Polysaccharides from
Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Weifeng [verfasserIn] Zhao, Jinmeng [verfasserIn] Yao, Qing [verfasserIn] Li, Wenqi [verfasserIn] Zhi, Wenbing [verfasserIn] Zang, Lulu [verfasserIn] Liu, Fang [verfasserIn] Niu, Xiaofeng [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of functional foods - Amsterdam [u.a.] : Elsevier, 2009, 60 |
|---|---|
| Übergeordnetes Werk: |
volume:60 |
| DOI / URN: |
10.1016/j.jff.2019.05.047 |
|---|
| Katalog-ID: |
ELV002628716 |
|---|
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| 520 | |a Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. | ||
| 650 | 4 | |a Polysaccharides from | |
| 650 | 4 | |a Vascular smooth muscle cells | |
| 650 | 4 | |a Proliferation | |
| 650 | 4 | |a Migration | |
| 650 | 4 | |a TLR4/NF-κB | |
| 700 | 1 | |a Zhao, Jinmeng |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wenqi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhi, Wenbing |e verfasserin |4 aut | |
| 700 | 1 | |a Zang, Lulu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Xiaofeng |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:60 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_32 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_90 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_100 | ||
| 912 | |a GBV_ILN_101 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_150 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_165 | ||
| 912 | |a GBV_ILN_187 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_224 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2008 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2056 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4335 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
| 912 | |a GBV_ILN_4700 | ||
| 951 | |a AR | ||
| 952 | |d 60 | ||
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2019 |
| publishDate |
2019 |
| allfields |
10.1016/j.jff.2019.05.047 doi (DE-627)ELV002628716 (ELSEVIER)S1756-4646(19)30312-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Li, Weifeng verfasserin aut Polysaccharides from 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. Polysaccharides from Vascular smooth muscle cells Proliferation Migration TLR4/NF-κB Zhao, Jinmeng verfasserin aut Yao, Qing verfasserin aut Li, Wenqi verfasserin aut Zhi, Wenbing verfasserin aut Zang, Lulu verfasserin aut Liu, Fang verfasserin aut Niu, Xiaofeng verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 60 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:60 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 60 |
| spelling |
10.1016/j.jff.2019.05.047 doi (DE-627)ELV002628716 (ELSEVIER)S1756-4646(19)30312-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Li, Weifeng verfasserin aut Polysaccharides from 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. Polysaccharides from Vascular smooth muscle cells Proliferation Migration TLR4/NF-κB Zhao, Jinmeng verfasserin aut Yao, Qing verfasserin aut Li, Wenqi verfasserin aut Zhi, Wenbing verfasserin aut Zang, Lulu verfasserin aut Liu, Fang verfasserin aut Niu, Xiaofeng verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 60 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:60 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 60 |
| allfields_unstemmed |
10.1016/j.jff.2019.05.047 doi (DE-627)ELV002628716 (ELSEVIER)S1756-4646(19)30312-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Li, Weifeng verfasserin aut Polysaccharides from 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. Polysaccharides from Vascular smooth muscle cells Proliferation Migration TLR4/NF-κB Zhao, Jinmeng verfasserin aut Yao, Qing verfasserin aut Li, Wenqi verfasserin aut Zhi, Wenbing verfasserin aut Zang, Lulu verfasserin aut Liu, Fang verfasserin aut Niu, Xiaofeng verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 60 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:60 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 60 |
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10.1016/j.jff.2019.05.047 doi (DE-627)ELV002628716 (ELSEVIER)S1756-4646(19)30312-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Li, Weifeng verfasserin aut Polysaccharides from 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. Polysaccharides from Vascular smooth muscle cells Proliferation Migration TLR4/NF-κB Zhao, Jinmeng verfasserin aut Yao, Qing verfasserin aut Li, Wenqi verfasserin aut Zhi, Wenbing verfasserin aut Zang, Lulu verfasserin aut Liu, Fang verfasserin aut Niu, Xiaofeng verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 60 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:60 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 60 |
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10.1016/j.jff.2019.05.047 doi (DE-627)ELV002628716 (ELSEVIER)S1756-4646(19)30312-3 DE-627 ger DE-627 rda eng 630 640 610 DE-600 Li, Weifeng verfasserin aut Polysaccharides from 2019 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. Polysaccharides from Vascular smooth muscle cells Proliferation Migration TLR4/NF-κB Zhao, Jinmeng verfasserin aut Yao, Qing verfasserin aut Li, Wenqi verfasserin aut Zhi, Wenbing verfasserin aut Zang, Lulu verfasserin aut Liu, Fang verfasserin aut Niu, Xiaofeng verfasserin aut Enthalten in Journal of functional foods Amsterdam [u.a.] : Elsevier, 2009 60 Online-Ressource (DE-627)587138432 (DE-600)2467241-5 (DE-576)302178430 1756-4646 nnns volume:60 GBV_USEFLAG_U SYSFLAG_U GBV_ELV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 60 |
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Polysaccharides from Vascular smooth muscle cells Proliferation Migration TLR4/NF-κB |
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Li, Weifeng @@aut@@ Zhao, Jinmeng @@aut@@ Yao, Qing @@aut@@ Li, Wenqi @@aut@@ Zhi, Wenbing @@aut@@ Zang, Lulu @@aut@@ Liu, Fang @@aut@@ Niu, Xiaofeng @@aut@@ |
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Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. |
| abstractGer |
Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. |
| abstract_unstemmed |
Vascular smooth muscle cells (VSMCs) proliferation and migration causes the tunica intimal thickening in atherosclerosis. Poria cocos polysaccharides (PCP) is the central active component extracted from Poria cocos, it has remarkable biological functions. However, the role of PCP in atherosclerosis has not been elucidated. In response, we investigated the effect of PCP on ox-LDL-induced VSMCs proliferation and migration. We demonstrate that PCP exerts an inhibitory effect on VSMCs proliferation through G0/G1 cell cycle arrest with the down-regulation of proliferating cell nuclear antigen (PCNA) and cyclinD1. Likewise, the inhibition of metalloproteinase-2 (MMP-2) and intercellular adhesion molecule 1 (ICAM-1) expression might be a mechanism behinds the suppressive effect of PCP on ox-LDL-induced VSMCs migration. PCP also exhibits the same effect to the inhibitor of TLR4/NF-κB on alleviating the expression of p-IκBα, p-NF-κB and TLR4. These results indicate that PCP inhibits ox-LDL-induced VSMCs proliferation and migration through the suppression of TLR4/NF-κB p65 signaling pathway. |
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| score |
7.3982153 |