Metabolites and biological activities of

Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite prof...
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Gespeichert in:

Autor*in:	Abdul-Hamid, Nur Ashikin [verfasserIn] Abas, Faridah [verfasserIn] Ismail, Intan Safinar [verfasserIn] Tham, Chau Ling [verfasserIn] Maulidiani, M. [verfasserIn] Mediani, Ahmed [verfasserIn] Swarup, Sanjay [verfasserIn] Umashankar, Shivshankar [verfasserIn] Zolkeflee, Nur Khaleeda Zulaikha [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Deglet dates Metabolomics Date seeds Date pulps Nitric oxide

Übergeordnetes Werk:	Enthalten in: Phytochemistry letters - Amsterdam [u.a.] : Elsevier, 2008, 31, Seite 20-32
Übergeordnetes Werk:	volume:31 ; pages:20-32

DOI / URN:	10.1016/j.phytol.2019.03.004

Katalog-ID:	ELV00235571X

Internformat


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520			\|a Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop.
650		4	\|a Deglet dates
650		4	\|a Metabolomics
650		4	\|a Date seeds
650		4	\|a Date pulps
650		4	\|a Nitric oxide
700	1		\|a Abas, Faridah \|e verfasserin \|4 aut
700	1		\|a Ismail, Intan Safinar \|e verfasserin \|4 aut
700	1		\|a Tham, Chau Ling \|e verfasserin \|4 aut
700	1		\|a Maulidiani, M. \|e verfasserin \|4 aut
700	1		\|a Mediani, Ahmed \|e verfasserin \|4 aut
700	1		\|a Swarup, Sanjay \|e verfasserin \|4 aut
700	1		\|a Umashankar, Shivshankar \|e verfasserin \|4 aut
700	1		\|a Zolkeflee, Nur Khaleeda Zulaikha \|e verfasserin \|4 aut
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912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
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912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
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912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
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author_variant	n a a h naa naah f a fa i s i is isi c l t cl clt m m mm a m am s s ss s u su n k z z nkz nkzz
matchkey_str	article:18743900:2019----::eaoieadilgclc
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publishDate	2019
allfields	10.1016/j.phytol.2019.03.004 doi (DE-627)ELV00235571X (ELSEVIER)S1874-3900(19)30018-7 DE-627 ger DE-627 rda eng 580 540 DE-600 BIODIV DE-30 fid Abdul-Hamid, Nur Ashikin verfasserin aut Metabolites and biological activities of 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop. Deglet dates Metabolomics Date seeds Date pulps Nitric oxide Abas, Faridah verfasserin aut Ismail, Intan Safinar verfasserin aut Tham, Chau Ling verfasserin aut Maulidiani, M. verfasserin aut Mediani, Ahmed verfasserin aut Swarup, Sanjay verfasserin aut Umashankar, Shivshankar verfasserin aut Zolkeflee, Nur Khaleeda Zulaikha verfasserin aut Enthalten in Phytochemistry letters Amsterdam [u.a.] : Elsevier, 2008 31, Seite 20-32 Online-Ressource (DE-627)566010879 (DE-600)2425258-X (DE-576)294350659 1874-3900 nnns volume:31 pages:20-32 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 31 20-32
spelling	10.1016/j.phytol.2019.03.004 doi (DE-627)ELV00235571X (ELSEVIER)S1874-3900(19)30018-7 DE-627 ger DE-627 rda eng 580 540 DE-600 BIODIV DE-30 fid Abdul-Hamid, Nur Ashikin verfasserin aut Metabolites and biological activities of 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop. Deglet dates Metabolomics Date seeds Date pulps Nitric oxide Abas, Faridah verfasserin aut Ismail, Intan Safinar verfasserin aut Tham, Chau Ling verfasserin aut Maulidiani, M. verfasserin aut Mediani, Ahmed verfasserin aut Swarup, Sanjay verfasserin aut Umashankar, Shivshankar verfasserin aut Zolkeflee, Nur Khaleeda Zulaikha verfasserin aut Enthalten in Phytochemistry letters Amsterdam [u.a.] : Elsevier, 2008 31, Seite 20-32 Online-Ressource (DE-627)566010879 (DE-600)2425258-X (DE-576)294350659 1874-3900 nnns volume:31 pages:20-32 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 31 20-32
allfields_unstemmed	10.1016/j.phytol.2019.03.004 doi (DE-627)ELV00235571X (ELSEVIER)S1874-3900(19)30018-7 DE-627 ger DE-627 rda eng 580 540 DE-600 BIODIV DE-30 fid Abdul-Hamid, Nur Ashikin verfasserin aut Metabolites and biological activities of 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop. Deglet dates Metabolomics Date seeds Date pulps Nitric oxide Abas, Faridah verfasserin aut Ismail, Intan Safinar verfasserin aut Tham, Chau Ling verfasserin aut Maulidiani, M. verfasserin aut Mediani, Ahmed verfasserin aut Swarup, Sanjay verfasserin aut Umashankar, Shivshankar verfasserin aut Zolkeflee, Nur Khaleeda Zulaikha verfasserin aut Enthalten in Phytochemistry letters Amsterdam [u.a.] : Elsevier, 2008 31, Seite 20-32 Online-Ressource (DE-627)566010879 (DE-600)2425258-X (DE-576)294350659 1874-3900 nnns volume:31 pages:20-32 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 31 20-32
allfieldsGer	10.1016/j.phytol.2019.03.004 doi (DE-627)ELV00235571X (ELSEVIER)S1874-3900(19)30018-7 DE-627 ger DE-627 rda eng 580 540 DE-600 BIODIV DE-30 fid Abdul-Hamid, Nur Ashikin verfasserin aut Metabolites and biological activities of 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop. Deglet dates Metabolomics Date seeds Date pulps Nitric oxide Abas, Faridah verfasserin aut Ismail, Intan Safinar verfasserin aut Tham, Chau Ling verfasserin aut Maulidiani, M. verfasserin aut Mediani, Ahmed verfasserin aut Swarup, Sanjay verfasserin aut Umashankar, Shivshankar verfasserin aut Zolkeflee, Nur Khaleeda Zulaikha verfasserin aut Enthalten in Phytochemistry letters Amsterdam [u.a.] : Elsevier, 2008 31, Seite 20-32 Online-Ressource (DE-627)566010879 (DE-600)2425258-X (DE-576)294350659 1874-3900 nnns volume:31 pages:20-32 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 31 20-32
allfieldsSound	10.1016/j.phytol.2019.03.004 doi (DE-627)ELV00235571X (ELSEVIER)S1874-3900(19)30018-7 DE-627 ger DE-627 rda eng 580 540 DE-600 BIODIV DE-30 fid Abdul-Hamid, Nur Ashikin verfasserin aut Metabolites and biological activities of 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop. Deglet dates Metabolomics Date seeds Date pulps Nitric oxide Abas, Faridah verfasserin aut Ismail, Intan Safinar verfasserin aut Tham, Chau Ling verfasserin aut Maulidiani, M. verfasserin aut Mediani, Ahmed verfasserin aut Swarup, Sanjay verfasserin aut Umashankar, Shivshankar verfasserin aut Zolkeflee, Nur Khaleeda Zulaikha verfasserin aut Enthalten in Phytochemistry letters Amsterdam [u.a.] : Elsevier, 2008 31, Seite 20-32 Online-Ressource (DE-627)566010879 (DE-600)2425258-X (DE-576)294350659 1874-3900 nnns volume:31 pages:20-32 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 31 20-32
language	English
source	Enthalten in Phytochemistry letters 31, Seite 20-32 volume:31 pages:20-32
sourceStr	Enthalten in Phytochemistry letters 31, Seite 20-32 volume:31 pages:20-32
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Deglet dates Metabolomics Date seeds Date pulps Nitric oxide
dewey-raw	580
isfreeaccess_bool	false
container_title	Phytochemistry letters
authorswithroles_txt_mv	Abdul-Hamid, Nur Ashikin @@aut@@ Abas, Faridah @@aut@@ Ismail, Intan Safinar @@aut@@ Tham, Chau Ling @@aut@@ Maulidiani, M. @@aut@@ Mediani, Ahmed @@aut@@ Swarup, Sanjay @@aut@@ Umashankar, Shivshankar @@aut@@ Zolkeflee, Nur Khaleeda Zulaikha @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	566010879
dewey-sort	3580
id	ELV00235571X
language_de	englisch
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author	Abdul-Hamid, Nur Ashikin
spellingShingle	Abdul-Hamid, Nur Ashikin ddc 580 fid BIODIV misc Deglet dates misc Metabolomics misc Date seeds misc Date pulps misc Nitric oxide Metabolites and biological activities of
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topic_title	580 540 DE-600 BIODIV DE-30 fid Metabolites and biological activities of Deglet dates Metabolomics Date seeds Date pulps Nitric oxide
topic	ddc 580 fid BIODIV misc Deglet dates misc Metabolomics misc Date seeds misc Date pulps misc Nitric oxide
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author_browse	Abdul-Hamid, Nur Ashikin Abas, Faridah Ismail, Intan Safinar Tham, Chau Ling Maulidiani, M. Mediani, Ahmed Swarup, Sanjay Umashankar, Shivshankar Zolkeflee, Nur Khaleeda Zulaikha
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title_sort	metabolites and biological activities of
title_auth	Metabolites and biological activities of
abstract	Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop.
abstractGer	Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop.
abstract_unstemmed	Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop.
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title_short	Metabolites and biological activities of
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author2	Abas, Faridah Ismail, Intan Safinar Tham, Chau Ling Maulidiani, M. Mediani, Ahmed Swarup, Sanjay Umashankar, Shivshankar Zolkeflee, Nur Khaleeda Zulaikha
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