Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment

Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complet...
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Gespeichert in:

Autor*in:	Steward, Kayla A. [verfasserIn] Kennedy, Richard [verfasserIn] Erus, Guray [verfasserIn] Nasrallah, Ilya M. [verfasserIn] Wadley, Virginia G. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging

Übergeordnetes Werk:	Enthalten in: Neuropsychologia - Amsterdam [u.a.] : Elsevier Science, 1963, 129, Seite 372-378
Übergeordnetes Werk:	volume:129 ; pages:372-378

DOI / URN:	10.1016/j.neuropsychologia.2019.04.023

Katalog-ID:	ELV002413604

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245	1	0	\|a Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment
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520			\|a Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association.
650		4	\|a Mild cognitive impairment
650		4	\|a Alzheimer's disease
650		4	\|a Self-awareness
650		4	\|a Instrumental activities of daily living
650		4	\|a Structural magnetic resonance imaging
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700	1		\|a Erus, Guray \|e verfasserin \|4 aut
700	1		\|a Nasrallah, Ilya M. \|e verfasserin \|4 aut
700	1		\|a Wadley, Virginia G. \|e verfasserin \|4 aut
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publishDate	2019
allfields	10.1016/j.neuropsychologia.2019.04.023 doi (DE-627)ELV002413604 (ELSEVIER)S0028-3932(19)30109-5 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 77.50 bkl 44.00 bkl Steward, Kayla A. verfasserin aut Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association. Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging Kennedy, Richard verfasserin aut Erus, Guray verfasserin aut Nasrallah, Ilya M. verfasserin aut Wadley, Virginia G. verfasserin aut Enthalten in Neuropsychologia Amsterdam [u.a.] : Elsevier Science, 1963 129, Seite 372-378 Online-Ressource (DE-627)306661268 (DE-600)1500656-6 (DE-576)08198684X 1873-3514 nnns volume:129 pages:372-378 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.00 Medizin: Allgemeines AR 129 372-378
spelling	10.1016/j.neuropsychologia.2019.04.023 doi (DE-627)ELV002413604 (ELSEVIER)S0028-3932(19)30109-5 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 77.50 bkl 44.00 bkl Steward, Kayla A. verfasserin aut Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association. Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging Kennedy, Richard verfasserin aut Erus, Guray verfasserin aut Nasrallah, Ilya M. verfasserin aut Wadley, Virginia G. verfasserin aut Enthalten in Neuropsychologia Amsterdam [u.a.] : Elsevier Science, 1963 129, Seite 372-378 Online-Ressource (DE-627)306661268 (DE-600)1500656-6 (DE-576)08198684X 1873-3514 nnns volume:129 pages:372-378 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.00 Medizin: Allgemeines AR 129 372-378
allfields_unstemmed	10.1016/j.neuropsychologia.2019.04.023 doi (DE-627)ELV002413604 (ELSEVIER)S0028-3932(19)30109-5 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 77.50 bkl 44.00 bkl Steward, Kayla A. verfasserin aut Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association. Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging Kennedy, Richard verfasserin aut Erus, Guray verfasserin aut Nasrallah, Ilya M. verfasserin aut Wadley, Virginia G. verfasserin aut Enthalten in Neuropsychologia Amsterdam [u.a.] : Elsevier Science, 1963 129, Seite 372-378 Online-Ressource (DE-627)306661268 (DE-600)1500656-6 (DE-576)08198684X 1873-3514 nnns volume:129 pages:372-378 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.00 Medizin: Allgemeines AR 129 372-378
allfieldsGer	10.1016/j.neuropsychologia.2019.04.023 doi (DE-627)ELV002413604 (ELSEVIER)S0028-3932(19)30109-5 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 77.50 bkl 44.00 bkl Steward, Kayla A. verfasserin aut Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association. Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging Kennedy, Richard verfasserin aut Erus, Guray verfasserin aut Nasrallah, Ilya M. verfasserin aut Wadley, Virginia G. verfasserin aut Enthalten in Neuropsychologia Amsterdam [u.a.] : Elsevier Science, 1963 129, Seite 372-378 Online-Ressource (DE-627)306661268 (DE-600)1500656-6 (DE-576)08198684X 1873-3514 nnns volume:129 pages:372-378 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.00 Medizin: Allgemeines AR 129 372-378
allfieldsSound	10.1016/j.neuropsychologia.2019.04.023 doi (DE-627)ELV002413604 (ELSEVIER)S0028-3932(19)30109-5 DE-627 ger DE-627 rda eng 610 DE-600 LING DE-30 fid 77.50 bkl 44.00 bkl Steward, Kayla A. verfasserin aut Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association. Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging Kennedy, Richard verfasserin aut Erus, Guray verfasserin aut Nasrallah, Ilya M. verfasserin aut Wadley, Virginia G. verfasserin aut Enthalten in Neuropsychologia Amsterdam [u.a.] : Elsevier Science, 1963 129, Seite 372-378 Online-Ressource (DE-627)306661268 (DE-600)1500656-6 (DE-576)08198684X 1873-3514 nnns volume:129 pages:372-378 GBV_USEFLAG_U SYSFLAG_U GBV_ELV FID-LING SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 77.50 Psychophysiologie 44.00 Medizin: Allgemeines AR 129 372-378
language	English
source	Enthalten in Neuropsychologia 129, Seite 372-378 volume:129 pages:372-378
sourceStr	Enthalten in Neuropsychologia 129, Seite 372-378 volume:129 pages:372-378
format_phy_str_mv	Article
bklname	Psychophysiologie Medizin: Allgemeines
institution	findex.gbv.de
topic_facet	Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging
dewey-raw	610
isfreeaccess_bool	false
container_title	Neuropsychologia
authorswithroles_txt_mv	Steward, Kayla A. @@aut@@ Kennedy, Richard @@aut@@ Erus, Guray @@aut@@ Nasrallah, Ilya M. @@aut@@ Wadley, Virginia G. @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	306661268
dewey-sort	3610
id	ELV002413604
language_de	englisch
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author	Steward, Kayla A.
spellingShingle	Steward, Kayla A. ddc 610 fid LING bkl 77.50 bkl 44.00 misc Mild cognitive impairment misc Alzheimer's disease misc Self-awareness misc Instrumental activities of daily living misc Structural magnetic resonance imaging Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment
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topic_title	610 DE-600 LING DE-30 fid 77.50 bkl 44.00 bkl Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment Mild cognitive impairment Alzheimer's disease Self-awareness Instrumental activities of daily living Structural magnetic resonance imaging
topic	ddc 610 fid LING bkl 77.50 bkl 44.00 misc Mild cognitive impairment misc Alzheimer's disease misc Self-awareness misc Instrumental activities of daily living misc Structural magnetic resonance imaging
topic_unstemmed	ddc 610 fid LING bkl 77.50 bkl 44.00 misc Mild cognitive impairment misc Alzheimer's disease misc Self-awareness misc Instrumental activities of daily living misc Structural magnetic resonance imaging
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title	Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment
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title_full	Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment
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title_sort	poor awareness of iadl deficits is associated with reduced regional brain volume in older adults with cognitive impairment
title_auth	Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment
abstract	Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association.
abstractGer	Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association.
abstract_unstemmed	Performance of instrumental activities of daily living (IADLs) can become compromised in older adults with mild cognitive impairment (MCI). Patients’ level of insight into their everyday functioning varies both amongst individuals and across domains assessed, with some individuals exhibiting complete unawareness of deficits. The current cross-sectional study examined the neuroanatomical substrates of self-awareness in order to help explain the variability in this phenomenon in older adults across a continuum of cognitive impairment. Eighty-five participants (ages 54–88, mean age = 73 years, 57% female, 89% Caucasian) diagnosed with MCI or mild probable dementia underwent structural magnetic resonance imaging. Level of self-awareness was assessed by calculating the discrepancy between objective and subjective performance across six IADLs (Financial Management, Driving, Grocery Shopping, Nutrition Evaluation, Medication Management, and Telephone Use). Over-estimation of current abilities occurred in 13–31% of the sample depending on which IADL was evaluated. Poor awareness was significantly related to reduced volume in the bilateral medial prefrontal cortex, middle and posterior cingulate cortex, right insular cortex, and cerebellum. No associations were found with total white matter lesion load. These findings were broadly consistent across all functional domains assessed, supporting the theory that cortical midline and cerebellar structures are involved in self-referential processing across a variety of different cognitive and behavioral skills. Longitudinal studies are needed to confirm this association.
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title_short	Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment
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Poor awareness of IADL deficits is associated with reduced regional brain volume in older adults with cognitive impairment

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