Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis
Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Blank, Nina R. [verfasserIn] Hibler, Brian P. [verfasserIn] Tattersall, Ian W. [verfasserIn] Ensslin, Courtney J. [verfasserIn] Lee, Erica H. [verfasserIn] Dusza, Stephen W. [verfasserIn] Nehal, Kishwer S. [verfasserIn] Busam, Klaus J. [verfasserIn] Rossi, Anthony M. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation |
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| Übergeordnetes Werk: |
Enthalten in: Journal of the American Academy of Dermatology - American Academy of Dermatology ; ID: gnd/1053786-7, Amsterdam [u.a.] : Elsevier, 1979, 80, Seite 1403-1409 |
|---|---|
| Übergeordnetes Werk: |
volume:80 ; pages:1403-1409 |
| DOI / URN: |
10.1016/j.jaad.2019.01.005 |
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ELV002065266 |
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| 245 | 1 | 0 | |a Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis |
| 264 | 1 | |c 2019 | |
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| 520 | |a Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. | ||
| 650 | 4 | |a ambiguous melanocytic lesions | |
| 650 | 4 | |a atypical intraepidermal melanocytic proliferation | |
| 650 | 4 | |a atypical junctional melanocytic hyperplasia | |
| 650 | 4 | |a atypical junctional melanocytic proliferation | |
| 650 | 4 | |a atypical melanocytic proliferation | |
| 650 | 4 | |a biopsy | |
| 650 | 4 | |a excision | |
| 650 | 4 | |a lentiginous junctional melanocytic proliferation | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a melanoma in situ | |
| 700 | 1 | |a Hibler, Brian P. |e verfasserin |4 aut | |
| 700 | 1 | |a Tattersall, Ian W. |e verfasserin |4 aut | |
| 700 | 1 | |a Ensslin, Courtney J. |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Erica H. |e verfasserin |4 aut | |
| 700 | 1 | |a Dusza, Stephen W. |e verfasserin |4 aut | |
| 700 | 1 | |a Nehal, Kishwer S. |e verfasserin |4 aut | |
| 700 | 1 | |a Busam, Klaus J. |e verfasserin |4 aut | |
| 700 | 1 | |a Rossi, Anthony M. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a American Academy of Dermatology ; ID: gnd/1053786-7 |t Journal of the American Academy of Dermatology |d Amsterdam [u.a.] : Elsevier, 1979 |g 80, Seite 1403-1409 |h Online-Ressource |w (DE-627)320411745 |w (DE-600)2001404-1 |w (DE-576)094426791 |x 1097-6787 |7 nnns |
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2019 |
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10.1016/j.jaad.2019.01.005 doi (DE-627)ELV002065266 (ELSEVIER)S0190-9622(19)30072-6 DE-627 ger DE-627 rda eng 610 DE-600 44.93 bkl Blank, Nina R. verfasserin aut Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. ambiguous melanocytic lesions atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation biopsy excision lentiginous junctional melanocytic proliferation melanoma melanoma in situ Hibler, Brian P. verfasserin aut Tattersall, Ian W. verfasserin aut Ensslin, Courtney J. verfasserin aut Lee, Erica H. verfasserin aut Dusza, Stephen W. verfasserin aut Nehal, Kishwer S. verfasserin aut Busam, Klaus J. verfasserin aut Rossi, Anthony M. verfasserin aut Enthalten in American Academy of Dermatology ; ID: gnd/1053786-7 Journal of the American Academy of Dermatology Amsterdam [u.a.] : Elsevier, 1979 80, Seite 1403-1409 Online-Ressource (DE-627)320411745 (DE-600)2001404-1 (DE-576)094426791 1097-6787 nnns volume:80 pages:1403-1409 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.93 Dermatologie AR 80 1403-1409 |
| spelling |
10.1016/j.jaad.2019.01.005 doi (DE-627)ELV002065266 (ELSEVIER)S0190-9622(19)30072-6 DE-627 ger DE-627 rda eng 610 DE-600 44.93 bkl Blank, Nina R. verfasserin aut Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. ambiguous melanocytic lesions atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation biopsy excision lentiginous junctional melanocytic proliferation melanoma melanoma in situ Hibler, Brian P. verfasserin aut Tattersall, Ian W. verfasserin aut Ensslin, Courtney J. verfasserin aut Lee, Erica H. verfasserin aut Dusza, Stephen W. verfasserin aut Nehal, Kishwer S. verfasserin aut Busam, Klaus J. verfasserin aut Rossi, Anthony M. verfasserin aut Enthalten in American Academy of Dermatology ; ID: gnd/1053786-7 Journal of the American Academy of Dermatology Amsterdam [u.a.] : Elsevier, 1979 80, Seite 1403-1409 Online-Ressource (DE-627)320411745 (DE-600)2001404-1 (DE-576)094426791 1097-6787 nnns volume:80 pages:1403-1409 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.93 Dermatologie AR 80 1403-1409 |
| allfields_unstemmed |
10.1016/j.jaad.2019.01.005 doi (DE-627)ELV002065266 (ELSEVIER)S0190-9622(19)30072-6 DE-627 ger DE-627 rda eng 610 DE-600 44.93 bkl Blank, Nina R. verfasserin aut Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. ambiguous melanocytic lesions atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation biopsy excision lentiginous junctional melanocytic proliferation melanoma melanoma in situ Hibler, Brian P. verfasserin aut Tattersall, Ian W. verfasserin aut Ensslin, Courtney J. verfasserin aut Lee, Erica H. verfasserin aut Dusza, Stephen W. verfasserin aut Nehal, Kishwer S. verfasserin aut Busam, Klaus J. verfasserin aut Rossi, Anthony M. verfasserin aut Enthalten in American Academy of Dermatology ; ID: gnd/1053786-7 Journal of the American Academy of Dermatology Amsterdam [u.a.] : Elsevier, 1979 80, Seite 1403-1409 Online-Ressource (DE-627)320411745 (DE-600)2001404-1 (DE-576)094426791 1097-6787 nnns volume:80 pages:1403-1409 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.93 Dermatologie AR 80 1403-1409 |
| allfieldsGer |
10.1016/j.jaad.2019.01.005 doi (DE-627)ELV002065266 (ELSEVIER)S0190-9622(19)30072-6 DE-627 ger DE-627 rda eng 610 DE-600 44.93 bkl Blank, Nina R. verfasserin aut Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. ambiguous melanocytic lesions atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation biopsy excision lentiginous junctional melanocytic proliferation melanoma melanoma in situ Hibler, Brian P. verfasserin aut Tattersall, Ian W. verfasserin aut Ensslin, Courtney J. verfasserin aut Lee, Erica H. verfasserin aut Dusza, Stephen W. verfasserin aut Nehal, Kishwer S. verfasserin aut Busam, Klaus J. verfasserin aut Rossi, Anthony M. verfasserin aut Enthalten in American Academy of Dermatology ; ID: gnd/1053786-7 Journal of the American Academy of Dermatology Amsterdam [u.a.] : Elsevier, 1979 80, Seite 1403-1409 Online-Ressource (DE-627)320411745 (DE-600)2001404-1 (DE-576)094426791 1097-6787 nnns volume:80 pages:1403-1409 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.93 Dermatologie AR 80 1403-1409 |
| allfieldsSound |
10.1016/j.jaad.2019.01.005 doi (DE-627)ELV002065266 (ELSEVIER)S0190-9622(19)30072-6 DE-627 ger DE-627 rda eng 610 DE-600 44.93 bkl Blank, Nina R. verfasserin aut Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. ambiguous melanocytic lesions atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation biopsy excision lentiginous junctional melanocytic proliferation melanoma melanoma in situ Hibler, Brian P. verfasserin aut Tattersall, Ian W. verfasserin aut Ensslin, Courtney J. verfasserin aut Lee, Erica H. verfasserin aut Dusza, Stephen W. verfasserin aut Nehal, Kishwer S. verfasserin aut Busam, Klaus J. verfasserin aut Rossi, Anthony M. verfasserin aut Enthalten in American Academy of Dermatology ; ID: gnd/1053786-7 Journal of the American Academy of Dermatology Amsterdam [u.a.] : Elsevier, 1979 80, Seite 1403-1409 Online-Ressource (DE-627)320411745 (DE-600)2001404-1 (DE-576)094426791 1097-6787 nnns volume:80 pages:1403-1409 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.93 Dermatologie AR 80 1403-1409 |
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Blank, Nina R. @@aut@@ Hibler, Brian P. @@aut@@ Tattersall, Ian W. @@aut@@ Ensslin, Courtney J. @@aut@@ Lee, Erica H. @@aut@@ Dusza, Stephen W. @@aut@@ Nehal, Kishwer S. @@aut@@ Busam, Klaus J. @@aut@@ Rossi, Anthony M. @@aut@@ |
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Blank, Nina R. |
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Blank, Nina R. ddc 610 bkl 44.93 misc ambiguous melanocytic lesions misc atypical intraepidermal melanocytic proliferation misc atypical junctional melanocytic hyperplasia misc atypical junctional melanocytic proliferation misc atypical melanocytic proliferation misc biopsy misc excision misc lentiginous junctional melanocytic proliferation misc melanoma misc melanoma in situ Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis |
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610 DE-600 44.93 bkl Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis ambiguous melanocytic lesions atypical intraepidermal melanocytic proliferation atypical junctional melanocytic hyperplasia atypical junctional melanocytic proliferation atypical melanocytic proliferation biopsy excision lentiginous junctional melanocytic proliferation melanoma melanoma in situ |
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ddc 610 bkl 44.93 misc ambiguous melanocytic lesions misc atypical intraepidermal melanocytic proliferation misc atypical junctional melanocytic hyperplasia misc atypical junctional melanocytic proliferation misc atypical melanocytic proliferation misc biopsy misc excision misc lentiginous junctional melanocytic proliferation misc melanoma misc melanoma in situ |
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ddc 610 bkl 44.93 misc ambiguous melanocytic lesions misc atypical intraepidermal melanocytic proliferation misc atypical junctional melanocytic hyperplasia misc atypical junctional melanocytic proliferation misc atypical melanocytic proliferation misc biopsy misc excision misc lentiginous junctional melanocytic proliferation misc melanoma misc melanoma in situ |
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ddc 610 bkl 44.93 misc ambiguous melanocytic lesions misc atypical intraepidermal melanocytic proliferation misc atypical junctional melanocytic hyperplasia misc atypical junctional melanocytic proliferation misc atypical melanocytic proliferation misc biopsy misc excision misc lentiginous junctional melanocytic proliferation misc melanoma misc melanoma in situ |
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Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis |
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Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis |
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Blank, Nina R. |
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Journal of the American Academy of Dermatology |
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Blank, Nina R. Hibler, Brian P. Tattersall, Ian W. Ensslin, Courtney J. Lee, Erica H. Dusza, Stephen W. Nehal, Kishwer S. Busam, Klaus J. Rossi, Anthony M. |
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10.1016/j.jaad.2019.01.005 |
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melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: a retrospective cross-sectional analysis |
| title_auth |
Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis |
| abstract |
Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. |
| abstractGer |
Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. |
| abstract_unstemmed |
Background: There is little evidence to guide surgical management of biopsies yielding the histologic descriptor atypical intraepidermal melanocytic proliferation (AIMP).Objective: Determine frequency of and factors associated with melanoma and melanoma in-situ (MIS) diagnoses after excision of AIMP and evaluate margins used to completely excise AIMP.Methods: Retrospective, cross-sectional study of 1127 biopsies reported as AIMP and subsequently excised within one academic institution.Results: Melanoma (in situ, stage 1A) was diagnosed after excision in 8.2% (92/1127) of AIMP samples. Characteristics associated with melanoma/MIS diagnosis included age 60-79 years (odds ratio [OR] 8.1, 95% confidence interval [CI] 2.5-26.2), age ≥80 years (OR 7.2, 95% CI 1.7-31.5), head/neck location (OR 4.9, 95% CI 3.1-7.7), clinical lesion partially biopsied (OR 11.0, 95% CI 6.7-18.1), and lesion extending to deep biopsy margin (OR 15.1, 95% CI 1.7-136.0). Average ± standard deviation surgical margin used to excise AIMP lesions was 4.5 ± 1.8 mm.Limitations: Single-site, retrospective, observational study; interobserver variability across dermatopathologists.Conclusion: Dermatologists and pathologists can endeavor to avoid ambiguous melanocytic designations whenever possible through excisional biopsy technique, interdisciplinary communication, and ancillary studies. In the event of AIMP biopsy, physicians should consider the term a histologic description rather than a diagnosis, and, during surgical planning, use clinicopathologic correlation while bearing in mind factors that might predict true melanoma/MIS. |
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Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis |
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