Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia
Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dal Mas, Caroline [verfasserIn] Nani, João V. [verfasserIn] Noto, Cristiano [verfasserIn] Yonamine, Camila M. [verfasserIn] da Cunha, Graccielle Rodrigues [verfasserIn] Mansur, Rodrigo B. [verfasserIn] Ota, Vanessa K. [verfasserIn] Belangero, Sintia Iole [verfasserIn] Cordeiro, Quirino [verfasserIn] Kapczinski, Flávio [verfasserIn] Brietzke, Elisa [verfasserIn] Bressan, Rodrigo A. [verfasserIn] Gadelha, Ary [verfasserIn] Hayashi, Mirian A.F. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Schizophrenia research - Amsterdam [u.a.] : Elsevier Science, 1988, 208, Seite 202-208 |
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| Übergeordnetes Werk: |
volume:208 ; pages:202-208 |
| DOI / URN: |
10.1016/j.schres.2019.02.021 |
|---|
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ELV002325128 |
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| 245 | 1 | 0 | |a Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia |
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| 520 | |a Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. | ||
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Ultra-high risk for psychosis | |
| 650 | 4 | |a First-episode psychosis | |
| 650 | 4 | |a Ndel1 enzyme activity | |
| 650 | 4 | |a Central nervous system | |
| 650 | 4 | |a Antipsychotic | |
| 700 | 1 | |a Nani, João V. |e verfasserin |4 aut | |
| 700 | 1 | |a Noto, Cristiano |e verfasserin |0 (orcid)0000-0002-2706-9118 |4 aut | |
| 700 | 1 | |a Yonamine, Camila M. |e verfasserin |4 aut | |
| 700 | 1 | |a da Cunha, Graccielle Rodrigues |e verfasserin |4 aut | |
| 700 | 1 | |a Mansur, Rodrigo B. |e verfasserin |4 aut | |
| 700 | 1 | |a Ota, Vanessa K. |e verfasserin |4 aut | |
| 700 | 1 | |a Belangero, Sintia Iole |e verfasserin |4 aut | |
| 700 | 1 | |a Cordeiro, Quirino |e verfasserin |4 aut | |
| 700 | 1 | |a Kapczinski, Flávio |e verfasserin |4 aut | |
| 700 | 1 | |a Brietzke, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Bressan, Rodrigo A. |e verfasserin |4 aut | |
| 700 | 1 | |a Gadelha, Ary |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Mirian A.F. |e verfasserin |4 aut | |
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10.1016/j.schres.2019.02.021 doi (DE-627)ELV002325128 (ELSEVIER)S0920-9964(19)30081-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Dal Mas, Caroline verfasserin aut Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic Nani, João V. verfasserin aut Noto, Cristiano verfasserin (orcid)0000-0002-2706-9118 aut Yonamine, Camila M. verfasserin aut da Cunha, Graccielle Rodrigues verfasserin aut Mansur, Rodrigo B. verfasserin aut Ota, Vanessa K. verfasserin aut Belangero, Sintia Iole verfasserin aut Cordeiro, Quirino verfasserin aut Kapczinski, Flávio verfasserin aut Brietzke, Elisa verfasserin aut Bressan, Rodrigo A. verfasserin aut Gadelha, Ary verfasserin aut Hayashi, Mirian A.F. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 208, Seite 202-208 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:208 pages:202-208 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 208 202-208 |
| spelling |
10.1016/j.schres.2019.02.021 doi (DE-627)ELV002325128 (ELSEVIER)S0920-9964(19)30081-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Dal Mas, Caroline verfasserin aut Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic Nani, João V. verfasserin aut Noto, Cristiano verfasserin (orcid)0000-0002-2706-9118 aut Yonamine, Camila M. verfasserin aut da Cunha, Graccielle Rodrigues verfasserin aut Mansur, Rodrigo B. verfasserin aut Ota, Vanessa K. verfasserin aut Belangero, Sintia Iole verfasserin aut Cordeiro, Quirino verfasserin aut Kapczinski, Flávio verfasserin aut Brietzke, Elisa verfasserin aut Bressan, Rodrigo A. verfasserin aut Gadelha, Ary verfasserin aut Hayashi, Mirian A.F. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 208, Seite 202-208 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:208 pages:202-208 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 208 202-208 |
| allfields_unstemmed |
10.1016/j.schres.2019.02.021 doi (DE-627)ELV002325128 (ELSEVIER)S0920-9964(19)30081-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Dal Mas, Caroline verfasserin aut Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic Nani, João V. verfasserin aut Noto, Cristiano verfasserin (orcid)0000-0002-2706-9118 aut Yonamine, Camila M. verfasserin aut da Cunha, Graccielle Rodrigues verfasserin aut Mansur, Rodrigo B. verfasserin aut Ota, Vanessa K. verfasserin aut Belangero, Sintia Iole verfasserin aut Cordeiro, Quirino verfasserin aut Kapczinski, Flávio verfasserin aut Brietzke, Elisa verfasserin aut Bressan, Rodrigo A. verfasserin aut Gadelha, Ary verfasserin aut Hayashi, Mirian A.F. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 208, Seite 202-208 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:208 pages:202-208 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 208 202-208 |
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10.1016/j.schres.2019.02.021 doi (DE-627)ELV002325128 (ELSEVIER)S0920-9964(19)30081-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Dal Mas, Caroline verfasserin aut Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic Nani, João V. verfasserin aut Noto, Cristiano verfasserin (orcid)0000-0002-2706-9118 aut Yonamine, Camila M. verfasserin aut da Cunha, Graccielle Rodrigues verfasserin aut Mansur, Rodrigo B. verfasserin aut Ota, Vanessa K. verfasserin aut Belangero, Sintia Iole verfasserin aut Cordeiro, Quirino verfasserin aut Kapczinski, Flávio verfasserin aut Brietzke, Elisa verfasserin aut Bressan, Rodrigo A. verfasserin aut Gadelha, Ary verfasserin aut Hayashi, Mirian A.F. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 208, Seite 202-208 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:208 pages:202-208 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 208 202-208 |
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10.1016/j.schres.2019.02.021 doi (DE-627)ELV002325128 (ELSEVIER)S0920-9964(19)30081-7 DE-627 ger DE-627 rda eng 610 DE-600 44.91 bkl Dal Mas, Caroline verfasserin aut Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic Nani, João V. verfasserin aut Noto, Cristiano verfasserin (orcid)0000-0002-2706-9118 aut Yonamine, Camila M. verfasserin aut da Cunha, Graccielle Rodrigues verfasserin aut Mansur, Rodrigo B. verfasserin aut Ota, Vanessa K. verfasserin aut Belangero, Sintia Iole verfasserin aut Cordeiro, Quirino verfasserin aut Kapczinski, Flávio verfasserin aut Brietzke, Elisa verfasserin aut Bressan, Rodrigo A. verfasserin aut Gadelha, Ary verfasserin aut Hayashi, Mirian A.F. verfasserin aut Enthalten in Schizophrenia research Amsterdam [u.a.] : Elsevier Science, 1988 208, Seite 202-208 Online-Ressource (DE-627)306710307 (DE-600)1500726-1 (DE-576)082435820 1573-2509 nnns volume:208 pages:202-208 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.91 Psychiatrie Psychopathologie AR 208 202-208 |
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Enthalten in Schizophrenia research 208, Seite 202-208 volume:208 pages:202-208 |
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Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic |
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Dal Mas, Caroline @@aut@@ Nani, João V. @@aut@@ Noto, Cristiano @@aut@@ Yonamine, Camila M. @@aut@@ da Cunha, Graccielle Rodrigues @@aut@@ Mansur, Rodrigo B. @@aut@@ Ota, Vanessa K. @@aut@@ Belangero, Sintia Iole @@aut@@ Cordeiro, Quirino @@aut@@ Kapczinski, Flávio @@aut@@ Brietzke, Elisa @@aut@@ Bressan, Rodrigo A. @@aut@@ Gadelha, Ary @@aut@@ Hayashi, Mirian A.F. @@aut@@ |
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2019-01-01T00:00:00Z |
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Dal Mas, Caroline ddc 610 bkl 44.91 misc Schizophrenia misc Ultra-high risk for psychosis misc First-episode psychosis misc Ndel1 enzyme activity misc Central nervous system misc Antipsychotic Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia |
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610 DE-600 44.91 bkl Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia Schizophrenia Ultra-high risk for psychosis First-episode psychosis Ndel1 enzyme activity Central nervous system Antipsychotic |
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Dal Mas, Caroline Nani, João V. Noto, Cristiano Yonamine, Camila M. da Cunha, Graccielle Rodrigues Mansur, Rodrigo B. Ota, Vanessa K. Belangero, Sintia Iole Cordeiro, Quirino Kapczinski, Flávio Brietzke, Elisa Bressan, Rodrigo A. Gadelha, Ary Hayashi, Mirian A.F. |
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ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia |
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Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia |
| abstract |
Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. |
| abstractGer |
Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. |
| abstract_unstemmed |
Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Conversely, Ndel1 activity in HC groups was higher than in FEP even before (FEP-0) or after the treatment with risperidone (FEP-2 M and FEP-1Y), and with progressive decrease of Ndel1 activity and significant improvement of symptoms observed after this treatment. In addition, a positive correlation was observed for Ndel1 activity with clinical symptoms as assessed by PANSS, while a negative correlation was seen for GAF scores. Our results suggest that reductions in Ndel1 activity in FEP may be possibly related to responses to the illness, rather than to the pharmacological effects of antipsychotics, which might be acting essentially in the symptoms suppression. This hypothesis might be further evaluated in prospective long-term follow-up studies with a larger sample cohort. |
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Nani, João V. Noto, Cristiano Yonamine, Camila M. da Cunha, Graccielle Rodrigues Mansur, Rodrigo B. Ota, Vanessa K. Belangero, Sintia Iole Cordeiro, Quirino Kapczinski, Flávio Brietzke, Elisa Bressan, Rodrigo A. Gadelha, Ary Hayashi, Mirian A.F. |
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