Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study
Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation...
Ausführliche Beschreibung
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E-Artikel |
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Sprache: |
Englisch |
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2019 |
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Übergeordnetes Werk: |
Enthalten in: The journal of allergy and clinical immunology - Amsterdam [u.a.] : Elsevier, 1971, 143, Seite 2238-2253 |
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Übergeordnetes Werk: |
volume:143 ; pages:2238-2253 |
DOI / URN: |
10.1016/j.jaci.2018.12.1010 |
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Katalog-ID: |
ELV002384590 |
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100 | 1 | |a Ferrua, Francesca |e verfasserin |4 aut | |
245 | 1 | 0 | |a Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study |
264 | 1 | |c 2019 | |
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. | ||
650 | 4 | |a CD40 ligand | |
650 | 4 | |a hematopoietic stem cell transplantation | |
650 | 4 | |a X-linked hyper-IgM syndrome | |
650 | 4 | |a primary immunodeficiency | |
700 | 1 | |a Galimberti, Stefania |e verfasserin |4 aut | |
700 | 1 | |a Courteille, Virginie |e verfasserin |4 aut | |
700 | 1 | |a Slatter, Mary Anne |e verfasserin |4 aut | |
700 | 1 | |a Booth, Claire |e verfasserin |4 aut | |
700 | 1 | |a Moshous, Despina |e verfasserin |4 aut | |
700 | 1 | |a Neven, Benedicte |e verfasserin |4 aut | |
700 | 1 | |a Blanche, Stephane |e verfasserin |4 aut | |
700 | 1 | |a Cavazzana, Marina |e verfasserin |4 aut | |
700 | 1 | |a Laberko, Alexandra |e verfasserin |4 aut | |
700 | 1 | |a Shcherbina, Anna |e verfasserin |4 aut | |
700 | 1 | |a Balashov, Dmitry |e verfasserin |4 aut | |
700 | 1 | |a Soncini, Elena |e verfasserin |4 aut | |
700 | 1 | |a Porta, Fulvio |e verfasserin |4 aut | |
700 | 1 | |a Al-Mousa, Hamoud |e verfasserin |4 aut | |
700 | 1 | |a Al-Saud, Bandar |e verfasserin |4 aut | |
700 | 1 | |a Al-Dhekri, Hasan |e verfasserin |4 aut | |
700 | 1 | |a Arnaout, Rand |e verfasserin |4 aut | |
700 | 1 | |a Formankova, Renata |e verfasserin |4 aut | |
700 | 1 | |a Bertrand, Yves |e verfasserin |4 aut | |
700 | 1 | |a Lange, Andrzej |e verfasserin |4 aut | |
700 | 1 | |a Smart, Joanne |e verfasserin |4 aut | |
700 | 1 | |a Wolska-Kusnierz, Beata |e verfasserin |4 aut | |
700 | 1 | |a Aquino, Victor M. |e verfasserin |4 aut | |
700 | 1 | |a Dvorak, Christopher C. |e verfasserin |4 aut | |
700 | 1 | |a Fasth, Anders |e verfasserin |4 aut | |
700 | 1 | |a Fouyssac, Fanny |e verfasserin |4 aut | |
700 | 1 | |a Heilmann, Carsten |e verfasserin |4 aut | |
700 | 1 | |a Hoenig, Manfred |e verfasserin |4 aut | |
700 | 1 | |a Schuetz, Catharina |e verfasserin |4 aut | |
700 | 1 | |a Kelečić, Jadranka |e verfasserin |4 aut | |
700 | 1 | |a Bredius, Robbert G.M. |e verfasserin |4 aut | |
700 | 1 | |a Lankester, Arjan C. |e verfasserin |4 aut | |
700 | 1 | |a Lindemans, Caroline A. |e verfasserin |4 aut | |
700 | 1 | |a Suarez, Felipe |e verfasserin |4 aut | |
700 | 1 | |a Sullivan, Kathleen E. |e verfasserin |4 aut | |
700 | 1 | |a Albert, Michael H. |e verfasserin |4 aut | |
700 | 1 | |a Kałwak, Krzysztof |e verfasserin |4 aut | |
700 | 1 | |a Barlogis, Vincent |e verfasserin |4 aut | |
700 | 1 | |a Bhatia, Monica |e verfasserin |4 aut | |
700 | 1 | |a Bordon, Victoria |e verfasserin |4 aut | |
700 | 1 | |a Czogala, Wojciech |e verfasserin |4 aut | |
700 | 1 | |a Alonso, Laura |e verfasserin |4 aut | |
700 | 1 | |a Dogu, Figen |e verfasserin |4 aut | |
700 | 1 | |a Gozdzik, Jolanta |e verfasserin |4 aut | |
700 | 1 | |a Ikinciogullari, Aydan |e verfasserin |4 aut | |
700 | 1 | |a Kriván, Gergely |e verfasserin |4 aut | |
700 | 1 | |a Ljungman, Per |e verfasserin |4 aut | |
700 | 1 | |a Meyts, Isabelle |e verfasserin |4 aut | |
700 | 1 | |a Mustillo, Peter |e verfasserin |4 aut | |
700 | 1 | |a Smith, Angela R. |e verfasserin |4 aut | |
700 | 1 | |a Speckmann, Carsten |e verfasserin |4 aut | |
700 | 1 | |a Sundin, Mikael |e verfasserin |4 aut | |
700 | 1 | |a Keogh, Steven John |e verfasserin |4 aut | |
700 | 1 | |a Shaw, Peter John |e verfasserin |4 aut | |
700 | 1 | |a Boelens, Jaap Jan |e verfasserin |4 aut | |
700 | 1 | |a Schulz, Ansgar S. |e verfasserin |4 aut | |
700 | 1 | |a Sedlacek, Petr |e verfasserin |4 aut | |
700 | 1 | |a Veys, Paul |e verfasserin |4 aut | |
700 | 1 | |a Mahlaoui, Nizar |e verfasserin |4 aut | |
700 | 1 | |a Janda, Ales |e verfasserin |4 aut | |
700 | 1 | |a Davies, E. Graham |e verfasserin |4 aut | |
700 | 1 | |a Fischer, Alain |e verfasserin |4 aut | |
700 | 1 | |a Cowan, Morton J. |e verfasserin |4 aut | |
700 | 1 | |a Gennery, Andrew Richard |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The journal of allergy and clinical immunology |d Amsterdam [u.a.] : Elsevier, 1971 |g 143, Seite 2238-2253 |h Online-Ressource |w (DE-627)32045553X |w (DE-600)2006613-2 |w (DE-576)094478864 |x 1097-6825 |7 nnns |
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936 | b | k | |a 44.45 |j Immunologie |
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10.1016/j.jaci.2018.12.1010 doi (DE-627)ELV002384590 (ELSEVIER)S0091-6749(19)30034-X DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Ferrua, Francesca verfasserin aut Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency Galimberti, Stefania verfasserin aut Courteille, Virginie verfasserin aut Slatter, Mary Anne verfasserin aut Booth, Claire verfasserin aut Moshous, Despina verfasserin aut Neven, Benedicte verfasserin aut Blanche, Stephane verfasserin aut Cavazzana, Marina verfasserin aut Laberko, Alexandra verfasserin aut Shcherbina, Anna verfasserin aut Balashov, Dmitry verfasserin aut Soncini, Elena verfasserin aut Porta, Fulvio verfasserin aut Al-Mousa, Hamoud verfasserin aut Al-Saud, Bandar verfasserin aut Al-Dhekri, Hasan verfasserin aut Arnaout, Rand verfasserin aut Formankova, Renata verfasserin aut Bertrand, Yves verfasserin aut Lange, Andrzej verfasserin aut Smart, Joanne verfasserin aut Wolska-Kusnierz, Beata verfasserin aut Aquino, Victor M. verfasserin aut Dvorak, Christopher C. verfasserin aut Fasth, Anders verfasserin aut Fouyssac, Fanny verfasserin aut Heilmann, Carsten verfasserin aut Hoenig, Manfred verfasserin aut Schuetz, Catharina verfasserin aut Kelečić, Jadranka verfasserin aut Bredius, Robbert G.M. verfasserin aut Lankester, Arjan C. verfasserin aut Lindemans, Caroline A. verfasserin aut Suarez, Felipe verfasserin aut Sullivan, Kathleen E. verfasserin aut Albert, Michael H. verfasserin aut Kałwak, Krzysztof verfasserin aut Barlogis, Vincent verfasserin aut Bhatia, Monica verfasserin aut Bordon, Victoria verfasserin aut Czogala, Wojciech verfasserin aut Alonso, Laura verfasserin aut Dogu, Figen verfasserin aut Gozdzik, Jolanta verfasserin aut Ikinciogullari, Aydan verfasserin aut Kriván, Gergely verfasserin aut Ljungman, Per verfasserin aut Meyts, Isabelle verfasserin aut Mustillo, Peter verfasserin aut Smith, Angela R. verfasserin aut Speckmann, Carsten verfasserin aut Sundin, Mikael verfasserin aut Keogh, Steven John verfasserin aut Shaw, Peter John verfasserin aut Boelens, Jaap Jan verfasserin aut Schulz, Ansgar S. verfasserin aut Sedlacek, Petr verfasserin aut Veys, Paul verfasserin aut Mahlaoui, Nizar verfasserin aut Janda, Ales verfasserin aut Davies, E. Graham verfasserin aut Fischer, Alain verfasserin aut Cowan, Morton J. verfasserin aut Gennery, Andrew Richard verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 143, Seite 2238-2253 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:143 pages:2238-2253 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 143 2238-2253 |
spelling |
10.1016/j.jaci.2018.12.1010 doi (DE-627)ELV002384590 (ELSEVIER)S0091-6749(19)30034-X DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Ferrua, Francesca verfasserin aut Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency Galimberti, Stefania verfasserin aut Courteille, Virginie verfasserin aut Slatter, Mary Anne verfasserin aut Booth, Claire verfasserin aut Moshous, Despina verfasserin aut Neven, Benedicte verfasserin aut Blanche, Stephane verfasserin aut Cavazzana, Marina verfasserin aut Laberko, Alexandra verfasserin aut Shcherbina, Anna verfasserin aut Balashov, Dmitry verfasserin aut Soncini, Elena verfasserin aut Porta, Fulvio verfasserin aut Al-Mousa, Hamoud verfasserin aut Al-Saud, Bandar verfasserin aut Al-Dhekri, Hasan verfasserin aut Arnaout, Rand verfasserin aut Formankova, Renata verfasserin aut Bertrand, Yves verfasserin aut Lange, Andrzej verfasserin aut Smart, Joanne verfasserin aut Wolska-Kusnierz, Beata verfasserin aut Aquino, Victor M. verfasserin aut Dvorak, Christopher C. verfasserin aut Fasth, Anders verfasserin aut Fouyssac, Fanny verfasserin aut Heilmann, Carsten verfasserin aut Hoenig, Manfred verfasserin aut Schuetz, Catharina verfasserin aut Kelečić, Jadranka verfasserin aut Bredius, Robbert G.M. verfasserin aut Lankester, Arjan C. verfasserin aut Lindemans, Caroline A. verfasserin aut Suarez, Felipe verfasserin aut Sullivan, Kathleen E. verfasserin aut Albert, Michael H. verfasserin aut Kałwak, Krzysztof verfasserin aut Barlogis, Vincent verfasserin aut Bhatia, Monica verfasserin aut Bordon, Victoria verfasserin aut Czogala, Wojciech verfasserin aut Alonso, Laura verfasserin aut Dogu, Figen verfasserin aut Gozdzik, Jolanta verfasserin aut Ikinciogullari, Aydan verfasserin aut Kriván, Gergely verfasserin aut Ljungman, Per verfasserin aut Meyts, Isabelle verfasserin aut Mustillo, Peter verfasserin aut Smith, Angela R. verfasserin aut Speckmann, Carsten verfasserin aut Sundin, Mikael verfasserin aut Keogh, Steven John verfasserin aut Shaw, Peter John verfasserin aut Boelens, Jaap Jan verfasserin aut Schulz, Ansgar S. verfasserin aut Sedlacek, Petr verfasserin aut Veys, Paul verfasserin aut Mahlaoui, Nizar verfasserin aut Janda, Ales verfasserin aut Davies, E. Graham verfasserin aut Fischer, Alain verfasserin aut Cowan, Morton J. verfasserin aut Gennery, Andrew Richard verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 143, Seite 2238-2253 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:143 pages:2238-2253 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 143 2238-2253 |
allfields_unstemmed |
10.1016/j.jaci.2018.12.1010 doi (DE-627)ELV002384590 (ELSEVIER)S0091-6749(19)30034-X DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Ferrua, Francesca verfasserin aut Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency Galimberti, Stefania verfasserin aut Courteille, Virginie verfasserin aut Slatter, Mary Anne verfasserin aut Booth, Claire verfasserin aut Moshous, Despina verfasserin aut Neven, Benedicte verfasserin aut Blanche, Stephane verfasserin aut Cavazzana, Marina verfasserin aut Laberko, Alexandra verfasserin aut Shcherbina, Anna verfasserin aut Balashov, Dmitry verfasserin aut Soncini, Elena verfasserin aut Porta, Fulvio verfasserin aut Al-Mousa, Hamoud verfasserin aut Al-Saud, Bandar verfasserin aut Al-Dhekri, Hasan verfasserin aut Arnaout, Rand verfasserin aut Formankova, Renata verfasserin aut Bertrand, Yves verfasserin aut Lange, Andrzej verfasserin aut Smart, Joanne verfasserin aut Wolska-Kusnierz, Beata verfasserin aut Aquino, Victor M. verfasserin aut Dvorak, Christopher C. verfasserin aut Fasth, Anders verfasserin aut Fouyssac, Fanny verfasserin aut Heilmann, Carsten verfasserin aut Hoenig, Manfred verfasserin aut Schuetz, Catharina verfasserin aut Kelečić, Jadranka verfasserin aut Bredius, Robbert G.M. verfasserin aut Lankester, Arjan C. verfasserin aut Lindemans, Caroline A. verfasserin aut Suarez, Felipe verfasserin aut Sullivan, Kathleen E. verfasserin aut Albert, Michael H. verfasserin aut Kałwak, Krzysztof verfasserin aut Barlogis, Vincent verfasserin aut Bhatia, Monica verfasserin aut Bordon, Victoria verfasserin aut Czogala, Wojciech verfasserin aut Alonso, Laura verfasserin aut Dogu, Figen verfasserin aut Gozdzik, Jolanta verfasserin aut Ikinciogullari, Aydan verfasserin aut Kriván, Gergely verfasserin aut Ljungman, Per verfasserin aut Meyts, Isabelle verfasserin aut Mustillo, Peter verfasserin aut Smith, Angela R. verfasserin aut Speckmann, Carsten verfasserin aut Sundin, Mikael verfasserin aut Keogh, Steven John verfasserin aut Shaw, Peter John verfasserin aut Boelens, Jaap Jan verfasserin aut Schulz, Ansgar S. verfasserin aut Sedlacek, Petr verfasserin aut Veys, Paul verfasserin aut Mahlaoui, Nizar verfasserin aut Janda, Ales verfasserin aut Davies, E. Graham verfasserin aut Fischer, Alain verfasserin aut Cowan, Morton J. verfasserin aut Gennery, Andrew Richard verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 143, Seite 2238-2253 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:143 pages:2238-2253 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 143 2238-2253 |
allfieldsGer |
10.1016/j.jaci.2018.12.1010 doi (DE-627)ELV002384590 (ELSEVIER)S0091-6749(19)30034-X DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Ferrua, Francesca verfasserin aut Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency Galimberti, Stefania verfasserin aut Courteille, Virginie verfasserin aut Slatter, Mary Anne verfasserin aut Booth, Claire verfasserin aut Moshous, Despina verfasserin aut Neven, Benedicte verfasserin aut Blanche, Stephane verfasserin aut Cavazzana, Marina verfasserin aut Laberko, Alexandra verfasserin aut Shcherbina, Anna verfasserin aut Balashov, Dmitry verfasserin aut Soncini, Elena verfasserin aut Porta, Fulvio verfasserin aut Al-Mousa, Hamoud verfasserin aut Al-Saud, Bandar verfasserin aut Al-Dhekri, Hasan verfasserin aut Arnaout, Rand verfasserin aut Formankova, Renata verfasserin aut Bertrand, Yves verfasserin aut Lange, Andrzej verfasserin aut Smart, Joanne verfasserin aut Wolska-Kusnierz, Beata verfasserin aut Aquino, Victor M. verfasserin aut Dvorak, Christopher C. verfasserin aut Fasth, Anders verfasserin aut Fouyssac, Fanny verfasserin aut Heilmann, Carsten verfasserin aut Hoenig, Manfred verfasserin aut Schuetz, Catharina verfasserin aut Kelečić, Jadranka verfasserin aut Bredius, Robbert G.M. verfasserin aut Lankester, Arjan C. verfasserin aut Lindemans, Caroline A. verfasserin aut Suarez, Felipe verfasserin aut Sullivan, Kathleen E. verfasserin aut Albert, Michael H. verfasserin aut Kałwak, Krzysztof verfasserin aut Barlogis, Vincent verfasserin aut Bhatia, Monica verfasserin aut Bordon, Victoria verfasserin aut Czogala, Wojciech verfasserin aut Alonso, Laura verfasserin aut Dogu, Figen verfasserin aut Gozdzik, Jolanta verfasserin aut Ikinciogullari, Aydan verfasserin aut Kriván, Gergely verfasserin aut Ljungman, Per verfasserin aut Meyts, Isabelle verfasserin aut Mustillo, Peter verfasserin aut Smith, Angela R. verfasserin aut Speckmann, Carsten verfasserin aut Sundin, Mikael verfasserin aut Keogh, Steven John verfasserin aut Shaw, Peter John verfasserin aut Boelens, Jaap Jan verfasserin aut Schulz, Ansgar S. verfasserin aut Sedlacek, Petr verfasserin aut Veys, Paul verfasserin aut Mahlaoui, Nizar verfasserin aut Janda, Ales verfasserin aut Davies, E. Graham verfasserin aut Fischer, Alain verfasserin aut Cowan, Morton J. verfasserin aut Gennery, Andrew Richard verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 143, Seite 2238-2253 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:143 pages:2238-2253 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 143 2238-2253 |
allfieldsSound |
10.1016/j.jaci.2018.12.1010 doi (DE-627)ELV002384590 (ELSEVIER)S0091-6749(19)30034-X DE-627 ger DE-627 rda eng 610 DE-600 44.45 bkl 44.78 bkl Ferrua, Francesca verfasserin aut Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency Galimberti, Stefania verfasserin aut Courteille, Virginie verfasserin aut Slatter, Mary Anne verfasserin aut Booth, Claire verfasserin aut Moshous, Despina verfasserin aut Neven, Benedicte verfasserin aut Blanche, Stephane verfasserin aut Cavazzana, Marina verfasserin aut Laberko, Alexandra verfasserin aut Shcherbina, Anna verfasserin aut Balashov, Dmitry verfasserin aut Soncini, Elena verfasserin aut Porta, Fulvio verfasserin aut Al-Mousa, Hamoud verfasserin aut Al-Saud, Bandar verfasserin aut Al-Dhekri, Hasan verfasserin aut Arnaout, Rand verfasserin aut Formankova, Renata verfasserin aut Bertrand, Yves verfasserin aut Lange, Andrzej verfasserin aut Smart, Joanne verfasserin aut Wolska-Kusnierz, Beata verfasserin aut Aquino, Victor M. verfasserin aut Dvorak, Christopher C. verfasserin aut Fasth, Anders verfasserin aut Fouyssac, Fanny verfasserin aut Heilmann, Carsten verfasserin aut Hoenig, Manfred verfasserin aut Schuetz, Catharina verfasserin aut Kelečić, Jadranka verfasserin aut Bredius, Robbert G.M. verfasserin aut Lankester, Arjan C. verfasserin aut Lindemans, Caroline A. verfasserin aut Suarez, Felipe verfasserin aut Sullivan, Kathleen E. verfasserin aut Albert, Michael H. verfasserin aut Kałwak, Krzysztof verfasserin aut Barlogis, Vincent verfasserin aut Bhatia, Monica verfasserin aut Bordon, Victoria verfasserin aut Czogala, Wojciech verfasserin aut Alonso, Laura verfasserin aut Dogu, Figen verfasserin aut Gozdzik, Jolanta verfasserin aut Ikinciogullari, Aydan verfasserin aut Kriván, Gergely verfasserin aut Ljungman, Per verfasserin aut Meyts, Isabelle verfasserin aut Mustillo, Peter verfasserin aut Smith, Angela R. verfasserin aut Speckmann, Carsten verfasserin aut Sundin, Mikael verfasserin aut Keogh, Steven John verfasserin aut Shaw, Peter John verfasserin aut Boelens, Jaap Jan verfasserin aut Schulz, Ansgar S. verfasserin aut Sedlacek, Petr verfasserin aut Veys, Paul verfasserin aut Mahlaoui, Nizar verfasserin aut Janda, Ales verfasserin aut Davies, E. Graham verfasserin aut Fischer, Alain verfasserin aut Cowan, Morton J. verfasserin aut Gennery, Andrew Richard verfasserin aut Enthalten in The journal of allergy and clinical immunology Amsterdam [u.a.] : Elsevier, 1971 143, Seite 2238-2253 Online-Ressource (DE-627)32045553X (DE-600)2006613-2 (DE-576)094478864 1097-6825 nnns volume:143 pages:2238-2253 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie 44.78 Immunkrankheiten AR 143 2238-2253 |
language |
English |
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Enthalten in The journal of allergy and clinical immunology 143, Seite 2238-2253 volume:143 pages:2238-2253 |
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Enthalten in The journal of allergy and clinical immunology 143, Seite 2238-2253 volume:143 pages:2238-2253 |
format_phy_str_mv |
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bklname |
Immunologie Immunkrankheiten |
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findex.gbv.de |
topic_facet |
CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency |
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The journal of allergy and clinical immunology |
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Ferrua, Francesca @@aut@@ Galimberti, Stefania @@aut@@ Courteille, Virginie @@aut@@ Slatter, Mary Anne @@aut@@ Booth, Claire @@aut@@ Moshous, Despina @@aut@@ Neven, Benedicte @@aut@@ Blanche, Stephane @@aut@@ Cavazzana, Marina @@aut@@ Laberko, Alexandra @@aut@@ Shcherbina, Anna @@aut@@ Balashov, Dmitry @@aut@@ Soncini, Elena @@aut@@ Porta, Fulvio @@aut@@ Al-Mousa, Hamoud @@aut@@ Al-Saud, Bandar @@aut@@ Al-Dhekri, Hasan @@aut@@ Arnaout, Rand @@aut@@ Formankova, Renata @@aut@@ Bertrand, Yves @@aut@@ Lange, Andrzej @@aut@@ Smart, Joanne @@aut@@ Wolska-Kusnierz, Beata @@aut@@ Aquino, Victor M. @@aut@@ Dvorak, Christopher C. @@aut@@ Fasth, Anders @@aut@@ Fouyssac, Fanny @@aut@@ Heilmann, Carsten @@aut@@ Hoenig, Manfred @@aut@@ Schuetz, Catharina @@aut@@ Kelečić, Jadranka @@aut@@ Bredius, Robbert G.M. @@aut@@ Lankester, Arjan C. @@aut@@ Lindemans, Caroline A. @@aut@@ Suarez, Felipe @@aut@@ Sullivan, Kathleen E. @@aut@@ Albert, Michael H. @@aut@@ Kałwak, Krzysztof @@aut@@ Barlogis, Vincent @@aut@@ Bhatia, Monica @@aut@@ Bordon, Victoria @@aut@@ Czogala, Wojciech @@aut@@ Alonso, Laura @@aut@@ Dogu, Figen @@aut@@ Gozdzik, Jolanta @@aut@@ Ikinciogullari, Aydan @@aut@@ Kriván, Gergely @@aut@@ Ljungman, Per @@aut@@ Meyts, Isabelle @@aut@@ Mustillo, Peter @@aut@@ Smith, Angela R. @@aut@@ Speckmann, Carsten @@aut@@ Sundin, Mikael @@aut@@ Keogh, Steven John @@aut@@ Shaw, Peter John @@aut@@ Boelens, Jaap Jan @@aut@@ Schulz, Ansgar S. @@aut@@ Sedlacek, Petr @@aut@@ Veys, Paul @@aut@@ Mahlaoui, Nizar @@aut@@ Janda, Ales @@aut@@ Davies, E. Graham @@aut@@ Fischer, Alain @@aut@@ Cowan, Morton J. @@aut@@ Gennery, Andrew Richard @@aut@@ |
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2019-01-01T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV002384590</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524155851.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230429s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jaci.2018.12.1010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV002384590</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0091-6749(19)30034-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.45</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.78</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ferrua, Francesca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. 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Ferrua, Francesca ddc 610 bkl 44.45 bkl 44.78 misc CD40 ligand misc hematopoietic stem cell transplantation misc X-linked hyper-IgM syndrome misc primary immunodeficiency Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study |
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610 DE-600 44.45 bkl 44.78 bkl Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study CD40 ligand hematopoietic stem cell transplantation X-linked hyper-IgM syndrome primary immunodeficiency |
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Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study |
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Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study |
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Ferrua, Francesca Galimberti, Stefania Courteille, Virginie Slatter, Mary Anne Booth, Claire Moshous, Despina Neven, Benedicte Blanche, Stephane Cavazzana, Marina Laberko, Alexandra Shcherbina, Anna Balashov, Dmitry Soncini, Elena Porta, Fulvio Al-Mousa, Hamoud Al-Saud, Bandar Al-Dhekri, Hasan Arnaout, Rand Formankova, Renata Bertrand, Yves Lange, Andrzej Smart, Joanne Wolska-Kusnierz, Beata Aquino, Victor M. Dvorak, Christopher C. Fasth, Anders Fouyssac, Fanny Heilmann, Carsten Hoenig, Manfred Schuetz, Catharina Kelečić, Jadranka Bredius, Robbert G.M. Lankester, Arjan C. Lindemans, Caroline A. Suarez, Felipe Sullivan, Kathleen E. Albert, Michael H. Kałwak, Krzysztof Barlogis, Vincent Bhatia, Monica Bordon, Victoria Czogala, Wojciech Alonso, Laura Dogu, Figen Gozdzik, Jolanta Ikinciogullari, Aydan Kriván, Gergely Ljungman, Per Meyts, Isabelle Mustillo, Peter Smith, Angela R. Speckmann, Carsten Sundin, Mikael Keogh, Steven John Shaw, Peter John Boelens, Jaap Jan Schulz, Ansgar S. Sedlacek, Petr Veys, Paul Mahlaoui, Nizar Janda, Ales Davies, E. Graham Fischer, Alain Cowan, Morton J. Gennery, Andrew Richard |
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10.1016/j.jaci.2018.12.1010 |
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hematopoietic stem cell transplantation for cd40 ligand deficiency: results from an ebmt/esid-iewp-scetide-pidtc study |
title_auth |
Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study |
abstract |
Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. |
abstractGer |
Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. |
abstract_unstemmed |
Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. Prospective studies are required to compare the risks of HSCT with those of lifelong supportive therapy. |
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Galimberti, Stefania Courteille, Virginie Slatter, Mary Anne Booth, Claire Moshous, Despina Neven, Benedicte Blanche, Stephane Cavazzana, Marina Laberko, Alexandra Shcherbina, Anna Balashov, Dmitry Soncini, Elena Porta, Fulvio Al-Mousa, Hamoud Al-Saud, Bandar Al-Dhekri, Hasan Arnaout, Rand Formankova, Renata Bertrand, Yves Lange, Andrzej Smart, Joanne Wolska-Kusnierz, Beata Aquino, Victor M. Dvorak, Christopher C. Fasth, Anders Fouyssac, Fanny Heilmann, Carsten Hoenig, Manfred Schuetz, Catharina Kelečić, Jadranka Bredius, Robbert G.M. Lankester, Arjan C. Lindemans, Caroline A. Suarez, Felipe Sullivan, Kathleen E. Albert, Michael H. Kałwak, Krzysztof Barlogis, Vincent Bhatia, Monica Bordon, Victoria Czogala, Wojciech Alonso, Laura Dogu, Figen Gozdzik, Jolanta Ikinciogullari, Aydan Kriván, Gergely Ljungman, Per Meyts, Isabelle Mustillo, Peter Smith, Angela R. Speckmann, Carsten Sundin, Mikael Keogh, Steven John Shaw, Peter John Boelens, Jaap Jan Schulz, Ansgar S. Sedlacek, Petr Veys, Paul Mahlaoui, Nizar Janda, Ales Davies, E. Graham Fischer, Alain Cowan, Morton J. Gennery, Andrew Richard |
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Galimberti, Stefania Courteille, Virginie Slatter, Mary Anne Booth, Claire Moshous, Despina Neven, Benedicte Blanche, Stephane Cavazzana, Marina Laberko, Alexandra Shcherbina, Anna Balashov, Dmitry Soncini, Elena Porta, Fulvio Al-Mousa, Hamoud Al-Saud, Bandar Al-Dhekri, Hasan Arnaout, Rand Formankova, Renata Bertrand, Yves Lange, Andrzej Smart, Joanne Wolska-Kusnierz, Beata Aquino, Victor M. Dvorak, Christopher C. Fasth, Anders Fouyssac, Fanny Heilmann, Carsten Hoenig, Manfred Schuetz, Catharina Kelečić, Jadranka Bredius, Robbert G.M. Lankester, Arjan C. Lindemans, Caroline A. Suarez, Felipe Sullivan, Kathleen E. Albert, Michael H. Kałwak, Krzysztof Barlogis, Vincent Bhatia, Monica Bordon, Victoria Czogala, Wojciech Alonso, Laura Dogu, Figen Gozdzik, Jolanta Ikinciogullari, Aydan Kriván, Gergely Ljungman, Per Meyts, Isabelle Mustillo, Peter Smith, Angela R. Speckmann, Carsten Sundin, Mikael Keogh, Steven John Shaw, Peter John Boelens, Jaap Jan Schulz, Ansgar S. Sedlacek, Petr Veys, Paul Mahlaoui, Nizar Janda, Ales Davies, E. Graham Fischer, Alain Cowan, Morton J. Gennery, Andrew Richard |
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10.1016/j.jaci.2018.12.1010 |
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2024-07-07T00:33:04.328Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV002384590</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524155851.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230429s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jaci.2018.12.1010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV002384590</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0091-6749(19)30034-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.45</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.78</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ferrua, Francesca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment is hematopoietic stem cell transplantation (HSCT).Objective: We performed an international collaborative study to improve patients' management, aiming to individualize risk factors and determine optimal HSCT characteristics.Methods: We retrospectively collected data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015. We analyzed outcome and variables' relevance with respect to survival and cure.Results: Overall survival (OS), event-free survival (EFS), and disease-free survival (DFS) were 78.2%, 58.1%, and 72.3% 5 years after HSCT. Results were better in transplantations performed in 2000 or later and in children less than 10 years old at the time of HSCT. Pre-existing organ damage negatively influenced outcome. Sclerosing cholangitis was the most important risk factor. After 2000, superior OS was achieved with matched donors. Use of myeloablative regimens and HSCT at 2 years or less from diagnosis associated with higher OS and DFS. EFS was best with matched sibling donors, myeloablative conditioning (MAC), and bone marrow–derived stem cells. Most rejections occurred after reduced-intensity or nonmyeloablative conditioning, which associated with poor donor cell engraftment. Mortality occurred mainly early after HSCT, predominantly from infections. Among survivors who ceased immunoglobulin replacement, T-lymphocyte chimerism was 50% or greater donor in 85.2%.Conclusion: HSCT is curative in patients with CD40L deficiency, with improved outcome if performed before organ damage development. MAC is associated with better OS, EFS, and DFS. 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|
score |
7.400278 |