Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing

CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We addit...
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Autor*in:	Murataeva, Natalia [verfasserIn] Miller, Sally [verfasserIn] Dhopeshwarkar, Amey [verfasserIn] Leishman, Emma [verfasserIn] Daily, Laura [verfasserIn] Taylor, Xavier [verfasserIn] Morton, Brian [verfasserIn] Lashmet, Matthew [verfasserIn] Bradshaw, Heather [verfasserIn] Hillard, Cecilia J. [verfasserIn] Romero, Julian [verfasserIn] Straiker, Alex [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis

Übergeordnetes Werk:	Enthalten in: Experimental eye research - Amsterdam [u.a.] : Elsevier, 1962, 182, Seite 74-84
Übergeordnetes Werk:	volume:182 ; pages:74-84

DOI / URN:	10.1016/j.exer.2019.03.011

Katalog-ID:	ELV002189542

Internformat


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245	1	0	\|a Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
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520			\|a CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion.
650		4	\|a Cornea
650		4	\|a Corneal wound healing
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700	1		\|a Taylor, Xavier \|e verfasserin \|0 (orcid)0000-0002-1129-4038 \|4 aut
700	1		\|a Morton, Brian \|e verfasserin \|4 aut
700	1		\|a Lashmet, Matthew \|e verfasserin \|4 aut
700	1		\|a Bradshaw, Heather \|e verfasserin \|4 aut
700	1		\|a Hillard, Cecilia J. \|e verfasserin \|4 aut
700	1		\|a Romero, Julian \|e verfasserin \|4 aut
700	1		\|a Straiker, Alex \|e verfasserin \|4 aut
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allfields	10.1016/j.exer.2019.03.011 doi (DE-627)ELV002189542 (ELSEVIER)S0014-4835(18)30720-6 DE-627 ger DE-627 rda eng 610 DE-600 44.95 bkl Murataeva, Natalia verfasserin aut Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion. Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis Miller, Sally verfasserin aut Dhopeshwarkar, Amey verfasserin (orcid)0000-0001-8155-4897 aut Leishman, Emma verfasserin (orcid)0000-0002-8310-1821 aut Daily, Laura verfasserin aut Taylor, Xavier verfasserin (orcid)0000-0002-1129-4038 aut Morton, Brian verfasserin aut Lashmet, Matthew verfasserin aut Bradshaw, Heather verfasserin aut Hillard, Cecilia J. verfasserin aut Romero, Julian verfasserin aut Straiker, Alex verfasserin aut Enthalten in Experimental eye research Amsterdam [u.a.] : Elsevier, 1962 182, Seite 74-84 Online-Ressource (DE-627)266018033 (DE-600)1466924-9 (DE-576)104193697 1096-0007 nnns volume:182 pages:74-84 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.95 Augenheilkunde AR 182 74-84
spelling	10.1016/j.exer.2019.03.011 doi (DE-627)ELV002189542 (ELSEVIER)S0014-4835(18)30720-6 DE-627 ger DE-627 rda eng 610 DE-600 44.95 bkl Murataeva, Natalia verfasserin aut Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion. Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis Miller, Sally verfasserin aut Dhopeshwarkar, Amey verfasserin (orcid)0000-0001-8155-4897 aut Leishman, Emma verfasserin (orcid)0000-0002-8310-1821 aut Daily, Laura verfasserin aut Taylor, Xavier verfasserin (orcid)0000-0002-1129-4038 aut Morton, Brian verfasserin aut Lashmet, Matthew verfasserin aut Bradshaw, Heather verfasserin aut Hillard, Cecilia J. verfasserin aut Romero, Julian verfasserin aut Straiker, Alex verfasserin aut Enthalten in Experimental eye research Amsterdam [u.a.] : Elsevier, 1962 182, Seite 74-84 Online-Ressource (DE-627)266018033 (DE-600)1466924-9 (DE-576)104193697 1096-0007 nnns volume:182 pages:74-84 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.95 Augenheilkunde AR 182 74-84
allfields_unstemmed	10.1016/j.exer.2019.03.011 doi (DE-627)ELV002189542 (ELSEVIER)S0014-4835(18)30720-6 DE-627 ger DE-627 rda eng 610 DE-600 44.95 bkl Murataeva, Natalia verfasserin aut Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion. Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis Miller, Sally verfasserin aut Dhopeshwarkar, Amey verfasserin (orcid)0000-0001-8155-4897 aut Leishman, Emma verfasserin (orcid)0000-0002-8310-1821 aut Daily, Laura verfasserin aut Taylor, Xavier verfasserin (orcid)0000-0002-1129-4038 aut Morton, Brian verfasserin aut Lashmet, Matthew verfasserin aut Bradshaw, Heather verfasserin aut Hillard, Cecilia J. verfasserin aut Romero, Julian verfasserin aut Straiker, Alex verfasserin aut Enthalten in Experimental eye research Amsterdam [u.a.] : Elsevier, 1962 182, Seite 74-84 Online-Ressource (DE-627)266018033 (DE-600)1466924-9 (DE-576)104193697 1096-0007 nnns volume:182 pages:74-84 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.95 Augenheilkunde AR 182 74-84
allfieldsGer	10.1016/j.exer.2019.03.011 doi (DE-627)ELV002189542 (ELSEVIER)S0014-4835(18)30720-6 DE-627 ger DE-627 rda eng 610 DE-600 44.95 bkl Murataeva, Natalia verfasserin aut Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion. Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis Miller, Sally verfasserin aut Dhopeshwarkar, Amey verfasserin (orcid)0000-0001-8155-4897 aut Leishman, Emma verfasserin (orcid)0000-0002-8310-1821 aut Daily, Laura verfasserin aut Taylor, Xavier verfasserin (orcid)0000-0002-1129-4038 aut Morton, Brian verfasserin aut Lashmet, Matthew verfasserin aut Bradshaw, Heather verfasserin aut Hillard, Cecilia J. verfasserin aut Romero, Julian verfasserin aut Straiker, Alex verfasserin aut Enthalten in Experimental eye research Amsterdam [u.a.] : Elsevier, 1962 182, Seite 74-84 Online-Ressource (DE-627)266018033 (DE-600)1466924-9 (DE-576)104193697 1096-0007 nnns volume:182 pages:74-84 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.95 Augenheilkunde AR 182 74-84
allfieldsSound	10.1016/j.exer.2019.03.011 doi (DE-627)ELV002189542 (ELSEVIER)S0014-4835(18)30720-6 DE-627 ger DE-627 rda eng 610 DE-600 44.95 bkl Murataeva, Natalia verfasserin aut Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion. Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis Miller, Sally verfasserin aut Dhopeshwarkar, Amey verfasserin (orcid)0000-0001-8155-4897 aut Leishman, Emma verfasserin (orcid)0000-0002-8310-1821 aut Daily, Laura verfasserin aut Taylor, Xavier verfasserin (orcid)0000-0002-1129-4038 aut Morton, Brian verfasserin aut Lashmet, Matthew verfasserin aut Bradshaw, Heather verfasserin aut Hillard, Cecilia J. verfasserin aut Romero, Julian verfasserin aut Straiker, Alex verfasserin aut Enthalten in Experimental eye research Amsterdam [u.a.] : Elsevier, 1962 182, Seite 74-84 Online-Ressource (DE-627)266018033 (DE-600)1466924-9 (DE-576)104193697 1096-0007 nnns volume:182 pages:74-84 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.95 Augenheilkunde AR 182 74-84
language	English
source	Enthalten in Experimental eye research 182, Seite 74-84 volume:182 pages:74-84
sourceStr	Enthalten in Experimental eye research 182, Seite 74-84 volume:182 pages:74-84
format_phy_str_mv	Article
bklname	Augenheilkunde
institution	findex.gbv.de
topic_facet	Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis
dewey-raw	610
isfreeaccess_bool	false
container_title	Experimental eye research
authorswithroles_txt_mv	Murataeva, Natalia @@aut@@ Miller, Sally @@aut@@ Dhopeshwarkar, Amey @@aut@@ Leishman, Emma @@aut@@ Daily, Laura @@aut@@ Taylor, Xavier @@aut@@ Morton, Brian @@aut@@ Lashmet, Matthew @@aut@@ Bradshaw, Heather @@aut@@ Hillard, Cecilia J. @@aut@@ Romero, Julian @@aut@@ Straiker, Alex @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	266018033
dewey-sort	3610
id	ELV002189542
language_de	englisch
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author	Murataeva, Natalia
spellingShingle	Murataeva, Natalia ddc 610 bkl 44.95 misc Cornea misc Corneal wound healing misc Lag phase misc Cannabinoid misc Endocannabinoid misc CB2 misc Chemotaxis Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
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topic_title	610 DE-600 44.95 bkl Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing Cornea Corneal wound healing Lag phase Cannabinoid Endocannabinoid CB2 Chemotaxis
topic	ddc 610 bkl 44.95 misc Cornea misc Corneal wound healing misc Lag phase misc Cannabinoid misc Endocannabinoid misc CB2 misc Chemotaxis
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title	Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
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title_full	Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
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title_sort	cannabinoid cb2r receptors are upregulated with corneal injury and regulate the course of corneal wound healing
title_auth	Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
abstract	CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion.
abstractGer	CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion.
abstract_unstemmed	CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal wound healing. We examined the functional contribution of CB2R receptors to the course of wound closure in an in vivo murine model. We additionally examined corneal expression of CB2R receptors in mouse and the consequences of their activation on cellular signaling, migration and proliferation in cultured bovine corneal epithelial cells (CECs). Using a novel mouse model, we provide evidence that corneal injury increases CB2R receptor expression in cornea. The CB2R agonist JWH133 induces chemorepulsion in cultured bovine CECs but does not alter CEC proliferation. The signaling profile of CB2R activation is activating MAPK and increasing cAMP accumulation, the latter perhaps due to Gs-coupling. Lipidomic analysis in bovine cornea shows a rise in acylethanolamines including the endocannabinoid anandamide 1 h after injury. In vivo, CB2R deletion and pharmacological block result in a delayed course of wound closure. In summary, we find evidence that CB2R receptor promoter activity is increased by corneal injury and that these receptors are required for the normal course of wound closure, possibly via chemorepulsion.
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title_short	Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
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author2	Miller, Sally Dhopeshwarkar, Amey Leishman, Emma Daily, Laura Taylor, Xavier Morton, Brian Lashmet, Matthew Bradshaw, Heather Hillard, Cecilia J. Romero, Julian Straiker, Alex
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up_date	2024-07-06T23:54:44.781Z
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Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing

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