Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study
Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter pro...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Polterauer, Stephan [verfasserIn] Schwameis, Richard [verfasserIn] Grimm, Christoph [verfasserIn] Hillemanns, Peter [verfasserIn] Jückstock, Julia [verfasserIn] Hilpert, Felix [verfasserIn] de Gregorio, Nikolaus [verfasserIn] Hasenburg, Annette [verfasserIn] Sehouli, Jalid [verfasserIn] Fürst, Sophie Theresa [verfasserIn] Strauß, Hans Georg [verfasserIn] Baumann, Klaus [verfasserIn] Thiel, Falk [verfasserIn] Mustea, Alexander [verfasserIn] Harter, Philipp [verfasserIn] Wimberger, Pauline [verfasserIn] Kölbl, Heinz [verfasserIn] Reinthaller, Alexander [verfasserIn] Woelber, Linn [verfasserIn] Mahner, Sven [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Gynecologic oncology - Orlando, Fla. : Academic Press, 1972, 153 |
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| Übergeordnetes Werk: |
volume:153 |
| DOI / URN: |
10.1016/j.ygyno.2019.02.007 |
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ELV002122049 |
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| 024 | 7 | |a 10.1016/j.ygyno.2019.02.007 |2 doi | |
| 035 | |a (DE-627)ELV002122049 | ||
| 035 | |a (ELSEVIER)S0090-8258(19)30112-X | ||
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| 100 | 1 | |a Polterauer, Stephan |e verfasserin |0 (orcid)0000-0002-9649-4505 |4 aut | |
| 245 | 1 | 0 | |a Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study |
| 264 | 1 | |c 2019 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. | ||
| 650 | 4 | |a Lymph node metastases | |
| 650 | 4 | |a Lymph node ratio | |
| 650 | 4 | |a Cancer prognosis | |
| 650 | 4 | |a Cancer recurrence | |
| 650 | 4 | |a Vulvar cancer | |
| 700 | 1 | |a Schwameis, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Grimm, Christoph |e verfasserin |0 (orcid)0000-0003-2948-8129 |4 aut | |
| 700 | 1 | |a Hillemanns, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Jückstock, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Hilpert, Felix |e verfasserin |4 aut | |
| 700 | 1 | |a de Gregorio, Nikolaus |e verfasserin |4 aut | |
| 700 | 1 | |a Hasenburg, Annette |e verfasserin |4 aut | |
| 700 | 1 | |a Sehouli, Jalid |e verfasserin |4 aut | |
| 700 | 1 | |a Fürst, Sophie Theresa |e verfasserin |4 aut | |
| 700 | 1 | |a Strauß, Hans Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Baumann, Klaus |e verfasserin |4 aut | |
| 700 | 1 | |a Thiel, Falk |e verfasserin |4 aut | |
| 700 | 1 | |a Mustea, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Harter, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Wimberger, Pauline |e verfasserin |4 aut | |
| 700 | 1 | |a Kölbl, Heinz |e verfasserin |4 aut | |
| 700 | 1 | |a Reinthaller, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Woelber, Linn |e verfasserin |4 aut | |
| 700 | 1 | |a Mahner, Sven |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gynecologic oncology |d Orlando, Fla. : Academic Press, 1972 |g 153 |h Online-Ressource |w (DE-627)266881351 |w (DE-600)1467974-7 |w (DE-576)104193735 |x 1095-6859 |7 nnns |
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2019 |
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2019 |
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10.1016/j.ygyno.2019.02.007 doi (DE-627)ELV002122049 (ELSEVIER)S0090-8258(19)30112-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Polterauer, Stephan verfasserin (orcid)0000-0002-9649-4505 aut Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer Schwameis, Richard verfasserin aut Grimm, Christoph verfasserin (orcid)0000-0003-2948-8129 aut Hillemanns, Peter verfasserin aut Jückstock, Julia verfasserin aut Hilpert, Felix verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Sehouli, Jalid verfasserin aut Fürst, Sophie Theresa verfasserin aut Strauß, Hans Georg verfasserin aut Baumann, Klaus verfasserin aut Thiel, Falk verfasserin aut Mustea, Alexander verfasserin aut Harter, Philipp verfasserin aut Wimberger, Pauline verfasserin aut Kölbl, Heinz verfasserin aut Reinthaller, Alexander verfasserin aut Woelber, Linn verfasserin aut Mahner, Sven verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 153 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:153 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 153 |
| spelling |
10.1016/j.ygyno.2019.02.007 doi (DE-627)ELV002122049 (ELSEVIER)S0090-8258(19)30112-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Polterauer, Stephan verfasserin (orcid)0000-0002-9649-4505 aut Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer Schwameis, Richard verfasserin aut Grimm, Christoph verfasserin (orcid)0000-0003-2948-8129 aut Hillemanns, Peter verfasserin aut Jückstock, Julia verfasserin aut Hilpert, Felix verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Sehouli, Jalid verfasserin aut Fürst, Sophie Theresa verfasserin aut Strauß, Hans Georg verfasserin aut Baumann, Klaus verfasserin aut Thiel, Falk verfasserin aut Mustea, Alexander verfasserin aut Harter, Philipp verfasserin aut Wimberger, Pauline verfasserin aut Kölbl, Heinz verfasserin aut Reinthaller, Alexander verfasserin aut Woelber, Linn verfasserin aut Mahner, Sven verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 153 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:153 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 153 |
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10.1016/j.ygyno.2019.02.007 doi (DE-627)ELV002122049 (ELSEVIER)S0090-8258(19)30112-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Polterauer, Stephan verfasserin (orcid)0000-0002-9649-4505 aut Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer Schwameis, Richard verfasserin aut Grimm, Christoph verfasserin (orcid)0000-0003-2948-8129 aut Hillemanns, Peter verfasserin aut Jückstock, Julia verfasserin aut Hilpert, Felix verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Sehouli, Jalid verfasserin aut Fürst, Sophie Theresa verfasserin aut Strauß, Hans Georg verfasserin aut Baumann, Klaus verfasserin aut Thiel, Falk verfasserin aut Mustea, Alexander verfasserin aut Harter, Philipp verfasserin aut Wimberger, Pauline verfasserin aut Kölbl, Heinz verfasserin aut Reinthaller, Alexander verfasserin aut Woelber, Linn verfasserin aut Mahner, Sven verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 153 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:153 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 153 |
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10.1016/j.ygyno.2019.02.007 doi (DE-627)ELV002122049 (ELSEVIER)S0090-8258(19)30112-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Polterauer, Stephan verfasserin (orcid)0000-0002-9649-4505 aut Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer Schwameis, Richard verfasserin aut Grimm, Christoph verfasserin (orcid)0000-0003-2948-8129 aut Hillemanns, Peter verfasserin aut Jückstock, Julia verfasserin aut Hilpert, Felix verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Sehouli, Jalid verfasserin aut Fürst, Sophie Theresa verfasserin aut Strauß, Hans Georg verfasserin aut Baumann, Klaus verfasserin aut Thiel, Falk verfasserin aut Mustea, Alexander verfasserin aut Harter, Philipp verfasserin aut Wimberger, Pauline verfasserin aut Kölbl, Heinz verfasserin aut Reinthaller, Alexander verfasserin aut Woelber, Linn verfasserin aut Mahner, Sven verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 153 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:153 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 153 |
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10.1016/j.ygyno.2019.02.007 doi (DE-627)ELV002122049 (ELSEVIER)S0090-8258(19)30112-X DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.92 bkl Polterauer, Stephan verfasserin (orcid)0000-0002-9649-4505 aut Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer Schwameis, Richard verfasserin aut Grimm, Christoph verfasserin (orcid)0000-0003-2948-8129 aut Hillemanns, Peter verfasserin aut Jückstock, Julia verfasserin aut Hilpert, Felix verfasserin aut de Gregorio, Nikolaus verfasserin aut Hasenburg, Annette verfasserin aut Sehouli, Jalid verfasserin aut Fürst, Sophie Theresa verfasserin aut Strauß, Hans Georg verfasserin aut Baumann, Klaus verfasserin aut Thiel, Falk verfasserin aut Mustea, Alexander verfasserin aut Harter, Philipp verfasserin aut Wimberger, Pauline verfasserin aut Kölbl, Heinz verfasserin aut Reinthaller, Alexander verfasserin aut Woelber, Linn verfasserin aut Mahner, Sven verfasserin aut Enthalten in Gynecologic oncology Orlando, Fla. : Academic Press, 1972 153 Online-Ressource (DE-627)266881351 (DE-600)1467974-7 (DE-576)104193735 1095-6859 nnns volume:153 GBV_USEFLAG_U SYSFLAG_U GBV_ELV GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.92 Gynäkologie AR 153 |
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English |
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Enthalten in Gynecologic oncology 153 volume:153 |
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Enthalten in Gynecologic oncology 153 volume:153 |
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Onkologie Gynäkologie |
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findex.gbv.de |
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Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer |
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Gynecologic oncology |
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Polterauer, Stephan @@aut@@ Schwameis, Richard @@aut@@ Grimm, Christoph @@aut@@ Hillemanns, Peter @@aut@@ Jückstock, Julia @@aut@@ Hilpert, Felix @@aut@@ de Gregorio, Nikolaus @@aut@@ Hasenburg, Annette @@aut@@ Sehouli, Jalid @@aut@@ Fürst, Sophie Theresa @@aut@@ Strauß, Hans Georg @@aut@@ Baumann, Klaus @@aut@@ Thiel, Falk @@aut@@ Mustea, Alexander @@aut@@ Harter, Philipp @@aut@@ Wimberger, Pauline @@aut@@ Kölbl, Heinz @@aut@@ Reinthaller, Alexander @@aut@@ Woelber, Linn @@aut@@ Mahner, Sven @@aut@@ |
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2019-01-01T00:00:00Z |
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3610 |
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englisch |
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Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. 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Polterauer, Stephan |
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Polterauer, Stephan ddc 610 bkl 44.81 bkl 44.92 misc Lymph node metastases misc Lymph node ratio misc Cancer prognosis misc Cancer recurrence misc Vulvar cancer Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study |
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610 DE-600 44.81 bkl 44.92 bkl Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study Lymph node metastases Lymph node ratio Cancer prognosis Cancer recurrence Vulvar cancer |
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ddc 610 bkl 44.81 bkl 44.92 misc Lymph node metastases misc Lymph node ratio misc Cancer prognosis misc Cancer recurrence misc Vulvar cancer |
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ddc 610 bkl 44.81 bkl 44.92 misc Lymph node metastases misc Lymph node ratio misc Cancer prognosis misc Cancer recurrence misc Vulvar cancer |
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Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study |
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Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study |
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Polterauer, Stephan |
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Gynecologic oncology |
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Polterauer, Stephan Schwameis, Richard Grimm, Christoph Hillemanns, Peter Jückstock, Julia Hilpert, Felix de Gregorio, Nikolaus Hasenburg, Annette Sehouli, Jalid Fürst, Sophie Theresa Strauß, Hans Georg Baumann, Klaus Thiel, Falk Mustea, Alexander Harter, Philipp Wimberger, Pauline Kölbl, Heinz Reinthaller, Alexander Woelber, Linn Mahner, Sven |
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10.1016/j.ygyno.2019.02.007 |
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lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: results from the ago-care-1 study |
| title_auth |
Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study |
| abstract |
Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. |
| abstractGer |
Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. |
| abstract_unstemmed |
Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.Methods: The AGO-CaRE-1 study multicenter database was used for analysis. LNR was defined as ratio of number of positive lymph nodes (LN) to the number of resected. Previously established LNR risk groups were used to stratify patients. LNR was investigated with respect to clinical parameters. Univariate and multivariable survival analyses were performed to assess the value of LNR in order to predict overall (OS) and progression-free (PFS) survival.Results: In total, 1047 patients treated with surgery including inguinal lymph node resection for squamous cell carcinoma of the vulva were identified from the database. Of these, 370 (35.3%) were found to have positive inguinal LN. In total, 677 (64.7%) had a LNR of 0% (N0), 255 (24.4%) a LNR of >0% < 20%, and 115 (11%) a LNR of ≥20%. Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. LNR generally showed stronger correlation than number of affected LN when comparing the two different multivariable models.Conclusions: In women with vulvar cancer LNR appears to be a consistent, independent prognostic parameter for both PFS and OS and allows patient stratification into three distinct risk groups. In survival analyses, LNR outperformed nodal status and number of positive nodes. |
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| title_short |
Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study |
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true |
| author2 |
Schwameis, Richard Grimm, Christoph Hillemanns, Peter Jückstock, Julia Hilpert, Felix de Gregorio, Nikolaus Hasenburg, Annette Sehouli, Jalid Fürst, Sophie Theresa Strauß, Hans Georg Baumann, Klaus Thiel, Falk Mustea, Alexander Harter, Philipp Wimberger, Pauline Kölbl, Heinz Reinthaller, Alexander Woelber, Linn Mahner, Sven |
| author2Str |
Schwameis, Richard Grimm, Christoph Hillemanns, Peter Jückstock, Julia Hilpert, Felix de Gregorio, Nikolaus Hasenburg, Annette Sehouli, Jalid Fürst, Sophie Theresa Strauß, Hans Georg Baumann, Klaus Thiel, Falk Mustea, Alexander Harter, Philipp Wimberger, Pauline Kölbl, Heinz Reinthaller, Alexander Woelber, Linn Mahner, Sven |
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266881351 |
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| doi_str |
10.1016/j.ygyno.2019.02.007 |
| up_date |
2024-07-06T23:41:21.179Z |
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Patients with higher LNR were found to have larger tumor size (P < .001), advanced tumor stage (P < .001), high tumor grade (P < .001), and deep stromal invasion (P < .001), more frequently. Three-year PFS rates were 75.7%, 44.2%, and 23.1% and three-year OS rates were 89.7%, 65.4%, and 41.9%, in patients with LNRs 0%, >0% < 20%, and ≥20%, respectively (P < .001, P < .001). On multivariable analyses LNR (HR 7.75, 95%-CI 4.01–14.98, P < .001), FIGO stage (HR 1.41, 95%-CI 1.18–1.69, P < .001), and patient's performance status (HR 1.59, 95%-CI 1.39–1.82, P < .001), were associated with PFS. In addition, LNR (HR 12.74, 95%-CI 5.64–28.78, P < .001), and performance status (HR 1.72, 95%-CI 1.44–2.07, P < .001) were also the only two parameters independently associated with OS. 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| score |
7.400133 |