The effect of a treatment delay on outcome in metastatic renal cell carcinoma
Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Iacovelli, Roberto [verfasserIn] Galli, Luca [verfasserIn] De Giorgi, Ugo [verfasserIn] Porta, Camillo [verfasserIn] Nolè, Franco [verfasserIn] Zucali, Paolo [verfasserIn] Sabbatini, Roberto [verfasserIn] Mosca, Alessandra [verfasserIn] Atzori, Francesco [verfasserIn] Santini, Daniele [verfasserIn] Facchini, Gaetano [verfasserIn] Fornarini, Giuseppe [verfasserIn] Buti, Sebastiano [verfasserIn] Massari, Francesco [verfasserIn] Masini, Cristina [verfasserIn] Ricotta, Riccardo [verfasserIn] Biasco, Elisa [verfasserIn] Lolli, Cristian [verfasserIn] Gri, Nicole [verfasserIn] Verri, Elena [verfasserIn] Miggiano, Chiara [verfasserIn] Vitale, Maria Giuseppa [verfasserIn] Tortora, Giampaolo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Urologic oncology - Amsterdam [u.a.] : Elsevier Science, 1995, 37, Seite 529.e1-529.e7 |
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| Übergeordnetes Werk: |
volume:37 ; pages:529.e1-529.e7 |
| DOI / URN: |
10.1016/j.urolonc.2019.03.005 |
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| Katalog-ID: |
ELV002627728 |
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| 024 | 7 | |a 10.1016/j.urolonc.2019.03.005 |2 doi | |
| 035 | |a (DE-627)ELV002627728 | ||
| 035 | |a (ELSEVIER)S1078-1439(19)30098-5 | ||
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| 084 | |a 44.81 |2 bkl | ||
| 084 | |a 44.88 |2 bkl | ||
| 100 | 1 | |a Iacovelli, Roberto |e verfasserin |0 (orcid)0000-0002-1750-2117 |4 aut | |
| 245 | 1 | 0 | |a The effect of a treatment delay on outcome in metastatic renal cell carcinoma |
| 264 | 1 | |c 2019 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. | ||
| 650 | 4 | |a mRCC | |
| 650 | 4 | |a First-line | |
| 650 | 4 | |a Cytoreductive nephrectomy | |
| 650 | 4 | |a Tyrosine kinase inhibitors | |
| 650 | 4 | |a Treatment delay | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Galli, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a De Giorgi, Ugo |e verfasserin |4 aut | |
| 700 | 1 | |a Porta, Camillo |e verfasserin |4 aut | |
| 700 | 1 | |a Nolè, Franco |e verfasserin |4 aut | |
| 700 | 1 | |a Zucali, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Sabbatini, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Mosca, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Atzori, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Santini, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Facchini, Gaetano |e verfasserin |4 aut | |
| 700 | 1 | |a Fornarini, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Buti, Sebastiano |e verfasserin |0 (orcid)0000-0003-0876-0226 |4 aut | |
| 700 | 1 | |a Massari, Francesco |e verfasserin |0 (orcid)0000-0001-6476-6871 |4 aut | |
| 700 | 1 | |a Masini, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Ricotta, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Biasco, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Lolli, Cristian |e verfasserin |4 aut | |
| 700 | 1 | |a Gri, Nicole |e verfasserin |4 aut | |
| 700 | 1 | |a Verri, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Miggiano, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Vitale, Maria Giuseppa |e verfasserin |4 aut | |
| 700 | 1 | |a Tortora, Giampaolo |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Urologic oncology |d Amsterdam [u.a.] : Elsevier Science, 1995 |g 37, Seite 529.e1-529.e7 |h Online-Ressource |w (DE-627)320491021 |w (DE-600)2011021-2 |w (DE-576)272349585 |x 1873-2496 |7 nnns |
| 773 | 1 | 8 | |g volume:37 |g pages:529.e1-529.e7 |
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| 936 | b | k | |a 44.81 |j Onkologie |
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| 952 | |d 37 |h 529.e1-529.e7 | ||
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r i ri l g lg g u d gu gud c p cp f n fn p z pz r s rs a m am f a fa d s ds g f gf g f gf s b sb f m fm c m cm r r rr e b eb c l cl n g ng e v ev c m cm m g v mg mgv g t gt |
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article:18732496:2019----::hefcoaramndlynucmimtsair |
| hierarchy_sort_str |
2019 |
| bklnumber |
44.81 44.88 |
| publishDate |
2019 |
| allfields |
10.1016/j.urolonc.2019.03.005 doi (DE-627)ELV002627728 (ELSEVIER)S1078-1439(19)30098-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.88 bkl Iacovelli, Roberto verfasserin (orcid)0000-0002-1750-2117 aut The effect of a treatment delay on outcome in metastatic renal cell carcinoma 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival Galli, Luca verfasserin aut De Giorgi, Ugo verfasserin aut Porta, Camillo verfasserin aut Nolè, Franco verfasserin aut Zucali, Paolo verfasserin aut Sabbatini, Roberto verfasserin aut Mosca, Alessandra verfasserin aut Atzori, Francesco verfasserin aut Santini, Daniele verfasserin aut Facchini, Gaetano verfasserin aut Fornarini, Giuseppe verfasserin aut Buti, Sebastiano verfasserin (orcid)0000-0003-0876-0226 aut Massari, Francesco verfasserin (orcid)0000-0001-6476-6871 aut Masini, Cristina verfasserin aut Ricotta, Riccardo verfasserin aut Biasco, Elisa verfasserin aut Lolli, Cristian verfasserin aut Gri, Nicole verfasserin aut Verri, Elena verfasserin aut Miggiano, Chiara verfasserin aut Vitale, Maria Giuseppa verfasserin aut Tortora, Giampaolo verfasserin aut Enthalten in Urologic oncology Amsterdam [u.a.] : Elsevier Science, 1995 37, Seite 529.e1-529.e7 Online-Ressource (DE-627)320491021 (DE-600)2011021-2 (DE-576)272349585 1873-2496 nnns volume:37 pages:529.e1-529.e7 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.88 Urologie Nephrologie AR 37 529.e1-529.e7 |
| spelling |
10.1016/j.urolonc.2019.03.005 doi (DE-627)ELV002627728 (ELSEVIER)S1078-1439(19)30098-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.88 bkl Iacovelli, Roberto verfasserin (orcid)0000-0002-1750-2117 aut The effect of a treatment delay on outcome in metastatic renal cell carcinoma 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival Galli, Luca verfasserin aut De Giorgi, Ugo verfasserin aut Porta, Camillo verfasserin aut Nolè, Franco verfasserin aut Zucali, Paolo verfasserin aut Sabbatini, Roberto verfasserin aut Mosca, Alessandra verfasserin aut Atzori, Francesco verfasserin aut Santini, Daniele verfasserin aut Facchini, Gaetano verfasserin aut Fornarini, Giuseppe verfasserin aut Buti, Sebastiano verfasserin (orcid)0000-0003-0876-0226 aut Massari, Francesco verfasserin (orcid)0000-0001-6476-6871 aut Masini, Cristina verfasserin aut Ricotta, Riccardo verfasserin aut Biasco, Elisa verfasserin aut Lolli, Cristian verfasserin aut Gri, Nicole verfasserin aut Verri, Elena verfasserin aut Miggiano, Chiara verfasserin aut Vitale, Maria Giuseppa verfasserin aut Tortora, Giampaolo verfasserin aut Enthalten in Urologic oncology Amsterdam [u.a.] : Elsevier Science, 1995 37, Seite 529.e1-529.e7 Online-Ressource (DE-627)320491021 (DE-600)2011021-2 (DE-576)272349585 1873-2496 nnns volume:37 pages:529.e1-529.e7 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.88 Urologie Nephrologie AR 37 529.e1-529.e7 |
| allfields_unstemmed |
10.1016/j.urolonc.2019.03.005 doi (DE-627)ELV002627728 (ELSEVIER)S1078-1439(19)30098-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.88 bkl Iacovelli, Roberto verfasserin (orcid)0000-0002-1750-2117 aut The effect of a treatment delay on outcome in metastatic renal cell carcinoma 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival Galli, Luca verfasserin aut De Giorgi, Ugo verfasserin aut Porta, Camillo verfasserin aut Nolè, Franco verfasserin aut Zucali, Paolo verfasserin aut Sabbatini, Roberto verfasserin aut Mosca, Alessandra verfasserin aut Atzori, Francesco verfasserin aut Santini, Daniele verfasserin aut Facchini, Gaetano verfasserin aut Fornarini, Giuseppe verfasserin aut Buti, Sebastiano verfasserin (orcid)0000-0003-0876-0226 aut Massari, Francesco verfasserin (orcid)0000-0001-6476-6871 aut Masini, Cristina verfasserin aut Ricotta, Riccardo verfasserin aut Biasco, Elisa verfasserin aut Lolli, Cristian verfasserin aut Gri, Nicole verfasserin aut Verri, Elena verfasserin aut Miggiano, Chiara verfasserin aut Vitale, Maria Giuseppa verfasserin aut Tortora, Giampaolo verfasserin aut Enthalten in Urologic oncology Amsterdam [u.a.] : Elsevier Science, 1995 37, Seite 529.e1-529.e7 Online-Ressource (DE-627)320491021 (DE-600)2011021-2 (DE-576)272349585 1873-2496 nnns volume:37 pages:529.e1-529.e7 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.88 Urologie Nephrologie AR 37 529.e1-529.e7 |
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10.1016/j.urolonc.2019.03.005 doi (DE-627)ELV002627728 (ELSEVIER)S1078-1439(19)30098-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.88 bkl Iacovelli, Roberto verfasserin (orcid)0000-0002-1750-2117 aut The effect of a treatment delay on outcome in metastatic renal cell carcinoma 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival Galli, Luca verfasserin aut De Giorgi, Ugo verfasserin aut Porta, Camillo verfasserin aut Nolè, Franco verfasserin aut Zucali, Paolo verfasserin aut Sabbatini, Roberto verfasserin aut Mosca, Alessandra verfasserin aut Atzori, Francesco verfasserin aut Santini, Daniele verfasserin aut Facchini, Gaetano verfasserin aut Fornarini, Giuseppe verfasserin aut Buti, Sebastiano verfasserin (orcid)0000-0003-0876-0226 aut Massari, Francesco verfasserin (orcid)0000-0001-6476-6871 aut Masini, Cristina verfasserin aut Ricotta, Riccardo verfasserin aut Biasco, Elisa verfasserin aut Lolli, Cristian verfasserin aut Gri, Nicole verfasserin aut Verri, Elena verfasserin aut Miggiano, Chiara verfasserin aut Vitale, Maria Giuseppa verfasserin aut Tortora, Giampaolo verfasserin aut Enthalten in Urologic oncology Amsterdam [u.a.] : Elsevier Science, 1995 37, Seite 529.e1-529.e7 Online-Ressource (DE-627)320491021 (DE-600)2011021-2 (DE-576)272349585 1873-2496 nnns volume:37 pages:529.e1-529.e7 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.88 Urologie Nephrologie AR 37 529.e1-529.e7 |
| allfieldsSound |
10.1016/j.urolonc.2019.03.005 doi (DE-627)ELV002627728 (ELSEVIER)S1078-1439(19)30098-5 DE-627 ger DE-627 rda eng 610 DE-600 44.81 bkl 44.88 bkl Iacovelli, Roberto verfasserin (orcid)0000-0002-1750-2117 aut The effect of a treatment delay on outcome in metastatic renal cell carcinoma 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival Galli, Luca verfasserin aut De Giorgi, Ugo verfasserin aut Porta, Camillo verfasserin aut Nolè, Franco verfasserin aut Zucali, Paolo verfasserin aut Sabbatini, Roberto verfasserin aut Mosca, Alessandra verfasserin aut Atzori, Francesco verfasserin aut Santini, Daniele verfasserin aut Facchini, Gaetano verfasserin aut Fornarini, Giuseppe verfasserin aut Buti, Sebastiano verfasserin (orcid)0000-0003-0876-0226 aut Massari, Francesco verfasserin (orcid)0000-0001-6476-6871 aut Masini, Cristina verfasserin aut Ricotta, Riccardo verfasserin aut Biasco, Elisa verfasserin aut Lolli, Cristian verfasserin aut Gri, Nicole verfasserin aut Verri, Elena verfasserin aut Miggiano, Chiara verfasserin aut Vitale, Maria Giuseppa verfasserin aut Tortora, Giampaolo verfasserin aut Enthalten in Urologic oncology Amsterdam [u.a.] : Elsevier Science, 1995 37, Seite 529.e1-529.e7 Online-Ressource (DE-627)320491021 (DE-600)2011021-2 (DE-576)272349585 1873-2496 nnns volume:37 pages:529.e1-529.e7 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.81 Onkologie 44.88 Urologie Nephrologie AR 37 529.e1-529.e7 |
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Enthalten in Urologic oncology 37, Seite 529.e1-529.e7 volume:37 pages:529.e1-529.e7 |
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mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival |
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Iacovelli, Roberto @@aut@@ Galli, Luca @@aut@@ De Giorgi, Ugo @@aut@@ Porta, Camillo @@aut@@ Nolè, Franco @@aut@@ Zucali, Paolo @@aut@@ Sabbatini, Roberto @@aut@@ Mosca, Alessandra @@aut@@ Atzori, Francesco @@aut@@ Santini, Daniele @@aut@@ Facchini, Gaetano @@aut@@ Fornarini, Giuseppe @@aut@@ Buti, Sebastiano @@aut@@ Massari, Francesco @@aut@@ Masini, Cristina @@aut@@ Ricotta, Riccardo @@aut@@ Biasco, Elisa @@aut@@ Lolli, Cristian @@aut@@ Gri, Nicole @@aut@@ Verri, Elena @@aut@@ Miggiano, Chiara @@aut@@ Vitale, Maria Giuseppa @@aut@@ Tortora, Giampaolo @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV002627728</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230524161355.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230429s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.urolonc.2019.03.005</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV002627728</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1078-1439(19)30098-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.81</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.88</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Iacovelli, Roberto</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-1750-2117</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The effect of a treatment delay on outcome in metastatic renal cell carcinoma</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. 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Iacovelli, Roberto |
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Iacovelli, Roberto ddc 610 bkl 44.81 bkl 44.88 misc mRCC misc First-line misc Cytoreductive nephrectomy misc Tyrosine kinase inhibitors misc Treatment delay misc Survival The effect of a treatment delay on outcome in metastatic renal cell carcinoma |
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610 DE-600 44.81 bkl 44.88 bkl The effect of a treatment delay on outcome in metastatic renal cell carcinoma mRCC First-line Cytoreductive nephrectomy Tyrosine kinase inhibitors Treatment delay Survival |
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ddc 610 bkl 44.81 bkl 44.88 misc mRCC misc First-line misc Cytoreductive nephrectomy misc Tyrosine kinase inhibitors misc Treatment delay misc Survival |
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The effect of a treatment delay on outcome in metastatic renal cell carcinoma |
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The effect of a treatment delay on outcome in metastatic renal cell carcinoma |
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Urologic oncology |
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Iacovelli, Roberto Galli, Luca De Giorgi, Ugo Porta, Camillo Nolè, Franco Zucali, Paolo Sabbatini, Roberto Mosca, Alessandra Atzori, Francesco Santini, Daniele Facchini, Gaetano Fornarini, Giuseppe Buti, Sebastiano Massari, Francesco Masini, Cristina Ricotta, Riccardo Biasco, Elisa Lolli, Cristian Gri, Nicole Verri, Elena Miggiano, Chiara Vitale, Maria Giuseppa Tortora, Giampaolo |
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10.1016/j.urolonc.2019.03.005 |
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the effect of a treatment delay on outcome in metastatic renal cell carcinoma |
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The effect of a treatment delay on outcome in metastatic renal cell carcinoma |
| abstract |
Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. |
| abstractGer |
Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. |
| abstract_unstemmed |
Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.Patients and methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.Results: A total of 835 patients were assessed and 635 were included in the final analysis. The median TD was 6.3 weeks. No significant differences were found in baseline characteristics between patients experiencing a TD below/equal to or above the median value, with the exceptions being the rate of bone metastases (25.3% vs. 35.9%) and advanced disease at diagnosis (34.7% vs. 54.9%). In patients who had received a previous nephrectomy for localized disease, the TD was 5.3 compared to 8.0 weeks for those with metastatic disease at diagnosis (P = 0.001). Among this latter group, 68.7% had received a cytoreductive nephrectomy. In patients with a TD below/equal to and above the median value, the median progression-free survival was 10.3 and 11.2 months, respectively (hazard ratio = 1.03; 95% confidence intervals, 0.86–1.22; P = 0.78); the median overall survival was 27.3 and 28.2 months, respectively (hazard ratio = 1.04; 95% confidence intervals, 0.86–1.27; P = 0.68). The lack of differences was confirmed when adjusted for prognostic factors and baseline characteristics.Conclusions: This study reports that patients with bone metastases and advanced disease at diagnosis have a significant probability of experiencing delayed first-line therapy of more than 6 weeks from the time of diagnosis. However, a TD does not significantly affect outcomes and survival. |
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| title_short |
The effect of a treatment delay on outcome in metastatic renal cell carcinoma |
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true |
| author2 |
Galli, Luca De Giorgi, Ugo Porta, Camillo Nolè, Franco Zucali, Paolo Sabbatini, Roberto Mosca, Alessandra Atzori, Francesco Santini, Daniele Facchini, Gaetano Fornarini, Giuseppe Buti, Sebastiano Massari, Francesco Masini, Cristina Ricotta, Riccardo Biasco, Elisa Lolli, Cristian Gri, Nicole Verri, Elena Miggiano, Chiara Vitale, Maria Giuseppa Tortora, Giampaolo |
| author2Str |
Galli, Luca De Giorgi, Ugo Porta, Camillo Nolè, Franco Zucali, Paolo Sabbatini, Roberto Mosca, Alessandra Atzori, Francesco Santini, Daniele Facchini, Gaetano Fornarini, Giuseppe Buti, Sebastiano Massari, Francesco Masini, Cristina Ricotta, Riccardo Biasco, Elisa Lolli, Cristian Gri, Nicole Verri, Elena Miggiano, Chiara Vitale, Maria Giuseppa Tortora, Giampaolo |
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320491021 |
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c |
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false |
| doi_str |
10.1016/j.urolonc.2019.03.005 |
| up_date |
2024-07-06T16:54:41.479Z |
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1803849439883821056 |
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