Bevacizumab (BVZ) is an antiangiogenic agent approved by the Food and Drug Administration that is used for the treatment of recurrent glioblastoma. Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. Mean tumor vessel density may be decreased after treatment with BVZ. |
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Surgery for Recurrent High-Grade Glioma After Treatment with Bevacizumab |
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true |
| author2 |
Kanner, Andrew A. Aizenstein, Orna Cagnano, Emanuela Greenberg, Ariel Hershkovitz, Dov Ram, Zvi Bokstein, Felix |
| author2Str |
Kanner, Andrew A. Aizenstein, Orna Cagnano, Emanuela Greenberg, Ariel Hershkovitz, Dov Ram, Zvi Bokstein, Felix |
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615134904 |
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| doi_str |
10.1016/j.wneu.2017.11.105 |
| up_date |
2024-07-06T23:06:33.371Z |
| _version_ |
1803872835598286848 |
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Complications related to impaired healing may adversely affect patients resected for recurrent high-grade glioma (HGG) after treatment with BVZ.Objective: To examine the complication rate, outcome, and tumor vasculature in patients resected for recurrent HGG after treatment with BVZ.Methods: Data were reviewed retrospectively from patients undergoing surgery for recurrent HGG after treatment with BVZ. Results were compared with a control group of recurrently operated BVZ-naïve HGG. Tumor samples and magnetic resonance imaging scans were analyzed.Results: Fifteen patients underwent HGG resection after progression after BVZ. Forty-four BVZ-naïve patients who underwent surgeries for tumor recurrence were included as controls. Median time from BVZ treatment to surgery was 30 days (2–107). Median overall survival from time of tumor diagnosis was 21.0 months (12–83.0), and median survival from post-BVZ surgery was 5.0 months (2.0–19.0), compared with 8.1 months in BVZ-naïve controls measured from time of their last reoperation. Five of the 15 patients survived 6 or more months after post-BVZ surgery. Nine patients developed postsurgical complications requiring intervention. Complication rates for surgery after BVZ treatment were 66.7% compared with 38.6% in the control group (P = 0.077). We did not see overt changes in histopathology or immunohistochemistry staining; however, tumor vasculature in tumors resected after treatment with BVZ showed a significant decrease in mean vessel density.Conclusions: Surgery for recurrent HGG may be feasible in a select group of patients. 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